IL135284A - Method and reagents for n-alkylating ureides - Google Patents
Method and reagents for n-alkylating ureidesInfo
- Publication number
- IL135284A IL135284A IL13528498A IL13528498A IL135284A IL 135284 A IL135284 A IL 135284A IL 13528498 A IL13528498 A IL 13528498A IL 13528498 A IL13528498 A IL 13528498A IL 135284 A IL135284 A IL 135284A
- Authority
- IL
- Israel
- Prior art keywords
- reagents
- ureides
- methoxymethyl
- alkylating
- alkylating ureides
- Prior art date
Links
- 150000007945 N-acyl ureas Chemical class 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- SQCVEQVZGPHNTJ-UHFFFAOYSA-N 1-(methoxymethyl)-5,5-diphenyl-1,3-diazinane-2,4,6-trione Chemical compound O=C1N(COC)C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 SQCVEQVZGPHNTJ-UHFFFAOYSA-N 0.000 abstract 1
- 229960002767 ethosuximide Drugs 0.000 abstract 1
- 229960002972 glutethimide Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/942,636 US6093820A (en) | 1997-10-02 | 1997-10-02 | Method and reagents for N-alkylating ureides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL135284A true IL135284A (en) | 2005-11-20 |
Family
ID=25478386
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13528498A IL135284A (en) | 1997-10-02 | 1998-10-02 | Method and reagents for n-alkylating ureides |
| IL16508004A IL165080A0 (en) | 1997-10-02 | 2004-11-07 | Method and reagents for n-alkylating ureides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16508004A IL165080A0 (en) | 1997-10-02 | 2004-11-07 | Method and reagents for n-alkylating ureides |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6093820A (da) |
| EP (2) | EP1027339B1 (da) |
| JP (2) | JP4061018B2 (da) |
| CN (2) | CN1193019C (da) |
| AT (2) | ATE299500T1 (da) |
| AU (1) | AU758506B2 (da) |
| CA (1) | CA2304970C (da) |
| DE (2) | DE69820895T2 (da) |
| DK (2) | DK1027339T3 (da) |
| ES (2) | ES2214736T3 (da) |
| IL (2) | IL135284A (da) |
| PT (2) | PT1342718E (da) |
| WO (1) | WO1999018084A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093820A (en) * | 1997-10-02 | 2000-07-25 | Taro Pharmaceutical Industries Ltd. | Method and reagents for N-alkylating ureides |
| US7683071B2 (en) * | 2000-07-26 | 2010-03-23 | Taro Pharmaceuticals Industries Ltd. | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
| US6939873B2 (en) * | 2000-07-26 | 2005-09-06 | Taro Pharmaceuticals Industries Limited | Non-sedating barbituric acid derivatives |
| US6756379B2 (en) | 2001-07-26 | 2004-06-29 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
| JP2005516052A (ja) * | 2002-01-30 | 2005-06-02 | タロ ファーマシューティカル インダストリーズ リミテッド | 非鎮静性バルビツール酸誘導体 |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| CL2003002588A1 (es) * | 2002-12-11 | 2005-01-07 | Taro Pharmaceuticals Ireland L | Uso de una composicion farmaceutica que comprende acido n,n-dimetoximetildifenil barbiturico, acido n-metoximetildifenil barbiturico o acido difenil barbiturico o una sal farmaceuticamente aceptable del mismo para preparar un medicamento util en el t |
| CN102358738A (zh) * | 2003-07-30 | 2012-02-22 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途 |
