IL134647A0 - Tie receptor tyrosine kinase ligand homologues - Google Patents

Tie receptor tyrosine kinase ligand homologues

Info

Publication number
IL134647A0
IL134647A0 IL13464798A IL13464798A IL134647A0 IL 134647 A0 IL134647 A0 IL 134647A0 IL 13464798 A IL13464798 A IL 13464798A IL 13464798 A IL13464798 A IL 13464798A IL 134647 A0 IL134647 A0 IL 134647A0
Authority
IL
Israel
Prior art keywords
tyrosine kinase
receptor tyrosine
ligand homologues
tie receptor
kinase ligand
Prior art date
Application number
IL13464798A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL134647A0 publication Critical patent/IL134647A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL13464798A 1997-09-19 1998-09-14 Tie receptor tyrosine kinase ligand homologues IL134647A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/934,494 US6030831A (en) 1997-09-19 1997-09-19 Tie ligand homologues
PCT/US1998/019094 WO1999015654A2 (fr) 1997-09-19 1998-09-14 Homologues du ligand 'tie' du type tyrosine kinase receptrice

Publications (1)

Publication Number Publication Date
IL134647A0 true IL134647A0 (en) 2001-04-30

Family

ID=25465645

Family Applications (3)

Application Number Title Priority Date Filing Date
IL13464798A IL134647A0 (en) 1997-09-19 1998-09-14 Tie receptor tyrosine kinase ligand homologues
IL177638A IL177638A0 (en) 1997-09-19 2006-08-22 Tie receptor tyrosine kinase ligand homologues
IL187847A IL187847A (en) 1997-09-19 2007-12-03 Nl6 polypeptides, nucleic acid molecules encoding them, antibodies directed thereto, compositions and conjugates thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL177638A IL177638A0 (en) 1997-09-19 2006-08-22 Tie receptor tyrosine kinase ligand homologues
IL187847A IL187847A (en) 1997-09-19 2007-12-03 Nl6 polypeptides, nucleic acid molecules encoding them, antibodies directed thereto, compositions and conjugates thereof

Country Status (16)

