IL149366A0 - Novel apparatus and process for preparing crystalline particles - Google Patents

Novel apparatus and process for preparing crystalline particles

Info

Publication number
IL149366A0
IL149366A0 IL14936600A IL14936600A IL149366A0 IL 149366 A0 IL149366 A0 IL 149366A0 IL 14936600 A IL14936600 A IL 14936600A IL 14936600 A IL14936600 A IL 14936600A IL 149366 A0 IL149366 A0 IL 149366A0
Authority
IL
Israel
Prior art keywords
crystalline particles
mixing chamber
substance
liquid
reservoir
Prior art date
Application number
IL14936600A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IL149366A0 publication Critical patent/IL149366A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Steroid Compounds (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
IL14936600A 1999-11-03 2000-11-03 Novel apparatus and process for preparing crystalline particles IL149366A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9925934.3A GB9925934D0 (en) 1999-11-03 1999-11-03 Novel apparatus and process
GBGB0024511.8A GB0024511D0 (en) 1999-11-03 2000-10-06 Novel apparatus and process
PCT/GB2000/004237 WO2001032125A2 (en) 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles

Publications (1)

Publication Number Publication Date
IL149366A0 true IL149366A0 (en) 2002-11-10

Family

ID=10863815

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14936600A IL149366A0 (en) 1999-11-03 2000-11-03 Novel apparatus and process for preparing crystalline particles

Country Status (25)

Country Link
EP (2) EP1225875B1 (de)
JP (1) JP4700247B2 (de)
KR (1) KR20020047322A (de)
CN (1) CN1409627A (de)
AT (1) ATE271853T1 (de)
AU (1) AU768915B2 (de)
BR (1) BR0015271A (de)
CA (1) CA2389908A1 (de)
CZ (1) CZ20021555A3 (de)
DE (1) DE60012558T2 (de)
DK (1) DK1225875T3 (de)
ES (1) ES2225247T3 (de)
GB (2) GB9925934D0 (de)
HK (1) HK1045268B (de)
HU (1) HUP0203278A3 (de)
IL (1) IL149366A0 (de)
MX (1) MXPA02004394A (de)
NO (1) NO20022059L (de)
NZ (1) NZ518565A (de)
PL (1) PL356746A1 (de)
PT (1) PT1225875E (de)
SI (1) SI1225875T1 (de)
TR (1) TR200402709T4 (de)
WO (1) WO2001032125A2 (de)
ZA (1) ZA200203434B (de)

