ATE356216T1 - Heterologe herstellung von polyketiden - Google Patents

Heterologe herstellung von polyketiden

Info

Publication number
ATE356216T1
ATE356216T1 AT00972384T AT00972384T ATE356216T1 AT E356216 T1 ATE356216 T1 AT E356216T1 AT 00972384 T AT00972384 T AT 00972384T AT 00972384 T AT00972384 T AT 00972384T AT E356216 T1 ATE356216 T1 AT E356216T1
Authority
AT
Austria
Prior art keywords
polyketides
production
heterologue
host cells
coli host
Prior art date
Application number
AT00972384T
Other languages
English (en)
Inventor
Daniel Santi
Larry Peck
Linda Dayem
James Kealey
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Application granted granted Critical
Publication of ATE356216T1 publication Critical patent/ATE356216T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00972384T 1999-10-27 2000-10-27 Heterologe herstellung von polyketiden ATE356216T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16170399P 1999-10-27 1999-10-27

Publications (1)

Publication Number Publication Date
ATE356216T1 true ATE356216T1 (de) 2007-03-15

Family

ID=22582342

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00972384T ATE356216T1 (de) 1999-10-27 2000-10-27 Heterologe herstellung von polyketiden

Country Status (12)

Country Link
US (4) US7011959B1 (de)
EP (1) EP1224300B9 (de)
JP (1) JP2003512073A (de)
AT (1) ATE356216T1 (de)
AU (1) AU1105201A (de)
CA (1) CA2388422A1 (de)
DE (1) DE60033835T2 (de)
ES (1) ES2283323T3 (de)
IL (1) IL148934A0 (de)
MX (1) MXPA02004153A (de)
NZ (1) NZ518259A (de)
WO (1) WO2001031035A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6790605B1 (en) 1995-12-07 2004-09-14 Diversa Corporation Methods for obtaining a desired bioactivity or biomolecule using DNA libraries from an environmental source
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6939691B1 (en) * 1999-10-13 2005-09-06 Board Of Trustees Of The Leland Stanford Junior University E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production
EP1224317B1 (de) 1999-10-25 2006-03-08 Kosan Biosciences, Inc. Herstellung von polyketiden
JP2005506044A (ja) * 2001-02-28 2005-03-03 ザ、ボード、オブ、トラスティーズ、オブ、ザ、リーランド、スタンフォード、ジュニア、ユニバーシティ ポリケチドシンターゼ基質の生合成
US7413878B2 (en) 2002-07-15 2008-08-19 Kosan Biosciences, Inc. Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit
WO2004024744A2 (en) * 2002-07-31 2004-03-25 The Board Of Trustees Of The Leland Stanford Junior University Production of glycosylated macrolides in e. coli
SI1532131T1 (sl) 2002-08-29 2009-04-30 Pfizer Motilidne spojine
US7067290B2 (en) 2002-11-12 2006-06-27 Kosan Biosciences Incorporated Method for production of polyketides
US20070122885A1 (en) * 2005-08-22 2007-05-31 Fermalogic, Inc. Methods of increasing production of secondary metabolites by manipulating metabolic pathways that include methylmalonyl-coa
DE102006025821A1 (de) * 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
BRPI0605166A (pt) * 2006-11-03 2008-07-01 Inst Fleury método de determinação de ácido metilmalÈnico baseado na extração alquilativa associada à cromatografia lìquida acoplada à espectrometria de massas
CN102695792B (zh) 2009-10-08 2015-02-18 加利福尼亚大学董事会 对辛伐他汀合成表现出改善性质的LovD突变体
BR112013003003A2 (pt) 2010-08-06 2016-06-14 Mascoma Corp produção de produtos malonil-coa derivados através de rotas anaeróbicas
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
CN103060248B (zh) * 2011-10-19 2017-05-17 中国科学院上海有机化学研究所 一种构建基因工程fk506高产菌株的方法和筑波链霉菌高产菌株
EP2971022B1 (de) 2013-03-15 2020-08-19 Consejo Nacional De Investigaciones Cientificas Y Tecnicas Manipulierte organismen zur herstellung von neuartigen lipiden
DE102013112501A1 (de) 2013-11-13 2015-05-13 Bergische Universität Wuppertal Verfahren zur Herstellung chiraler Verbindungen
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN112410274B (zh) * 2019-08-23 2023-01-24 上海医药工业研究院 一种生产子囊霉素的基因工程菌及其制备方法和用途
CN114874931B (zh) * 2021-12-22 2023-06-27 河北省科学院生物研究所 一种复合微生物菌剂及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
CA2232230C (en) 1995-10-13 2005-06-28 Ralph H. Lambalot Phosphopantetheinyl transferases and uses thereof
US6033883A (en) * 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
NZ500693A (en) 1997-04-30 2004-01-30 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
WO1999002669A2 (en) 1997-07-10 1999-01-21 Kosan Biosciences, Inc. Production of polyketides in plants
AU1094699A (en) * 1997-10-15 1999-05-03 Diversa Corporation Screening for novel compounds which regulate biological interactions
MXPA01003376A (es) * 1998-10-02 2002-11-07 Kosan Biosciences Inc Enzimas policetido sintetasa y construcciones de acido desoxirribonucleico recombinante para las mismas.
WO2000031247A2 (en) * 1998-11-20 2000-06-02 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
ES2335385T3 (es) 1999-10-13 2010-03-26 The Board Of Trustees Of The Leland Stanford Junior University Biosintesis de sustratos de policetido sintasa.

Also Published As

Publication number Publication date
US20090098615A1 (en) 2009-04-16
MXPA02004153A (es) 2002-10-17
WO2001031035A2 (en) 2001-05-03
US20020142401A1 (en) 2002-10-03
EP1224300A2 (de) 2002-07-24
ES2283323T3 (es) 2007-11-01
JP2003512073A (ja) 2003-04-02
EP1224300B1 (de) 2007-03-07
US7291486B2 (en) 2007-11-06
IL148934A0 (en) 2002-09-12
NZ518259A (en) 2004-03-26
WO2001031035A3 (en) 2001-11-22
US20040185541A1 (en) 2004-09-23
AU1105201A (en) 2001-05-08
US7011959B1 (en) 2006-03-14
DE60033835T2 (de) 2007-11-15
CA2388422A1 (en) 2001-05-03
EP1224300B9 (de) 2007-09-26
DE60033835D1 (de) 2007-04-19

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