IL138829A0 - Method for increasing bone toughness and stiffness and reducing fractures - Google Patents

Method for increasing bone toughness and stiffness and reducing fractures

Info

Publication number
IL138829A0
IL138829A0 IL13882999A IL13882999A IL138829A0 IL 138829 A0 IL138829 A0 IL 138829A0 IL 13882999 A IL13882999 A IL 13882999A IL 13882999 A IL13882999 A IL 13882999A IL 138829 A0 IL138829 A0 IL 138829A0
Authority
IL
Israel
Prior art keywords
stiffness
increasing bone
reducing fractures
bone toughness
toughness
Prior art date
Application number
IL13882999A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26792729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL138829(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL138829A0 publication Critical patent/IL138829A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Steroid Compounds (AREA)
  • Materials For Medical Uses (AREA)
IL13882999A 1998-08-19 1999-08-19 Method for increasing bone toughness and stiffness and reducing fractures IL138829A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9715198P 1998-08-19 1998-08-19
US9974698P 1998-09-10 1998-09-10
PCT/US1999/018961 WO2000010596A1 (fr) 1998-08-19 1999-08-19 Procede permettant d'augmenter la solidite et la rigidite osseuse et de reduire l'incidence ou la gravite d'une fracture

Publications (1)

Publication Number Publication Date
IL138829A0 true IL138829A0 (en) 2001-10-31

Family

ID=26792729

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13882999A IL138829A0 (en) 1998-08-19 1999-08-19 Method for increasing bone toughness and stiffness and reducing fractures
IL138829A IL138829A (en) 1998-08-19 2000-10-03 Use of a parathyroid hormone containing the 34-1 amino acid sequence of human parathyroid hormone in the preparation of a drug to increase bone strength and reduce the risk of bone fracture

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL138829A IL138829A (en) 1998-08-19 2000-10-03 Use of a parathyroid hormone containing the 34-1 amino acid sequence of human parathyroid hormone in the preparation of a drug to increase bone strength and reduce the risk of bone fracture

Country Status (32)

