IL149143A0 - Bicyclic amino acids as pharmaceutical agents - Google Patents

Bicyclic amino acids as pharmaceutical agents

Info

Publication number: IL149143A0
Authority: IL; Israel
Prior art keywords: amino acids; pharmaceutical agents; bicyclic amino; bicyclic; pharmaceutical
Prior art date: 1999-10-20

Application number

IL14914300A

Other languages

English (en)

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-20

Filing date

2000-10-17

Publication date

2002-11-10

2000-10-17 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2002-11-10 Publication of IL149143A0 publication Critical patent/IL149143A0/xx

Links

-1 Bicyclic amino acids Chemical class 0.000 title 1
239000008177 pharmaceutical agent Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/22—All rings being cycloaliphatic the ring system containing eight carbon atoms, e.g. pentalene
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Psychology (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)

IL14914300A 1999-10-20 2000-10-17 Bicyclic amino acids as pharmaceutical agents IL149143A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16072599P	1999-10-20	1999-10-20
PCT/US2000/028687 WO2001028978A1 (en)	1999-10-20	2000-10-17	Bicyclic amino acids as pharmaceutical agents

Publications (1)

Publication Number	Publication Date
IL149143A0 true IL149143A0 (en)	2002-11-10

Family

ID=22578159

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL14914300A IL149143A0 (en)	1999-10-20	2000-10-17	Bicyclic amino acids as pharmaceutical agents
IL16406000A IL164060A0 (en)	1999-10-20	2000-10-17	Bicyclic amino acids as pharmaceutical agents
IL149143A IL149143A (en)	1999-10-20	2002-04-15	Amino-ring amino acids as pharmaceuticals

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL16406000A IL164060A0 (en)	1999-10-20	2000-10-17	Bicyclic amino acids as pharmaceutical agents
IL149143A IL149143A (en)	1999-10-20	2002-04-15	Amino-ring amino acids as pharmaceuticals

Country Status (50)

Country	Link
US (2)	US6689906B1 (de)
EP (2)	EP1226110B1 (de)
JP (2)	JP3632191B2 (de)
KR (2)	KR100593349B1 (de)
CN (1)	CN1165518C (de)
AP (2)	AP2004003186A0 (de)
AR (2)	AR026087A1 (de)
AT (2)	ATE293590T1 (de)
AU (2)	AU778871B2 (de)
BG (2)	BG108860A (de)
BR (1)	BR0014972B1 (de)
CA (1)	CA2386297C (de)
CO (1)	CO5280060A1 (de)
CR (1)	CR6620A (de)
CU (1)	CU23112A3 (de)
CZ (1)	CZ295960B6 (de)
DE (2)	DE60019628T2 (de)
DO (1)	DOP2000000083A (de)
DZ (1)	DZ3197A1 (de)
EA (1)	EA005206B1 (de)
EC (1)	ECSP045393A (de)
EE (1)	EE200200211A (de)
ES (2)	ES2237464T3 (de)
GE (1)	GEP20043297B (de)
GT (2)	GT200000183A (de)
HK (1)	HK1049826B (de)
HN (1)	HN2000000224A (de)
HR (2)	HRP20020428B1 (de)
HU (1)	HUP0203325A3 (de)
IL (3)	IL149143A0 (de)
IS (2)	IS6348A (de)
MA (1)	MA26842A1 (de)
MX (1)	MXPA02003229A (de)
MY (1)	MY127678A (de)
NO (2)	NO20021780L (de)
NZ (1)	NZ517961A (de)
OA (1)	OA12070A (de)
PA (1)	PA8505201A1 (de)
PE (1)	PE20010740A1 (de)
PL (1)	PL354607A1 (de)
PT (1)	PT1226110E (de)
SI (1)	SI1226110T1 (de)
SK (1)	SK5232002A3 (de)
SV (1)	SV2001000188A (de)
TR (2)	TR200201094T2 (de)
TW (2)	TW200505824A (de)
UA (1)	UA72931C2 (de)
WO (1)	WO2001028978A1 (de)
YU (2)	YU29302A (de)
ZA (1)	ZA200202543B (de)

