IL148442A - Process for preparing salts of methylene bisphosphonic acid - Google Patents

Process for preparing salts of methylene bisphosphonic acid

Info

Publication number: IL148442A
Authority: IL; Israel
Prior art keywords: bisphosphonic acid; preparing salts; methylene bisphosphonic; methylene; salts
Prior art date: 1999-09-17

Application number

IL14844200A

Other languages

English (en)

Other versions

IL148442A0 (en

Inventor

Mark Purdie

Original Assignee

Astrazeneca Uk Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-17

Filing date

2000-09-11

Publication date

2005-08-31

2000-09-11 Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd

2002-09-12 Publication of IL148442A0 publication Critical patent/IL148442A0/xx

2005-08-31 Publication of IL148442A publication Critical patent/IL148442A/xx

Links

238000004519 manufacturing process Methods 0.000 title 1
MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical class OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3843—Polyphosphonic acids containing no further substituents than -PO3H2 groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL14844200A 1999-09-17 2000-09-11 Process for preparing salts of methylene bisphosphonic acid IL148442A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9903345A SE9903345D0 (sv)	1999-09-17	1999-09-17	Novel process
PCT/GB2000/003473 WO2001021629A1 (en)	1999-09-17	2000-09-11	Process for preparing methylene bisphosphonic and salts

Publications (2)

Publication Number	Publication Date
IL148442A0 IL148442A0 (en)	2002-09-12
IL148442A true IL148442A (en)	2005-08-31

Family

ID=20417040

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL14844200A IL148442A (en)	1999-09-17	2000-09-11	Process for preparing salts of methylene bisphosphonic acid
IL168246A IL168246A (en)	1999-09-17	2005-04-26	Mono salts of a substituted or unsubstituted methylene biphosphonic acid

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL168246A IL168246A (en)	1999-09-17	2005-04-26	Mono salts of a substituted or unsubstituted methylene biphosphonic acid

Country Status (24)

Country	Link
US (2)	US6657076B1 (da)
EP (1)	EP1216253B1 (da)
JP (1)	JP4881524B2 (da)
KR (1)	KR100776105B1 (da)
CN (1)	CN1150200C (da)
AR (1)	AR029393A1 (da)
AT (1)	ATE242778T1 (da)
AU (1)	AU771628B2 (da)
BR (1)	BR0014057A (da)
CA (1)	CA2383829C (da)
CO (1)	CO5231228A1 (da)
DE (1)	DE60003323T2 (da)
DK (1)	DK1216253T3 (da)
ES (1)	ES2200921T3 (da)
HK (1)	HK1045696B (da)
IL (2)	IL148442A (da)
MY (1)	MY119965A (da)
NO (1)	NO331532B1 (da)
NZ (1)	NZ517552A (da)
PT (1)	PT1216253E (da)
SE (1)	SE9903345D0 (da)
TW (1)	TWI274057B (da)
WO (1)	WO2001021629A1 (da)
ZA (1)	ZA200201661B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9903345D0 (sv) *	1999-09-17	1999-09-17	Astra Pharma Prod	Novel process
JP2009511449A (ja) *	2005-10-06	2009-03-19	イナート・ファルマ	有機塩基のリン酸化抗原塩およびその結晶化方法
JP5363045B2 (ja) *	2008-07-24	2013-12-11	大八化学工業株式会社	ホスホン酸の製造方法
MA41326A (fr)	2015-01-14	2021-04-28	Chiesi Farm Spa	Formulations pharmaceutiques comprenant du cangrelor de haute pureté et leurs procédés de préparation et d'utilisation
CN111647016A (zh) *	2020-07-10	2020-09-11	成都纽瑞特医疗科技股份有限公司	羟基亚甲基二膦酸盐的制备方法
CN121039286A (zh)	2023-05-03	2025-11-28	Dna斯克瑞普特公司	用于3'-o-氨基多核苷酸的去保护的试剂
WO2025093659A1 (en)	2023-11-04	2025-05-08	Dna Script	3'-o-aminooxymethyl blocked nucleotides and use thereof in enzymatic synthesis of polynucleotides

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3251907A (en) *	1962-08-23	1966-05-17	Procter & Gamble	Method for preparing tetra-secondary alkyl methylenediphosphonates
CA777769A (en) *	1963-03-18	1968-02-06	H. Roy Clarence	Substituted methylene diphosphonic acid compounds and detergent compositions
JPS54125777A (en)	1978-03-20	1979-09-29	Kao Corp	Bleaching composition
IT1201087B (it) *	1982-04-15	1989-01-27	Gentili Ist Spa	Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4478763A (en) *	1982-10-20	1984-10-23	Univ. Of Southern California	Process for preparing alpha-fluorinated alkanediphosphonates
JPS61123709A (ja) *	1984-11-19	1986-06-11	Nippon Soken Inc	排気ガス微粒子浄化機能を有する内燃機関の制御装置
US4689123A (en) *	1986-12-23	1987-08-25	The Dow Chemical Company	Novel tetraphosphonic acid compounds, intermediates and a process for their production
FI83421C (fi) *	1989-06-21	1991-07-10	Huhtamaeki Oy	Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
FI83657C (fi)	1989-09-08	1991-08-12	Huhtamaeki Oy	Foerfarande foer framstaellning av metylenbisfosfonsyror.
FI89366C (fi)	1990-12-20	1993-09-27	Leiras Oy	Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
SK281309B6 (sk)	1993-02-10	2001-02-12	Astra Pharmaceuticals Limited	N-alkyl-2-substituované adenozíntrifosfátové deriváty, spôsob ich prípravy, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov
EP0742279A1 (en)	1995-05-10	1996-11-13	The Procter & Gamble Company	Acidic aqueous liquid compositions
SE9701219D0 (sv)	1997-04-04	1997-04-04	Astra Pharma Prod	New compounds
FI109088B (fi)	1997-09-19	2002-05-31	Leiras Oy	Tabletti ja menetelmä sen valmistamiseksi
SE9903345D0 (sv) *	1999-09-17	1999-09-17	Astra Pharma Prod	Novel process

1999
- 1999-09-17 SE SE9903345A patent/SE9903345D0/xx unknown
2000
- 2000-09-11 AU AU70270/00A patent/AU771628B2/en not_active Expired
- 2000-09-11 IL IL14844200A patent/IL148442A/xx active IP Right Grant
- 2000-09-11 HK HK02107336.6A patent/HK1045696B/en not_active IP Right Cessation
- 2000-09-11 KR KR1020027003519A patent/KR100776105B1/ko not_active Expired - Lifetime
- 2000-09-11 US US10/088,177 patent/US6657076B1/en not_active Expired - Lifetime
- 2000-09-11 DE DE60003323T patent/DE60003323T2/de not_active Expired - Lifetime
- 2000-09-11 WO PCT/GB2000/003473 patent/WO2001021629A1/en not_active Ceased
- 2000-09-11 EP EP00958856A patent/EP1216253B1/en not_active Expired - Lifetime
- 2000-09-11 NZ NZ517552A patent/NZ517552A/en not_active IP Right Cessation
- 2000-09-11 PT PT00958856T patent/PT1216253E/pt unknown
- 2000-09-11 CN CNB008121826A patent/CN1150200C/zh not_active Expired - Lifetime
- 2000-09-11 CA CA002383829A patent/CA2383829C/en not_active Expired - Lifetime
- 2000-09-11 ES ES00958856T patent/ES2200921T3/es not_active Expired - Lifetime
- 2000-09-11 AT AT00958856T patent/ATE242778T1/de active
- 2000-09-11 BR BR0014057-0A patent/BR0014057A/pt not_active Application Discontinuation
- 2000-09-11 DK DK00958856T patent/DK1216253T3/da active
- 2000-09-11 JP JP2001525004A patent/JP4881524B2/ja not_active Expired - Lifetime
- 2000-09-14 TW TW089118778A patent/TWI274057B/zh not_active IP Right Cessation
- 2000-09-15 MY MYPI20004298A patent/MY119965A/en unknown
- 2000-09-15 AR ARP000104849A patent/AR029393A1/es active IP Right Grant
- 2000-09-18 CO CO00070530A patent/CO5231228A1/es active IP Right Grant
2002
- 2002-02-27 ZA ZA200201661A patent/ZA200201661B/en unknown
- 2002-03-14 NO NO20021269A patent/NO331532B1/no not_active IP Right Cessation
2003
- 2003-12-01 US US10/725,820 patent/US7288673B2/en not_active Expired - Lifetime
2005
- 2005-04-26 IL IL168246A patent/IL168246A/en active IP Right Grant

Also Published As

Publication number	Publication date
US7288673B2 (en)	2007-10-30
PT1216253E (pt)	2003-10-31
ZA200201661B (en)	2003-08-27
HK1045696A1 (en)	2002-12-06
AR029393A1 (es)	2003-06-25
JP2003509517A (ja)	2003-03-11
US20040171870A1 (en)	2004-09-02
CA2383829A1 (en)	2001-03-29
EP1216253B1 (en)	2003-06-11
EP1216253A1 (en)	2002-06-26
JP4881524B2 (ja)	2012-02-22
HK1045696B (en)	2003-11-21
MY119965A (en)	2005-08-30
ES2200921T3 (es)	2004-03-16
NO20021269L (no)	2002-03-14
NZ517552A (en)	2003-09-26
SE9903345D0 (sv)	1999-09-17
CA2383829C (en)	2009-01-20
DE60003323D1 (de)	2003-07-17
ATE242778T1 (de)	2003-06-15
IL148442A0 (en)	2002-09-12
AU771628B2 (en)	2004-04-01
CO5231228A1 (es)	2002-12-27
KR20020029135A (ko)	2002-04-17
DK1216253T3 (da)	2003-09-15
CN1150200C (zh)	2004-05-19
US6657076B1 (en)	2003-12-02
BR0014057A (pt)	2002-05-21
NO331532B1 (no)	2012-01-23
IL168246A (en)	2010-05-17
DE60003323T2 (de)	2004-04-29
WO2001021629A1 (en)	2001-03-29
KR100776105B1 (ko)	2007-11-15
NO20021269D0 (no)	2002-03-14
CN1371383A (zh)	2002-09-25
AU7027000A (en)	2001-04-24
TWI274057B (en)	2007-02-21

Legal Events

Date	Code	Title
2006-02-21	FF	Patent granted
2006-03-12	KB	Patent renewed
2006-10-30	KB	Patent renewed
2010-11-30	KB	Patent renewed
2014-08-31	KB	Patent renewed
2018-08-30	KB	Patent renewed

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