IL138829A0 - Method for increasing bone toughness and stiffness and reducing fractures - Google Patents

Method for increasing bone toughness and stiffness and reducing fractures

Info

Publication number
IL138829A0
IL138829A0 IL13882999A IL13882999A IL138829A0 IL 138829 A0 IL138829 A0 IL 138829A0 IL 13882999 A IL13882999 A IL 13882999A IL 13882999 A IL13882999 A IL 13882999A IL 138829 A0 IL138829 A0 IL 138829A0
Authority
IL
Israel
Prior art keywords
stiffness
increasing bone
reducing fractures
bone toughness
toughness
Prior art date
Application number
IL13882999A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26792729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL138829(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL138829A0 publication Critical patent/IL138829A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
IL13882999A 1998-08-19 1999-08-19 Method for increasing bone toughness and stiffness and reducing fractures IL138829A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9715198P 1998-08-19 1998-08-19
US9974698P 1998-09-10 1998-09-10
PCT/US1999/018961 WO2000010596A1 (fr) 1998-08-19 1999-08-19 Procede permettant d'augmenter la solidite et la rigidite osseuse et de reduire l'incidence ou la gravite d'une fracture

Publications (1)

Publication Number Publication Date
IL138829A0 true IL138829A0 (en) 2001-10-31

Family

ID=26792729

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13882999A IL138829A0 (en) 1998-08-19 1999-08-19 Method for increasing bone toughness and stiffness and reducing fractures
IL138829A IL138829A (en) 1998-08-19 2000-10-03 Use of a parathyroid hormone containing the 34-1 amino acid sequence of human parathyroid hormone in the preparation of a drug to increase bone strength and reduce the risk of bone fracture

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL138829A IL138829A (en) 1998-08-19 2000-10-03 Use of a parathyroid hormone containing the 34-1 amino acid sequence of human parathyroid hormone in the preparation of a drug to increase bone strength and reduce the risk of bone fracture

Country Status (32)

Country Link
US (2) US6977077B1 (fr)
EP (3) EP2266598B1 (fr)
JP (5) JP2002523375A (fr)
KR (1) KR100454207B1 (fr)
CN (1) CN1205997C (fr)
AR (1) AR033639A1 (fr)
AT (1) ATE231000T1 (fr)
AU (1) AU746277B2 (fr)
BR (1) BR9909445A (fr)
CA (1) CA2325371C (fr)
CO (1) CO5130020A1 (fr)
CY (2) CY1113343T1 (fr)
CZ (1) CZ301017B6 (fr)
DE (2) DE15152726T1 (fr)
DK (4) DK2266598T3 (fr)
DZ (1) DZ2873A1 (fr)
EA (1) EA003362B1 (fr)
ES (4) ES2393200T3 (fr)
HR (1) HRP20000755A2 (fr)
HU (2) HU1200430D0 (fr)
ID (1) ID29039A (fr)
IL (2) IL138829A0 (fr)
MY (1) MY129227A (fr)
NO (2) NO323984B1 (fr)
NZ (1) NZ507056A (fr)
PE (1) PE20001089A1 (fr)
PL (1) PL201688B1 (fr)
PT (4) PT1769804E (fr)
TR (1) TR200003455T2 (fr)
TW (1) TW576747B (fr)
UA (1) UA72205C2 (fr)
WO (1) WO2000010596A1 (fr)

Families Citing this family (40)