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US7164034B2 (en)	1999-06-10	2007-01-16	Pfizer Inc.	Alpha2delta ligands for fibromyalgia and other disorders
ATE390133T1 (de) *	2000-06-26	2008-04-15	Warner Lambert Co	Gabapentinanaloga für schlafstörungen
US6620829B2 (en)	2000-10-17	2003-09-16	Warner-Lambert Company	Method of treating noninflammatory cartilage damage
EP1226820A1 (de) *	2001-01-26	2002-07-31	Warner-Lambert Company	Verwendung von bicyclische Aminosäuren zur Prophylaxe und Behandlung von Eingeweideschmerzen und gastrointestinalen Erkrankungen
WO2002085839A1 (en)	2001-04-19	2002-10-31	Warner-Lambert Company Llc	Fused bicyclic or tricyclic amino acids
GB2375109A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Process for preparing bicyclic amino acid
GB2375108A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Production of a bicycloheptanone
US6818787B2 (en)	2001-06-11	2004-11-16	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
MXPA03011566A (es) *	2001-06-11	2004-10-28	Xenoport Inc	Formas de dosificacion de profarmacos de analogos de gaba administrados oralmente que tienen toxicidad reducida.
US7232924B2 (en)	2001-06-11	2007-06-19	Xenoport, Inc.	Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en)	2005-04-06	2011-11-01	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en)	2001-06-11	2007-03-06	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
EP1469841A1 (de) *	2002-01-31	2004-10-27	Warner-Lambert Company	Alpha 2 delta ligands zur behandlung von ohrensausen
PL372210A1 (en) *	2002-02-22	2005-07-11	Warner-Lambert Company Llc	Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2
EP1515709A2 (de) *	2002-06-27	2005-03-23	Warner-Lambert Company LLC	Verwendung eines alpha2delta liganden wie zum beispiel gabapentin oder pregabalin zur behandlung von hyperaktivität mit aufmerksamkeitsstörungen
JP2005539092A (ja) *	2002-08-15	2005-12-22	ファイザー・インク	縮合二環式または三環式アミノ酸の治療における使用
US7419981B2 (en)	2002-08-15	2008-09-02	Pfizer Inc.	Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
GB0219024D0 (en) *	2002-08-15	2002-09-25	Pfizer Ltd	Synergistic combinations
GB0223072D0 (en)	2002-10-04	2002-11-13	Pfizer Ltd	Cyclic nitromethyl acetic acid derivatives
US7018818B2 (en)	2002-10-04	2006-03-28	Pfizer Inc.	Intermediates in the preparation of therapeutic fused bicyclic amino acids
US7060727B2 (en)	2002-12-11	2006-06-13	Xenoport, Inc.	Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof
DE60332387D1 (de)	2002-12-13	2010-06-10	Warner Lambert Co	Alpha-2-delta-ligand zur behandlung vonsymptomen der unteren harnwege
CN101862317A (zh)	2002-12-13	2010-10-20	沃尼尔·朗伯有限责任公司	用于治疗纤维肌痛和其它疾病的普加巴林衍生物
CA2451267A1 (en)	2002-12-13	2004-06-13	Warner-Lambert Company Llc	Pharmaceutical uses for alpha2delta ligands
DE602004024317D1 (de)	2003-09-12	2010-01-07	Pfizer	Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern
WO2006092692A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
AR061728A1 (es) *	2006-06-30	2008-09-17	Pfizer Prod Inc	Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
ATE511860T1 (de)	2006-12-22	2011-06-15	Recordati Ireland Ltd	Kombinationstherapie für erkrankungen der unteren harnwege mit 2 liganden und nsar
KR101409079B1 (ko)	2007-09-28	2014-06-18	다이이찌 산쿄 가부시키가이샤	2 고리성 γ-아미노산 유도체
KR101674700B1 (ko) *	2009-03-26	2016-11-09	다이이찌 산쿄 가부시키가이샤	2고리성 γ-아미노산 유도체의 제조 방법
WO2012169475A1 (ja)	2011-06-08	2012-12-13	第一三共株式会社	クライゼン転位反応による二環性化合物の製造方法
EP2719676B1 (de)	2011-06-08	2017-12-13	Daiichi Sankyo Company, Limited	Verfahren zur herstellung einer bicyclischen verbindung mithilfe eines iminiumsalzes
ES2686929T3 (es)	2011-12-15	2018-10-22	Daiichi Sankyo Company, Limited	Procedimiento de resolución óptica para compuesto bicíclico utilizando catalizador asimétrico
KR101976891B1 (ko)	2012-04-10	2019-05-09	다이이찌 산쿄 가부시키가이샤	효소를 사용하는 2 고리성 화합물의 광학 분할 방법
US9066853B2 (en)	2013-01-15	2015-06-30	Warsaw Orthopedic, Inc.	Clonidine compounds in a biodegradable fiber
TWI635071B (zh)	2013-07-08	2018-09-11	第一三共股份有限公司	光學活性二環γ－胺基酸衍生物及其製造方法
WO2018166855A1 (en)	2017-03-16	2018-09-20	Basf Se	Heterobicyclic substituted dihydroisoxazoles
CN113045410A (zh) *	2021-03-29	2021-06-29	华东理工大学	一种双环降二萜类化合物及其合成基因及制备方法

