IL133390A0 - Benzo (5, 6) cyclohepta (1, 2b) pyridine derivatives useful for inhibition of farnesyl protein transferase - Google Patents

Benzo (5, 6) cyclohepta (1, 2b) pyridine derivatives useful for inhibition of farnesyl protein transferase

Info

Publication number: IL133390A0
Authority: IL; Israel
Prior art keywords: aryl; alkyl; aralkyl; heteroaryl; protein transferase
Prior art date: 1997-06-17

Application number

IL13339098A

Other languages

English (en)

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-17

Filing date

1998-06-15

Publication date

2001-04-30

1998-06-15 Application filed by Schering Corp filed Critical Schering Corp

2001-04-30 Publication of IL133390A0 publication Critical patent/IL133390A0/xx

Links

102000004357 Transferases Human genes 0.000 title abstract 2
108090000992 Transferases Proteins 0.000 title abstract 2
125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
PTRWZUIFMORETL-UHFFFAOYSA-N 4-azatricyclo[9.4.0.03,8]pentadeca-1(15),2,5,7,9,11,13-heptaene Chemical class C1=CC2=CC=CC=C2C=C2NC=CC=C21 PTRWZUIFMORETL-UHFFFAOYSA-N 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000003710 aryl alkyl group Chemical group 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 5
125000001072 heteroaryl group Chemical group 0.000 abstract 4
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IL13339098A 1997-06-17 1998-06-15 Benzo (5, 6) cyclohepta (1, 2b) pyridine derivatives useful for inhibition of farnesyl protein transferase IL133390A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US87767397A	1997-06-17	1997-06-17
PCT/US1998/011498 WO1998057962A1 (fr)	1997-06-17	1998-06-15	Derives de benzo(5,6)cyclohepta(1,2-b)pyridine inhibiteurs de la farnesyl proteine transferase

Publications (1)

Publication Number	Publication Date
IL133390A0 true IL133390A0 (en)	2001-04-30

Family

ID=25370476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13339098A IL133390A0 (en)	1997-06-17	1998-06-15	Benzo (5, 6) cyclohepta (1, 2b) pyridine derivatives useful for inhibition of farnesyl protein transferase

Country Status (13)

Country	Link
EP (1)	EP0993460B1 (fr)
JP (1)	JP2002504147A (fr)
KR (1)	KR20010013828A (fr)
CN (1)	CN1172932C (fr)
AT (1)	ATE276247T1 (fr)
AU (1)	AU753533B2 (fr)
CA (1)	CA2293372C (fr)
DE (1)	DE69826281T2 (fr)
ES (1)	ES2226142T3 (fr)
HU (1)	HUP0004806A3 (fr)
IL (1)	IL133390A0 (fr)
NZ (1)	NZ501615A (fr)
WO (1)	WO1998057962A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7645771B2 (en) *	2002-12-13	2010-01-12	Smithkline Beecham Corp.	CCR5 antagonists as therapeutic agents
DE10334493B4 (de) *	2003-07-29	2006-01-05	Klingelnberg Gmbh	Verfahren zum Fräsen von Spiralkegelrädern
WO2019142900A1 (fr) *	2018-01-19	2019-07-25	有機合成薬品工業株式会社	Procédé de fabrication de dérivé de n-alcoxycarbonylpipéridine, et intermédiaire de celui-ci

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5089496A (en) *	1986-10-31	1992-02-18	Schering Corporation	Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
WO1989010369A1 (fr) *	1988-04-28	1989-11-02	Schering Corporation	Nouveaux composes, compositions, procedes de fabrication et d'utilisation de benzopyrido piperidine, piperidylidene et piperazine
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) *	1993-10-15	1998-02-17	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

1998
- 1998-06-15 CN CNB988082055A patent/CN1172932C/zh not_active Expired - Fee Related
- 1998-06-15 NZ NZ501615A patent/NZ501615A/en unknown
- 1998-06-15 ES ES98926278T patent/ES2226142T3/es not_active Expired - Lifetime
- 1998-06-15 WO PCT/US1998/011498 patent/WO1998057962A1/fr not_active Ceased
- 1998-06-15 DE DE69826281T patent/DE69826281T2/de not_active Expired - Lifetime
- 1998-06-15 JP JP50449399A patent/JP2002504147A/ja not_active Ceased
- 1998-06-15 EP EP98926278A patent/EP0993460B1/fr not_active Expired - Lifetime
- 1998-06-15 KR KR1019997011848A patent/KR20010013828A/ko not_active Ceased
- 1998-06-15 AT AT98926278T patent/ATE276247T1/de not_active IP Right Cessation
- 1998-06-15 CA CA002293372A patent/CA2293372C/fr not_active Expired - Fee Related
- 1998-06-15 AU AU78153/98A patent/AU753533B2/en not_active Ceased
- 1998-06-15 HU HU0004806A patent/HUP0004806A3/hu unknown
- 1998-06-15 IL IL13339098A patent/IL133390A0/xx unknown

Also Published As

Publication number	Publication date
AU7815398A (en)	1999-01-04
HUP0004806A2 (hu)	2001-10-28
ES2226142T3 (es)	2005-03-16
AU753533B2 (en)	2002-10-17
CA2293372A1 (fr)	1998-12-23
CN1172932C (zh)	2004-10-27
WO1998057962A1 (fr)	1998-12-23
KR20010013828A (ko)	2001-02-26
HUP0004806A3 (en)	2002-11-28
CN1267298A (zh)	2000-09-20
DE69826281D1 (de)	2004-10-21
JP2002504147A (ja)	2002-02-05
EP0993460A1 (fr)	2000-04-19
ATE276247T1 (de)	2004-10-15
HK1028238A1 (en)	2001-02-09
NZ501615A (en)	2002-02-01
EP0993460B1 (fr)	2004-09-15
CA2293372C (fr)	2009-01-13
DE69826281T2 (de)	2005-11-17

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