IL145140A0 - Improved aqueous solubility pharmaceutical formulations - Google Patents

Improved aqueous solubility pharmaceutical formulations

Info

Publication number
IL145140A0
IL145140A0 IL14514000A IL14514000A IL145140A0 IL 145140 A0 IL145140 A0 IL 145140A0 IL 14514000 A IL14514000 A IL 14514000A IL 14514000 A IL14514000 A IL 14514000A IL 145140 A0 IL145140 A0 IL 145140A0
Authority
IL
Israel
Prior art keywords
active agent
stabilized
formulation
composition
pharmaceutical formulations
Prior art date
Application number
IL14514000A
Other languages
English (en)
Original Assignee
Fmc Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Corp filed Critical Fmc Corp
Publication of IL145140A0 publication Critical patent/IL145140A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL14514000A 1999-03-24 2000-03-20 Improved aqueous solubility pharmaceutical formulations IL145140A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12591499P 1999-03-24 1999-03-24
US14968099P 1999-08-19 1999-08-19
PCT/US2000/007298 WO2000056726A1 (en) 1999-03-24 2000-03-20 Improved aqueous solubility pharmaceutical formulations

Publications (1)

Publication Number Publication Date
IL145140A0 true IL145140A0 (en) 2002-06-30

Family

ID=26824087

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14514000A IL145140A0 (en) 1999-03-24 2000-03-20 Improved aqueous solubility pharmaceutical formulations
IL145140A IL145140A (en) 1999-03-24 2001-08-27 A granular particle, a solid dosage form containing it and a method for its preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL145140A IL145140A (en) 1999-03-24 2001-08-27 A granular particle, a solid dosage form containing it and a method for its preparation

Country Status (14)

Country Link
US (3) US6497905B1 (da)
EP (1) EP1163234B1 (da)
JP (1) JP2003531099A (da)
CN (1) CN1156461C (da)
AT (1) ATE307808T1 (da)
AU (1) AU3900300A (da)
BR (1) BR0009176A (da)
CA (1) CA2362728C (da)
DE (1) DE60023465T2 (da)
DK (1) DK1163234T3 (da)
ES (1) ES2251985T3 (da)
IL (2) IL145140A0 (da)
TW (1) TWI245644B (da)
WO (1) WO2000056726A1 (da)

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Also Published As

Publication number Publication date
CA2362728A1 (en) 2000-09-28
BR0009176A (pt) 2001-12-18
TWI245644B (en) 2005-12-21
CA2362728C (en) 2009-06-23
DE60023465D1 (de) 2005-12-01
EP1163234A4 (en) 2003-05-02
ATE307808T1 (de) 2005-11-15
DK1163234T3 (da) 2006-02-27
EP1163234A1 (en) 2001-12-19
US20020037324A1 (en) 2002-03-28
DE60023465T2 (de) 2006-07-20
AU3900300A (en) 2000-10-09
US6379707B2 (en) 2002-04-30
CN1379768A (zh) 2002-11-13
IL145140A (en) 2006-08-20
WO2000056726A1 (en) 2000-09-28
US6511681B2 (en) 2003-01-28
JP2003531099A (ja) 2003-10-21
CN1156461C (zh) 2004-07-07
US6497905B1 (en) 2002-12-24
US20020012706A1 (en) 2002-01-31
ES2251985T3 (es) 2006-05-16
EP1163234B1 (en) 2005-10-26

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