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DE2460891C2 (de) *	1974-12-21	1982-09-23	Gödecke AG, 1000 Berlin	1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) *	1974-12-21	1978-05-02	Warner-Lambert Company	Treatment of cranial dysfunctions using novel cyclic amino acids
KR100589066B1 (ko)	1997-10-27	2006-06-13	워너-램버트 캄파니 엘엘씨	약제로서 유용한 시클릭 아미노산 및 그의 유도체

2000
- 2000-10-05 HN HN2000000224A patent/HN2000000224A/es unknown
- 2000-10-06 SV SV2000000188A patent/SV2001000188A/es not_active Application Discontinuation
- 2000-10-17 NZ NZ517961A patent/NZ517961A/xx unknown
- 2000-10-17 KR KR1020027005036A patent/KR100593349B1/ko not_active Expired - Fee Related
- 2000-10-17 PT PT00972226T patent/PT1226110E/pt unknown
- 2000-10-17 BR BRPI0014972-1A patent/BR0014972B1/pt not_active IP Right Cessation
- 2000-10-17 ES ES00972226T patent/ES2237464T3/es not_active Expired - Lifetime
- 2000-10-17 OA OA1200200117A patent/OA12070A/en unknown
- 2000-10-17 US US10/130,023 patent/US6689906B1/en not_active Expired - Fee Related
- 2000-10-17 WO PCT/US2000/028687 patent/WO2001028978A1/en not_active Ceased
- 2000-10-17 CN CNB008145644A patent/CN1165518C/zh not_active Expired - Fee Related
- 2000-10-17 IL IL14914300A patent/IL149143A0/xx not_active IP Right Cessation
- 2000-10-17 AP AP2004003186A patent/AP2004003186A0/xx unknown
- 2000-10-17 EP EP00972226A patent/EP1226110B1/de not_active Expired - Lifetime
- 2000-10-17 CZ CZ20021310A patent/CZ295960B6/cs not_active IP Right Cessation
- 2000-10-17 KR KR1020067002249A patent/KR100566462B1/ko not_active Expired - Fee Related
- 2000-10-17 PL PL00354607A patent/PL354607A1/xx not_active Application Discontinuation
- 2000-10-17 YU YU29302A patent/YU29302A/sh unknown
- 2000-10-17 SK SK523-2002A patent/SK5232002A3/sk unknown
- 2000-10-17 IL IL16406000A patent/IL164060A0/xx unknown
- 2000-10-17 MX MXPA02003229A patent/MXPA02003229A/es active IP Right Grant
- 2000-10-17 DE DE60019628T patent/DE60019628T2/de not_active Expired - Lifetime
- 2000-10-17 ES ES04027485T patent/ES2282785T3/es not_active Expired - Lifetime
- 2000-10-17 EA EA200200293A patent/EA005206B1/ru unknown
- 2000-10-17 HR HR20020428A patent/HRP20020428B1/xx not_active IP Right Cessation
- 2000-10-17 HK HK03101868.4A patent/HK1049826B/zh not_active IP Right Cessation
- 2000-10-17 YU YU73004A patent/YU73004A/sh unknown
- 2000-10-17 HU HU0203325A patent/HUP0203325A3/hu unknown
- 2000-10-17 DZ DZ003197A patent/DZ3197A1/xx active
- 2000-10-17 GE GE4783A patent/GEP20043297B/en unknown
- 2000-10-17 EP EP04027485A patent/EP1506955B1/de not_active Expired - Lifetime
- 2000-10-17 UA UA2002032434A patent/UA72931C2/uk unknown
- 2000-10-17 TR TR2002/01094T patent/TR200201094T2/xx unknown
- 2000-10-17 AT AT00972226T patent/ATE293590T1/de not_active IP Right Cessation
- 2000-10-17 TR TR2005/00221T patent/TR200500221T2/xx unknown
- 2000-10-17 AP APAP/P/2002/002517A patent/AP2002002517A0/en unknown
- 2000-10-17 EE EEP200200211A patent/EE200200211A/xx unknown
- 2000-10-17 JP JP2001531783A patent/JP3632191B2/ja not_active Expired - Fee Related
- 2000-10-17 HR HRP20040709 patent/HRP20040709A2/xx not_active Application Discontinuation
- 2000-10-17 SI SI200030670T patent/SI1226110T1/xx unknown
- 2000-10-17 DE DE60034157T patent/DE60034157T2/de not_active Expired - Lifetime
- 2000-10-17 AT AT04027485T patent/ATE358116T1/de not_active IP Right Cessation
- 2000-10-17 AU AU10920/01A patent/AU778871B2/en not_active Ceased
- 2000-10-17 CA CA2386297A patent/CA2386297C/en not_active Expired - Fee Related
- 2000-10-18 PA PA20008505201A patent/PA8505201A1/es unknown
- 2000-10-18 MY MYPI20004896A patent/MY127678A/en unknown
- 2000-10-19 GT GT200000183A patent/GT200000183A/es unknown
- 2000-10-19 AR ARP000105497A patent/AR026087A1/es unknown
- 2000-10-19 PE PE2000001116A patent/PE20010740A1/es not_active Application Discontinuation
