IL144411A0 - Human liver progenitors - Google Patents
Human liver progenitorsInfo
- Publication number
- IL144411A0 IL144411A0 IL14441100A IL14441100A IL144411A0 IL 144411 A0 IL144411 A0 IL 144411A0 IL 14441100 A IL14441100 A IL 14441100A IL 14441100 A IL14441100 A IL 14441100A IL 144411 A0 IL144411 A0 IL 144411A0
- Authority
- IL
- Israel
- Prior art keywords
- progenitors
- suspension
- human liver
- cell
- cell lineages
- Prior art date
Links
- 210000004185 liver Anatomy 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 5
- 239000000725 suspension Substances 0.000 abstract 4
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 abstract 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 abstract 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 abstract 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 abstract 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 abstract 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 abstract 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 abstract 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 abstract 2
- 102000028180 Glycophorins Human genes 0.000 abstract 1
- 108091005250 Glycophorins Proteins 0.000 abstract 1
- 239000006285 cell suspension Substances 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 210000005229 liver cell Anatomy 0.000 abstract 1
- 210000005228 liver tissue Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/22—Zinc; Zn chelators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11633199P | 1999-01-19 | 1999-01-19 | |
| PCT/US2000/001116 WO2000043498A2 (en) | 1999-01-19 | 2000-01-19 | Human liver progenitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL144411A0 true IL144411A0 (en) | 2002-05-23 |
Family
ID=22366551
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14441100A IL144411A0 (en) | 1999-01-19 | 2000-01-19 | Human liver progenitors |
| IL144411A IL144411A (en) | 1999-01-19 | 2001-07-18 | Human respectable stem cells |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL144411A IL144411A (en) | 1999-01-19 | 2001-07-18 | Human respectable stem cells |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20020182188A1 (de) |
| EP (2) | EP2048228B8 (de) |
| JP (1) | JP5068901B2 (de) |
| KR (1) | KR100873690B1 (de) |
| CN (2) | CN102703379B (de) |
| AT (1) | ATE414143T1 (de) |
| AU (1) | AU779706B2 (de) |
| CA (2) | CA2877233A1 (de) |
| CY (1) | CY1108806T1 (de) |
| DE (1) | DE60040782D1 (de) |
| DK (2) | DK1147179T3 (de) |
| ES (2) | ES2569778T3 (de) |
| HK (1) | HK1046930B (de) |
| IL (2) | IL144411A0 (de) |
| NZ (3) | NZ513150A (de) |
| PT (1) | PT1147179E (de) |
| RU (1) | RU2247565C2 (de) |
| WO (1) | WO2000043498A2 (de) |
| ZA (1) | ZA200106306B (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020187133A1 (en) | 1999-10-01 | 2002-12-12 | Hiroshi Kubota | Methods of isolating bipotent hepatic progenitor cells |
| AU1954001A (en) * | 1999-12-10 | 2001-06-18 | Ariad Gene Therapeutics, Inc. | Methods for high level expression of genes in primates |
| WO2001053462A1 (en) | 2000-01-19 | 2001-07-26 | University Of North Carolina At Chapel Hill | Liver tissue source |
| FR2806911B1 (fr) * | 2000-03-28 | 2003-01-10 | Univ Rene Descartes | Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires |
| US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| US7256042B2 (en) | 2000-04-27 | 2007-08-14 | Geron Corporation | Process for making hepatocytes from pluripotent stem cells |
