DK0692025T3 - Gærceller, der er konstrueret således, at de producerer surrogater for proteiner i feromonsystemet, og anvendelser deraf - Google Patents

Gærceller, der er konstrueret således, at de producerer surrogater for proteiner i feromonsystemet, og anvendelser deraf

Info

Publication number: DK0692025T3
Authority: DK; Denmark
Prior art keywords: yeast cells; surrogate; surrogates; proteins; produce
Prior art date: 1993-03-31

Application number

DK94912292T

Other languages

English (en)

Inventor

Dana Merriman Fowlkes

Jim Broach

John Manfredi

Christine Klein

Andrew J Murphy

Jeremy Paul

Joshua Trueheart

Original Assignee

Cadus Pharmaceutical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-31

Filing date

1994-03-23

Publication date

2002-02-11

1994-03-23 Application filed by Cadus Pharmaceutical Corp filed Critical Cadus Pharmaceutical Corp

2002-02-11 Application granted granted Critical

2002-02-11 Publication of DK0692025T3 publication Critical patent/DK0692025T3/da

Links

210000005253 yeast cell Anatomy 0.000 title abstract 3
239000003016 pheromone Substances 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 title abstract 2
102000004169 proteins and genes Human genes 0.000 title abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
108010038049 Mating Factor Proteins 0.000 abstract 1
101800001357 Potential peptide Proteins 0.000 abstract 1
102400000745 Potential peptide Human genes 0.000 abstract 1
102100038344 Vomeronasal type-1 receptor 2 Human genes 0.000 abstract 1
IXKSXJFAGXLQOQ-XISFHERQSA-N WHWLQLKPGQPMY Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 IXKSXJFAGXLQOQ-XISFHERQSA-N 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
239000002427 pheromone receptor Substances 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Mycology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cash Registers Or Receiving Machines (AREA)
Inspection Of Paper Currency And Valuable Securities (AREA)
Investigating Or Analysing Biological Materials (AREA)

DK94912292T 1993-03-31 1994-03-23 Gærceller, der er konstrueret således, at de producerer surrogater for proteiner i feromonsystemet, og anvendelser deraf DK0692025T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US4143193A	1993-03-31	1993-03-31
US19032894A	1994-01-31	1994-01-31
PCT/US1994/003143 WO1994023025A1 (en)	1993-03-31	1994-03-23	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor

Publications (1)

Publication Number	Publication Date
DK0692025T3 true DK0692025T3 (da)	2002-02-11

Family

ID=26718132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94912292T DK0692025T3 (da)	1993-03-31	1994-03-23	Gærceller, der er konstrueret således, at de producerer surrogater for proteiner i feromonsystemet, og anvendelser deraf

Country Status (10)

