IL137545A0 - New cytotoxic tris(oxazole)-containing macrolides - Google Patents
New cytotoxic tris(oxazole)-containing macrolidesInfo
- Publication number
- IL137545A0 IL137545A0 IL13754599A IL13754599A IL137545A0 IL 137545 A0 IL137545 A0 IL 137545A0 IL 13754599 A IL13754599 A IL 13754599A IL 13754599 A IL13754599 A IL 13754599A IL 137545 A0 IL137545 A0 IL 137545A0
- Authority
- IL
- Israel
- Prior art keywords
- represents hydrogen
- lower alkyl
- macrolides
- oxazole
- hydrogen
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 4
- 229940041033 macrolides Drugs 0.000 title abstract 4
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title abstract 2
- 239000007983 Tris buffer Substances 0.000 title abstract 2
- 231100000433 cytotoxic Toxicity 0.000 title abstract 2
- 230000001472 cytotoxic effect Effects 0.000 title abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 150000002431 hydrogen Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9801741.1A GB9801741D0 (en) | 1998-01-27 | 1998-01-27 | New cytotoxic tris (oxazole)-containing macrolides |
| PCT/GB1999/000277 WO1999037653A1 (en) | 1998-01-27 | 1999-01-27 | New cytotoxic tris(oxazole)-containing macrolides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL137545A0 true IL137545A0 (en) | 2001-07-24 |
Family
ID=10825984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13754599A IL137545A0 (en) | 1998-01-27 | 1999-01-27 | New cytotoxic tris(oxazole)-containing macrolides |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6391900B1 (cs) |
| EP (1) | EP1051420B1 (cs) |
| JP (1) | JP4511027B2 (cs) |
| KR (1) | KR20010034413A (cs) |
| CN (1) | CN1131869C (cs) |
| AT (1) | ATE229024T1 (cs) |
| AU (1) | AU760184B2 (cs) |
| BR (1) | BR9907748A (cs) |
| CA (1) | CA2319032C (cs) |
| CZ (1) | CZ291931B6 (cs) |
| DE (1) | DE69904294T2 (cs) |
| DK (1) | DK1051420T3 (cs) |
| ES (1) | ES2186324T3 (cs) |
| GB (1) | GB9801741D0 (cs) |
| HU (1) | HUP0101321A3 (cs) |
| IL (1) | IL137545A0 (cs) |
| MX (1) | MXPA00007381A (cs) |
| PL (1) | PL342040A1 (cs) |
| PT (1) | PT1051420E (cs) |
| RU (1) | RU2217433C2 (cs) |
| WO (1) | WO1999037653A1 (cs) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100471727B1 (ko) * | 2002-10-14 | 2005-02-21 | 학교법인 포항공과대학교 | 이속사졸린 고리와 불소를 포함하는 거대고리 화합물 및그의 제조방법 |
| CN100360515C (zh) * | 2004-04-09 | 2008-01-09 | 中国科学院上海药物研究所 | 抗肿瘤活性成份陵水醇、制备方法和用途 |
| ES2276629B1 (es) * | 2005-12-15 | 2009-04-01 | Pharma Mar, S.A. | Compuestos antitumorales. |
| CA2729620A1 (en) * | 2008-07-03 | 2010-01-07 | Pharma Mar, S.A. | Antitumoral macrolides |
| KR102491180B1 (ko) | 2017-04-27 | 2023-01-20 | 파르마 마르 에스.에이. | 항종양 화합물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6256493A (ja) * | 1985-09-06 | 1987-03-12 | Yamanouchi Pharmaceut Co Ltd | カビラマイド類 |
