IL145189A0 - Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs - Google Patents

Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs

Info

Publication number: IL145189A0
Authority: IL; Israel
Prior art keywords: long; viral replication; nucleoside analogs; chain hydrocarbons; synergistic inhibition
Prior art date: 1999-03-10

Application number

IL14518900A

Other languages

English (en)

Original Assignee

Avanir Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-10

Filing date

2000-03-08

Publication date

2002-06-30

2000-03-08 Application filed by Avanir Pharmaceuticals filed Critical Avanir Pharmaceuticals

2002-06-30 Publication of IL145189A0 publication Critical patent/IL145189A0/xx

Links

239000002777 nucleoside Chemical class 0.000 title abstract 2
150000003833 nucleoside derivatives Chemical class 0.000 title abstract 2
229930195733 hydrocarbon Natural products 0.000 title 1
150000002430 hydrocarbons Chemical class 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
230000002195 synergetic effect Effects 0.000 title 1
230000029812 viral genome replication Effects 0.000 title 1
239000000203 mixture Substances 0.000 abstract 2
ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 abstract 2
208000036142 Viral infection Diseases 0.000 abstract 1
150000007824 aliphatic compounds Chemical class 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
229960005102 foscarnet Drugs 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A—HUMAN NECESSITIES
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- A61K31/16—Amides, e.g. hydroxamic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61P31/12—Antivirals
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oil, Petroleum & Natural Gas (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL14518900A 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs IL145189A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/265,922 US6440980B1 (en)	1996-09-17	1999-03-10	Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
PCT/US2000/005965 WO2000053167A2 (fr)	1999-03-10	2000-03-08	Inhibition synergique de replication virale par des hydrocarbures et analogues nucleosidiques a chaine longue

Publications (1)

Publication Number	Publication Date
IL145189A0 true IL145189A0 (en)	2002-06-30

Family

ID=23012439

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14518900A IL145189A0 (en)	1999-03-10	2000-03-08	Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs

Country Status (20)

Country	Link
US (2)	US6440980B1 (fr)
EP (1)	EP1156797B1 (fr)
JP (1)	JP2002538200A (fr)
KR (1)	KR20020005615A (fr)
CN (1)	CN1208065C (fr)
AT (1)	ATE376445T1 (fr)
AU (1)	AU771510B2 (fr)
BR (1)	BR0008829A (fr)
CA (1)	CA2364251C (fr)
CZ (1)	CZ20013120A3 (fr)
DE (1)	DE60036862T2 (fr)
HK (1)	HK1041438B (fr)
HU (1)	HUP0200294A3 (fr)
IL (1)	IL145189A0 (fr)
NO (1)	NO20014347L (fr)
NZ (2)	NZ513849A (fr)
PL (1)	PL350660A1 (fr)
RU (1)	RU2251415C2 (fr)
WO (1)	WO2000053167A2 (fr)
ZA (1)	ZA200108283B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6440980B1 (en)	1996-09-17	2002-08-27	Avanir Pharmaceuticals	Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
PL371945A1 (en) *	2001-10-16	2005-07-11	Avanir Pharmacueticals	Viral inhibition by n-docosanol
JP2005527499A (ja) *	2002-02-13	2005-09-15	メルク　エンド　カムパニー　インコーポレーテッド	ヌクレオシド化合物を用いてオルトポックスウイルスの複製を阻害する方法
WO2006105216A1 (fr) *	2005-03-30	2006-10-05	Novartis Ag	Famciclovir pour le traitement de l'herpes labial recurrent pendant une periode d'un jour
US20070258996A1 (en) *	2005-12-23	2007-11-08	The Sterilex Corporation	Antimicrobial compositions
US20080194518A1 (en) *	2005-12-23	2008-08-14	MOOKERJEE Pradip	Antimicrobial Compositions
US20090312279A1 (en) *	2005-12-23	2009-12-17	Sterilex Technologies, Llc	Antimicrobial compositions
JP2007182398A (ja) *	2006-01-06	2007-07-19	Nakajima Kagaku Sangyo Kk	抗ウィルス性潤滑剤
US8236768B2 (en)	2008-10-03	2012-08-07	3B Pharmaceuticals, Inc.	Topical antiviral formulations
US8541360B2 (en) *	2008-11-19	2013-09-24	Ben Venue Laboratories, Inc.	Parenteral formulations comprising sugar-based esters and ethers
WO2012174535A1 (fr) *	2011-06-17	2012-12-20	Constitution Medical, Inc.	Solutions de traitement d'échantillons biologiques
US9125911B2 (en) *	2013-03-14	2015-09-08	Quadex Pharmaceuticals, Llc	Combined systemic and topical treatment of disordered tissues
JP6125962B2 (ja) *	2013-09-24	2017-05-10	株式会社デンソー	抗ウイルス剤
US11071745B2 (en) *	2014-07-07	2021-07-27	Elian Llc	Viral prophylaxis treatment methods and pre-exposure prophylaxis kits
FR3054454B1 (fr)	2016-07-26	2020-04-10	IFP Energies Nouvelles	Catalyseur comprenant une zeolithe izm-2 ayant un rapport molaire si/al optimise pour l'isomerisation de coupes c8 aromatiques
MX2020004151A (es)	2017-10-30	2020-08-13	Takeda Pharmaceuticals Co	Detergentes compatibles con el medio ambiente para la inactivacion de virus envueltos en lipidos.
FR3104458B1 (fr)	2019-12-17	2022-01-07	Ifp Energies Now	Catalyseur a base de zeolithe izm-2 ayant une teneur en alcalin faible et son utilisation pour l’isomerisation de la coupe c8 aromatique
CN111743888B (zh) *	2020-06-16	2021-10-22	广州医科大学附属第一医院	(2z,4e)-2,4-癸二烯酸在制备用于治疗流感病毒引起的炎症的药物方面的应用