Country	Link
EP (2)	EP0915154A1 (da)
JP (3)	JPH08510115A (da)
AT (1)	ATE207118T1 (da)
AU (2)	AU685103B2 (da)
CA (1)	CA2158274C (da)
DE (1)	DE69428689T2 (da)
DK (1)	DK0692025T3 (da)
ES (1)	ES2166371T3 (da)
PT (1)	PT692025E (da)
WO (1)	WO1994023025A1 (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5876951A (en) *	1993-03-31	1999-03-02	Cadus Pharmaceutical Corporation	Yeast cells engineered to produce pheromone system protein surrogates and uses therefor
US7416881B1 (en)	1993-03-31	2008-08-26	Cadus Technologies, Inc.	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US6864060B1 (en)	1993-03-31	2005-03-08	Cadus Technologies, Inc.	Yeast cells expressing modified G proteins and methods of use therefor
US5789184A (en) *	1993-03-31	1998-08-04	Cadus Pharmaceutical Corporation	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US20030054402A1 (en)	1993-03-31	2003-03-20	Cadus Pharmaceutical Corporation	Methods and compositions for identifying receptor effectors
US6255059B1 (en)	1993-03-31	2001-07-03	Cadus Pharmaceutical Corporation	Methods for identifying G protein coupled receptor effectors
US7235648B1 (en)	1993-03-31	2007-06-26	Cadus Technologies, Inc.	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US6100042A (en)	1993-03-31	2000-08-08	Cadus Pharmaceutical Corporation	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US5691188A (en)	1994-02-14	1997-11-25	American Cyanamid Company	Transformed yeast cells expressing heterologous G-protein coupled receptor
CA2188950C (en) *	1994-04-26	2001-07-03	James R. Broach	Functional expression of mammalian adenylyl cyclase in yeast
CA2219136A1 (en) *	1995-04-24	1996-10-31	Chromaxome Corp.	Methods for generating and screening novel metabolic pathways
AU6110896A (en) *	1995-06-07	1996-12-30	Cadus Pharmaceutical Corporation	Expression of functional vertebrate phospholipases in yeast
EP0862614A1 (en) *	1995-09-20	1998-09-09	Molecular Geriatrics Corporation	Yeast receptor and g-protein fusion protein
AU3055697A (en) *	1996-04-23	1997-11-12	Cadus Pharmaceutical Corporation	Functional expression of heterologous adenylyl cyclase
US6242211B1 (en)	1996-04-24	2001-06-05	Terragen Discovery, Inc.	Methods for generating and screening novel metabolic pathways
US5783431A (en) *	1996-04-24	1998-07-21	Chromaxome Corporation	Methods for generating and screening novel metabolic pathways
CA2252886C (en) *	1996-04-26	2008-02-12	Massachusetts Institute Of Technology	Three-hybrid screening assay
AU733007B2 (en) *	1996-09-24	2001-05-03	Cadus Pharmaceutical Corporation	Methods and compositions for identifying receptor effectors
CA2293270A1 (en)	1997-06-11	1998-12-17	New York University	Prenylcysteine carboxyl methyltransferase, dna encoding same, and a method of screening for inhibitors thereof
JP2001519157A (ja) *	1997-10-07	2001-10-23	ケイダスファーマスーティカルコーポレイション	改変ｇ蛋白質を発現する酵母細胞及びそれらの利用方法
US6355473B1 (en)	1998-05-06	2002-03-12	Cadus Pharmaceutical Corp.	Yeast cells having mutations in stp22 and uses therefor
US6733991B1 (en)	1998-05-08	2004-05-11	Osi Pharmaceuticals, Inc.	AGS proteins and nucleic acid molecules and uses therefor
US6746852B1 (en)	1998-05-08	2004-06-08	Osi Pharmaceuticals, Inc.	AGS proteins and nucleic acid molecules and uses thereof
WO1999058670A1 (en) *	1998-05-08	1999-11-18	Cadus Pharmaceutical Corporation	Ags proteins and nucleic acid molecules and uses therefor
US20020015967A1 (en) *	1998-06-02	2002-02-07	Lauren Silverman	Functional expression of adenosine receptors in yeast
US7081360B2 (en)	1998-07-28	2006-07-25	Cadus Technologies, Inc.	Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
US7273747B2 (en)	1998-08-27	2007-09-25	Cadus Technologies, Inc.	Cell having amplified signal transduction pathway responses and uses therefor
US6251605B1 (en)	1998-10-27	2001-06-26	Cadus Pharmaceutical Corporation	Yeast cells having mutations in Cav1 and uses therefor
AU2030000A (en)	1998-11-25	2000-06-13	Cadus Pharmaceutical Corporation	Methods and compositions for identifying receptor effectors
US6504008B1 (en)	1999-02-01	2003-01-07	Cadus Technologies, Inc.	Cell based signal generation
US6555325B1 (en)	1999-06-14	2003-04-29	Cadus Technologies, Inc.	System for detection of a functional interaction between a compound and a cellular signal transduction component
US7223533B2 (en)	1999-09-10	2007-05-29	Cadus Technologies, Inc.	Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways
GB0030038D0 (en) *	2000-12-08	2001-01-24	Univ Warwick	Yeast-based assay
ATE497603T1 (de)	2001-03-02	2011-02-15	Gpc Biotech Ag	Drei-hybrid-assaysystem
NZ513755A (en) *	2001-08-24	2001-09-28	Ann Rachel Holmes	Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
AU2013212008A1 (en) *	2012-01-25	2014-07-10	Alfa Wassermann S.P.A.	Rifaximin derivative and uses thereof
EP3844273A1 (en) *	2018-08-29	2021-07-07	Amyris, Inc.	Cells and methods for selection based assay
CN109593773B (zh) *	2018-11-22	2021-07-30	北京利德曼生化股份有限公司	一种应用酵母表达系统表达可溶性生长刺激表达基因2蛋白的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1988010308A1 (en) *	1987-06-24	1988-12-29	Whitehead Institute For Biomedical Research	Pheromone-inducible yeast promoter
US5284746A (en) *	1990-02-08	1994-02-08	Zymogenetics, Inc.	Methods of producing hybrid G protein-coupled receptors
DK0548165T3 (da) *	1990-09-13	2001-07-16	Univ Duke	Ekspression af G-proteinkoblede receptorer i gær

