IL142899A0 - Antagonistic analogs of gh-rh inhibiting igf-1 and -ii - Google Patents

Antagonistic analogs of gh-rh inhibiting igf-1 and -ii

Info

Publication number
IL142899A0
IL142899A0 IL14289999A IL14289999A IL142899A0 IL 142899 A0 IL142899 A0 IL 142899A0 IL 14289999 A IL14289999 A IL 14289999A IL 14289999 A IL14289999 A IL 14289999A IL 142899 A0 IL142899 A0 IL 142899A0
Authority
IL
Israel
Prior art keywords
inhibiting igf
antagonistic analogs
antagonistic
analogs
igf
Prior art date
Application number
IL14289999A
Other languages
English (en)
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of IL142899A0 publication Critical patent/IL142899A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL14289999A 1998-11-25 1999-11-23 Antagonistic analogs of gh-rh inhibiting igf-1 and -ii IL142899A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/199,381 US6057422A (en) 1998-11-25 1998-11-25 Antagonistic analogs of GH-RH inhibiting IGF-I and -II
PCT/US1999/027822 WO2000031136A1 (en) 1998-11-25 1999-11-23 Antagonistic analogs of gh-rh inhibiting igf-i and -ii

Publications (1)

Publication Number Publication Date
IL142899A0 true IL142899A0 (en) 2002-04-21

Family

ID=22737273

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14289999A IL142899A0 (en) 1998-11-25 1999-11-23 Antagonistic analogs of gh-rh inhibiting igf-1 and -ii

Country Status (28)

Country Link
US (2) US6057422A (cs)
EP (1) EP1133522B1 (cs)
JP (1) JP2002530432A (cs)
KR (1) KR100629013B1 (cs)
CN (1) CN100422211C (cs)
AR (1) AR022392A1 (cs)
AT (1) ATE332310T1 (cs)
AU (1) AU757222B2 (cs)
BG (1) BG65137B1 (cs)
BR (1) BR9915512A (cs)
CA (1) CA2351665C (cs)
CO (1) CO5180565A1 (cs)
CZ (1) CZ20011794A3 (cs)
DE (1) DE69932255T2 (cs)
DK (1) DK1133522T3 (cs)
ES (1) ES2264279T3 (cs)
HU (1) HUP0105094A3 (cs)
IL (1) IL142899A0 (cs)
NO (1) NO20012489L (cs)
NZ (1) NZ511307A (cs)
PL (1) PL197471B1 (cs)
PT (1) PT1133522E (cs)
RU (1) RU2235099C2 (cs)
SK (1) SK7252001A3 (cs)
TR (1) TR200101492T2 (cs)
TW (1) TW585873B (cs)
UA (1) UA68407C2 (cs)
WO (1) WO2000031136A1 (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2454135A1 (en) * 2001-07-12 2003-01-23 Exelixis, Inc. Gpcs as modifiers of the irrtk and p21 pathways and methods of use
US20040121407A1 (en) * 2002-09-06 2004-06-24 Elixir Pharmaceuticals, Inc. Regulation of the growth hormone/IGF-1 axis
KR20050071498A (ko) * 2002-09-18 2005-07-07 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 성장 호르몬 방출 호르몬 유사체
TW200517400A (en) * 2003-08-05 2005-06-01 Univ Tulane Antagonistic analogs of GH-RH (2003)
CA2718146C (en) * 2008-03-28 2016-09-20 The University Of Miami Novel n- and c-terminal substituted antagonistic analogs of gh-rh
US8691942B2 (en) 2008-03-28 2014-04-08 University Of Miami N- and C- terminal substituted antagonistic analogs of GH-RH
CN102083451A (zh) 2008-06-12 2011-06-01 赛恩泰新公司 癌症的抑制
CA2727082C (en) 2008-06-12 2019-02-26 Syntaxin Limited Fusion proteins for use in suppression of acromegaly
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists
KR20140027284A (ko) 2011-04-21 2014-03-06 쎄러테크놀로지스 인코포레이티드 성장 호르몬 방출 인자(grf) 유사체 및 이의 용도
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
WO2014100816A2 (en) 2012-12-21 2014-06-26 University Of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
US9855312B2 (en) 2012-12-21 2018-01-02 University Of Miami GHRH agonists for the treatment of ischemic disorders
WO2016077620A1 (en) 2014-11-12 2016-05-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Treatment of hormonal disorders of growth
CA3129405A1 (en) 2019-02-08 2020-08-13 United States Government As Represented By The Department Of Veterans Affairs Growth hormone-releasing hormone antagonists and uses thereof
CN114126653B (zh) 2019-07-18 2024-02-20 迈阿密大学 用于治疗结节病的方法的ghrh拮抗剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659693A (en) * 1984-04-30 1987-04-21 Syntex (U.S.A.) Inc. N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides
CA2082059A1 (en) * 1990-05-04 1991-11-05 David H. Coy Synthetic grf analogs
RU2119800C1 (ru) * 1990-11-14 1998-10-10 Дзе Апджон Компани Аналог пептида фактора гормона роста (фгр), способ стимулирования секреции гормона роста и композиция для стимулирования секреции
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
US5942489A (en) * 1996-05-03 1999-08-24 The Administrators Of The Tulane Educational Fund HGH-RH(1-29)NH2 analogues having antagonistic activity

Also Published As

Publication number Publication date
CA2351665A1 (en) 2000-06-02
US7026281B1 (en) 2006-04-11
NZ511307A (en) 2005-01-28
CN1328570A (zh) 2001-12-26
PT1133522E (pt) 2006-11-30
PL349877A1 (en) 2002-09-23
BG105638A (en) 2002-01-31
UA68407C2 (en) 2004-08-16
WO2000031136A1 (en) 2000-06-02
CA2351665C (en) 2008-09-02
KR20010101079A (ko) 2001-11-14
TR200101492T2 (tr) 2001-11-21
DE69932255T2 (de) 2007-05-31
WO2000031136A9 (en) 2001-07-19
DE69932255D1 (de) 2006-08-17
RU2235099C2 (ru) 2004-08-27
ATE332310T1 (de) 2006-07-15
TW585873B (en) 2004-05-01
HK1036461A1 (en) 2002-01-04
HUP0105094A3 (en) 2002-05-28
AR022392A1 (es) 2002-09-04
DK1133522T3 (da) 2006-11-06
HUP0105094A2 (hu) 2002-04-29
SK7252001A3 (en) 2002-02-05
NO20012489L (no) 2001-07-04
BR9915512A (pt) 2001-08-07
BG65137B1 (bg) 2007-03-30
CZ20011794A3 (cs) 2002-02-13
US6057422A (en) 2000-05-02
CO5180565A1 (es) 2002-07-30
PL197471B1 (pl) 2008-04-30
NO20012489D0 (no) 2001-05-21
JP2002530432A (ja) 2002-09-17
KR100629013B1 (ko) 2006-09-26
ES2264279T3 (es) 2006-12-16
AU757222B2 (en) 2003-02-06
EP1133522A1 (en) 2001-09-19
CN100422211C (zh) 2008-10-01
AU2029100A (en) 2000-06-13
EP1133522B1 (en) 2006-07-05

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees