NO20091055L - Gener for biosyntesen av epotiloner - Google Patents

Gener for biosyntesen av epotiloner

Info

Publication number
NO20091055L
NO20091055L NO20091055A NO20091055A NO20091055L NO 20091055 L NO20091055 L NO 20091055L NO 20091055 A NO20091055 A NO 20091055A NO 20091055 A NO20091055 A NO 20091055A NO 20091055 L NO20091055 L NO 20091055L
Authority
NO
Norway
Prior art keywords
epothilone
biosynthesis
genes
epothilones
cancer
Prior art date
Application number
NO20091055A
Other languages
English (en)
Inventor
Thomas Schupp
James Madison Ligon
Istvan Molnar
Ross Zirkle
Jorn Gorlach
Devon Cyr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20091055L publication Critical patent/NO20091055L/no
Application filed by Novartis Ag filed Critical Novartis Ag

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Nukleinsyremolekyler ble isolert fra Sorangium cellulosum som koder for polypeptider som er nødvendige for biosyntesen av epotilon. Det er omtalt metoder for fremstillingen av epotilonet i rekombinante verter transformert med gener ifølge oppfinnelsen. Epotilonet kan på denne måten bli fremstilt i mengder som er store nok for å muliggjøre rensning av disse og anvendelse i farmasøytiske formuleringer slik som for behandlingen av cancer.
NO20091055A 1998-06-18 2009-03-09 Gener for biosyntesen av epotiloner NO20091055L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9950498A 1998-06-18 1998-06-18
US10163198P 1998-09-24 1998-09-24
US11890699P 1999-02-05 1999-02-05
PCT/EP1999/004171 WO1999066028A2 (en) 1998-06-18 1999-06-16 Genes for the biosynthesis of epothilones

Publications (1)

Publication Number Publication Date
NO20091055L true NO20091055L (no) 2001-02-16

Family

ID=27378840

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20006195A NO20006195L (no) 1998-06-18 2000-12-06 Gener for biosyntesen av epothiloner
NO20091055A NO20091055L (no) 1998-06-18 2009-03-09 Gener for biosyntesen av epotiloner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20006195A NO20006195L (no) 1998-06-18 2000-12-06 Gener for biosyntesen av epothiloner

Country Status (16)

Country Link
EP (1) EP1088078A2 (no)
JP (3) JP2002518004A (no)
KR (1) KR100511233B1 (no)
CN (1) CN100374565C (no)
AU (1) AU753567B2 (no)
BR (1) BR9911349A (no)
CA (1) CA2329774A1 (no)
HU (1) HUP0102186A3 (no)
ID (1) ID29128A (no)
IL (3) IL139735A0 (no)
NO (2) NO20006195L (no)
NZ (1) NZ508326A (no)
PL (1) PL200157B1 (no)
SK (1) SK19242000A3 (no)
TR (1) TR200003759T2 (no)
WO (1) WO1999066028A2 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242469B1 (en) 1996-12-03 2001-06-05 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
DE19846493A1 (de) * 1998-10-09 2000-04-13 Biotechnolog Forschung Gmbh DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
KR100851418B1 (ko) * 1998-11-20 2008-08-08 코산 바이오사이언시즈, 인코포레이티드 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질
WO2001053533A2 (en) * 2000-01-21 2001-07-26 Kosan Biosciences, Inc. Method for cloning polyketide synthase genes
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
DE60114865T2 (de) * 2000-04-28 2006-07-27 Kosan Biosciences, Inc., Hayward Heterologe herstellung von polyketiden
AU2002213248A1 (en) 2000-10-13 2002-04-22 The University Of Mississipi Synthesis of epothilones and relates analogs
US7257562B2 (en) 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
JP4971997B2 (ja) * 2005-01-31 2012-07-11 メルク・シャープ・エンド・ドーム・コーポレイション プラスミドｄｎａの精製方法
AU2012211052A1 (en) 2011-01-28 2013-09-05 Amyris, Inc. Gel-encapsulated microcolony screening
BR112013027954A2 (pt) 2011-05-13 2017-01-17 Amyris Inc métodos e composições para detectar a produção microbiana de compostos imiscíveis em água
WO2014025941A1 (en) 2012-08-07 2014-02-13 Jiang Hanxiao Methods for stabilizing production of acetyl-coenzyme a derived compounds
CN105189772B (zh) 2013-03-15 2019-09-13 阿迈瑞斯公司 磷酸转酮酶和磷酸转乙酰酶生产乙酰-辅酶a衍生化合物的用途
AU2013397496B2 (en) 2013-08-07 2020-03-12 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
WO2016210350A1 (en) 2015-06-25 2016-12-29 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN106916834B (zh) * 2015-12-24 2022-08-05 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN111138444B (zh) * 2020-01-08 2022-05-03 山东大学 一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4274583B2 (ja) * 1996-11-18 2009-06-10 ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ） エポチロンｃ，ｄ，ｅ及びｆ、製造と薬剤

Also Published As

Publication number Publication date
JP2008092958A (ja) 2008-04-24
KR100511233B1 (ko) 2005-08-31
BR9911349A (pt) 2001-03-13
CA2329774A1 (en) 1999-12-23
CN100374565C (zh) 2008-03-12
NO20006195L (no) 2001-02-16
PL345579A1 (en) 2001-12-17
HUP0102186A2 (hu) 2001-10-28
WO1999066028A2 (en) 1999-12-23
CN1305530A (zh) 2001-07-25
EP1088078A2 (en) 2001-04-04
AU4611699A (en) 2000-01-05
JP2002518004A (ja) 2002-06-25
IL139735A0 (en) 2002-02-10
SK19242000A3 (sk) 2001-07-10
NZ508326A (en) 2003-10-31
IL190391A0 (en) 2008-11-03
NO20006195D0 (no) 2000-12-06
ID29128A (id) 2001-08-02
IL139735A (en) 2009-06-15
HUP0102186A3 (en) 2005-10-28
WO1999066028A3 (en) 2000-06-29
TR200003759T2 (tr) 2001-06-21
AU753567B2 (en) 2002-10-24
KR20010052962A (ko) 2001-06-25
PL200157B1 (pl) 2008-12-31
JP2006061166A (ja) 2006-03-09

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