Country Link
US (2) US6977077B1 (fr)
EP (3) EP2907522B1 (fr)
JP (5) JP2002523375A (fr)
KR (1) KR100454207B1 (fr)
CN (1) CN1205997C (fr)
AR (1) AR033639A1 (fr)
AT (1) ATE231000T1 (fr)
AU (1) AU746277B2 (fr)
BR (1) BR9909445A (fr)
CA (1) CA2325371C (fr)
CO (1) CO5130020A1 (fr)
CY (2) CY1113343T1 (fr)
CZ (1) CZ301017B6 (fr)
DE (2) DE15152726T1 (fr)
DK (4) DK1059933T3 (fr)
DZ (1) DZ2873A1 (fr)
EA (1) EA003362B1 (fr)
ES (4) ES2549551T3 (fr)
HR (1) HRP20000755A2 (fr)
HU (2) HU230697B1 (fr)
ID (1) ID29039A (fr)
IL (2) IL138829A0 (fr)
MY (1) MY129227A (fr)
NO (2) NO323984B1 (fr)
NZ (1) NZ507056A (fr)
PE (1) PE20001089A1 (fr)
PL (1) PL201688B1 (fr)
PT (4) PT2266598T (fr)
TR (1) TR200003455T2 (fr)
TW (1) TW576747B (fr)
UA (1) UA72205C2 (fr)
WO (1) WO2000010596A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770623B1 (en) * 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
US20040033950A1 (en) * 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
DZ2873A1 (fr) * 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
WO2001022093A1 (fr) * 1999-09-20 2001-03-29 Eli Lilly And Company Procede remettant d'effectuer le suivi du traitement avec une hormone parathyroidienne
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
WO2003059291A2 (fr) * 2002-01-10 2003-07-24 Osteotrophin Llc Traitement des affections osseuses avec des medicaments anabolisants du squelette
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
WO2005027915A1 (fr) * 2003-09-19 2005-03-31 Pfizer Products Inc. Compositions pharmaceutiques et methodes de traitement consistant en des associations d'un derive de la 2-alkylidene-19-nor-vitamine d et de l'hormone parathyroidienne
US20060189533A1 (en) * 2004-05-10 2006-08-24 Nastech Pharmaceutical Company Inc. Stable pharmaceutical dosage forms of teriparatide
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human
CN101151048A (zh) * 2004-05-10 2008-03-26 纳斯泰克制药公司 增强甲状旁腺激素粘膜递送的组合物和方法
JP5007427B2 (ja) 2004-05-13 2012-08-22 アルザ コーポレイション 副甲状腺ホルモン剤の経皮送達のための装置および方法
US7648965B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060069021A1 (en) * 2004-08-13 2006-03-30 Nastech Pharmaceutical Company Inc. Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs
WO2006073711A2 (fr) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Traitement local des deficits osseux
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
EP1879608A4 (fr) * 2005-05-11 2009-11-11 Unigene Lab Inc Methode pour stimuler la formation et la preservation des os
US20070173447A1 (en) * 2005-10-25 2007-07-26 Nastech Pharmaceutical Company Inc. Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent
BRPI0618469A2 (pt) * 2005-11-10 2011-08-30 Univ Michigan Tech hormÈnio paratiróide de urso preto e métodos de uso de hormÈnio paratiróide de urso preto
US20080051332A1 (en) * 2005-11-18 2008-02-28 Nastech Pharmaceutical Company Inc. Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone
US20080119408A1 (en) * 2006-07-07 2008-05-22 Nastech Pharmaceutical Company Inc. Pth formulations for intranasal delivery
EP1961765A1 (fr) * 2006-12-08 2008-08-27 Zealand Pharma A/S Peptides PTH tronqués à formation cyclique
EP2136850B1 (fr) 2007-04-13 2012-02-01 Kuros Biosurgery AG Agent de scellement tissulaire polymère
US20110137243A1 (en) * 2007-09-06 2011-06-09 Abbott Cardiovascular Systems Inc. Coating On A Balloon Device
EP2217260B1 (fr) * 2007-12-04 2016-11-09 Ben-Gurion University Of The Negev Research And Development Authority Matrices peptidiques amphiphiles pour le traitement de l'ostéoporose
JP2012512812A (ja) 2007-12-28 2012-06-07 クロス・バイオサージェリー・アクチェンゲゼルシャフト フィブリンフォームに組込まれたｐｄｇｆ融合タンパク質
CN103893746A (zh) * 2009-09-09 2014-07-02 旭化成制药株式会社 含有pth的骨质疏松症治疗/预防剂
CA2782640A1 (fr) 2009-12-07 2011-06-16 Michigan Technological University Hormone parathyroide de l'ours noir et ses procedes d'utilisation
US9295663B2 (en) 2010-07-14 2016-03-29 Abbott Cardiovascular Systems Inc. Drug coated balloon with in-situ formed drug containing microspheres
WO2012111852A1 (fr) * 2011-02-17 2012-08-23 帝人ファーマ株式会社 Agent thérapeutique pour fracture de corps vertébral et procédé pour évaluer celui-ci
WO2012123028A1 (fr) 2011-03-16 2012-09-20 Kuros Biosurgery Ag Formulation pharmaceutique destinée à être utilisée dans une fusion des vertèbres
KR101787956B1 (ko) 2011-06-07 2017-10-18 아사히 가세이 파마 가부시키가이샤 고순도 ｐｔｈ 함유 동결 건조 제제 및 그의 제조 방법
US9700485B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
EP3411066B1 (fr) * 2016-02-01 2026-05-13 Eli Lilly and Company Hormone parathyroïde anti-rank anticorps composés de fusion
WO2018144719A1 (fr) * 2017-02-01 2018-08-09 The Johns Hopkins University Hormone parathyroïdienne et régénération ade disques dégénératifs
US20200289621A1 (en) * 2017-09-22 2020-09-17 Asahi Kasei Pharma Corporation Teriparatide-containing liquid pharmaceutical composition having excellent stability
CA3101326C (fr) 2018-10-29 2023-08-01 Asahi Kasei Pharma Corporation Methode de prevention ou de traitement de l'osteoporose caracterisee par l'administration de teriparatide ou d'un sel connexe a frequence de deux fois par semaine
EP4010360A1 (fr) 2019-08-09 2022-06-15 Flagship Pioneering Innovations VI, LLC Modulateurs du récepteur de l'hormone parathyroïdienne (pthr1)
GB2590692A (en) * 2019-12-24 2021-07-07 Corthotec Ltd Composition for improved bone fracture healing