| US7282366B2 (en) | 2000-04-27 | 2007-10-16 | Geron Corporation | Hepatocytes for therapy and drug screening made from embryonic stem cells |
| US7473555B2 (en) | 2000-04-27 | 2009-01-06 | Geron Corporation | Protocols for making hepatocytes from embryonic stem cells |
| WO2002028997A2 (en) * | 2000-10-03 | 2002-04-11 | University Of North Carolina | Methods of isolating bipotent hepatic progenitor cells |
| CA2424779C (en) * | 2000-10-03 | 2016-08-23 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
| EP1381673B1 (de) | 2001-03-27 | 2009-05-13 | Vertex Pharmaceuticals Incorporated | Für hcv-infektion geeignete zusammensetzungen und verfahren |
| EP1559777A1 (de) * | 2001-04-24 | 2005-08-03 | Hokkaido Technology Licensing Office Co., Ltd. | Methode zur Reifung von Kolonien, die an kleinen Leberzellen reich sind, zu Lebergewebe |
| US20040259246A1 (en) * | 2001-07-10 | 2004-12-23 | Dhillon Amar Paul | Liver cell progenitor and use for treatment of liver diseases |
| US7332589B2 (en) * | 2001-09-26 | 2008-02-19 | University Of North Carolina At Chapel Hill | Variants of alpha-fetoprotein coding and expression sequences |
| EP1496066A4 (de) * | 2002-03-25 | 2006-09-13 | Japan Science & Tech Agency | Antikörper, der proliferative humane leberzellen erkennt, proliferative humane leberzellen und funktionelle humane leberzellen |
| US7074561B2 (en) * | 2002-10-22 | 2006-07-11 | Biomerieux, Inc. | Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA |
| JP3762975B2 (ja) * | 2003-03-18 | 2006-04-05 | 学校法人慶應義塾 | 単球由来多能性細胞momc |
| CN1875101A (zh) * | 2003-09-02 | 2006-12-06 | 北卡罗来纳-查佩尔山大学 | 生物可降解聚合物-配体偶联物及其在细胞亚群的分离和细胞的低温保藏、培养和移植中的应用 |
| WO2005045012A1 (en) * | 2003-11-05 | 2005-05-19 | Regents Of The University Of Minnesota | Endodermal stem cells in liver and methods for isolation thereof |
| US20050106554A1 (en) * | 2003-11-19 | 2005-05-19 | Palecek Sean P. | Cryopreservation of pluripotent stem cells |
| US20080220520A1 (en) * | 2003-11-19 | 2008-09-11 | Palecek Sean P | Cryopreservation of human embryonic stem cells in microwells |
| WO2005073366A1 (en) * | 2004-01-30 | 2005-08-11 | Lifecord Inc. | Method for isolating and culturing multipotent progenitor/stem cells from umbilical cord blood and method for inducing differentiation thereof |
| WO2006017274A2 (en) * | 2004-07-13 | 2006-02-16 | U.S. Genomics, Inc. | Systems and methods for sample modification using fluidic chambers |
| RU2272638C1 (ru) * | 2004-08-18 | 2006-03-27 | ЗАО "РеМеТэкс" | Биотрансплантат, способ его получения и способ лечения хронического гепатита и цирроза печени (варианты) |
| WO2006019162A1 (ja) * | 2004-08-20 | 2006-02-23 | Daiichi Pure Chemicals Co., Ltd. | 薬物のヒトにおける肝代謝及び肝機能を予測する方法 |
| US20080213332A1 (en) * | 2004-11-10 | 2008-09-04 | Shimon Slavin | Cells Isolated from Placenta, Device for Isolating Same, and Uses Thereof |
| RU2283113C2 (ru) * | 2004-12-14 | 2006-09-10 | Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН | Способ лечения хронических диффузных заболеваний печени |
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| RU2295565C2 (ru) * | 2005-03-21 | 2007-03-20 | Всероссийский государственный научно-исследовательский институт животноводства (ВИЖ) | Способ определения стволовых клеток молочной железы животных in vitro |
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| WO2006126219A1 (en) | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
| KR20160116024A (ko) | 2005-06-22 | 2016-10-06 | 아스테리아스 바이오세라퓨틱스, 인크. | 인간 배아 줄기 세포의 현탁 배양 |
| JP2009515558A (ja) * | 2005-11-16 | 2009-04-16 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 肝前駆細胞の増殖又は分化用細胞外マトリックス成分 |
| CN101356264B (zh) * | 2005-12-21 | 2014-05-14 | 鲁汶大学 | 分离的肝脏干细胞 |
| WO2007075812A2 (en) | 2005-12-22 | 2007-07-05 | Vesta Therapeutics, Inc. | Method of using hepatic progenitors in treating liver dysfunction |
| RU2302814C1 (ru) * | 2006-01-10 | 2007-07-20 | Сергей Александрович Пышкин | Способ прогнозирования эффективности трансплантации фетальных тканей при лечении заболеваний печени |
| US7989204B2 (en) * | 2006-04-28 | 2011-08-02 | Viacyte, Inc. | Hepatocyte lineage cells |
| HUE036729T2 (hu) * | 2006-05-26 | 2018-07-30 | Univ North Carolina Chapel Hill | Máj stellát sejt prekurzorok és eljárások azok elõállítására |
| US8148151B2 (en) | 2006-06-02 | 2012-04-03 | Geron Corporation | Differentiation of primate pluripotent cells to hepatocyte-lineage cells |
| GB0622475D0 (en) * | 2006-11-10 | 2006-12-20 | Univ Glasgow | Assay system |
| CN101275121B (zh) * | 2007-03-26 | 2011-05-11 | 芦银雪 | 体外培养扩增的人肝脏祖先细胞及其制备方法 |
| AU2008266992A1 (en) * | 2007-06-15 | 2008-12-24 | University Of North Carolina At Chapel Hill | Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same |
| JP2010534065A (ja) * | 2007-07-20 | 2010-11-04 | セルアーティス アーベー | ヒト胚盤胞幹細胞に、胚体内胚葉(DE‐hep)を介して由来する新規な肝細胞の集団 |
| WO2009111778A2 (en) * | 2008-03-07 | 2009-09-11 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Lymph nodes as a site for regeneration |
| RU2010152354A (ru) * | 2008-05-22 | 2012-06-27 | Веста Терапьютикс, Инк. (Us) | Способ дифференцировки клеток-предшественников млекопитающих в инсулин-продуцирующие островковые клетки поджелудочной железы |
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| US8956867B2 (en) * | 2008-11-07 | 2015-02-17 | Wisconsin Alumni Research Foundation | Method for culturing stem cells |
| CA3169831C (en) * | 2009-10-30 | 2025-11-18 | Sapienza Universita Di Roma | Pluripodent Stem Cells from the Extrahepatic Biliary Tree and Methods for Their Isolation |
| CA2798458C (en) * | 2010-05-07 | 2022-04-19 | University Of North Carolina At Chapel Hill | Method of engrafting cells from solid tissues |
| ES2747951T3 (es) | 2013-10-24 | 2020-03-12 | Ospedale San Raffaele Srl | Método |
| EP3083941B1 (de) | 2013-12-16 | 2023-02-22 | Fresenius Medical Care Deutschland GmbH | Pankreasinselähnliche zellstrukturen und verfahren zur herstellung davon |
| WO2016054288A1 (en) * | 2014-09-30 | 2016-04-07 | Taylor Lansing D | A human liver microphysiology platform and self assembly liver acinus model and methods of their use |
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| US10786614B2 (en) * | 2016-10-24 | 2020-09-29 | Henley Development Corporation | Antigenic decoy entrapment filtration device and treatment methods for autoimmune disorders |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US20220220445A1 (en) * | 2019-04-30 | 2022-07-14 | Promethera Therapeutics Sa | Preparation of human allogeneic liver-derived progenitor cells |
| CN111394391B (zh) * | 2019-07-11 | 2022-12-06 | 上海赛立维生物科技有限公司 | 肝祖细胞样细胞库的构建方法及其制备的细胞株与应用 |
| US20220330530A1 (en) * | 2019-09-13 | 2022-10-20 | The University Of North Carolina At Chapel Hill | Method of making human mouse xenografts |
| WO2025117474A1 (en) * | 2023-11-30 | 2025-06-05 | Immorta Bio, Inc. | Treatment of liver failure using personalized progenitor cells and derivatives thereof |
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