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1109119A (en)	1910-03-29	1914-09-01	Ellis Foster Co	Solidified oil and process of making same.
US3031376A (en)	1956-10-11	1962-04-24	Levin	Compositions comprising octacosanol, triacontanol, tetracosanol, or hexacosanol, andmethods employing same
US3584115A (en)	1968-05-31	1971-06-08	Arthur Ira Gebhart	Method of applying visible aerosol compositions
US3592930A (en)	1968-07-19	1971-07-13	Syntex Corp	Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
US3946035A (en)	1972-06-29	1976-03-23	L'oreal	Anti-inflammatory polymers, pharmaceutical compositions containing the same and process for producing said polymers
US4076799A (en)	1972-12-27	1978-02-28	Cincinnati Milacron, Inc.	Method of inhibiting skin irritation
GB1459233A (en)	1973-08-29	1976-12-22	Inst Rech Chim Biolog	Medicament containing a higher alkanol
US3987198A (en)	1973-10-16	1976-10-19	Syntex (U.S.A.) Inc.	Method for lowering the free fatty acid content in sebum using certain fatty acid amides
US4199574A (en) *	1974-09-02	1980-04-22	Burroughs Wellcome Co.	Methods and compositions for treating viral infections and guanine acyclic nucleosides
GB1523865A (en)	1974-09-02	1978-09-06	Wellcome Found	Purine compunds and salts thereof
US4025645A (en)	1976-01-27	1977-05-24	Jelenko Iii Carl	Non-steroid topical agent for alleviating inflammation in mammals
US4200655A (en)	1978-08-15	1980-04-29	Sterling Drug Inc.	Benzyl alcohol virucidal process
US4258029A (en)	1979-04-23	1981-03-24	Connaught Laboratories Limited	Synthetic adjuvants for stimulation of antigenic responses
US4670471A (en)	1981-11-03	1987-06-02	Clark Lealand L	Treatment for inflammatory skin disease
DE3318989C2 (de)	1982-05-28	1996-11-21	Eisai Co Ltd	ß,gamma-Dihydropolyprenylalkoholderivate und diese enthaltende Arzneimittel und deren Verwendung
AU546872B2 (en)	1982-06-16	1985-09-26	Unilever Plc	Skin treatment compositions containing a fatty acid or ester
US4513008A (en)	1982-07-30	1985-04-23	The Vinoxen Company, Inc.	Virucidal compositions and therapy
DE3421468A1 (de) *	1984-06-08	1985-12-19	Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim	Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
US4684479A (en)	1985-08-14	1987-08-04	Arrigo Joseph S D	Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
GB8602346D0 (en)	1986-01-30	1986-03-05	Wellcome Found	Antiviral combinations
US5208257A (en)	1986-04-21	1993-05-04	Kabara Jon J	Topical antimicrobial pharmaceutical compositions and methods
US4879109A (en)	1986-05-15	1989-11-07	Emory University	Method for treating burns
US5030448A (en)	1986-05-15	1991-07-09	Emory University	Method of delivering drugs to damaged or diseased tissue
US4940586A (en)	1987-02-26	1990-07-10	Alza Corporation	Skin permeation enhancer compositions using sucrose esters
US4900555A (en)	1987-02-26	1990-02-13	Alza Corporation	Skin permeation enhancer compositions using sucrose esters
US4865848A (en)	1987-02-26	1989-09-12	Alza Corporation	Skin permeation enhancer compositions using sucrose esters
IT1203934B (it)	1987-04-17	1989-02-23	Consiglio Nazionale Ricerche	Composizioni farmaceutiche contenenti alcoli superiori per il trattamento di patologie della prostata
US5380754A (en)	1988-02-29	1995-01-10	Virotex Corporation	Topical composition enhancing healing of viral lesions
US5135956A (en)	1988-10-18	1992-08-04	The Regents Of The University Of California	Method of using cytoprotective alcohols to treat neural disease and neural injury
IE980216A1 (en)	1989-04-17	2000-02-23	Scotia Holdings Plc	Anti-virals
US5071879A (en)	1989-04-28	1991-12-10	Lidak Pharmaceuticals	Systemic antiviral treatment
US5070107A (en)	1989-04-28	1991-12-03	Lidak Pharmaceuticals	Systemic antiviral treatment
US4874794A (en)	1989-04-28	1989-10-17	Lidak Biopharmaceuticals	Inflammatory disease treatment
US5104656A (en)	1989-06-16	1992-04-14	Seth Pyare L	Percutaneous treatment with a high potency non-steroidal anti-inflammatory agent
US5194654A (en) *	1989-11-22	1993-03-16	Vical, Inc.	Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
US4956171A (en)	1989-07-21	1990-09-11	Paco Pharmaceutical Services, Inc.	Transdermal drug delivery using a dual permeation enhancer and method of performing the same
