IL142093A - Transfer hydrogenation process - Google Patents

Transfer hydrogenation process

Info

Publication number: IL142093A
Authority: IL; Israel
Prior art keywords: hydrogenation process; transfer hydrogenation; bidentate ligands; employed; transfer
Prior art date: 1998-09-29

Application number

IL14209399A

Other languages

English (en)

Other versions

IL142093A0 (en

Original Assignee

Avecia Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-29

Filing date

1999-09-22

Publication date

2005-11-20

1999-09-22 Application filed by Avecia Ltd filed Critical Avecia Ltd

2002-03-10 Publication of IL142093A0 publication Critical patent/IL142093A0/xx

2005-11-20 Publication of IL142093A publication Critical patent/IL142093A/xx

Links

238000000034 method Methods 0.000 title abstract 4
238000009901 transfer hydrogenation reaction Methods 0.000 title abstract 2
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
239000003446 ligand Substances 0.000 abstract 2
229910052751 metal Inorganic materials 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
150000001414 amino alcohols Chemical class 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
150000004985 diamines Chemical class 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
239000000852 hydrogen donor Substances 0.000 abstract 1
150000007975 iminium salts Chemical class 0.000 abstract 1
229910052741 iridium Inorganic materials 0.000 abstract 1
GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 abstract 1
150000002739 metals Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
229910052703 rhodium Inorganic materials 0.000 abstract 1
239000010948 rhodium Substances 0.000 abstract 1
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
229910052707 ruthenium Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

IL14209399A 1998-09-29 1999-09-22 Transfer hydrogenation process IL142093A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9821067.7A GB9821067D0 (en)	1998-09-29	1998-09-29	Transfer hydrogenation process
PCT/GB1999/003176 WO2000018708A1 (en)	1998-09-29	1999-09-22	Transfer hydrogenation process

Publications (2)

Publication Number	Publication Date
IL142093A0 IL142093A0 (en)	2002-03-10
IL142093A true IL142093A (en)	2005-11-20

Family

ID=10839587

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14209399A IL142093A (en)	1998-09-29	1999-09-22	Transfer hydrogenation process

Country Status (19)

Country	Link
US (1)	US6509467B1 (es)
EP (1)	EP1117627B1 (es)
JP (1)	JP2002525342A (es)
KR (1)	KR100674631B1 (es)
CN (1)	CN1231433C (es)
AT (1)	ATE241578T1 (es)
AU (1)	AU764996B2 (es)
CA (1)	CA2343088C (es)
CZ (1)	CZ299368B6 (es)
DE (1)	DE69908390T2 (es)
DK (1)	DK1117627T3 (es)
ES (1)	ES2201780T3 (es)
GB (1)	GB9821067D0 (es)
HK (1)	HK1042887B (es)
HU (1)	HU225492B1 (es)
IL (1)	IL142093A (es)
NO (1)	NO325921B1 (es)
PT (1)	PT1117627E (es)
WO (1)	WO2000018708A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6562850B1 (en)	1998-07-17	2003-05-13	The University Of Tennessee Research Corporation	Methods of synthesizing sultams and anti-viral compositions
US6353112B1 (en)	1998-07-17	2002-03-05	The University Of Tennessee Research Corporation	Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions
US6458962B1 (en)	1999-03-25	2002-10-01	The University Of Tennesseee Research Corporation	Sultams: catalyst systems for asymmetric reduction of a C=N intermediate biological compositions and methods for making the sultams
GB0029356D0 (en) *	2000-12-01	2001-01-17	Avecia Ltd	Transfer hydrogenation
US6743921B2 (en)	2002-01-24	2004-06-01	Dsm Catalytica Pharmaceuticals, Inc.	Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
WO2004096735A2 (en) *	2003-05-02	2004-11-11	Kamaluddin Abdur-Rashid	Transfer hydrogenation processes and catalysts
WO2008080138A1 (en)	2006-12-22	2008-07-03	Richmond Chemical Corporation	Stereoinversion of amino acids
TWI433674B (zh)	2006-12-28	2014-04-11	Infinity Discovery Inc	環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
AU2008207580B2 (en) *	2007-05-04	2011-04-14	SpecGx LLC	Improved process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
WO2009012005A1 (en) *	2007-07-17	2009-01-22	Mallinckrodt Inc.	Preparation of n-alkylated opiates by reductive amination
CN104059124A (zh)	2007-12-27	2014-09-24	无限药品股份有限公司	立体选择性还原的方法
US8269006B2 (en) *	2008-09-30	2012-09-18	Mallinckrodt Llc	Processes for the selective amination of ketomorphinans
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
CN102803267A (zh) *	2009-06-11	2012-11-28	马林克罗特有限公司	通过催化氢转移的6-α-氨基N-取代的吗啡喃的制备
CN102459274B (zh) *	2009-06-11	2015-07-15	马林克罗特有限公司	6-酮基去甲吗啡喃通过催化氢转移的还原胺化
TW201105635A (en) *	2009-06-30	2011-02-16	Actelion Pharmaceuticals Ltd	Process for the preparation of an enantiomerically pure trisubstituted 1,2,3,4-tetrahydroisoquinoline derivative
JP6141015B2 (ja)	2009-08-05	2017-06-07	インフィニティファーマスーティカルズ、インク．	シクロパミン類似体の酵素によるアミノ基転移
US9376447B2 (en)	2010-09-14	2016-06-28	Infinity Pharmaceuticals, Inc.	Transfer hydrogenation of cyclopamine analogs
MX2013013634A (es)	2011-06-09	2013-12-12	Mallinckrodt Llc	Aminacion reductiva de 6-ceto-morfinanos por transfrencia catalitica de hidrogeno.
CN103917543A (zh)	2011-09-08	2014-07-09	马林克罗特有限公司	在不分离中间体的情况下制备生物碱
HRP20251395T1 (hr)	2015-06-04	2026-02-13	Sol-Gel Technologies Ltd.	Topikalne formulacije za isporuku spojeva inhibitora hedgehog signalnog puta i njihova uporaba

