IL139775A0 - A substituted triazolo-pyridazine derivative and pharmaceutical compositions made therefrom - Google Patents

A substituted triazolo-pyridazine derivative and pharmaceutical compositions made therefrom

Info

Publication number: IL139775A0
Authority: IL; Israel
Prior art keywords: pharmaceutical compositions; made therefrom; compositions made; pyridazine derivative; substituted triazolo
Prior art date: 1998-06-24

Application number

IL13977599A

Other languages

English (en)

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-24

Filing date

1999-06-15

Publication date

2002-02-10

1999-06-15 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2002-02-10 Publication of IL139775A0 publication Critical patent/IL139775A0/xx

Links

CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical class N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL13977599A 1998-06-24 1999-06-15 A substituted triazolo-pyridazine derivative and pharmaceutical compositions made therefrom IL139775A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9813576.7A GB9813576D0 (en)	1998-06-24	1998-06-24	Therapeutic agents
PCT/GB1999/001897 WO1999067245A1 (en)	1998-06-24	1999-06-15	A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom

Publications (1)

Publication Number	Publication Date
IL139775A0 true IL139775A0 (en)	2002-02-10

Family

ID=10834265

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL13977599A IL139775A0 (en)	1998-06-24	1999-06-15	A substituted triazolo-pyridazine derivative and pharmaceutical compositions made therefrom
IL139775A IL139775A (en)	1998-06-24	2000-11-20	7 - (1, 1 - dimethylethyl) - 6 - (2 - ethyl - 2H - 1, 2, 4 - triazole - 3 - ilmethoxy) - 3 - (2 - fluorophenyl) - 1, 2, 4 - triazolo [4, 3 - b] Pyridazine, processes for its preparation and pharmaceutical preparations containing it

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL139775A IL139775A (en)	1998-06-24	2000-11-20	7 - (1, 1 - dimethylethyl) - 6 - (2 - ethyl - 2H - 1, 2, 4 - triazole - 3 - ilmethoxy) - 3 - (2 - fluorophenyl) - 1, 2, 4 - triazolo [4, 3 - b] Pyridazine, processes for its preparation and pharmaceutical preparations containing it

Country Status (35)

