IL148934A0 - Heterologous production of polyketides - Google Patents

Heterologous production of polyketides

Info

Publication number
IL148934A0
IL148934A0 IL14893400A IL14893400A IL148934A0 IL 148934 A0 IL148934 A0 IL 148934A0 IL 14893400 A IL14893400 A IL 14893400A IL 14893400 A IL14893400 A IL 14893400A IL 148934 A0 IL148934 A0 IL 148934A0
Authority
IL
Israel
Prior art keywords
polyketides
host cells
coli host
methylmalonyl coa
propionibacterium shermanii
Prior art date
Application number
IL14893400A
Other languages
English (en)
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of IL148934A0 publication Critical patent/IL148934A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
IL14893400A 1999-10-27 2000-10-27 Heterologous production of polyketides IL148934A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16170399P 1999-10-27 1999-10-27
PCT/US2000/029775 WO2001031035A2 (en) 1999-10-27 2000-10-27 Heterologous production of polyketides

Publications (1)

Publication Number Publication Date
IL148934A0 true IL148934A0 (en) 2002-09-12

Family

ID=22582342

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14893400A IL148934A0 (en) 1999-10-27 2000-10-27 Heterologous production of polyketides

Country Status (12)

Country Link
US (4) US7011959B1 (de)
EP (1) EP1224300B9 (de)
JP (1) JP2003512073A (de)
AT (1) ATE356216T1 (de)
AU (1) AU1105201A (de)
CA (1) CA2388422A1 (de)
DE (1) DE60033835T2 (de)
ES (1) ES2283323T3 (de)
IL (1) IL148934A0 (de)
MX (1) MXPA02004153A (de)
NZ (1) NZ518259A (de)
WO (1) WO2001031035A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6790605B1 (en) 1995-12-07 2004-09-14 Diversa Corporation Methods for obtaining a desired bioactivity or biomolecule using DNA libraries from an environmental source
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US6939691B1 (en) * 1999-10-13 2005-09-06 Board Of Trustees Of The Leland Stanford Junior University E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production
AU1231701A (en) 1999-10-25 2001-05-08 Kosan Biosciences, Inc. Production of polyketides
JP2005506044A (ja) * 2001-02-28 2005-03-03 ザ、ボード、オブ、トラスティーズ、オブ、ザ、リーランド、スタンフォード、ジュニア、ユニバーシティ ポリケチドシンターゼ基質の生合成
AU2003253949A1 (en) 2002-07-15 2004-02-02 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
EP1527160A4 (de) * 2002-07-31 2005-09-14 Univ Leland Stanford Junior Herstellung von glykosylierten makroliden in e. coli
WO2004019879A2 (en) 2002-08-29 2004-03-11 Kosan Biosciences, Inc. Motilide compounds
AU2003291534A1 (en) 2002-11-12 2004-06-03 Kosan Biosciences, Inc. Method for producing polyketides
WO2007024997A2 (en) * 2005-08-22 2007-03-01 Fermalogic, Inc. Methods of increasing production of secondary metabolites
DE102006025821A1 (de) * 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
BRPI0605166A (pt) * 2006-11-03 2008-07-01 Inst Fleury método de determinação de ácido metilmalÈnico baseado na extração alquilativa associada à cromatografia lìquida acoplada à espectrometria de massas
CN102695792B (zh) 2009-10-08 2015-02-18 加利福尼亚大学董事会 对辛伐他汀合成表现出改善性质的LovD突变体
US10138504B2 (en) 2010-08-06 2018-11-27 Lallemand Hungary Liquidity Management Llc Production of malonyl-CoA derived products via anaerobic pathways
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
CN103060248B (zh) * 2011-10-19 2017-05-17 中国科学院上海有机化学研究所 一种构建基因工程fk506高产菌株的方法和筑波链霉菌高产菌株
US10119145B2 (en) 2013-03-15 2018-11-06 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet) Engineered organisms for production of novel lipids
DE102013112501A1 (de) 2013-11-13 2015-05-13 Bergische Universität Wuppertal Verfahren zur Herstellung chiraler Verbindungen
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN112410274B (zh) * 2019-08-23 2023-01-24 上海医药工业研究院 一种生产子囊霉素的基因工程菌及其制备方法和用途
CN114874931B (zh) * 2021-12-22 2023-06-27 河北省科学院生物研究所 一种复合微生物菌剂及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
EP0861321B1 (de) 1995-10-13 2006-05-31 President And Fellows Of Harvard College Phosphopantethenyltransferasen und deren verwendungen
US6033883A (en) * 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
IL132590A0 (en) 1997-04-30 2001-03-19 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold
NZ501998A (en) * 1997-07-10 2001-04-27 Kosan Biosciences Inc Production of polyketides in plants
AU1094699A (en) * 1997-10-15 1999-05-03 Diversa Corporation Screening for novel compounds which regulate biological interactions
NZ510819A (en) * 1998-10-02 2004-03-26 Kosan Biosciences Inc Polyketide synthase enzymes and recombinant DNA constructs therefor
KR100851418B1 (ko) * 1998-11-20 2008-08-08 코산 바이오사이언시즈, 인코포레이티드 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질
WO2001027306A2 (en) 1999-10-13 2001-04-19 The Board Of Trustees Of The Leland Stanford Junior University Biosynthesis of polyketide synthase substrates

Also Published As

Publication number Publication date
ES2283323T3 (es) 2007-11-01
US20090098615A1 (en) 2009-04-16
EP1224300A2 (de) 2002-07-24
DE60033835D1 (de) 2007-04-19
CA2388422A1 (en) 2001-05-03
US20040185541A1 (en) 2004-09-23
EP1224300B1 (de) 2007-03-07
DE60033835T2 (de) 2007-11-15
US7011959B1 (en) 2006-03-14
WO2001031035A3 (en) 2001-11-22
JP2003512073A (ja) 2003-04-02
AU1105201A (en) 2001-05-08
WO2001031035A2 (en) 2001-05-03
NZ518259A (en) 2004-03-26
MXPA02004153A (es) 2002-10-17
US7291486B2 (en) 2007-11-06
EP1224300B9 (de) 2007-09-26
US20020142401A1 (en) 2002-10-03
ATE356216T1 (de) 2007-03-15

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