IL145920A - Process for preparation of pharmaceutical grade gabapentin - Google Patents

Process for preparation of pharmaceutical grade gabapentin

Info

Publication number: IL145920A
Authority: IL; Israel
Prior art keywords: pharmaceutical grade; gabapentin; preparation; grade gabapentin; neutralizing
Prior art date: 1999-04-26

Application number

IL14592000A

Other languages

English (en)

Other versions

IL145920A0 (en

Original Assignee

Medichem Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-26

Filing date

2000-04-04

Publication date

2005-09-25

2000-04-04 Application filed by Medichem Sa filed Critical Medichem Sa

2002-07-25 Publication of IL145920A0 publication Critical patent/IL145920A0/xx

2005-09-25 Publication of IL145920A publication Critical patent/IL145920A/xx

Links

UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title abstract 6
229960002870 gabapentin Drugs 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
XBUDZAQEMFGLEU-UHFFFAOYSA-N 2-[1-(aminomethyl)cyclohexyl]acetic acid;hydron;chloride Chemical compound Cl.OC(=O)CC1(CN)CCCCC1 XBUDZAQEMFGLEU-UHFFFAOYSA-N 0.000 abstract 1
230000001476 alcoholic effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000003456 ion exchange resin Substances 0.000 abstract 1
229920003303 ion-exchange polymer Polymers 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
230000003472 neutralizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL14592000A 1999-04-26 2000-04-04 Process for preparation of pharmaceutical grade gabapentin IL145920A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009900858A ES2164527B1 (es)	1999-04-26	1999-04-26	Procedimiento de obtencion de gabapentina de calidad farmaceutica.
PCT/ES2000/000121 WO2000064857A1 (es)	1999-04-26	2000-04-04	Procedimiento de obtencion de gabapentina de calidad farmaceutica

Publications (2)

Publication Number	Publication Date
IL145920A0 IL145920A0 (en)	2002-07-25
IL145920A true IL145920A (en)	2005-09-25

Family

ID=8308147

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14592000A IL145920A (en)	1999-04-26	2000-04-04	Process for preparation of pharmaceutical grade gabapentin

Country Status (13)

Country	Link
US (1)	US6528682B1 (de)
EP (1)	EP1174418B1 (de)
AT (1)	ATE257818T1 (de)
AU (1)	AU3559200A (de)
CA (1)	CA2371210A1 (de)
DE (1)	DE60007734T2 (de)
DK (1)	DK1174418T3 (de)
ES (2)	ES2164527B1 (de)
HU (1)	HUP0200741A3 (de)
IL (1)	IL145920A (de)
PT (1)	PT1174418E (de)
SI (1)	SI1174418T1 (de)
WO (1)	WO2000064857A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001266992B8 (en) *	2000-06-16	2005-12-01	Teva Pharmaceutical Industries Ltd.	Stable gabapentin having pH within a controlled range
IT1319234B1 (it)	2000-10-23	2003-09-26	Zambon Spa	Processo di preparazione di gabapentina.
EP1494996A1 (de) *	2002-04-16	2005-01-12	Taro Pharmaceutical Industries Limited	Verfahren zur herstellung von gabapentin
EP1615875A2 (de)	2003-04-21	2006-01-18	Matrix Laboratories Limited	Verfahren zur herstellung von gabapentin form-ii
US20070043236A1 (en) *	2003-05-19	2007-02-22	Chandiran Thakashina M	Process for preparation of gabapentin
US7169812B2 (en) *	2003-07-01	2007-01-30	Medtronic, Inc.	Process for producing injectable gabapentin compositions
US20050187295A1 (en) *	2004-02-19	2005-08-25	Surendra Kalyan	Processes for the preparation of gabapentin
WO2005117526A2 (en) *	2004-06-03	2005-12-15	Matrix Laboratories Ltd	An improved process for the purification of gabapentin
GB0416228D0 (en)	2004-07-20	2004-08-25	Sandoz Ind Products S A	Process for the preparation of gabapentin
US20080103334A1 (en) *	2006-10-26	2008-05-01	Ipca Laboratories Ltd	Process For Synthesis Of Gabapentin
IN2015DN02697A (de) *	2012-11-16	2015-09-04	Lonza Ag

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4894476A (en) *	1988-05-02	1990-01-16	Warner-Lambert Company	Gabapentin monohydrate and a process for producing the same
IL119890A (en) *	1996-12-24	2002-03-10	Teva Pharma	Gabapentin form iii and preparation of gabapentin form ii
ES2137137B1 (es) *	1998-05-25	2000-08-16	Medichem Sa	Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica.
ITMI981535A1 (it) *	1998-07-03	2000-01-03	Zambon Spa	Processo per la preparazione di gabapentina

1999
- 1999-04-26 ES ES009900858A patent/ES2164527B1/es not_active Expired - Fee Related
2000
- 2000-04-04 AT AT00914185T patent/ATE257818T1/de not_active IP Right Cessation
- 2000-04-04 DE DE60007734T patent/DE60007734T2/de not_active Expired - Fee Related
- 2000-04-04 IL IL14592000A patent/IL145920A/xx unknown
- 2000-04-04 EP EP00914185A patent/EP1174418B1/de not_active Expired - Lifetime
- 2000-04-04 HU HU0200741A patent/HUP0200741A3/hu unknown
- 2000-04-04 WO PCT/ES2000/000121 patent/WO2000064857A1/es not_active Ceased
- 2000-04-04 PT PT00914185T patent/PT1174418E/pt unknown
- 2000-04-04 CA CA002371210A patent/CA2371210A1/en not_active Abandoned
- 2000-04-04 SI SI200030345T patent/SI1174418T1/xx unknown
- 2000-04-04 DK DK00914185T patent/DK1174418T3/da active
- 2000-04-04 ES ES00914185T patent/ES2213571T3/es not_active Expired - Lifetime
- 2000-04-04 AU AU35592/00A patent/AU3559200A/en not_active Abandoned
- 2000-04-04 US US09/959,183 patent/US6528682B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE60007734T2 (de)	2004-12-02
SI1174418T1 (en)	2004-06-30
AU3559200A (en)	2000-11-10
US6528682B1 (en)	2003-03-04
DK1174418T3 (da)	2004-05-10
ES2213571T3 (es)	2004-09-01
HUP0200741A3 (en)	2002-11-28
HUP0200741A2 (hu)	2002-07-29
EP1174418A1 (de)	2002-01-23
ATE257818T1 (de)	2004-01-15
WO2000064857A1 (es)	2000-11-02
PT1174418E (pt)	2004-05-31
ES2164527A1 (es)	2002-02-16
IL145920A0 (en)	2002-07-25
CA2371210A1 (en)	2000-11-02
DE60007734D1 (de)	2004-02-19
ES2164527B1 (es)	2003-04-01
EP1174418B1 (de)	2004-01-14

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Legal Events

Date	Code	Title	Description
2006-07-05	KB	Patent renewed