IL133129A0 - Prenylcysteine carboxyl methyltransferase dna encoding same and a method of screening for inhibistors thereof - Google Patents

Prenylcysteine carboxyl methyltransferase dna encoding same and a method of screening for inhibistors thereof

Info

Publication number
IL133129A0
IL133129A0 IL13312998A IL13312998A IL133129A0 IL 133129 A0 IL133129 A0 IL 133129A0 IL 13312998 A IL13312998 A IL 13312998A IL 13312998 A IL13312998 A IL 13312998A IL 133129 A0 IL133129 A0 IL 133129A0
Authority
IL
Israel
Prior art keywords
inhibistors
screening
carboxyl methyltransferase
dna encoding
encoding same
Prior art date
Application number
IL13312998A
Other languages
English (en)
Original Assignee
Univ New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York filed Critical Univ New York
Publication of IL133129A0 publication Critical patent/IL133129A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL13312998A 1997-06-11 1998-06-11 Prenylcysteine carboxyl methyltransferase dna encoding same and a method of screening for inhibistors thereof IL133129A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4930497P 1997-06-11 1997-06-11
PCT/US1998/012328 WO1998056924A1 (fr) 1997-06-11 1998-06-11 Prenylcysteine carboxyle methyltransferase, adn codant pour celle-ci, et procede de criblage pour rechercher des inhibiteurs de celle-ci

Publications (1)

Publication Number Publication Date
IL133129A0 true IL133129A0 (en) 2001-03-19

Family

ID=21959118

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13312998A IL133129A0 (en) 1997-06-11 1998-06-11 Prenylcysteine carboxyl methyltransferase dna encoding same and a method of screening for inhibistors thereof

Country Status (9)

Country Link
US (3) US6184016B1 (fr)
EP (1) EP1009833B1 (fr)
JP (1) JP2002504827A (fr)
AT (1) ATE380873T1 (fr)
AU (1) AU8142598A (fr)
CA (1) CA2293270A1 (fr)
DE (1) DE69838843D1 (fr)
IL (1) IL133129A0 (fr)
WO (1) WO1998056924A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030181355A1 (en) * 1992-05-29 2003-09-25 Glenn Jeffrey S. Method for inhibition of viral infection
US5503973A (en) * 1992-05-29 1996-04-02 The Regents Of The University Of California Method for inhibition of viral morphogenesis
US20020034725A1 (en) * 1996-04-15 2002-03-21 W. Gillies Mckenna Sensitization of cells to radiation and and chemotherapy
FR2773261B1 (fr) * 1997-12-30 2000-01-28 Commissariat Energie Atomique Procede pour le transfert d'un film mince comportant une etape de creation d'inclusions
EP1071788A1 (fr) * 1998-04-24 2001-01-31 Onyx Pharmaceuticals, Inc. Nouveaux acides nucleiques et polypeptides apparentes a une carboxymethyltransferase cysteine dirigee farnesyl
WO2003006987A1 (fr) * 2000-12-11 2003-01-23 The Salk Institute For Biological Studies Procedes et compositions pour determiner l'activite enzymatique et la specificite des methyltransferases
US20030228688A1 (en) * 2002-05-31 2003-12-11 Isis Pharmaceuticals Inc. Antisense modulation of isoprenylcysteine carboxyl methyltransferase expression
EP2400030B1 (fr) 2004-05-18 2016-01-20 The Board of Trustees of the Leland Stanford Junior University Détection de translocation de protéines par complémentation de fragment de rapporteur béta-galactosidase
WO2014041349A1 (fr) 2012-09-12 2014-03-20 Cancer Therapeutics Crc Pty Ltd Pyrimidines ou pyridazines tétrahydropyran-4-yléthylamino- ou tétrahydropyranyl-4-éthyloxy utiles comme inhibiteurs de l'isoprényl-cystéine-carboxy-méthyl-transférase
EP4282419A1 (fr) 2012-12-20 2023-11-29 Purdue Research Foundation Cellules t exprimant un récepteur d'antigène chimérique et produits thérapeutiques anticancéreux
EP3439675A4 (fr) 2016-04-08 2019-12-18 Purdue Research Foundation Méthodes et compositions pour thérapie par lymphocytes t car
US11649288B2 (en) 2017-02-07 2023-05-16 Seattle Children's Hospital Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
WO2018160622A1 (fr) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions et méthodes de thérapie par lymphocytes t car
US11311576B2 (en) 2018-01-22 2022-04-26 Seattle Children's Hospital Methods of use for CAR T cells
US12312416B2 (en) 2018-02-06 2025-05-27 Seattle Children's Hospital Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors
AU2019225174B2 (en) 2018-02-23 2025-11-20 Endocyte, Inc. Sequencing method for CAR T cell therapy
CN115210252A (zh) 2020-02-04 2022-10-18 西雅图儿童医院（Dba西雅图儿童研究所） 抗二硝基苯酚的嵌合抗原受体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043268A (en) 1990-05-04 1991-08-27 The Trustees Of Princeton University Substrates and inhibitors for prenyl cysteine methyltransferase enzymes
US5202456A (en) 1991-04-15 1993-04-13 The President And Fellows Of Harvard College Compounds for inhibition of protein methylation
DK0692025T3 (da) 1993-03-31 2002-02-11 Cadus Pharmaceutical Corp Gærceller, der er konstrueret således, at de producerer surrogater for proteiner i feromonsystemet, og anvendelser deraf
AU733007B2 (en) 1996-09-24 2001-05-03 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
US5876055A (en) 1998-03-04 1999-03-02 Fontaine; John P. K. Automatic tolerance reducing greaseless fifth wheel using a wedge and jaw locking system that eliminates squirting
EP1071788A1 (fr) 1998-04-24 2001-01-31 Onyx Pharmaceuticals, Inc. Nouveaux acides nucleiques et polypeptides apparentes a une carboxymethyltransferase cysteine dirigee farnesyl