US5166219A (en)	1989-11-02	1992-11-24	Lidak Pharmaceuticals	Systemic anti-inflammatory treatment
US5194451A (en)	1989-11-02	1993-03-16	Katz David H	Systemic anti-inflammatory treatment
JPH03157349A (ja)	1989-11-14	1991-07-05	Lion Corp	乳化組成物
EP0955056A1 (fr) *	1990-08-23	1999-11-10	Chiron Corporation	Facteur-1 recombinant stimulant la formation de colonies pour le traitement d' infections fongiques
US5202125A (en) *	1990-12-10	1993-04-13	Theratech, Inc.	Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
US5312837A (en) *	1991-01-29	1994-05-17	Genelabs Technologies, Inc.	Method of treating viral infections with aryl macrocyclic compounds
DE4111105A1 (de)	1991-04-05	1992-10-08	Max Planck Gesellschaft	Neue erucyl-, brassidyl- und nervonylderivate
US5250236A (en)	1991-08-05	1993-10-05	Gasco Maria R	Method for producing solid lipid microspheres having a narrow size distribution
US5580571A (en)	1991-10-15	1996-12-03	Hostetler; Karl Y.	Nucleoside analogues
IL105090A (en) *	1992-03-18	1998-08-16	Us Bioscience	Acid N) phosphonoacetyl (Aspartic L in a broad spectrum antiviral agent
DK169121B1 (da)	1992-09-09	1994-08-22	Gea Farmaceutisk Fabrik As	Antiviralt virksom farmaceutisk olie-i-vand-emulsion indeholdende 9-[(2-hydroxyethoxy)methyl]guanin (acyclovir) eller et salt eller en ester deraf
US5696109A (en) *	1992-12-07	1997-12-09	Eukarion, Inc.	Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
CA2153780C (fr)	1993-01-15	2004-04-13	Micro Vesicular Systems, Inc.	Methode d'inhibition de la reproduction virale
US5484911A (en)	1993-04-01	1996-01-16	Health Research, Inc.	Nucleoside 5'-diphosphate conjugates of ether lipids
JPH0717545U (ja) *	1993-08-27	1995-03-28	南工学株式会社	スクリーン印刷機におけるスクィージー装置
NZ261573A (en)	1993-09-10	1997-02-24	Recordati Chem Pharm	Process for the preparation of acyclovir (9-(2-hydroxy)-ethoxymethyl guanine)
ATE399004T1 (de)	1993-12-13	2008-07-15	Avanir Pharmaceuticals	Formulierungen aus c-20 bis c-28 alkoholen und saccharoseestern
ES2270426T3 (es) *	1994-03-18	2007-04-01	Supernus Pharmaceuticals, Inc.	Sistema de suministros de farmacos emulsionados.
US5447729A (en) *	1994-04-07	1995-09-05	Pharmavene, Inc.	Multilamellar drug delivery systems
DE4414755C2 (de) *	1994-04-27	2000-11-16	Lohmann Therapie Syst Lts	Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung
IL110380A0 (en)	1994-07-20	1994-10-21	Agis Ind 1983 Ltd	Antiviral topical pharmaceutical compositions
US5567816A (en)	1994-07-26	1996-10-22	Syntex (U.S.A.) Inc.	Preparation of acyclovir using 1,3 dioxolane
US5667492A (en) *	1994-10-07	1997-09-16	Columbia Laboratories, Inc.	Use and composition of an anti-sexually transmitted diseases formulation
US5883103A (en)	1995-06-07	1999-03-16	Shire Laboratories Inc.	Oral acyclovir delivery
CA2231837A1 (fr)	1995-09-13	1997-03-20	Florida State University	Taxanes a effet radiosensibilisant et leurs preparations pharmaceutiques
WO1997009978A1 (fr)	1995-09-13	1997-03-20	Morten Sloth Weidner	Utilisation d'esters de polyols pour augmenter la biodisponibilite orale de substances medicamenteuses, nouveaux esters et compositions pharmaceutiques les contenant
WO1997013528A1 (fr)	1995-10-12	1997-04-17	Gs Development Ab	Composition pharmaceutique pour l'administration d'un principe actif sur ou au travers d'une surface cutanee ou muqueuse
US5795909A (en) *	1996-05-22	1998-08-18	Neuromedica, Inc.	DHA-pharmaceutical agent conjugates of taxanes
KR100528816B1 (ko) *	1996-09-17	2005-11-16	아바니르 파마슈티컬스	장쇄 알코올, 알칸, 지방산 및 아미드에 의한 바이러스억제 방법
US5952392A (en)	1996-09-17	1999-09-14	Avanir Pharmaceuticals	Long-chain alcohols, alkanes, fatty acids and amides in the treatment of burns and viral inhibition
US6440980B1 (en)	1996-09-17	2002-08-27	Avanir Pharmaceuticals	Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
IT1287114B1 (it) *	1996-10-31	1998-08-04	Recordati Chem Pharm	Composizioni farmaceutiche antierpetiche per applicatori topici, contenenti aciclovir
US6019997A (en)	1997-01-09	2000-02-01	Minnesota Mining And Manufacturing	Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents
US5871763A (en) *	1997-04-24	1999-02-16	Fort James Corporation	Substrate treated with lotion

