IL139735A0 - Genes for the biosynthesis of epothilones - Google Patents

Genes for the biosynthesis of epothilones

Info

Publication number: IL139735A0
Authority: IL; Israel
Prior art keywords: epothilones; biosynthesis; genes
Prior art date: 1998-06-18

Application number

IL13973599A

Other languages

English (en)

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-18

Filing date

1999-06-16

Publication date

2002-02-10

1999-06-16 Application filed by Novartis Ag filed Critical Novartis Ag

2002-02-10 Publication of IL139735A0 publication Critical patent/IL139735A0/xx

Links

230000015572 biosynthetic process Effects 0.000 title 1
229930013356 epothilone Natural products 0.000 title 1
HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

IL13973599A 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones IL139735A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US9950498A	1998-06-18	1998-06-18
US10163198P	1998-09-24	1998-09-24
US11890699P	1999-02-05	1999-02-05
PCT/EP1999/004171 WO1999066028A2 (fr)	1998-06-18	1999-06-16	Genes pour la biosynthese d'epothilones

Publications (1)

Publication Number	Publication Date
IL139735A0 true IL139735A0 (en)	2002-02-10

Family

ID=27378840

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL13973599A IL139735A0 (en)	1998-06-18	1999-06-16	Genes for the biosynthesis of epothilones
IL139735A IL139735A (en)	1998-06-18	2000-11-16	Genes for the biosynthesis of epothilones
IL190391A IL190391A0 (en)	1998-06-18	2008-03-24	Genes for the biosynthesis of epothilones

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL139735A IL139735A (en)	1998-06-18	2000-11-16	Genes for the biosynthesis of epothilones
IL190391A IL190391A0 (en)	1998-06-18	2008-03-24	Genes for the biosynthesis of epothilones

Country Status (16)

Country	Link
EP (1)	EP1088078A2 (fr)
JP (3)	JP2002518004A (fr)
KR (1)	KR100511233B1 (fr)
CN (1)	CN100374565C (fr)
AU (1)	AU753567B2 (fr)
BR (1)	BR9911349A (fr)
CA (1)	CA2329774A1 (fr)
HU (1)	HUP0102186A3 (fr)
ID (1)	ID29128A (fr)
IL (3)	IL139735A0 (fr)
NO (2)	NO20006195L (fr)
NZ (1)	NZ508326A (fr)
PL (1)	PL200157B1 (fr)
SK (1)	SK19242000A3 (fr)
TR (1)	TR200003759T2 (fr)
WO (1)	WO1999066028A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2273083C (fr)	1996-12-03	2012-09-18	Sloan-Kettering Institute For Cancer Research	Synthese d'epothilones, intermediaires utilises dans leur synthese, analogues et utilisations de celles-ci
US6204388B1 (en)	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
FR2775187B1 (fr)	1998-02-25	2003-02-21	Novartis Ag	Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
DE19846493A1 (de) *	1998-10-09	2000-04-13	Biotechnolog Forschung Gmbh	DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
WO2000031247A2 (fr)	1998-11-20	2000-06-02	Kosan Biosciences, Inc.	Matieres et procedes recombinants destines a la production d'epothilone et de derives d'epothilone
US6410301B1 (en)	1998-11-20	2002-06-25	Kosan Biosciences, Inc.	Myxococcus host cells for the production of epothilones
AU2001245263A1 (en) *	2000-01-21	2001-07-31	Kosan Biosciences, Inc.	Method for cloning polyketide synthase genes
DK1652926T3 (da) *	2000-04-28	2010-02-15	Kosan Biosciences Inc	Krystallinsk epothilon D
US6998256B2 (en)	2000-04-28	2006-02-14	Kosan Biosciences, Inc.	Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
US7257562B2 (en)	2000-10-13	2007-08-14	Thallion Pharmaceuticals Inc.	High throughput method for discovery of gene clusters
IL155306A0 (en)	2000-10-13	2003-11-23	Univ Mississippi	Methods for producing epothilone derivatives and analogs and epothilone derivatives and analogs produced thereby
SI1483251T1 (sl)	2002-03-12	2010-03-31	Bristol Myers Squibb Co	C cian epotilonski derivati
AU2006211216B2 (en) *	2005-01-31	2011-02-03	Merck Sharp & Dohme Llc	Purification process for plasmid DNA
DK2668284T3 (en)	2011-01-28	2014-12-15	Amyris Inc	Screening of colony micro encapsulated in gel
CA2834783A1 (fr)	2011-05-13	2012-11-22	Amyris, Inc.	Procedes et compositions pour detecter la production microbienne de composes immiscibles avec l'eau
AU2013299608B2 (en)	2012-08-07	2019-02-21	Amyris, Inc.	Methods for stabilizing production of acetyl-coenzyme a derived compounds
JP6595449B2 (ja)	2013-03-15	2019-10-23	アミリス，インコーポレイテッド	アセチル補酵素ａ由来化合物を生産するためのホスホケトラーゼおよびホスホトランスアセチラーゼの使用
BR112016002526B1 (pt)	2013-08-07	2021-11-23	Total Marketing Services	Método para produção de um composto heterólogo não catabólico, e, composição de fermentação
US10808015B2 (en)	2015-06-25	2020-10-20	Amyris, Inc.	Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN106916834B (zh) *	2015-12-24	2022-08-05	武汉合生科技有限公司	化合物的生物合成基因簇及其应用
CN111138444B (zh) *	2020-01-08	2022-05-03	山东大学	一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2312695T3 (es) *	1996-11-18	2009-03-01	Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf)	Epotilones e y f.