1994
- 1994-03-23 DK DK94912292T patent/DK0692025T3/da active
- 1994-03-23 AU AU64909/94A patent/AU685103B2/en not_active Expired
- 1994-03-23 ES ES94912292T patent/ES2166371T3/es not_active Expired - Lifetime
- 1994-03-23 PT PT94912292T patent/PT692025E/pt unknown
- 1994-03-23 DE DE69428689T patent/DE69428689T2/de not_active Expired - Fee Related
- 1994-03-23 CA CA002158274A patent/CA2158274C/en not_active Expired - Fee Related
- 1994-03-23 WO PCT/US1994/003143 patent/WO1994023025A1/en not_active Ceased
- 1994-03-23 AT AT94912292T patent/ATE207118T1/de not_active IP Right Cessation
- 1994-03-23 EP EP98202997A patent/EP0915154A1/en not_active Withdrawn
- 1994-03-23 JP JP6522167A patent/JPH08510115A/ja active Pending
- 1994-03-23 EP EP94912292A patent/EP0692025B1/en not_active Expired - Lifetime
1998
- 1998-04-23 AU AU63541/98A patent/AU6354198A/en not_active Abandoned
2004
- 2004-07-13 JP JP2004206397A patent/JP2004357713A/ja active Pending
- 2004-07-14 JP JP2004207300A patent/JP2004337174A/ja active Pending

Also Published As

Publication number	Publication date
JP2004337174A (ja)	2004-12-02
PT692025E (pt)	2002-04-29
JP2004357713A (ja)	2004-12-24
AU685103B2 (en)	1998-01-15
EP0915154A1 (en)	1999-05-12
AU6490994A (en)	1994-10-24
DE69428689D1 (de)	2001-11-22
EP0692025B1 (en)	2001-10-17
EP0692025A1 (en)	1996-01-17
DE69428689T2 (de)	2002-08-08
JPH08510115A (ja)	1996-10-29
ES2166371T3 (es)	2002-04-16
CA2158274C (en)	2000-05-30
CA2158274A1 (en)	1994-10-13
AU6354198A (en)	1998-07-09
ATE207118T1 (de)	2001-11-15
WO1994023025A1 (en)	1994-10-13

Publication	Publication Date	Title
DK0692025T3 (da)	2002-02-11	Gærceller, der er konstrueret således, at de producerer surrogater for proteiner i feromonsystemet, og anvendelser deraf
NO961115L (no)	1996-03-19	Humane metabotrope glutamatreseptorsubtyper (HMR4, HMR6, HMR7) og relaterte DNA forbindelser
ATE290020T1 (de)	2005-03-15	Löslicher t zell rezeptor
ATE186551T1 (de)	1999-11-15	Medikamente bindendes protein
ES2149149T1 (es)	2000-11-01	Proteinas de fijacion de interleuquina-18, su preparacion y utilizacion.
ATE529509T1 (de)	2011-11-15	Selektion von proteinen unter verwendung von rna- protein-fusionen
ATE342915T1 (de)	2006-11-15	Chimäres lösliches interleukin-6 rezeptor/ligand protein, analoge und verwendungen
DK1140173T4 (da)	2013-06-10	Vaskulære endothelcellevækstfaktorantagonister og anvendelser deraf
GB9921155D0 (en)	1999-11-10	Selection system
AU6914798A (en)	1998-10-30	Compounds and methods for inhibiting the interaction between alpha-catenin and beta-catenin
ATE250426T1 (de)	2003-10-15	Verwendung von verbindungen die an ein zytoplasmatischen dipeptidase binden zur potenzierung des immunantworts
DE69703449D1 (de)	2000-12-07	Neuroaktive peptide
NO980198L (no)	1998-03-09	Modulatorer av funksjonen til FAS-reseptorer og andre proteiner
TR200001313T2 (tr)	2002-06-21	Protein etkileşimlerini ve fonksiyonel ilişkileri kaydeden tarama sistemleri
ATE311443T1 (de)	2005-12-15	Methoden zur durchforstung (screenen) von proteinen
DK0641861T3 (da)	2003-07-28	Fremgangsmåde til fremstilling af hydrofobe polypeptider, proteiner eller peptider
TR199800214T1 (xx)	1998-06-22	Allerjen-XCD32 f�zyon proteinler.
DE69315989D1 (de)	1998-02-05	Aminoterminale prokollagen 1(i) peptide
FI943218A7 (fi)	1994-07-05	Kaseinomakropeptidin peptidit, mainittujen peptidien vasta-aineet ja k äytöt
CA2199403A1 (en)	1997-02-06	Novel PKA-Binding Proteins and Uses Thereof
DE69826029D1 (de)	2004-10-07	Acetyl-coa-carboxylase von candida albicans
FR2762602B1 (fr)	1999-06-04	Moyens pour la detection precoce de pathologies auto-immunes inflammatoires
EP0600278A3 (en)	1995-01-25	Protein and gene of the glutamate receptor.
WO1996023883A3 (en)	1996-11-28	Modified ligands for receptor tyrosine kinases
DK1019500T3 (da)	2007-02-19	IFN receptor 1-bindende proteiner, DNA, som koder for dem, og fremgangsmåder til modulering af cellulært respons på interferoner