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Publication number Priority date Publication date Assignee Title
US6770623B1 (en) * 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
US20040033950A1 (en) * 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
DZ2873A1 (fr) 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
CA2387693A1 (fr) * 1999-09-20 2001-03-29 Eli Lilly And Company Procede remettant d'effectuer le suivi du traitement avec une hormone parathyroidienne
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
AU2003207512B2 (en) 2002-01-10 2008-06-12 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
KR20060058133A (ko) * 2003-09-19 2006-05-29 화이자 프로덕츠 인코포레이티드 2-알킬리덴-19-노르-비타민 ｄ 유도체 및 부갑상선호르몬의 조합을 포함하는 약학 조성물 및 방법
MXPA06012980A (es) * 2004-05-10 2007-06-12 Nastech Pharm Co Composiciones y metodos para el suministro mucosal mejorado de la hormona paratiroidea.
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human
US20060189533A1 (en) * 2004-05-10 2006-08-24 Nastech Pharmaceutical Company Inc. Stable pharmaceutical dosage forms of teriparatide
MXPA06013168A (es) 2004-05-13 2007-05-15 Johnson & Johnson Aparato y metodo para el suministro transdermico de agentes de la hormona paratiroidea.
US7648965B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060069021A1 (en) * 2004-08-13 2006-03-30 Nastech Pharmaceutical Company Inc. Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs
WO2006073711A2 (fr) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Traitement local des deficits osseux
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
JP2008540522A (ja) * 2005-05-11 2008-11-20 ユニジーン・ラボラトリーズ・インコーポレーテッド 骨の形成および保存を促進するための方法
US20070173447A1 (en) * 2005-10-25 2007-07-26 Nastech Pharmaceutical Company Inc. Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent
CN101355959B (zh) * 2005-11-10 2013-02-27 密歇根理工大学管理委员会 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法
US20080051332A1 (en) * 2005-11-18 2008-02-28 Nastech Pharmaceutical Company Inc. Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone
US20080119408A1 (en) * 2006-07-07 2008-05-22 Nastech Pharmaceutical Company Inc. Pth formulations for intranasal delivery
EP1961765A1 (fr) * 2006-12-08 2008-08-27 Zealand Pharma A/S Peptides PTH tronqués à formation cyclique
PL2136850T3 (pl) 2007-04-13 2012-07-31 Kuros Biosurgery Ag Polimeryczny uszczelniacz tkankowy
US20110137243A1 (en) * 2007-09-06 2011-06-09 Abbott Cardiovascular Systems Inc. Coating On A Balloon Device
US9457056B2 (en) * 2007-12-04 2016-10-04 Ben-Gurion University Of The Negev Research And Development Authority Peptides comprising alternating hydrophobic and anionic amino acids for treatment of osteoporosis
CA2710798A1 (fr) 2007-12-28 2009-07-09 Kuros Biosurgery Ag Proteines hybrides du pdgf incorporees dans des mousses de fibrine
ES2662018T3 (es) * 2009-09-09 2018-04-05 Asahi Kasei Pharma Corporation Agente terapéutico/profiláctico que contiene PTH para la osteoporosis, caracterizado porque la PTH se administra una vez por semana en una dosis unitaria de 200 unidades
EP2509996A1 (fr) 2009-12-07 2012-10-17 Michigan Technological University Hormone parathyroïde de l'ours noir et ses procédés d'utilisation
US9295663B2 (en) 2010-07-14 2016-03-29 Abbott Cardiovascular Systems Inc. Drug coated balloon with in-situ formed drug containing microspheres
WO2012111852A1 (fr) * 2011-02-17 2012-08-23 帝人ファーマ株式会社 Agent thérapeutique pour fracture de corps vertébral et procédé pour évaluer celui-ci
EP2686027B1 (fr) 2011-03-16 2021-05-05 Kuros Biosurgery AG Formulation pharmaceutique destinée à être utilisée dans une fusion des vertèbres
WO2012169435A1 (fr) 2011-06-07 2012-12-13 旭化成ファーマ株式会社 Préparation pharmaceutique lyophilisée contenant du pth de pureté élevée et son procédé de production
US9700485B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
CA3013443C (fr) 2016-02-01 2021-06-15 Eli Lilly And Company Composes de fusion parathormone-anticorps anti-rankl
US20190381341A1 (en) * 2017-02-01 2019-12-19 The Johns Hopkins University Parathyroid hormone and regeneration of degenerative discs disease
JP6577683B2 (ja) * 2017-09-22 2019-09-18 旭化成ファーマ株式会社 安定性に優れるテリパラチド含有液状医薬組成物
JP6618139B1 (ja) 2018-10-29 2019-12-11 旭化成ファーマ株式会社 週２回の頻度でテリパラチド又はその塩を投与することを特徴とする、骨粗鬆症の予防又は治療方法
US12344649B2 (en) 2019-08-09 2025-07-01 Flagship Pioneering Innovations Vi, Llc Modulators of parathyroid hormone receptor (PTHR1)
GB2590692A (en) * 2019-12-24 2021-07-07 Corthotec Ltd Composition for improved bone fracture healing