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KR100892864B1 (ko) 2001-08-02 2009-04-15 주식회사 엘지생명과학 4-아미노메틸렌-피롤리딘-3-온의 아미노-보호 유도체및/또는 4-아미노메틸렌-피롤리딘-3-알콕시이미노유도체들 및/또는 제미플록사신 또는 그것의 염의 제조를위한 공정
WO2003032951A1 (en) * 2001-08-29 2003-04-24 Dow Global Technologies Inc. A process for preparing crystalline drug particles by means of precipitation
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0202564D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
JP3691459B2 (ja) * 2002-06-14 2005-09-07 久光メディカル株式会社 粉末状吸入剤組成物
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
JP5154078B2 (ja) * 2003-02-21 2013-02-27 ザ ユニヴァーシティ オブ バース 粒子の製造プロセス
JP5090729B2 (ja) * 2003-03-04 2012-12-05 ファイブ・スター・テクノロジーズ・インコーポレイテッド 流体力学的キャビテーション結晶化装置および方法
AU2003220808B2 (en) 2003-03-27 2008-08-21 Bioactis Limited Powder medicine applicator for nasal cavity
US9808471B2 (en) 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US7811606B2 (en) 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) * 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
JP2007508240A (ja) * 2003-07-22 2007-04-05 バクスター・インターナショナル・インコーポレイテッド 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
JO3102B1 (ar) * 2004-03-17 2017-09-20 Chiesi Framaceutici S P A صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة
WO2006016530A1 (ja) 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
WO2006045795A2 (en) * 2004-10-29 2006-05-04 Akzo Nobel N.V. Processes involving the use of antisolvent crystallization
US20090259038A1 (en) * 2004-12-08 2009-10-15 Kuraray Co., Ltd. Process for producing (5alpha7alpha)-3-spiro-2'-(1',3'-dioxolan)-24-oxocholest-22-en-7-yl benzoate
MX2007009656A (es) 2005-02-10 2007-11-07 Glaxo Group Ltd Proceso para elaborar lactosa utilizando tecnicas de clasificacion previa y formulaciones farmaceuticas formadas de la misma.
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
US8337817B2 (en) 2006-12-26 2012-12-25 Shin Nippon Biomedical Laboratories, Ltd. Preparation for transnasal application
GB0705159D0 (en) 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
GB0724498D0 (en) 2007-12-15 2008-01-30 Univ Strathclyde Slow release compositions
CA2729644C (en) * 2008-07-18 2018-05-29 Prosonix Limited Process for improving crystallinity
WO2010131486A1 (en) 2009-05-15 2010-11-18 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
WO2011013003A2 (en) 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
PT105058B (pt) * 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos
AU2012282936B2 (en) * 2011-07-08 2016-11-10 Pfizer Limited Process for the preparation of fluticasone propionate form 1
CN102366405A (zh) * 2011-10-21 2012-03-07 江阴长风医药科技有限公司 以氢氟烷烃为抛射剂的氟替卡松丙酸酯气雾剂制剂
EP2802314B1 (de) * 2012-01-13 2020-11-25 XSpray Microparticles AB Verfahren zur herstellung stabiler, amorpher hybrider nanopartikel mit mindestens einem proteinkinaseinhibitor und mindestens einer polymeren stabilisierungs- und matrixformungskomponente
EP2847207B1 (de) 2012-05-08 2019-03-27 Nicox Ophthalmics, Inc. Nanokristalle von Fluticasonpropionat
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
EP2705838A1 (de) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium-Zubereitungen
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
MX2015015150A (es) * 2013-04-29 2016-02-18 Sanofi Sa Composiciones farmaceuticas inhalables y los dispositivos inhaladores que las contienen.
PT108368B (pt) * 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas
PT108885B (pt) * 2015-10-12 2019-02-13 Hovione Farm S A Método de produção de partículas compósitas inaláveis mediante a utilização de um atomizador de três fluidos
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
EP3860580A4 (de) * 2018-10-01 2022-07-20 Kindeva Drug Delivery L.P. Formulierung und aerosoldosen, inhalatoren und dergleichen mit der formulierung
CN110960504A (zh) * 2019-10-31 2020-04-07 上海新黄河制药有限公司 中空颗粒制备方法及干粉吸入制剂
EP4210864A2 (de) * 2020-09-08 2023-07-19 Genentech, Inc. Systeme und verfahren zur herstellung pharmazeutischer zusammensetzungen mit peristaltischen pumpen und dämpfern
CN112755301B (zh) * 2021-01-20 2022-03-29 孙洪坤 一种血液病造血干细胞移植用皮肤清洁器
CN117582373A (zh) * 2023-08-15 2024-02-23 中国药科大学 一种类球形无载体妥布霉素粉雾剂颗粒的湍流强化可控制备方法

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Also Published As

Publication number Publication date
GB9925934D0 (en) 1999-12-29
DE60012558D1 (de) 2004-09-02
NZ518565A (en) 2004-04-30
CN1409627A (zh) 2003-04-09
GB0024511D0 (en) 2000-11-22
CZ20021555A3 (cs) 2002-11-13
HUP0203278A2 (hu) 2003-01-28
DE60012558T2 (de) 2005-07-28
EP1466595A1 (de) 2004-10-13
HK1045268A1 (en) 2002-11-22
CA2389908A1 (en) 2001-05-10
NO20022059D0 (no) 2002-04-30
BR0015271A (pt) 2002-12-31
ATE271853T1 (de) 2004-08-15
AU768915B2 (en) 2004-01-08
DK1225875T3 (da) 2004-11-22
ES2225247T3 (es) 2005-03-16
AU1160401A (en) 2001-05-14
HUP0203278A3 (en) 2004-06-28
EP1225875B1 (de) 2004-07-28
HK1045268B (en) 2005-02-18
JP4700247B2 (ja) 2011-06-15
WO2001032125A2 (en) 2001-05-10
EP1225875A2 (de) 2002-07-31
PL356746A1 (en) 2004-06-28
WO2001032125A3 (en) 2002-05-16
NO20022059L (no) 2002-06-14
SI1225875T1 (en) 2004-12-31
PT1225875E (pt) 2004-12-31
TR200402709T4 (tr) 2004-11-22
MXPA02004394A (es) 2002-09-02
KR20020047322A (ko) 2002-06-21
ZA200203434B (en) 2003-02-25
JP2003512892A (ja) 2003-04-08

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