1999
- 1999-03-10 US US09/265,922 patent/US6440980B1/en not_active Expired - Lifetime
2000
- 2000-03-08 HU HU0200294A patent/HUP0200294A3/hu unknown
- 2000-03-08 PL PL00350660A patent/PL350660A1/xx not_active Application Discontinuation
- 2000-03-08 NZ NZ513849A patent/NZ513849A/xx not_active IP Right Cessation
- 2000-03-08 CA CA002364251A patent/CA2364251C/fr not_active Expired - Fee Related
- 2000-03-08 CZ CZ20013120A patent/CZ20013120A3/cs unknown
- 2000-03-08 KR KR1020017011487A patent/KR20020005615A/ko not_active Ceased
- 2000-03-08 CN CNB008063559A patent/CN1208065C/zh not_active Expired - Fee Related
- 2000-03-08 AT AT00912195T patent/ATE376445T1/de not_active IP Right Cessation
- 2000-03-08 JP JP2000603656A patent/JP2002538200A/ja active Pending
- 2000-03-08 NZ NZ530747A patent/NZ530747A/en not_active IP Right Cessation
- 2000-03-08 BR BR0008829-3A patent/BR0008829A/pt not_active Application Discontinuation
- 2000-03-08 EP EP00912195A patent/EP1156797B1/fr not_active Expired - Lifetime
- 2000-03-08 RU RU2001124333/15A patent/RU2251415C2/ru not_active IP Right Cessation
- 2000-03-08 IL IL14518900A patent/IL145189A0/xx unknown
- 2000-03-08 HK HK02101995.1A patent/HK1041438B/en not_active IP Right Cessation
- 2000-03-08 AU AU33962/00A patent/AU771510B2/en not_active Ceased
- 2000-03-08 WO PCT/US2000/005965 patent/WO2000053167A2/fr not_active Ceased
- 2000-03-08 DE DE60036862T patent/DE60036862T2/de not_active Expired - Lifetime
2001
- 2001-09-06 NO NO20014347A patent/NO20014347L/no unknown
- 2001-10-09 ZA ZA200108283A patent/ZA200108283B/xx unknown
2002
- 2002-07-16 US US10/197,283 patent/US7091190B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20030073651A1 (en)	2003-04-17
HUP0200294A2 (hu)	2002-07-29
NO20014347D0 (no)	2001-09-06
AU3396200A (en)	2000-09-28
CN1208065C (zh)	2005-06-29
ATE376445T1 (de)	2007-11-15
EP1156797A2 (fr)	2001-11-28
ZA200108283B (en)	2002-08-28
CZ20013120A3 (cs)	2002-02-13
HK1041438A1 (en)	2002-07-12
WO2000053167A3 (fr)	2001-02-15
US6440980B1 (en)	2002-08-27
RU2251415C2 (ru)	2005-05-10
PL350660A1 (en)	2003-01-27
CA2364251C (fr)	2004-11-02
WO2000053167A2 (fr)	2000-09-14
KR20020005615A (ko)	2002-01-17
NZ530747A (en)	2005-06-24
DE60036862D1 (de)	2007-12-06
DE60036862T2 (de)	2008-08-14
CN1424926A (zh)	2003-06-18
NO20014347L (no)	2001-10-05
US7091190B2 (en)	2006-08-15
CA2364251A1 (fr)	2000-09-14
HUP0200294A3 (en)	2002-10-28
JP2002538200A (ja)	2002-11-12
NZ513849A (en)	2004-03-26
BR0008829A (pt)	2001-12-18
HK1041438B (en)	2008-05-09
AU771510B2 (en)	2004-03-25
EP1156797B1 (fr)	2007-10-24