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086196A (en) 1975-03-28 1978-04-25 Armour Pharmaceutical Company Parathyroid hormone
IL78342A (en) * 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
DE3935738A1 (de) 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
US5556940A (en) 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
JPH0873376A (ja) * 1994-09-07 1996-03-19 Asahi Chem Ind Co Ltd 骨粗鬆症治療薬
JPH10511095A (ja) * 1994-12-19 1998-10-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド 副甲状腺ホルモン又はその作動薬の低用量継続投与
US5747456A (en) 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
PT806945E (pt) * 1994-12-22 2003-09-30 Astrazeneca Ab Preparacao terapeutica para inalacao que contem a hormona paratiroide, hpt
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
CA2302255C (fr) * 1997-09-09 2011-11-08 F. Hoffmann-La Roche Ag Guerison de fractures au moyen d'analogues de pthrp
ZA9811127B (en) 1997-12-09 2000-07-11 Lilly Co Eli Stabilized teriparatide solutions.
US20040033950A1 (en) * 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
DZ2873A1 (fr) * 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
US6907597B1 (en) 2000-10-13 2005-06-14 Ati International Srl Method and apparatus for constructing an executable program in memory
US6967759B2 (en) 2001-12-31 2005-11-22 Texas Instruments Incorporated Pulse width modulation sequence generation
JP5796714B2 (ja) 2012-01-13 2015-10-21 株式会社リコー 定着装置及び画像形成装置
EP2949301B1 (fr) 2014-05-27 2018-04-18 The Procter and Gamble Company Noyau absorbant avec des zones de matériau absorbant incurvées et droites

Also Published As

Publication number Publication date
JP2011021035A (ja) 2011-02-03
EP1059933B1 (fr) 2003-01-15
DZ2873A1 (fr) 2003-12-15
NO323984B1 (no) 2007-07-30
HUP0101594A3 (en) 2002-01-28
ES2549551T1 (es) 2015-10-29
IL138829A (en) 2011-01-31
HUP0101594A2 (hu) 2001-11-28
AU746277B2 (en) 2002-04-18
US7163684B2 (en) 2007-01-16
ES2549551T3 (es) 2017-11-27
CO5130020A1 (es) 2002-02-27
EP2266598A1 (fr) 2010-12-29
PT2266598T (pt) 2017-05-02
ES2621653T3 (es) 2017-07-04
PL201688B1 (pl) 2009-04-30
JP2002523375A (ja) 2002-07-30
NO20005947D0 (no) 2000-11-24
AU5575099A (en) 2000-03-14
CA2325371C (fr) 2004-08-17
DE69904918D1 (de) 2003-02-20
CZ301017B6 (cs) 2009-10-14
DK1059933T3 (da) 2003-04-07
PL343595A1 (en) 2001-08-27
CY1119552T1 (el) 2018-03-07
US6977077B1 (en) 2005-12-20
HRP20000755A2 (en) 2001-02-28
JP2015028065A (ja) 2015-02-12
DK1769804T3 (da) 2012-10-15
EA200001015A1 (ru) 2001-02-26
ES2393200T3 (es) 2012-12-19
JP6177718B2 (ja) 2017-08-09
HU1200430D0 (hu) 2001-11-28
TR200003455T2 (tr) 2001-06-21
NZ507056A (en) 2003-10-31
WO2000010596A1 (fr) 2000-03-02
US20050197294A1 (en) 2005-09-08
HK1102496A1 (en) 2007-11-23
BR9909445A (pt) 2000-12-12
EP2266598B1 (fr) 2017-02-22
ES2190244T3 (es) 2003-07-16
NO20005947L (no) 2000-11-24
JP2014139220A (ja) 2014-07-31
PT1059933E (pt) 2003-06-30
EP2907522B1 (fr) 2017-08-02
PT2907522T (pt) 2017-10-23
JP2017190332A (ja) 2017-10-19
DK2907522T3 (en) 2017-10-23
HK1212602A1 (en) 2016-06-17
EP2907522A1 (fr) 2015-08-19
DE15152726T1 (de) 2015-12-10
HK1030545A1 (en) 2001-05-11
TW576747B (en) 2004-02-21
CZ20004134A3 (cs) 2001-08-15
PT1769804E (pt) 2012-11-13
UA72205C2 (uk) 2005-02-15
CA2325371A1 (fr) 2000-03-02
EA003362B1 (ru) 2003-04-24
CY1113343T1 (el) 2016-06-22
AR033639A1 (es) 2004-01-07
EP1059933A1 (fr) 2000-12-20
DK2266598T3 (en) 2017-05-15
KR100454207B1 (ko) 2004-10-26
ID29039A (id) 2001-07-26
PE20001089A1 (es) 2000-11-04
MY129227A (en) 2007-03-30
CN1205997C (zh) 2005-06-15
KR20010072763A (ko) 2001-07-31
HU230697B1 (hu) 2017-09-28
ATE231000T1 (de) 2003-02-15
DK2907522T1 (da) 2015-10-19
CN1308545A (zh) 2001-08-15
DE69904918T2 (de) 2003-11-13
NO20072983L (no) 2000-11-24

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