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT333764B (de)	1972-06-20	1976-12-10	Fujisawa Pharmaceutical Co	Verfahren zur herstellung von neuen 1,2,3,4-tetrahydroisochinolinen und deren salzen
JPS553349B2 (es) *	1972-06-20	1980-01-24
JP3149989B2 (ja) *	1992-04-28	2001-03-26	広栄化学工業株式会社	２−クロロ−５−置換アミノメチルピリジン類の製法
GB9706321D0 (en) *	1997-03-26	1997-05-14	Zeneca Ltd	Catalytic hydrogenation

1998
- 1998-09-29 GB GBGB9821067.7A patent/GB9821067D0/en not_active Ceased
1999
- 1999-09-22 DE DE69908390T patent/DE69908390T2/de not_active Expired - Fee Related
- 1999-09-22 CZ CZ20011110A patent/CZ299368B6/cs not_active IP Right Cessation
- 1999-09-22 ES ES99949137T patent/ES2201780T3/es not_active Expired - Lifetime
- 1999-09-22 KR KR1020017003924A patent/KR100674631B1/ko not_active Expired - Fee Related
- 1999-09-22 PT PT99949137T patent/PT1117627E/pt unknown
- 1999-09-22 CA CA002343088A patent/CA2343088C/en not_active Expired - Fee Related
- 1999-09-22 DK DK99949137T patent/DK1117627T3/da active
- 1999-09-22 AU AU62125/99A patent/AU764996B2/en not_active Ceased
- 1999-09-22 IL IL14209399A patent/IL142093A/xx not_active IP Right Cessation
- 1999-09-22 AT AT99949137T patent/ATE241578T1/de not_active IP Right Cessation
- 1999-09-22 HK HK02102896.9A patent/HK1042887B/zh not_active IP Right Cessation
- 1999-09-22 EP EP99949137A patent/EP1117627B1/en not_active Expired - Lifetime
- 1999-09-22 HU HU0103510A patent/HU225492B1/hu not_active IP Right Cessation
- 1999-09-22 WO PCT/GB1999/003176 patent/WO2000018708A1/en not_active Ceased
- 1999-09-22 JP JP2000572172A patent/JP2002525342A/ja active Pending
- 1999-09-22 CN CNB998114472A patent/CN1231433C/zh not_active Expired - Fee Related
- 1999-09-22 US US09/787,707 patent/US6509467B1/en not_active Expired - Fee Related
2001
- 2001-03-28 NO NO20011573A patent/NO325921B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1321140A (zh)	2001-11-07
IL142093A0 (en)	2002-03-10
GB9821067D0 (en)	1998-11-18
KR20010075408A (ko)	2001-08-09
CA2343088A1 (en)	2000-04-06
EP1117627A1 (en)	2001-07-25
CN1231433C (zh)	2005-12-14
KR100674631B1 (ko)	2007-01-25
EP1117627B1 (en)	2003-05-28
DE69908390T2 (de)	2004-04-22
HK1042887A1 (en)	2002-08-30
CZ299368B6 (cs)	2008-07-02
HU225492B1 (en)	2007-01-29
CZ20011110A3 (cs)	2001-08-15
NO325921B1 (no)	2008-08-18
WO2000018708A1 (en)	2000-04-06
US6509467B1 (en)	2003-01-21
DK1117627T3 (da)	2003-09-15