Publication	Publication Date	Title
ZA200108283B (en)	2002-08-28	Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs.
PH12022553530A1 (en)	2024-06-24	1'-cyano nucleoside analogs and uses thereof
ES2161418T3 (es)	2001-12-01	Compuestos de piridilfurano y de piridiltiofeno y uso farmaceutico de los mismos.
HRP20031003A2 (en)	2004-06-30	4'-substituted nukleosides
EA200100298A1 (ru)	2001-08-27	ФАРМАЦЕВТИЧЕСКИЕ ПРЕПАРАТЫ С РЕГУЛИРУЕМЫМ ВЫСВОБОЖДЕНИЕМ, СОДЕРЖАЩИЕ ИНГИБИТОР cGMP-ФОСФОДИЭСТЕРАЗЫ-5
DE69811062D1 (de)	2003-03-06	Polyaromatische antivirale zusammensetzungen
BR9913319A (pt)	2001-05-22	Composições e métodos para tratamento de doenças mitocondriais
FI20001231A7 (fi)	2000-05-23	2-Deoksi-2,3-didehydro-N-asetyylineuramiinihapon johdannaisia ja niiden analogeja ja niiden käyttö antiviraalisina aineina
AU2330202A (en)	2002-06-11	Treatment of statin side effects
NZ513450A (en)	2004-03-26	Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1R,cis)-4-(6-amino-9H-purin-9-yl)-2-cyclopentene- 1-methanol useful as antiviral agents
CY2466B1 (en)	2005-06-03	Phenyl dihydrobenzofuranes.
CY2462B1 (en)	2005-06-03	Cyclohexyl dihydrobenzofuranes.
ES2187234A1 (es)	2003-05-16	Forma de dosificacion oral para tratar la disfuncion sexual.
GR3029370T3 (en)	1999-05-28	Compounds and methods for inhibition of hiv and related viruses
CA2100066A1 (fr)	1992-10-13	Michellamines utilisees comme agents antiviraux, composition et methode de traitement
AU567018B2 (en)	1987-11-05	Prazosin-pirbuterol combination for bronchoduation
MX2025012590A (es)	2025-11-03	Compuestos antivirales de 1,3-di-oxo-indeno
KR920019362A (ko)	1992-11-19	디데옥시 아데노신 및 아데노신 데아미나제 억제물질을 포함하는, 항-hiv활성을 지닌 치료학적 조성물
NZ503559A (en)	2002-12-20	Compositions and methods for the control of smoking containing a xanthine oxidase inhibitor
MX9202634A (es)	1994-01-31	Uso de analogos de nucleosido de 1,3-oxatiolano en el tratamiento de hepatitis b.