- 2000-10-19 DO DO2000000083A patent/DOP2000000083A/es unknown
- 2000-10-19 CO CO00079741A patent/CO5280060A1/es not_active Application Discontinuation
- 2000-10-19 GT GT200000183AK patent/GT200000183AA/es unknown
- 2000-10-20 TW TW093125953A patent/TW200505824A/zh unknown
- 2000-10-20 TW TW089122115A patent/TWI225855B/zh not_active IP Right Cessation
2002
- 2002-03-28 ZA ZA200202543A patent/ZA200202543B/xx unknown
- 2002-04-15 IL IL149143A patent/IL149143A/en unknown
- 2002-04-16 NO NO20021780A patent/NO20021780L/no not_active Application Discontinuation
- 2002-04-16 CU CU78A patent/CU23112A3/es unknown
- 2002-04-17 IS IS6348A patent/IS6348A/is unknown
- 2002-04-18 CR CR6620A patent/CR6620A/es not_active Application Discontinuation
- 2002-05-10 MA MA26634A patent/MA26842A1/fr unknown
- 2002-05-20 BG BG108860A patent/BG108860A/en unknown
- 2002-05-20 BG BG106719A patent/BG106719A/bg unknown
2004
- 2004-01-21 US US10/762,026 patent/US6835751B2/en not_active Expired - Fee Related
- 2004-07-28 EC EC2004005393A patent/ECSP045393A/es unknown
- 2004-08-17 AR ARP040102937A patent/AR045456A2/es unknown
- 2004-09-01 NO NO20043663A patent/NO20043663L/no not_active Application Discontinuation
- 2004-09-14 JP JP2004266488A patent/JP3744928B2/ja not_active Expired - Fee Related
- 2004-10-08 IS IS7497A patent/IS7497A/is unknown
2005
- 2005-03-23 AU AU2005201268A patent/AU2005201268A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AR045456A2 (es)	2005-10-26
TR200201094T2 (tr)	2002-09-23
YU73004A (sh)	2005-11-28
PL354607A1 (en)	2004-01-26
MA26842A1 (fr)	2004-12-20
JP2003512348A (ja)	2003-04-02
TW200505824A (en)	2005-02-16
DZ3197A1 (fr)	2001-04-26
JP3744928B2 (ja)	2006-02-15
CN1382118A (zh)	2002-11-27
ATE358116T1 (de)	2007-04-15
US20040152779A1 (en)	2004-08-05
KR20020040900A (ko)	2002-05-30
HRP20040709A2 (en)	2004-12-31
BG106719A (bg)	2003-02-28
PA8505201A1 (es)	2002-08-29
MXPA02003229A (es)	2002-09-30
AP2002002517A0 (en)	2002-06-30
EP1226110A1 (de)	2002-07-31
JP3632191B2 (ja)	2005-03-23
HK1049826B (zh)	2005-02-25
AP2004003186A0 (en)	2004-12-31
EP1506955B1 (de)	2007-03-28
AU2005201268A1 (en)	2005-04-21
HK1049826A1 (en)	2003-05-30
NZ517961A (en)	2002-12-20
KR100593349B1 (ko)	2006-06-26
JP2005036009A (ja)	2005-02-10
ES2282785T3 (es)	2007-10-16
PT1226110E (pt)	2005-07-29
CU23112A3 (es)	2006-02-27
BG108860A (en)	2006-03-31
SI1226110T1 (en)	2005-08-31
OA12070A (en)	2003-11-10
KR100566462B1 (ko)	2006-03-31
IS7497A (is)	2004-10-08
HRP20020428A2 (en)	2005-02-28
SV2001000188A (es)	2001-09-07
CZ295960B6 (cs)	2005-12-14
YU29302A (sh)	2005-06-10
KR20060013701A (ko)	2006-02-13
IL164060A0 (en)	2005-12-18
CA2386297C (en)	2010-02-09
AR026087A1 (es)	2002-12-26
IL149143A (en)	2007-02-11
NO20021780D0 (no)	2002-04-16
IS6348A (is)	2002-04-17
ECSP045393A (es)	2004-10-23
CA2386297A1 (en)	2001-04-26
HUP0203325A2 (hu)	2003-02-28
CZ20021310A3 (cs)	2003-05-14
DE60019628T2 (de)	2006-01-19
TR200500221T2 (tr)	2005-03-21
AU1092001A (en)	2001-04-30
AU778871B2 (en)	2004-12-23
MY127678A (en)	2006-12-29
ES2237464T3 (es)	2005-08-01
US6689906B1 (en)	2004-02-10
SK5232002A3 (en)	2003-07-01
UA72931C2 (uk)	2005-05-16
EA200200293A1 (ru)	2002-10-31
HUP0203325A3 (en)	2003-12-29
ATE293590T1 (de)	2005-05-15
US6835751B2 (en)	2004-12-28
BR0014972A (pt)	2002-07-16
EP1226110B1 (de)	2005-04-20
ZA200202543B (en)	2003-09-23
NO20043663L (no)	2002-04-16
GT200000183AA (es)	2005-06-17
TWI225855B (en)	2005-01-01
EA005206B1 (ru)	2004-12-30
HRP20020428B1 (en)	2006-02-28
NO20021780L (no)	2002-04-16
HN2000000224A (es)	2001-04-11
DOP2000000083A (es)	2002-03-30
EE200200211A (et)	2003-06-16
CO5280060A1 (es)	2003-05-30
WO2001028978A1 (en)	2001-04-26
CN1165518C (zh)	2004-09-08
DE60019628D1 (de)	2005-05-25
BR0014972B1 (pt)	2011-09-06
PE20010740A1 (es)	2001-07-27
GEP20043297B (en)	2004-01-12
GT200000183A (es)	2000-10-19
DE60034157D1 (de)	2007-05-10
CR6620A (es)	2004-02-02
EP1506955A1 (de)	2005-02-16
DE60034157T2 (de)	2007-12-13

