IL153097A0 - A process for selectively amplifying nucleic acid sequences - Google Patents

A process for selectively amplifying nucleic acid sequences

Info

Publication number
IL153097A0
IL153097A0 IL15309701A IL15309701A IL153097A0 IL 153097 A0 IL153097 A0 IL 153097A0 IL 15309701 A IL15309701 A IL 15309701A IL 15309701 A IL15309701 A IL 15309701A IL 153097 A0 IL153097 A0 IL 153097A0
Authority
IL
Israel
Prior art keywords
nucleic acid
acid sequences
amplifying nucleic
selectively amplifying
sequences
Prior art date
Application number
IL15309701A
Other languages
English (en)
Original Assignee
Molecular Staging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Staging Inc filed Critical Molecular Staging Inc
Publication of IL153097A0 publication Critical patent/IL153097A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL15309701A 2000-06-28 2001-06-27 A process for selectively amplifying nucleic acid sequences IL153097A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/605,192 US6323009B1 (en) 2000-06-28 2000-06-28 Multiply-primed amplification of nucleic acid sequences
PCT/US2001/020217 WO2002000934A2 (fr) 2000-06-28 2001-06-27 Amplification de sequences nucleotidiques par plusieurs amorces

Publications (1)

Publication Number Publication Date
IL153097A0 true IL153097A0 (en) 2003-06-24

Family

ID=24422608

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15309701A IL153097A0 (en) 2000-06-28 2001-06-27 A process for selectively amplifying nucleic acid sequences

Country Status (9)

Country Link
US (2) US6323009B1 (fr)
EP (1) EP1315833B1 (fr)
JP (1) JP4718756B2 (fr)
AT (1) ATE343003T1 (fr)
AU (2) AU2001268725B2 (fr)
CA (1) CA2410951A1 (fr)
DE (1) DE60123980T2 (fr)
IL (1) IL153097A0 (fr)
WO (1) WO2002000934A2 (fr)