| FR2664600B1 (fr) * | 1990-07-16 | 1994-09-02 | Rhone Poulenc Sante | Nouveau sel derive de la dialcoylaminoalcoyl-sulfonyl-26 pristinamycine iib. |
| GB9315914D0 (en) * | 1993-07-31 | 1993-09-15 | Smithkline Beecham Plc | Novel compound |
| EP0729950A4 (en) * | 1994-09-13 | 2001-02-07 | Kyowa Hakko Kogyo Kk | ANTI-HIV MEDICINAL PRODUCTS |
-
1998
- 1998-01-27 GB GBGB9801741.1A patent/GB9801741D0/en not_active Ceased
-
1999
- 1999-01-27 AU AU24319/99A patent/AU760184B2/en not_active Ceased
- 1999-01-27 HU HU0101321A patent/HUP0101321A3/hu unknown
- 1999-01-27 EP EP99903797A patent/EP1051420B1/en not_active Expired - Lifetime
- 1999-01-27 JP JP2000528574A patent/JP4511027B2/ja not_active Expired - Fee Related
- 1999-01-27 CN CN998045632A patent/CN1131869C/zh not_active Expired - Fee Related
- 1999-01-27 CA CA002319032A patent/CA2319032C/en not_active Expired - Fee Related
- 1999-01-27 AT AT99903797T patent/ATE229024T1/de not_active IP Right Cessation
- 1999-01-27 US US09/601,146 patent/US6391900B1/en not_active Expired - Fee Related
- 1999-01-27 CZ CZ20002754A patent/CZ291931B6/cs not_active IP Right Cessation
- 1999-01-27 IL IL13754599A patent/IL137545A0/xx unknown
- 1999-01-27 KR KR1020007008182A patent/KR20010034413A/ko not_active Ceased
- 1999-01-27 ES ES99903797T patent/ES2186324T3/es not_active Expired - Lifetime
- 1999-01-27 MX MXPA00007381A patent/MXPA00007381A/es unknown
- 1999-01-27 BR BR9907748-5A patent/BR9907748A/pt not_active IP Right Cessation
- 1999-01-27 WO PCT/GB1999/000277 patent/WO1999037653A1/en not_active Ceased
- 1999-01-27 DE DE69904294T patent/DE69904294T2/de not_active Expired - Lifetime
- 1999-01-27 PT PT99903797T patent/PT1051420E/pt unknown
- 1999-01-27 DK DK99903797T patent/DK1051420T3/da active
- 1999-01-27 PL PL99342040A patent/PL342040A1/xx unknown
- 1999-01-27 RU RU2000122441/04A patent/RU2217433C2/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002501074A (ja) | 2002-01-15 |
| ES2186324T3 (es) | 2003-05-01 |
| CZ291931B6 (cs) | 2003-06-18 |
| AU760184B2 (en) | 2003-05-08 |
| DE69904294D1 (de) | 2003-01-16 |
| WO1999037653A1 (en) | 1999-07-29 |
| DE69904294T2 (de) | 2003-08-21 |
| DK1051420T3 (da) | 2002-12-30 |
| KR20010034413A (ko) | 2001-04-25 |
| MXPA00007381A (es) | 2002-06-04 |
| CN1131869C (zh) | 2003-12-24 |
| CZ20002754A3 (cs) | 2002-02-13 |
| EP1051420A1 (en) | 2000-11-15 |
| PL342040A1 (en) | 2001-05-21 |
| RU2217433C2 (ru) | 2003-11-27 |
| CA2319032A1 (en) | 1999-07-29 |
| BR9907748A (pt) | 2000-10-17 |
| GB9801741D0 (en) | 1998-03-25 |
| PT1051420E (pt) | 2003-02-28 |
| HUP0101321A3 (en) | 2002-06-28 |
| AU2431999A (en) | 1999-08-09 |
| US6391900B1 (en) | 2002-05-21 |
| CA2319032C (en) | 2009-09-08 |
| HUP0101321A2 (hu) | 2001-09-28 |
| JP4511027B2 (ja) | 2010-07-28 |
| CN1320127A (zh) | 2001-10-31 |
| ATE229024T1 (de) | 2002-12-15 |
| EP1051420B1 (en) | 2002-12-04 |
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