| EP1781624A4 (en) * | 2004-07-02 | 2010-06-23 | Taro Pharma Ind | PROCESS FOR THE PREPARATION OF 1-METHOXYMETHYL-5,5-DIPHENYLBARBITURIC ACID |
| EP1625848A1 (en) * | 2004-08-10 | 2006-02-15 | Taro Pharmaceuticals North America, Inc. | Composition and method for enhanced delivery of 5,5-diphenyl barbituric acid |
| JP4801096B2 (ja) * | 2005-01-19 | 2011-10-26 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物のプロドラッグおよびそれらの使用 |
| US8853257B2 (en) | 2005-11-21 | 2014-10-07 | Mordechai Sharir | Succinimide derivatives as ocular hypotensive agents |
| WO2007057889A2 (en) * | 2005-11-21 | 2007-05-24 | Mordechai Sharir | Succinimide derivatives as ocular hypotensive agents |
| WO2008066704A2 (en) * | 2006-11-14 | 2008-06-05 | Taro Pharmaceuticals North America, Inc. | Method of improving bioavailability for non-sedating barbiturates |
| EP2632668A2 (en) | 2010-10-27 | 2013-09-04 | The Gillette Company | Composition dispensing device comprising a non-foaming hydrating composition |
| US20120278179A1 (en) * | 2011-04-28 | 2012-11-01 | Ray Campbell | Systems and methods for deducing user information from input device behavior |
| EP2744363A2 (en) | 2011-08-16 | 2014-06-25 | The Gillette Company | Composition dispensing device comprising a moisturizing composition |
| JP6423441B2 (ja) | 2013-11-01 | 2018-11-14 | ザ ジレット カンパニー リミテッド ライアビリティ カンパニーＴｈｅ Ｇｉｌｌｅｔｔｅ Ｃｏｍｐａｎｙ Ｌｌｃ | 液体分配式かみそり用の剃毛ケア組成物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2673205A (en) | 1951-02-13 | 1954-03-23 | Ciba Pharm Prod Inc | 3-disubstituted dioxopiperidines and the manufacture thereof |
| AR204518A1 (es) * | 1973-02-28 | 1976-02-12 | Kendall & Co | Procedimiento para preparar n-mono(alcoximetil)fenobarbital |
| DE2622981A1 (de) * | 1976-05-21 | 1977-12-08 | Unisearch Ltd | Verfahren zur herstellung von halogenalkylierten verbindungen |
| IL69722A (en) * | 1983-09-14 | 1986-09-30 | Taro Pharma Ind | Oxopyrimidine derivatives and pharmaceutical compositions containing them |
| DE4028040A1 (de) * | 1990-09-05 | 1992-03-12 | Chemie Linz Deutschland | Verfahren zur n-alkylierung von harnstoffen |
| DE19504623A1 (de) | 1995-02-13 | 1996-08-14 | Bayer Ag | Verfahren zur Herstellung von N-substituierten cyclischen Imiden |
| EP0949259B1 (en) | 1996-12-26 | 2001-06-20 | Nikken Chemicals Company, Limited | N-hydroxyurea derivatives and medicinal compositions containing the same |
| US6093820A (en) | 1997-10-02 | 2000-07-25 | Taro Pharmaceutical Industries Ltd. | Method and reagents for N-alkylating ureides |
| CA2331735A1 (en) | 1998-05-08 | 1999-11-18 | Smithkline Beecham P.L.C. | Phenylurea and phenylthio urea derivatives |
| MXPA00012647A (es) | 1998-05-26 | 2003-07-14 | Natural Drug Sciences Llc | Derivados n-sustituidos de acido 5-oxiiminobarbiturico. |
| CA2306170A1 (en) | 2000-04-18 | 2001-10-18 | Kenneth Curry | Novel amino, carboxy derivatives of barbituric acid |
| DE60132337T2 (de) | 2000-07-26 | 2009-02-12 | Taro Pharmaceutical Industries Ltd. | Nicht-sedierende barbituratverbindungen als neuroprotektive wirkstoffe |
-
1997