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086196A (en) 1975-03-28 1978-04-25 Armour Pharmaceutical Company Parathyroid hormone
IL78342A (en) 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
DE3935738A1 (de) 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
CA2126299C (fr) 1994-06-20 2000-12-12 Gordon E. Willick Analogues de l'hormone parathyroidienne utilises pour le traitement de l'osteoporose
JPH0873376A (ja) 1994-09-07 1996-03-19 Asahi Chem Ind Co Ltd 骨粗鬆症治療薬
US5747456A (en) * 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
WO1996019246A1 (fr) * 1994-12-19 1996-06-27 Beth Israel Hospital Association Administration en continu de faibles doses d'hormone parathyroïdienne ou de son agoniste
CA2206657C (fr) * 1994-12-22 2009-05-19 Astra Aktiebolag Preparation therapeutique a inhaler contenant de l'hormone parathyroidienne, hpt
JPH08310965A (ja) 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
RS49707B (sr) * 1997-09-09 2007-12-31 F.Hoffmann-La Roche Ag., Primena polipeptidnog analoga peptida srodnog paratireoidnom hormonu i njegovih soli za proizvodnju medikamenata za lečenje preloma kostiju
ZA9811127B (en) 1997-12-09 2000-07-11 Lilly Co Eli Stabilized teriparatide solutions.
DZ2873A1 (fr) * 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
US6907597B1 (en) 2000-10-13 2005-06-14 Ati International Srl Method and apparatus for constructing an executable program in memory
US6967759B2 (en) 2001-12-31 2005-11-22 Texas Instruments Incorporated Pulse width modulation sequence generation
JP5796714B2 (ja) 2012-01-13 2015-10-21 株式会社リコー 定着装置及び画像形成装置
EP2949301B1 (fr) 2014-05-27 2018-04-18 The Procter and Gamble Company Noyau absorbant avec des zones de matériau absorbant incurvées et droites

Also Published As

Publication number Publication date
JP2014139220A (ja) 2014-07-31
CZ20004134A3 (cs) 2001-08-15
HU230697B1 (hu) 2017-09-28
JP6177718B2 (ja) 2017-08-09
ID29039A (id) 2001-07-26
JP2017190332A (ja) 2017-10-19
EP1059933B1 (fr) 2003-01-15
JP2015028065A (ja) 2015-02-12
DE69904918T2 (de) 2003-11-13
PT1059933E (pt) 2003-06-30
AU746277B2 (en) 2002-04-18
ES2549551T1 (es) 2015-10-29
ES2621653T3 (es) 2017-07-04
DZ2873A1 (fr) 2003-12-15
PE20001089A1 (es) 2000-11-04
US7163684B2 (en) 2007-01-16
KR20010072763A (ko) 2001-07-31
DK2907522T3 (en) 2017-10-23
CZ301017B6 (cs) 2009-10-14
AR033639A1 (es) 2004-01-07
TW576747B (en) 2004-02-21
ES2393200T3 (es) 2012-12-19
BR9909445A (pt) 2000-12-12
CA2325371A1 (fr) 2000-03-02
NO20005947D0 (no) 2000-11-24
JP2011021035A (ja) 2011-02-03
HRP20000755A2 (en) 2001-02-28
WO2000010596A1 (fr) 2000-03-02
ES2549551T3 (es) 2017-11-27
EP2266598B1 (fr) 2017-02-22
HK1030545A1 (en) 2001-05-11
DK2907522T1 (da) 2015-10-19
DK2266598T3 (en) 2017-05-15
US20050197294A1 (en) 2005-09-08
TR200003455T2 (tr) 2001-06-21
CY1113343T1 (el) 2016-06-22
EP2266598A1 (fr) 2010-12-29
NZ507056A (en) 2003-10-31
DE15152726T1 (de) 2015-12-10
ATE231000T1 (de) 2003-02-15
PL343595A1 (en) 2001-08-27
DE69904918D1 (de) 2003-02-20
EP2907522A1 (fr) 2015-08-19
CA2325371C (fr) 2004-08-17
CO5130020A1 (es) 2002-02-27
EP1059933A1 (fr) 2000-12-20
HUP0101594A3 (en) 2002-01-28
ES2190244T3 (es) 2003-07-16
NO323984B1 (no) 2007-07-30
HUP0101594A2 (hu) 2001-11-28
AU5575099A (en) 2000-03-14
EA003362B1 (ru) 2003-04-24
PT2907522T (pt) 2017-10-23
PL201688B1 (pl) 2009-04-30
HU1200430D0 (hu) 2001-11-28
NO20072983L (no) 2000-11-24
EP2907522B1 (fr) 2017-08-02
HK1212602A1 (en) 2016-06-17
US6977077B1 (en) 2005-12-20
CN1308545A (zh) 2001-08-15
EA200001015A1 (ru) 2001-02-26
PT1769804E (pt) 2012-11-13
IL138829A (en) 2011-01-31
NO20005947L (no) 2000-11-24
JP2002523375A (ja) 2002-07-30
MY129227A (en) 2007-03-30
HK1102496A1 (en) 2007-11-23
CY1119552T1 (el) 2018-03-07
KR100454207B1 (ko) 2004-10-26
DK1769804T3 (da) 2012-10-15
DK1059933T3 (da) 2003-04-07
CN1205997C (zh) 2005-06-15
PT2266598T (pt) 2017-05-02
UA72205C2 (uk) 2005-02-15

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