Country Link
US (3) US6030831A (fr)
EP (3) EP1482040B1 (fr)
JP (3) JP3668795B2 (fr)
KR (3) KR100467186B1 (fr)
AT (3) ATE435912T1 (fr)
AU (1) AU744285B2 (fr)
CA (1) CA2304810C (fr)
CY (1) CY1105248T1 (fr)
DE (3) DE69833670T2 (fr)
DK (3) DK1482041T3 (fr)
ES (2) ES2260848T3 (fr)
IL (3) IL134647A0 (fr)
NZ (1) NZ502945A (fr)
PT (2) PT1015586E (fr)
WO (1) WO1999015654A2 (fr)
ZA (1) ZA988392B (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057435A (en) * 1997-09-19 2000-05-02 Genentech, Inc. Tie ligand homologues
US7169906B2 (en) 1997-09-17 2007-01-30 Genentech, Inc. PRO211 polypeptides
US20030054400A1 (en) * 1997-09-17 2003-03-20 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6974689B1 (en) * 1997-09-18 2005-12-13 Genentech, Inc. Nucleic acid encoding PRO211 polypeptides
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
WO1999032515A2 (fr) * 1997-12-19 1999-07-01 Zymogenetics, Inc. Homologue de l'angiopoietine, adn le codant et procede de production dudit homologue
US6706869B1 (en) * 1998-02-11 2004-03-16 Wyeth Map kinase phosphatases and polynucleotides encoding them
IL138216A0 (en) * 1998-03-02 2001-10-31 Millennium Pharm Inc Novel fdrg protein and nucleic acid molecules and uses therefor
US20030099994A1 (en) * 1998-03-02 2003-05-29 Millennium Pharamceuticals, Inc. Novel FDRG protein and nucleic acid molecules and uses therefor
WO1999055869A1 (fr) * 1998-04-27 1999-11-04 Zymogenetics, Inc. Nouveaux facteurs et materiels de croissance polypeptidiques et leurs procedes de production
SV1999000069A (es) * 1998-06-02 2000-04-11 Lilly Co Eli Angiopoyetina relacionada con secuencia del gen 3 en la cicatrizacion de la cara ref. x-12261
AU4643699A (en) * 1998-06-24 2000-01-10 Compugen Ltd. Angiopoietin-like growth factor sequences
US7488590B2 (en) * 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
JP3993746B2 (ja) * 1998-12-22 2007-10-17 ジェネンテック・インコーポレーテッド 腫瘍性細胞成長阻害のための組成物及び方法
ATE363489T1 (de) * 1999-03-08 2007-06-15 Genentech Inc In tumoren vervielfältigte gensequenzen und deren diagnostische verwendungen
EP1159419A1 (fr) * 1999-03-08 2001-12-05 Genentech, Inc. Activation et inhibition de l'angiogenese et de la cardiovascularisation
EP1179541B1 (fr) 1999-04-28 2004-06-16 Board Of Regents, The University Of Texas System Compositions et procédes de traitment du cancer par l'inhibition sélective du VEGF
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
WO2001002429A2 (fr) * 1999-07-02 2001-01-11 Bayer Aktiengesellschaft Angiopoietine 6 et ses utilisations
CA2379152A1 (fr) * 1999-07-16 2001-01-25 Hyseq, Inc. Nouveaux procedes et materiaux des angiopoietines
EP1196576A2 (fr) * 1999-07-20 2002-04-17 Curagen Corporation Polypeptides secretes et polynucleotides correspondants
AU4011300A (en) * 1999-07-20 2001-02-05 Genentech Inc. Compositions and methods for the treatment of immune related diseases
EP1484401A1 (fr) * 1999-07-20 2004-12-08 Curagen Corporation Protéines secrètées et polynicleotides correspondant
US7001766B2 (en) * 1999-07-20 2006-02-21 Curagen Corporation Nucleic acid sequences encoding human angiopoietin-like polypeptides
WO2001042499A1 (fr) * 1999-12-09 2001-06-14 Sankyo Company, Limited Procede d'essai d'agent curatif ou preventif de l'hyperlipemie
AU2001244509A1 (en) * 2000-03-30 2001-10-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treatment of conditions involving obstruction of blood flow
US20060073549A1 (en) * 2000-09-05 2006-04-06 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU2002232439A1 (en) * 2000-11-29 2002-06-11 Glaxo Group Limited Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US20030148952A1 (en) * 2001-10-18 2003-08-07 Crombleholme Timothy M. Methods and materials for the recruitment of endothelial cells
US20050123925A1 (en) * 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US20040067882A1 (en) * 2001-10-22 2004-04-08 Alsobrook John P. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
JP5105696B2 (ja) * 2001-11-16 2012-12-26 ジェネンテック， インコーポレイテッド アンジオポエチン様タンパク質３Ａｎｇｐｔｌ３含有組成物とその使用方法
AU2002359464A1 (en) * 2001-11-30 2003-06-17 Genvec, Inc. Angiopioetin related factors
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
GB0423554D0 (en) * 2004-10-22 2004-11-24 Cancer Rec Tech Ltd Therapeutic compounds
US20080119367A1 (en) * 2004-12-17 2008-05-22 Mayo Foundation For Medical Education And Research Prognosis of Renal Cell Carcinoma
GB0428082D0 (en) * 2004-12-22 2005-01-26 Welcome Trust The Ltd Therapeutic compounds
AU2007245495A1 (en) 2006-04-26 2007-11-08 Astex Therapeutics Limited Imidazo[4, 5-b]pyridin-2-one and oxazolo[4, 5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
PL2121751T3 (pl) * 2006-12-08 2017-07-31 Lexicon Pharmaceuticals, Inc. Przeciwciała monoklonalne przeciwko ANGPTL3
AU2008337286B2 (en) * 2007-12-19 2014-08-07 Cancer Research Technology Limited Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
GB0807609D0 (en) * 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use
NZ601085A (en) 2010-02-01 2015-04-24 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
AR087329A1 (es) 2011-06-17 2014-03-19 Regeneron Pharma Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana
US9301971B2 (en) 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
JO3564B1 (ar) * 2013-03-08 2020-07-05 Novartis Ag ببتيدات وتركيبات لعلاج ضرر المفاصل
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
WO2016020880A2 (fr) 2014-08-07 2016-02-11 Novartis Ag Anticorps de l'angiopoïétine-like 4 et procédés d'utilisation correspondants
WO2016020882A2 (fr) 2014-08-07 2016-02-11 Novartis Ag Anticorps de type angiopoétine 4 (angptl4) et procédés d'utilisation
JP7541810B2 (ja) 2016-03-03 2024-08-29 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ａｎｇｐｔｌ３阻害剤と組み合わせてｐｃｓｋ９阻害剤を投与することにより高脂血症を有する患者を処置するための方法
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
US12559551B2 (en) 2019-05-24 2026-02-24 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-ANGPTL3 antibodies