- 1997-10-02 US US08/942,636 patent/US6093820A/en not_active Ceased
-
1998
- 1998-10-02 JP JP2000514895A patent/JP4061018B2/ja not_active Expired - Fee Related
- 1998-10-02 CN CNB988098342A patent/CN1193019C/zh not_active Expired - Fee Related
- 1998-10-02 AT AT03011817T patent/ATE299500T1/de active
- 1998-10-02 DE DE69820895T patent/DE69820895T2/de not_active Expired - Lifetime
- 1998-10-02 ES ES98949706T patent/ES2214736T3/es not_active Expired - Lifetime
- 1998-10-02 WO PCT/US1998/020665 patent/WO1999018084A1/en not_active Ceased
- 1998-10-02 CA CA2304970A patent/CA2304970C/en not_active Expired - Fee Related
- 1998-10-02 EP EP98949706A patent/EP1027339B1/en not_active Expired - Lifetime
- 1998-10-02 ES ES03011817T patent/ES2243833T3/es not_active Expired - Lifetime
- 1998-10-02 IL IL13528498A patent/IL135284A/xx not_active IP Right Cessation
- 1998-10-02 EP EP03011817A patent/EP1342718B1/en not_active Expired - Lifetime
- 1998-10-02 DK DK98949706T patent/DK1027339T3/da active
- 1998-10-02 DE DE69830860T patent/DE69830860T2/de not_active Expired - Lifetime
- 1998-10-02 AU AU95976/98A patent/AU758506B2/en not_active Ceased
- 1998-10-02 AT AT98949706T patent/ATE257153T1/de active
- 1998-10-02 PT PT03011817T patent/PT1342718E/pt unknown
- 1998-10-02 CN CNA2005100026661A patent/CN1699349A/zh active Pending
- 1998-10-02 DK DK03011817T patent/DK1342718T3/da active
- 1998-10-02 PT PT98949706T patent/PT1027339E/pt unknown
-
2002
- 2002-02-12 US US10/073,051 patent/US6664262B2/en not_active Expired - Fee Related
-
2003
- 2003-02-27 US US10/375,340 patent/USRE38934E1/en not_active Expired - Lifetime
- 2003-10-17 US US10/687,712 patent/US6906079B2/en not_active Expired - Fee Related
-
2004
- 2004-11-07 IL IL16508004A patent/IL165080A0/xx unknown
-
2007
- 2007-10-23 JP JP2007275316A patent/JP2008101002A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK1027339T3 (da) | 2004-05-03 |
| DE69830860D1 (de) | 2005-08-18 |
| ES2214736T3 (es) | 2004-09-16 |
| WO1999018084A1 (en) | 1999-04-15 |
| JP2001519334A (ja) | 2001-10-23 |
| DE69820895T2 (de) | 2004-10-28 |
| US20030018080A1 (en) | 2003-01-23 |
| AU9597698A (en) | 1999-04-27 |
| US6906079B2 (en) | 2005-06-14 |
| PT1027339E (pt) | 2004-05-31 |
| DE69820895D1 (de) | 2004-02-05 |
| US20040167358A1 (en) | 2004-08-26 |
| EP1342718A1 (en) | 2003-09-10 |
| CA2304970C (en) | 2010-07-13 |
| USRE38934E1 (en) | 2006-01-10 |
| US6664262B2 (en) | 2003-12-16 |
| ES2243833T3 (es) | 2005-12-01 |
| CN1273581A (zh) | 2000-11-15 |
| PT1342718E (pt) | 2005-11-30 |
| EP1027339A1 (en) | 2000-08-16 |
| JP4061018B2 (ja) | 2008-03-12 |
| EP1342718B1 (en) | 2005-07-13 |
| DK1342718T3 (da) | 2005-09-26 |
| ATE299500T1 (de) | 2005-07-15 |
| CN1193019C (zh) | 2005-03-16 |
| IL165080A0 (en) | 2005-12-18 |
| EP1027339B1 (en) | 2004-01-02 |
| AU758506B2 (en) | 2003-03-20 |
| ATE257153T1 (de) | 2004-01-15 |
| CA2304970A1 (en) | 1999-04-15 |
| CN1699349A (zh) | 2005-11-23 |
| JP2008101002A (ja) | 2008-05-01 |
| US6093820A (en) | 2000-07-25 |
| DE69830860T2 (de) | 2006-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |