IL142093A - Transfer hydrogenation process - Google Patents

Transfer hydrogenation process

Info

Publication number: IL142093A
Authority: IL; Israel
Prior art keywords: hydrogenation process; transfer hydrogenation; bidentate ligands; employed; transfer
Prior art date: 1998-09-29

Application number

IL14209399A

Other languages

English (en)

Other versions

IL142093A0 (en

Original Assignee

Avecia Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-29

Filing date

1999-09-22

Publication date

2005-11-20

1999-09-22 Application filed by Avecia Ltd filed Critical Avecia Ltd

2002-03-10 Publication of IL142093A0 publication Critical patent/IL142093A0/xx

2005-11-20 Publication of IL142093A publication Critical patent/IL142093A/xx

Links

238000000034 method Methods 0.000 title abstract 4
238000009901 transfer hydrogenation reaction Methods 0.000 title abstract 2
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
239000003446 ligand Substances 0.000 abstract 2
229910052751 metal Inorganic materials 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
150000001414 amino alcohols Chemical class 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
150000004985 diamines Chemical class 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
239000000852 hydrogen donor Substances 0.000 abstract 1
150000007975 iminium salts Chemical class 0.000 abstract 1
229910052741 iridium Inorganic materials 0.000 abstract 1
GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 abstract 1
150000002739 metals Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
229910052703 rhodium Inorganic materials 0.000 abstract 1
239000010948 rhodium Substances 0.000 abstract 1
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
229910052707 ruthenium Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Indole Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

IL14209399A 1998-09-29 1999-09-22 Transfer hydrogenation process IL142093A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9821067.7A GB9821067D0 (en)	1998-09-29	1998-09-29	Transfer hydrogenation process
PCT/GB1999/003176 WO2000018708A1 (en)	1998-09-29	1999-09-22	Transfer hydrogenation process

Publications (2)

Publication Number	Publication Date
IL142093A0 IL142093A0 (en)	2002-03-10
IL142093A true IL142093A (en)	2005-11-20

Family

ID=10839587

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14209399A IL142093A (en)	1998-09-29	1999-09-22	Transfer hydrogenation process

Country Status (19)

Country	Link
US (1)	US6509467B1 (de)
EP (1)	EP1117627B1 (de)
JP (1)	JP2002525342A (de)
KR (1)	KR100674631B1 (de)
CN (1)	CN1231433C (de)
AT (1)	ATE241578T1 (de)
AU (1)	AU764996B2 (de)
CA (1)	CA2343088C (de)
CZ (1)	CZ299368B6 (de)
DE (1)	DE69908390T2 (de)
DK (1)	DK1117627T3 (de)
ES (1)	ES2201780T3 (de)
GB (1)	GB9821067D0 (de)
HK (1)	HK1042887B (de)
HU (1)	HU225492B1 (de)
IL (1)	IL142093A (de)
NO (1)	NO325921B1 (de)
PT (1)	PT1117627E (de)
WO (1)	WO2000018708A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6353112B1 (en)	1998-07-17	2002-03-05	The University Of Tennessee Research Corporation	Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions
US6562850B1 (en)	1998-07-17	2003-05-13	The University Of Tennessee Research Corporation	Methods of synthesizing sultams and anti-viral compositions
US6458962B1 (en)	1999-03-25	2002-10-01	The University Of Tennesseee Research Corporation	Sultams: catalyst systems for asymmetric reduction of a C=N intermediate biological compositions and methods for making the sultams
GB0029356D0 (en) *	2000-12-01	2001-01-17	Avecia Ltd	Transfer hydrogenation
US6743921B2 (en)	2002-01-24	2004-06-01	Dsm Catalytica Pharmaceuticals, Inc.	Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
WO2004096735A2 (en) *	2003-05-02	2004-11-11	Kamaluddin Abdur-Rashid	Transfer hydrogenation processes and catalysts
US8133717B2 (en)	2006-12-22	2012-03-13	Richmond Chemical Corporation	Stereoinversion of amino acids in a single reactor
TWI433674B (zh)	2006-12-28	2014-04-11	Infinity Discovery Inc	環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
ES2407033T3 (es) *	2007-05-04	2013-06-11	Mallinckrodt Llc	Procedimientos mejorados para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados
JP2010533719A (ja) *	2007-07-17	2010-10-28	マリンクロッド・インコーポレイテッド	還元的アミノ化によるｎ−アルキル化オピエートの調製
CA2710858A1 (en)	2007-12-27	2009-07-09	Infinity Pharmaceuticals, Inc.	Methods for stereoselective reduction
NZ607842A (en) *	2008-09-30	2013-12-20	Mallinckrodt Llc	Processes for the selective amination of ketomorphinans
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8471023B2 (en) *	2009-06-11	2013-06-25	Mallinckrodt Llc	Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
US8519133B2 (en) *	2009-06-11	2013-08-27	Mallinckrodt Llc	Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer
TW201105635A (en) *	2009-06-30	2011-02-16	Actelion Pharmaceuticals Ltd	Process for the preparation of an enantiomerically pure trisubstituted 1,2,3,4-tetrahydroisoquinoline derivative
AU2010279325B2 (en)	2009-08-05	2016-10-20	Infinity Pharmaceuticals, Inc.	Enzymatic transamination of cyclopamine analogs
US9394313B2 (en)	2010-09-14	2016-07-19	Infinity Pharmaceuticals, Inc.	Transfer hydrogenation of cyclopamine analogs
KR20140036215A (ko)	2011-06-09	2014-03-25	말린크로트 엘엘씨	촉매 수소 전달에 의한 6-케토 모르피난의 환원 아미노화
MX2014002630A (es)	2011-09-08	2014-04-14	Mallinckrodt Llc	Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
PL3302428T3 (pl)	2015-06-04	2026-04-13	Sol-Gel Technologies Ltd.	Preparaty do zastosowania miejscowego do dostarczania związków inhibitora hedgehog i ich zastosowanie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS553349B2 (de) *	1972-06-20	1980-01-24
AT333764B (de) *	1972-06-20	1976-12-10	Fujisawa Pharmaceutical Co	Verfahren zur herstellung von neuen 1,2,3,4-tetrahydroisochinolinen und deren salzen
JP3149989B2 (ja) *	1992-04-28	2001-03-26	広栄化学工業株式会社	２−クロロ−５−置換アミノメチルピリジン類の製法
GB9706321D0 (en) *	1997-03-26	1997-05-14	Zeneca Ltd	Catalytic hydrogenation