Country	Link
US (1)	US6630471B1 (sr)
EP (1)	EP1090004B1 (sr)
JP (1)	JP4749545B2 (sr)
KR (1)	KR100604108B1 (sr)
CN (1)	CN1138779C (sr)
AR (1)	AR018925A1 (sr)
AT (1)	ATE239730T1 (sr)
AU (1)	AU757315B2 (sr)
BG (1)	BG64989B1 (sr)
BR (1)	BR9911563A (sr)
CA (1)	CA2335328C (sr)
CO (1)	CO5031239A1 (sr)
CZ (1)	CZ291409B6 (sr)
DE (1)	DE69907675T2 (sr)
EA (1)	EA003332B1 (sr)
EE (1)	EE200000767A (sr)
ES (1)	ES2196824T3 (sr)
GB (1)	GB9813576D0 (sr)
GE (1)	GEP20033143B (sr)
HR (1)	HRP20000879A2 (sr)
HU (1)	HUP0102894A3 (sr)
ID (1)	ID27771A (sr)
IL (2)	IL139775A0 (sr)
IS (1)	IS2258B (sr)
MY (1)	MY124341A (sr)
NO (1)	NO317992B1 (sr)
NZ (1)	NZ508290A (sr)
PE (1)	PE20000710A1 (sr)
PL (1)	PL204650B1 (sr)
RS (1)	RS49746B (sr)
SK (1)	SK285307B6 (sr)
TR (1)	TR200003789T2 (sr)
TW (1)	TWI222449B (sr)
WO (1)	WO1999067245A1 (sr)
ZA (1)	ZA200007485B (sr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2345443A (en) *	1999-01-08	2000-07-12	Merck Sharp & Dohme	Use of triazolo-pyridazines for treating premenstrual syndrome
US20050042194A1 (en)	2000-05-11	2005-02-24	A.P. Pharma, Inc.	Semi-solid delivery vehicle and pharmaceutical compositions
GB0111191D0 (en) *	2001-05-08	2001-06-27	Merck Sharp & Dohme	Therapeutic agents
AU2003297161B8 (en)	2002-12-18	2011-03-31	Vertex Pharmaceuticals Incorporated	Triazolopyridazines as protein kinases inhibitors
WO2006061428A2 (en) *	2004-12-10	2006-06-15	Universität Zürich	Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
EP2454259A1 (en) *	2009-06-23	2012-05-23	Concert Pharmaceuticals Inc.	Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
EP2456311A4 (en) *	2009-07-24	2013-01-23	Concert Pharmaceuticals Inc	SUBSTITUTED IMIDASOTRIAZINES
US8278460B2 (en)	2009-10-15	2012-10-02	Concert Pharmaceuticals, Inc.	Substituted benzimidazoles
PH12012501361A1 (en)	2009-12-31	2012-10-22	Centro Nac De Investigaciones Oncologicas Cnio	Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) *	2011-01-18	2012-07-26	Centro Nacional De Investigaciones Oncológicas (Cnio)	6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
EP2760866B1 (en)	2011-09-27	2017-12-13	Genfit	Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
BR112018015386A2 (pt)	2016-01-27	2019-03-19	Universität Zürich	uso de moduladores de receptor gabaa para tratamento de prurido
CN112384513A (zh)	2018-04-18	2021-02-19	纽罗塞克医疗公司	Gabaa正变构调节剂化合物、其制备方法和用途
HUE060943T2 (hu) *	2018-09-13	2023-04-28	Saniona As	A gaba A receptor ligandum
HU231223B1 (hu)	2018-09-28	2022-01-28	Richter Gedeon Nyrt.	GABAA A5 receptor modulátor hatású biciklusos vegyületek
US12649738B2 (en)	2020-03-26	2026-06-09	Richter Gedeon Nyrt.	1,3-dihydro-2H-pyrrolo[3,4-c]pyridine derivatives as GABAA α5 receptor modulators
TWI901650B (zh)	2020-03-26	2025-10-21	匈牙利商羅特格登公司	啶及吡啶并〔３，４－ｃ〕嗒衍生物
AU2024411621A1 (en)	2023-12-27	2026-06-18	Saniona A/S	A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy
WO2026082004A1 (zh) *	2024-10-14	2026-04-23	上海京新生物医药有限公司	稠合杂芳基衍生物及其制备方法与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0915875B1 (en) *	1996-07-25	2003-04-09	MERCK SHARP & DOHME LTD.	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

1998
- 1998-06-24 GB GBGB9813576.7A patent/GB9813576D0/en not_active Ceased
1999
- 1999-06-15 SK SK1955-2000A patent/SK285307B6/sk not_active IP Right Cessation
- 1999-06-15 EA EA200100071A patent/EA003332B1/ru not_active IP Right Cessation
- 1999-06-15 AU AU46301/99A patent/AU757315B2/en not_active Ceased
- 1999-06-15 CN CNB998078352A patent/CN1138779C/zh not_active Expired - Fee Related
- 1999-06-15 HU HU0102894A patent/HUP0102894A3/hu unknown
- 1999-06-15 RS YUP-778/00A patent/RS49746B/sr unknown
- 1999-06-15 HR HR20000879A patent/HRP20000879A2/hr not_active Application Discontinuation
- 1999-06-15 NZ NZ508290A patent/NZ508290A/en unknown
- 1999-06-15 BR BR9911563-8A patent/BR9911563A/pt not_active Application Discontinuation
- 1999-06-15 PL PL345332A patent/PL204650B1/pl not_active IP Right Cessation
- 1999-06-15 JP JP2000555898A patent/JP4749545B2/ja not_active Expired - Fee Related
- 1999-06-15 DE DE69907675T patent/DE69907675T2/de not_active Expired - Lifetime
- 1999-06-15 CZ CZ20004872A patent/CZ291409B6/cs not_active IP Right Cessation
- 1999-06-15 ES ES99929508T patent/ES2196824T3/es not_active Expired - Lifetime
- 1999-06-15 US US09/719,184 patent/US6630471B1/en not_active Expired - Lifetime
- 1999-06-15 ID IDW20002717A patent/ID27771A/id unknown
- 1999-06-15 AT AT99929508T patent/ATE239730T1/de not_active IP Right Cessation
- 1999-06-15 CA CA002335328A patent/CA2335328C/en not_active Expired - Fee Related
- 1999-06-15 EP EP99929508A patent/EP1090004B1/en not_active Expired - Lifetime
- 1999-06-15 KR KR1020007014680A patent/KR100604108B1/ko not_active Expired - Fee Related
- 1999-06-15 TR TR2000/03789T patent/TR200003789T2/xx unknown
- 1999-06-15 EE EEP200000767A patent/EE200000767A/xx unknown
- 1999-06-15 IL IL13977599A patent/IL139775A0/xx active IP Right Grant
- 1999-06-15 GE GEAP19995726A patent/GEP20033143B/en unknown
- 1999-06-15 WO PCT/GB1999/001897 patent/WO1999067245A1/en not_active Ceased
- 1999-06-16 MY MYPI99002465A patent/MY124341A/en unknown
- 1999-06-18 CO CO99038282A patent/CO5031239A1/es unknown
- 1999-06-22 PE PE1999000557A patent/PE20000710A1/es not_active Application Discontinuation
- 1999-06-23 AR ARP990103008A patent/AR018925A1/es active IP Right Grant
- 1999-06-28 TW TW088110866A patent/TWI222449B/zh active
2000
- 2000-11-20 IL IL139775A patent/IL139775A/en not_active IP Right Cessation
- 2000-11-24 IS IS5730A patent/IS2258B/is unknown
- 2000-12-14 ZA ZA200007485A patent/ZA200007485B/en unknown
- 2000-12-21 NO NO20006576A patent/NO317992B1/no not_active IP Right Cessation
2001
- 2001-01-15 BG BG105152A patent/BG64989B1/bg unknown