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229495A (en) * 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
US5955291A (en) * 1992-01-09 1999-09-21 Alitalo; Kari Antibodies recognizing tie receptor tyrosine kinase and uses thereof
JPH07506242A (ja) * 1992-01-09 1995-07-13 ヘルシンキ　ユニバーシティ　ホルディング　リミテッド Ｔｉｅ，新規内皮細胞受容体チロシンキナーゼ
WO1994000469A1 (fr) * 1992-06-26 1994-01-06 Immunex Corporation Nouvelle tyrosine kinase
AU8143094A (en) * 1993-11-12 1995-05-29 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. (tie-2), a novel receptor tyrosine kinase
US5643755A (en) * 1994-10-07 1997-07-01 Regeneron Pharmaceuticals Inc. Nucleic acid encoding tie-2 ligand
AUPM379494A0 (en) * 1994-02-10 1994-03-03 Ludwig Institute For Cancer Research Immunointeractive molecules - ii
DE69534180T2 (de) * 1994-09-22 2006-03-02 Licentia Ltd. Promotor der tie rezeptor protein kinase
US5650490A (en) * 1994-10-07 1997-07-22 Regeneron Pharmaceuticals, Inc. Tie-2 ligand 2
US5814464A (en) * 1994-10-07 1998-09-29 Regeneron Pharma Nucleic acids encoding TIE-2 ligand-2
WO1996031598A1 (fr) * 1995-04-06 1996-10-10 Regeneron Pharmaceuticals, Inc. Ligands tie-2, procedes d'obtention de ces ligands et leurs utilisations
JP2000513932A (ja) * 1996-06-19 2000-10-24 リジェネロン ファーマシューティカルズ，インコーポレイテッド Ｔｉｅ―２レセプターリガンド（ｔｉｅリガンド―３；ｔｉｅリガンド―４）およびそれらの使用
US6265564B1 (en) * 1996-08-02 2001-07-24 Regeneron Pharmaceuticals, Inc. Expressed ligand-vascular intercellular signalling molecule
US5972338A (en) * 1997-09-19 1999-10-26 Genentech, Inc. Tie ligands homologues
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
WO1999055869A1 (fr) * 1998-04-27 1999-11-04 Zymogenetics, Inc. Nouveaux facteurs et materiels de croissance polypeptidiques et leurs procedes de production
SV1999000069A (es) * 1998-06-02 2000-04-11 Lilly Co Eli Angiopoyetina relacionada con secuencia del gen 3 en la cicatrizacion de la cara ref. x-12261
AU4643699A (en) * 1998-06-24 2000-01-10 Compugen Ltd. Angiopoietin-like growth factor sequences

Also Published As

Publication number Publication date
ATE329028T1 (de) 2006-06-15
JP2001517438A (ja) 2001-10-09
IL187847A (en) 2011-06-30
KR20010024143A (ko) 2001-03-26
JP3668795B2 (ja) 2005-07-06
ES2260848T3 (es) 2006-11-01
PT1015586E (pt) 2006-07-31
JP2005185284A (ja) 2005-07-14
KR20040097229A (ko) 2004-11-17
PT1482040E (pt) 2006-10-31
DE69833670D1 (de) 2006-04-27
JP4239018B2 (ja) 2009-03-18
AU744285B2 (en) 2002-02-21
US6074873A (en) 2000-06-13
EP1482041B1 (fr) 2009-07-08
JP2005176848A (ja) 2005-07-07
DE69834852D1 (de) 2006-07-20
EP1482040B1 (fr) 2006-06-07
NZ502945A (en) 2001-11-30
DE69833670T2 (de) 2006-09-21
KR100467186B1 (ko) 2005-01-24
DE69834852T2 (de) 2007-05-24
EP1482041A1 (fr) 2004-12-01
ATE435912T1 (de) 2009-07-15
WO1999015654A3 (fr) 1999-10-21
ES2268538T3 (es) 2007-03-16
DK1482041T3 (da) 2009-11-02
IL187847A0 (en) 2008-03-20
EP1015586B1 (fr) 2006-03-01
DK1015586T3 (da) 2006-07-03
EP1482040A3 (fr) 2004-12-08
US6348351B1 (en) 2002-02-19
US6030831A (en) 2000-02-29
ZA988392B (en) 2000-03-22
ATE318905T1 (de) 2006-03-15
AU9388198A (en) 1999-04-12
DE69840966D1 (de) 2009-08-20
KR20040097230A (ko) 2004-11-17
EP1015586A2 (fr) 2000-07-05
EP1482040A2 (fr) 2004-12-01
CA2304810C (fr) 2011-05-10
CY1105248T1 (el) 2010-03-03
KR100472262B1 (ko) 2005-03-07
KR100467185B1 (ko) 2005-01-24
DK1482040T3 (da) 2006-10-02
CA2304810A1 (fr) 1999-04-01
IL177638A0 (en) 2006-12-31
WO1999015654A2 (fr) 1999-04-01

Similar Documents

Publication Publication Date Title
IL187847A0 (en) Tie receptor tyrosine kinase ligand homologues
WO1999015653A3 (fr) Homologues du ligand 'tie'
WO2000001815A3 (fr) Facteurs neurotrophiques
IL180967A0 (en) Human toll homologues
WO2000018914A3 (fr) NOUVEAUX POLYPEPTIDES $i(DKR)
WO2000024771A3 (fr) Acides nucleiques codant pour des proteines semblables a l'osteoprotegerine et methodes d'utilisation associees
EP0885965A3 (fr) Polypeptides de la kinase de l'histidine
EP0892059A3 (fr) Polypeptides de la kinase de l'histidine
WO2000031254A3 (fr) Facteur d'induction de l'apoptose
EP0927763A3 (fr) Nouvelle aroA
IL142664A0 (en) Prv-1 gene, processes for detecting the prv-1 polypeptide and pharmaceutical compositions containing the same
AU3667397A (en) Recombinant n-proteinase, and the production, methods and uses thereof
EP0835936A3 (fr) Synthétase d'arginyl ARNt
WO2000002912A3 (fr) Homologues de disintegrine
DE69535039D1 (de) Cytoplasmische tyrosin kinase
EP0893501A3 (fr) Protéine de transport de ferrichrome liant l'ATP
EP0911405A3 (fr) Gapdh

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired