IL144866A0 - N- [2-hydroxy-3- (1-piperidinyl) propoxy] pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance - Google Patents

N- [2-hydroxy-3- (1-piperidinyl) propoxy] pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance

Info

Publication number
IL144866A0
IL144866A0 IL14486600A IL14486600A IL144866A0 IL 144866 A0 IL144866 A0 IL 144866A0 IL 14486600 A IL14486600 A IL 14486600A IL 14486600 A IL14486600 A IL 14486600A IL 144866 A0 IL144866 A0 IL 144866A0
Authority
IL
Israel
Prior art keywords
insulin resistance
piperidinyl
propoxy
pyridine
hydroxy
Prior art date
Application number
IL14486600A
Other languages
English (en)
Original Assignee
Biorex Kutato Fejlesztoe Kft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Kutato Fejlesztoe Kft filed Critical Biorex Kutato Fejlesztoe Kft
Publication of IL144866A0 publication Critical patent/IL144866A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL14486600A 1999-02-26 2000-02-24 N- [2-hydroxy-3- (1-piperidinyl) propoxy] pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance IL144866A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9900475A HUP9900475D0 (en) 1999-02-26 1999-02-26 O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
PCT/HU2000/000015 WO2000050403A1 (fr) 1999-02-26 2000-02-24 Chlorure de n-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxyde-3-carboximidoyl et ses utilisations dans le traitement de la resistance a l'insuline

Publications (1)

Publication Number Publication Date
IL144866A0 true IL144866A0 (en) 2002-06-30

Family

ID=90014224

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14486600A IL144866A0 (en) 1999-02-26 2000-02-24 N- [2-hydroxy-3- (1-piperidinyl) propoxy] pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance
IL144866A IL144866A (en) 1999-02-26 2001-08-13 N - [2 - Hydroxy - 3 - (1 - piperidinyl) propoxy] Pyridine - 1 - Oxide - 3 - Carboxymidoyl chloride and its uses in the treatment of insulin resistance

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL144866A IL144866A (en) 1999-02-26 2001-08-13 N - [2 - Hydroxy - 3 - (1 - piperidinyl) propoxy] Pyridine - 1 - Oxide - 3 - Carboxymidoyl chloride and its uses in the treatment of insulin resistance

Country Status (27)

Country Link
US (1) US6649628B1 (fr)
EP (1) EP1163224B1 (fr)
JP (1) JP4689838B2 (fr)
KR (1) KR100676124B1 (fr)
AT (1) ATE237590T1 (fr)
AU (1) AU779096B2 (fr)
BG (1) BG65178B1 (fr)
BR (1) BR0008969A (fr)
CA (1) CA2360451C (fr)
CZ (1) CZ297386B6 (fr)
DE (1) DE60002187T2 (fr)
DK (1) DK1163224T3 (fr)
EE (1) EE04961B1 (fr)
ES (1) ES2193055T3 (fr)
HR (1) HRP20010584B1 (fr)
HU (1) HUP9900475D0 (fr)
IL (2) IL144866A0 (fr)
NO (1) NO319793B1 (fr)
PL (1) PL197692B1 (fr)
PT (1) PT1163224E (fr)
RS (1) RS50083B (fr)
RU (1) RU2250901C2 (fr)
SI (1) SI1163224T1 (fr)
SK (1) SK287063B6 (fr)
UA (1) UA72495C2 (fr)
WO (1) WO2000050403A1 (fr)
ZA (1) ZA200106488B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0001583A2 (hu) * 2000-04-18 2002-11-28 BIOREX Kutató és Fejlesztő Rt. Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké
HU0103939D0 (en) * 2001-09-27 2001-11-28 Biorex Kutato Fejlesztoe Kft Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride
CA2471752A1 (fr) 2002-01-11 2003-07-17 Biorex Kutato Es Fejlesztoe Rt. Derives de carboxamidine et leur utilisation pour traiter des troubles vasculaires
HUP0303584A3 (en) * 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) * 2006-09-26 2008-08-01 Cytrx Corp Pharmaceutical compositions and methods for treating diseases
EP2484371B1 (fr) 2008-06-26 2014-12-17 Orphazyme APS Utilisation du HSP70 en tant que régulateur de l'activité enzymatique
KR20110084514A (ko) * 2008-11-18 2011-07-25 산텐 세이야꾸 가부시키가이샤 피리딘-3-카르발데히드 ｏ-(피페리딘-1-일-프로필)-옥심 유도체를 유효 성분으로서 함유하는 망맥락막 변성 질환의 치료제
RU2013125923A (ru) 2010-11-30 2015-01-10 Орфазиме Апс СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70
HUP1100535A2 (en) 2011-09-26 2013-04-29 Bracelia Invest Ltd Pharmaceutical composition for enhancement of stem cell treatment
HUP1100534A2 (en) 2011-09-26 2013-04-29 Balazs Dr Hazay Pharmaceutical composition for the treatment of muscle atrophy
PL2892540T3 (pl) * 2012-09-06 2018-12-31 Mcpharma Biotech Inc. Leczenie biegunki i biegunki po odsadzeniu przy pomocy opornej skrobi ziemniaczanej
ES2912524T3 (es) 2012-09-14 2022-05-26 Saint Gobain Cristal con un elemento de conexión eléctrica
WO2015015248A1 (fr) * 2013-07-30 2015-02-05 Debreceni Egyetem 67% Utilisation de composés présentant des propriétés co-induisant la protéine de choc thermique (hsp) pour améliorer l'effet de sensibilisation à l'insuline dans le traitement du diabète de type 2
US10709700B2 (en) * 2014-09-15 2020-07-14 Orphazyme A/S Arimoclomol formulation
EP3442530A1 (fr) 2016-04-13 2019-02-20 Orphazyme A/S Protéines de choc thermique et homéostasie du cholestérol
SI3448382T1 (sl) 2016-04-29 2021-03-31 Orphazyme A/S, c/o COBIS A/S Arimoclomol za zdravljenje motenj, povezanih z glukocerebrozidazo
JP2020520947A (ja) 2017-05-24 2020-07-16 オーファザイム エー／エス 熱ショックタンパク質誘導因子および前頭側頭障害
US20210164997A1 (en) 2018-05-28 2021-06-03 Orphazyme A/S Hsp70 protein levels in pbmc samples as biomarker for disease
HUP1800298A1 (hu) 2018-08-30 2020-05-28 N Gene Res Laboratories Inc Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
WO2021116487A1 (fr) 2019-12-13 2021-06-17 Som Innovation Biotech, S.A. Composés destinés à être utilisés dans le traitement d'une maladie de niemann-pick de type c
WO2021260120A1 (fr) 2020-06-24 2021-12-30 Orphazyme A/S Arimoclomol pour le traitement de la maladie de gaucher
CN116783164A (zh) * 2020-11-19 2023-09-19 泽维拉丹麦股份有限公司 制备柠檬酸阿瑞洛莫及其中间体的方法
WO2022106614A1 (fr) * 2020-11-19 2022-05-27 Orphazyme A/S Procédés de préparation de citrate d'arimoclomol et intermédiaires associés
JP2024502304A (ja) 2020-12-24 2024-01-18 ゼブラ デンマーク エー／エス Ｅｒ型ミスセンス変異を有する患者におけるニーマンピック病ｃ型の治療用アリモクロモル

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HUT78138A (hu) * 1995-12-22 2000-09-28 BIOREX Kutató és Fejlesztő Rt Hidroximsavszármazékot tartalmazó készítmény a növénytermesztés elősegítésére és alkalmazása
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells
HU220971B1 (hu) * 1997-04-03 2002-07-29 BIOREX Kutató és Fejlesztő Rt. Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására
HUP0001583A2 (hu) * 2000-04-18 2002-11-28 BIOREX Kutató és Fejlesztő Rt. Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké

Also Published As

Publication number Publication date
SK11582001A3 (sk) 2001-12-03
AU3182400A (en) 2000-09-14
DE60002187T2 (de) 2003-12-11
EE200100447A (et) 2002-12-16
IL144866A (en) 2007-07-04
ZA200106488B (en) 2002-08-07
WO2000050403A1 (fr) 2000-08-31
NO20014103L (no) 2001-10-22
CA2360451C (fr) 2011-01-04
PL350915A1 (en) 2003-02-10
SK287063B6 (sk) 2009-10-07
ES2193055T3 (es) 2003-11-01
NO20014103D0 (no) 2001-08-23
US6649628B1 (en) 2003-11-18
CZ20013053A3 (cs) 2002-01-16
AU779096B2 (en) 2005-01-06
PT1163224E (pt) 2003-07-31
RS50083B (sr) 2009-01-22
PL197692B1 (pl) 2008-04-30
BR0008969A (pt) 2001-11-27
DE60002187D1 (de) 2003-05-22
UA72495C2 (uk) 2005-03-15
KR100676124B1 (ko) 2007-01-31
BG105837A (en) 2002-03-29
ATE237590T1 (de) 2003-05-15
HUP9900475D0 (en) 1999-04-28
NO319793B1 (no) 2005-09-12
EP1163224A1 (fr) 2001-12-19
DK1163224T3 (da) 2003-08-04
JP4689838B2 (ja) 2011-05-25
HRP20010584A2 (en) 2002-08-31
HRP20010584B1 (en) 2010-08-31
RU2250901C2 (ru) 2005-04-27
CA2360451A1 (fr) 2000-08-31
SI1163224T1 (en) 2003-08-31
CZ297386B6 (cs) 2006-11-15
EE04961B1 (et) 2008-02-15
YU60301A (sh) 2004-05-12
JP2002537384A (ja) 2002-11-05
KR20010102410A (ko) 2001-11-15
EP1163224B1 (fr) 2003-04-16
BG65178B1 (bg) 2007-05-31

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