Also Published As

Publication number	Publication date
BG64989B1 (bg)	2006-11-30
RS49746B (sr)	2008-04-04
CA2335328A1 (en)	1999-12-29
EP1090004B1 (en)	2003-05-07
PE20000710A1 (es)	2000-08-14
PL345332A1 (en)	2001-12-17
IS2258B (is)	2007-06-15
HRP20000879A2 (en)	2001-06-30
AU4630199A (en)	2000-01-10
DE69907675T2 (de)	2004-03-04
ZA200007485B (en)	2002-01-07
IL139775A (en)	2007-02-11
CN1307579A (zh)	2001-08-08
ID27771A (id)	2001-04-26
NO20006576D0 (no)	2000-12-21
HUP0102894A3 (en)	2003-03-28
TWI222449B (en)	2004-10-21
GB9813576D0 (en)	1998-08-19
CZ291409B6 (cs)	2003-03-12
YU77800A (sh)	2003-10-31
MY124341A (en)	2006-06-30
JP2002518501A (ja)	2002-06-25
WO1999067245A1 (en)	1999-12-29
EA200100071A1 (ru)	2001-06-25
ES2196824T3 (es)	2003-12-16
GEP20033143B (en)	2003-12-25
SK19552000A3 (sk)	2001-08-06
KR100604108B1 (ko)	2006-07-26
US6630471B1 (en)	2003-10-07
EE200000767A (et)	2002-06-17
JP4749545B2 (ja)	2011-08-17
KR20010053136A (ko)	2001-06-25
NZ508290A (en)	2003-09-26
EA003332B1 (ru)	2003-04-24
NO317992B1 (no)	2005-01-17
NO20006576L (no)	2001-02-14
BG105152A (en)	2001-10-31
CA2335328C (en)	2007-11-27
PL204650B1 (pl)	2010-01-29
HUP0102894A2 (hu)	2001-11-28
EP1090004A1 (en)	2001-04-11
CN1138779C (zh)	2004-02-18
AU757315B2 (en)	2003-02-13
CZ20004872A3 (cs)	2001-07-11
DE69907675D1 (de)	2003-06-12
IS5730A (is)	2000-11-24
ATE239730T1 (de)	2003-05-15
TR200003789T2 (tr)	2001-04-20
AR018925A1 (es)	2001-12-12
BR9911563A (pt)	2001-03-20
CO5031239A1 (es)	2001-04-27
SK285307B6 (sk)	2006-10-05

Legal Events

Date	Code	Title
2007-07-24	FF	Patent granted
2007-07-24	KB	Patent renewed
2009-12-24	KB	Patent renewed

Publication	Publication Date	Title
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PL343627A1 (en)	2001-08-27	Medicinal compositions
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HUP0103203A3 (en)	2002-10-28	Azaadamantane derivatives and pharmaceutical compositions thereof
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