Also Published As

Publication number Publication date
US6184016B1 (en) 2001-02-06
EP1009833A1 (fr) 2000-06-21
US6432403B1 (en) 2002-08-13
AU8142598A (en) 1998-12-30
EP1009833B1 (fr) 2007-12-12
ATE380873T1 (de) 2007-12-15
JP2002504827A (ja) 2002-02-12
DE69838843D1 (de) 2008-01-24
WO1998056924A1 (fr) 1998-12-17
US6232108B1 (en) 2001-05-15
CA2293270A1 (fr) 1998-12-17

Similar Documents

Publication Publication Date Title
IL133129A0 (en) Prenylcysteine carboxyl methyltransferase dna encoding same and a method of screening for inhibistors thereof
EP0799317B8 (fr) Procedes concernant la secretion de polypeptides de thrombopoietine
CY2586B2 (en) Modulators of the function of FAS/APO1 receptors
AU3462899A (en) Sequence and method for genetic engineering of proteins with cell membrane translocating activity
PT672141E (pt) Metodos de preparacao de proteinas oligomericas soluveis
AU4781493A (en) Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
AU1750297A (en) Humanized green fluorescent protein genes and methods
GR3026230T3 (en) Expression of recombinant polypeptides with improved purification
YU47735B (sh) Postupak za sintezu biološki aktivnih polipeptida limfotoksina
EP0329127A3 (en) Novel, signal peptides capable of functioning in yeasts and secretory expression of heterologous proteins using same
IL109262A0 (en) Cell free system for protein synthesis and use of chaperon proteins therein
AU4469885A (en) Detection of cell membrane protein
AU2520595A (en) Virosome-mediated intracellular delivery of therapeutic agents
AR012499A1 (es) Una secuencia quimerica de acido nucleico que codifica una proteina de fusion, un vector de expresion que comprende dicha secuencia quimerica, una celula huesped transformada que contiene dicho vector, la proteina de fusion obtenida y un metodo in vitro para la preparacion de un polipeptido recombin
AU569896B2 (en) Process for the dissolution of peptides and proteins
WO1994025590A3 (fr) Thrichohyaline et transglutaminase-3 et procedes d'utilisation
TR200200048T2 (tr) Otoproteolitik klevaj vasıtasıyla proteinlerin üretimi.
GB9816514D0 (en) Novel method
ZA978503B (en) Vertebrate smoothened proteins
WO2000018909A3 (fr) Acides nucleiques et proteines provenant de cenarchaeum symbiosum
AU5657794A (en) Identification of compounds modulations protein/cell membrane association
AU8991098A (en) Regulation of protein secretion
Sandell et al. The molecular weight of the cell-free translation product of αl (I) procollagen mRNA
GB9309513D0 (en) Electrochemical method of modifying biomolecules in particular proteins
ZA944731B (en) Hellcobacter pylorl haemagglutinin/protease protein nucleic acid encoding therefor and antibodies specific thereto