HUP0103510A2 (hu)	2002-01-28
JP2002525342A (ja)	2002-08-13
DE69908390D1 (de)	2003-07-03
AU764996B2 (en)	2003-09-04
HK1042887B (zh)	2006-08-18
ES2201780T3 (es)	2004-03-16
NO20011573D0 (no)	2001-03-28
HUP0103510A3 (en)	2002-04-29
PT1117627E (pt)	2003-10-31
AU6212599A (en)	2000-04-17
ATE241578T1 (de)	2003-06-15
NO20011573L (no)	2001-03-28
CA2343088C (en)	2009-02-24

Legal Events

Date	Code	Title	Description
2006-02-21	FF	Patent granted
2010-11-30	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL142093A0 (en)	2002-03-10	Transfer hydrogenation process
GB9706321D0 (en)	1997-05-14	Catalytic hydrogenation
GB0029356D0 (en)	2001-01-17	Transfer hydrogenation
ATE212032T1 (de)	2002-02-15	Funktionalisierte ferrocenyldiphospine, verfahren zu ihrer herstellung und ihre verwendung
CA2104295A1 (en)	1992-09-14	Production of diesel fuel by hydrogenation of a diesel feed
MY121112A (en)	2005-12-30	Raney iron catalyst and a process for hydrogenating organic compounds using said catalyst.
Longley et al.	1986	Hydrogenation of imines by rhodium-phosphine complexes
DE59707151D1 (de)	2002-06-06	Verfahren zur Hydrierung von Zuckern mittels eines Schalenkatalysators
IL147673A0 (en)	2002-08-14	Transfer hydrogenation process
Ke et al.	2018	Homogeneously catalyzed hydrogenation and dehydrogenation reactions–From a mechanistic point of view
MY118960A (en)	2005-02-28	Improved process for preparing hexamethylenediamine
DE59506635D1 (de)	1999-09-23	Verfahren zur Hydrierung von Zuckern
ES8701770A1 (es)	1986-12-01	Procedimiento para preparar 1-bencil-3,4-bis-(difenilfosfino)-pirrolidina opticamente activa
MX9708720A (es)	1997-12-31	Preparacion de n-metil-2-(3,4-dimetoxifenil) etilamina.
AU7270896A (en)	1997-05-07	Chiral solid catalyst, its preparation and its use for the production of substantially enantiomerically pure products
IL122312A (en)	2001-08-26	Process for the hydrogenation of imines
WO2004043851A8 (en)	2004-07-29	Reduction of ammonia formation during fuel reforming
CREMER et al.	1982	Homogeneous hydrogenation of model-coal compounds[Ph. D. Thesis]
ES2327705A1 (es)	2009-11-02	Procedimiento para la hidrogenacion homogenea de cetonas utilizando sistemas cataliticos de rutenio.
RU99104494A (ru)	2001-01-27	Способ получения 6-аминокапронитрила
Jun et al.	1984	Stereospecific Coordination of 2, 2$^\prime $-Diaminobiphenyl in the Square Planar Platinum (Ⅱ) Comdlexes