Legal Events

Date	Code	Title	Description
2007-07-24	FF	Patent granted
2008-04-13	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
HRP20020428A2 (en)	2005-02-28	Bicyclic amino acids as pharmaceutical agents
HUP0100472A3 (en)	2003-03-28	Novel amines as pharmaceutical agents
HUP0203506A3 (en)	2012-09-28	Modified peptides as therapeutic agents
PL351387A1 (en)	2003-04-07	Pharmaceutical composition
SI0964856T1 (en)	2003-04-30	Bicyclic amino acids
EG23937A (en)	2008-01-14	Novel pharmaceutical
GB9909041D0 (en)	1999-06-16	Novel pharmaceutical
EG23946A (en)	2008-01-22	Novel pharmaceutical
GB9909154D0 (en)	1999-06-16	Pharmaceutical formulation
GB9926251D0 (en)	2000-01-12	Pharmaceutical formulation
HU0402095D0 (en)	2005-01-28	Bicyclic amino acids as pharmaceutically active ingredients
HUP9902307A3 (en)	2000-07-28	Novel bridged cyclic amino acids as pharmaceutical agents
SI0888325T1 (en)	2002-10-31	Novel cyclic amino acids as pharmaceutical agents
GB9930700D0 (en)	2000-02-16	Pharmaceutical formulation
GB9910633D0 (en)	1999-07-07	Pharmaceutical formulation
GB9927685D0 (en)	2000-01-19	Pharmaceutical formulation
GB9917774D0 (en)	1999-09-29	Pharmaceutical formulation
GB9917775D0 (en)	1999-09-29	Pharmaceutical formulation
GB9917772D0 (en)	1999-09-29	Pharmaceutical formulation
GB9919840D0 (en)	1999-10-27	Pharmaceutical formulation
GB9930878D0 (en)	2000-02-23	Pharmaceutical formulation
GB9910636D0 (en)	1999-07-07	Pharmaceutical formulation
GB9917777D0 (en)	1999-09-29	Pharmaceutical formulation
GB9922187D0 (en)	1999-11-17	Pharmaceutical formulation
GB9921396D0 (en)	1999-11-10	Pharmaceutical formulation