1998
- 1998-09-29 GB GBGB9821067.7A patent/GB9821067D0/en not_active Ceased
1999
- 1999-09-22 AT AT99949137T patent/ATE241578T1/de not_active IP Right Cessation
- 1999-09-22 US US09/787,707 patent/US6509467B1/en not_active Expired - Fee Related
- 1999-09-22 CA CA002343088A patent/CA2343088C/en not_active Expired - Fee Related
- 1999-09-22 CZ CZ20011110A patent/CZ299368B6/cs not_active IP Right Cessation
- 1999-09-22 JP JP2000572172A patent/JP2002525342A/ja active Pending
- 1999-09-22 ES ES99949137T patent/ES2201780T3/es not_active Expired - Lifetime
- 1999-09-22 WO PCT/GB1999/003176 patent/WO2000018708A1/en not_active Ceased
- 1999-09-22 PT PT99949137T patent/PT1117627E/pt unknown
- 1999-09-22 HU HU0103510A patent/HU225492B1/hu not_active IP Right Cessation
- 1999-09-22 DE DE69908390T patent/DE69908390T2/de not_active Expired - Fee Related
- 1999-09-22 CN CNB998114472A patent/CN1231433C/zh not_active Expired - Fee Related
- 1999-09-22 KR KR1020017003924A patent/KR100674631B1/ko not_active Expired - Fee Related
- 1999-09-22 DK DK99949137T patent/DK1117627T3/da active
- 1999-09-22 IL IL14209399A patent/IL142093A/xx not_active IP Right Cessation
- 1999-09-22 EP EP99949137A patent/EP1117627B1/de not_active Expired - Lifetime
- 1999-09-22 AU AU62125/99A patent/AU764996B2/en not_active Ceased
- 1999-09-22 HK HK02102896.9A patent/HK1042887B/zh not_active IP Right Cessation
2001
- 2001-03-28 NO NO20011573A patent/NO325921B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ299368B6 (cs)	2008-07-02
CA2343088A1 (en)	2000-04-06
CN1321140A (zh)	2001-11-07
HUP0103510A3 (en)	2002-04-29
EP1117627B1 (de)	2003-05-28
IL142093A0 (en)	2002-03-10
CA2343088C (en)	2009-02-24
AU6212599A (en)	2000-04-17
CN1231433C (zh)	2005-12-14
GB9821067D0 (en)	1998-11-18
HK1042887B (zh)	2006-08-18
HK1042887A1 (en)	2002-08-30
CZ20011110A3 (cs)	2001-08-15
DE69908390T2 (de)	2004-04-22
AU764996B2 (en)	2003-09-04
NO20011573L (no)	2001-03-28
JP2002525342A (ja)	2002-08-13
WO2000018708A1 (en)	2000-04-06
EP1117627A1 (de)	2001-07-25
ATE241578T1 (de)	2003-06-15
US6509467B1 (en)	2003-01-21
HU225492B1 (en)	2007-01-29
PT1117627E (pt)	2003-10-31
NO325921B1 (no)	2008-08-18
KR20010075408A (ko)	2001-08-09
ES2201780T3 (es)	2004-03-16
KR100674631B1 (ko)	2007-01-25
DE69908390D1 (de)	2003-07-03
HUP0103510A2 (hu)	2002-01-28
NO20011573D0 (no)	2001-03-28
DK1117627T3 (da)	2003-09-15

Legal Events

Date	Code	Title	Description
2006-02-21	FF	Patent granted
2010-11-30	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL142093A (en)	2005-11-20	Transfer hydrogenation process
GB9706321D0 (en)	1997-05-14	Catalytic hydrogenation
GB0029356D0 (en)	2001-01-17	Transfer hydrogenation
Zhang et al.	2018	Asymmetric transfer and pressure hydrogenation with earth‐abundant transition metal catalysts
ATE212032T1 (de)	2002-02-15	Funktionalisierte ferrocenyldiphospine, verfahren zu ihrer herstellung und ihre verwendung
CA2104295A1 (en)	1992-09-14	Production of diesel fuel by hydrogenation of a diesel feed
MY121112A (en)	2005-12-30	Raney iron catalyst and a process for hydrogenating organic compounds using said catalyst.
IL147673A0 (en)	2002-08-14	Transfer hydrogenation process
MX9708720A (es)	1997-12-31	Preparacion de n-metil-2-(3,4-dimetoxifenil) etilamina.
IL164915A (en)	2010-12-30	Process for hydrogenating unactivated imines using ruthenium complexes as catalysts
MY127864A (en)	2006-12-29	Improved process for the hydrogenation of maleic acid to 1,4-butanediol
AU7270896A (en)	1997-05-07	Chiral solid catalyst, its preparation and its use for the production of substantially enantiomerically pure products
IL122312A (en)	2001-08-26	Process for the hydrogenation of imines
ES8502072A1 (es)	1984-12-16	Procedimiento para preparar trifluoroetanol
WO2004043851A8 (en)	2004-07-29	Reduction of ammonia formation during fuel reforming
RU97117071A (ru)	1999-07-20	Способ жидкофазного гидрирования
CREMER et al.	1982	Homogeneous hydrogenation of model-coal compounds[Ph. D. Thesis]
RU99104494A (ru)	2001-01-27	Способ получения 6-аминокапронитрила
TW356432B (en)	1999-04-21	Hydrogenation catalyst and process
CA2181366A1 (en)	1995-08-10	Hydrogenation catalyst, process for the preparation thereof and hydrogenation process