1998
- 1998-06-12 NZ NZ508326A patent/NZ508326A/en not_active IP Right Cessation
1999
- 1999-06-16 TR TR2000/03759T patent/TR200003759T2/xx unknown
- 1999-06-16 KR KR10-2000-7014348A patent/KR100511233B1/ko not_active Expired - Fee Related
- 1999-06-16 CA CA002329774A patent/CA2329774A1/fr not_active Abandoned
- 1999-06-16 WO PCT/EP1999/004171 patent/WO1999066028A2/fr not_active Ceased
- 1999-06-16 AU AU46116/99A patent/AU753567B2/en not_active Ceased
- 1999-06-16 IL IL13973599A patent/IL139735A0/xx unknown
- 1999-06-16 CN CNB998074217A patent/CN100374565C/zh not_active Expired - Fee Related
- 1999-06-16 ID IDW20002594A patent/ID29128A/id unknown
- 1999-06-16 EP EP99929243A patent/EP1088078A2/fr not_active Withdrawn
- 1999-06-16 SK SK1924-2000A patent/SK19242000A3/sk not_active Application Discontinuation
- 1999-06-16 BR BR9911349-0A patent/BR9911349A/pt not_active Application Discontinuation
- 1999-06-16 PL PL345579A patent/PL200157B1/pl not_active IP Right Cessation
- 1999-06-16 JP JP2000554837A patent/JP2002518004A/ja not_active Withdrawn
- 1999-06-16 HU HU0102186A patent/HUP0102186A3/hu unknown
2000
- 2000-11-16 IL IL139735A patent/IL139735A/en not_active IP Right Cessation
- 2000-12-06 NO NO20006195A patent/NO20006195L/no unknown
2005
- 2005-10-20 JP JP2005305998A patent/JP2006061166A/ja active Pending
2007
- 2007-12-26 JP JP2007334606A patent/JP2008092958A/ja active Pending
2008
- 2008-03-24 IL IL190391A patent/IL190391A0/en unknown
2009
- 2009-03-09 NO NO20091055A patent/NO20091055L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2006061166A (ja)	2006-03-09
CA2329774A1 (fr)	1999-12-23
WO1999066028A2 (fr)	1999-12-23
IL139735A (en)	2009-06-15
HUP0102186A2 (hu)	2001-10-28
KR100511233B1 (ko)	2005-08-31
EP1088078A2 (fr)	2001-04-04
AU753567B2 (en)	2002-10-24
JP2002518004A (ja)	2002-06-25
HUP0102186A3 (en)	2005-10-28
SK19242000A3 (sk)	2001-07-10
PL200157B1 (pl)	2008-12-31
NO20006195D0 (no)	2000-12-06
AU4611699A (en)	2000-01-05
CN100374565C (zh)	2008-03-12
ID29128A (id)	2001-08-02
IL190391A0 (en)	2008-11-03
WO1999066028A3 (fr)	2000-06-29
BR9911349A (pt)	2001-03-13
TR200003759T2 (tr)	2001-06-21
NO20006195L (no)	2001-02-16
KR20010052962A (ko)	2001-06-25
JP2008092958A (ja)	2008-04-24
NO20091055L (no)	2001-02-16
CN1305530A (zh)	2001-07-25
NZ508326A (en)	2003-10-31
PL345579A1 (en)	2001-12-17

Publication	Publication Date	Title
IL190391A0 (en)	2008-11-03	Genes for the biosynthesis of epothilones
AU3771100A (en)	2000-10-16	Synthesis of epothilones
EP1153276A4 (fr)	2002-06-19	Transducteur a compensation de temperature
AU4775299A (en)	2000-01-10	Desmethyl epothilones
AU6336500A (en)	2001-01-09	Radiolabeled farnesyl-protein transferase inhibitors
IL137550A0 (en)	2001-07-24	Epothilone compositions
AU4097799A (en)	1999-12-13	Guidewire having exchangeable inner member
AU2530399A (en)	1999-09-06	Centralizer
PL348428A1 (en)	2002-05-20	Genes of the 1-desoxy-d-xylulose biosynthetic pathway
AU1488501A (en)	2001-06-04	Methods of inhibiting metastasis
AU2001276549A1 (en)	2002-02-18	Transglutaminase for inhibiting angiogenesis
AU5237699A (en)	2000-02-21	Benzothiazole dioxetanes
AU2001250428A1 (en)	2001-11-20	Genes of the 1-desoxy-d-xylulose biosynthesis path
AU6417799A (en)	2000-05-01	Matrix-remodeling genes
AU2001245953A1 (en)	2001-10-08	Oncogenic osteomalacia-related gene 1
AU1381600A (en)	2000-05-29	Identification of senv genotypes
AUPQ319899A0 (en)	1999-10-28	Amide compounds
AU1682400A (en)	2000-06-26	4-oxoimidazolidine-2-spiro-nitrogenous heterocycle compounds
HK1035557A (en)	2001-11-30	Genes for the biosynthesis of epothilones
AU2020099A (en)	1999-10-25	Enzymes responsible for the metabolism of zeatin
AU2002221623A1 (en)	2002-04-08	Gene 4
AU2685499A (en)	1999-09-15	Cyclopropane-fatty-acyl-phospholipid synthase
GB9805939D0 (en)	1998-05-13	Starch biosynthesis
AU1242400A (en)	2000-05-22	Coenzyme a-utilizing enzymes
AU6079199A (en)	2000-02-28	Sialyltransferase inhibitors