Families Citing this family (216)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261808B1 (en) * 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (fr) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Procedes d'amplification isothermique de molecules d'acide nucleique
AU714486B2 (en) * 1995-11-21 2000-01-06 Yale University Unimolecular segment amplification and detection
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US20080160524A1 (en) * 1996-01-24 2008-07-03 Third Wave Technologies, Inc. Methods and Compositions for Detecting Target Sequences
US20080220425A1 (en) * 1996-01-24 2008-09-11 Third Wave Technologies, Inc. Methods and Compositions for Detecting Target Sequences
US7205129B1 (en) 2000-02-28 2007-04-17 Qiagen Gmbh Method for reducing artifacts in nucleic acid amplification
US20020120409A1 (en) * 2000-05-19 2002-08-29 Affymetrix, Inc. Methods for gene expression analysis
US6531283B1 (en) 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
AU7172201A (en) 2000-06-30 2002-01-14 Molecular Staging Inc Signal amplification with lollipop probes
US6861222B2 (en) 2000-11-09 2005-03-01 Yale University Nucleic acid detection using structured probes
US8507662B2 (en) 2001-01-19 2013-08-13 General Electric Company Methods and kits for reducing non-specific nucleic acid amplification
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
DE10119006A1 (de) * 2001-04-18 2002-10-24 Roche Diagnostics Gmbh Verfahren zur Verbesserung der Stabilität linearer DNA in zellfreien in vitro Transkriptions/Translations-Systemen
WO2002090572A2 (fr) * 2001-05-09 2002-11-14 Third Wave Technologies, Inc. Detection d'acides nucleiques dans des echantillons groupes
AU2003303395A1 (en) * 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
US6861231B2 (en) * 2001-08-17 2005-03-01 Qiagen Gmbh Suppression of cross-reactivity and non-specific binding by antibodies using protein A
US6977148B2 (en) * 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
US6617137B2 (en) * 2001-10-15 2003-09-09 Molecular Staging Inc. Method of amplifying whole genomes without subjecting the genome to denaturing conditions
US7297485B2 (en) * 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7176002B2 (en) * 2002-05-16 2007-02-13 Applera Corporation Universal-tagged oligonucleotide primers and methods of use
US20050118602A1 (en) * 2002-10-10 2005-06-02 Yin-Xiong Li Gene profiling of single or multiple cells
US20040115643A1 (en) * 2002-12-12 2004-06-17 Lizardi Paul M. Thermodynamic equilibrium extension of primers
US9487823B2 (en) * 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
JP4886298B2 (ja) * 2002-12-20 2012-02-29 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング 核酸増幅
US7955795B2 (en) * 2003-06-06 2011-06-07 Qiagen Gmbh Method of whole genome amplification with reduced artifact production
US6977153B2 (en) 2002-12-31 2005-12-20 Qiagen Gmbh Rolling circle amplification of RNA
EP1590470A4 (fr) * 2003-02-03 2006-09-27 Ge Healthcare Bio Sciences Amplification d'adnc pour la formation de profils d'expression
US7192703B2 (en) * 2003-02-14 2007-03-20 Intel Corporation, Inc. Biomolecule analysis by rolling circle amplification and SERS detection
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
EP1618187A4 (fr) * 2003-04-29 2006-12-20 Ge Healthcare Bio Sciences Amplification de sequences d'acide nucleique par plusieurs amorces
US20050202453A1 (en) * 2003-05-28 2005-09-15 Wen-Yuan Song Nucleic acid amplification in yeast
WO2005010159A2 (fr) * 2003-07-17 2005-02-03 Children's Hospital Medical Center Amplification en cercle roulant d'echantillons de micro-arn
US20050069926A1 (en) * 2003-08-01 2005-03-31 Affymetrix, Inc. Helicase-amplified reverse transcription
WO2005030995A1 (fr) * 2003-09-23 2005-04-07 University Of Missouri Procede de synthese de polynucleotides a l'aide d'enzymes thermostable
WO2005108608A1 (fr) * 2004-05-10 2005-11-17 Kabushiki Kaisha Dnaform Procédé d'isolation d'isoformes d'acide nucléique
US20080318217A1 (en) 2004-09-14 2008-12-25 Yale University Identification of Gene Associated with Reading Disability and Uses Therefor
US7315019B2 (en) * 2004-09-17 2008-01-01 Pacific Biosciences Of California, Inc. Arrays of optical confinements and uses thereof
US7170050B2 (en) * 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US20080305142A1 (en) * 2004-12-11 2008-12-11 Cytogenix, Inc. Cell Free Biosynthesis of High-Quality Nucleic Acid and Uses Thereof
US20060252032A1 (en) * 2005-01-28 2006-11-09 Third Wave Technologies, Inc. Detection of human herpesviruses
US8309303B2 (en) 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
US20070020667A1 (en) * 2005-06-30 2007-01-25 Ruff David W Methods and compositions for amplifying nucleic acids
EP1762627A1 (fr) 2005-09-09 2007-03-14 Qiagen GmbH Procédé pour l'activation d'acides nucléiques pour effectuer une réaction d'une polymérase
US7482127B2 (en) * 2005-11-03 2009-01-27 Third Wave Technologies, Inc. Nucleic acid detection assays employing blocker oligonucleotides
US20080057499A1 (en) * 2006-02-06 2008-03-06 Affymetrix, Inc. Methods for high specificity whole genome amplification and hybridization
US20080131875A1 (en) * 2006-06-07 2008-06-05 Third Wave Technologies, Inc. Multiplex assays
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
EP2520935A3 (fr) 2006-08-09 2013-02-13 Homestead Clinical Corporation Protéines spécifiques d'organes et leurs procédés d'utilisation
US8420798B2 (en) * 2006-09-01 2013-04-16 Ventana Medical Systems, Inc. Method for producing nucleic acid probes
WO2008045251A2 (fr) 2006-10-04 2008-04-17 Third Wave Technologies, Inc. Amorces snap-back et structures en epingle a cheveux detectables
US20100184152A1 (en) * 2006-10-23 2010-07-22 Vladislav Sandler Target-oriented whole genome amplification of nucleic acids
US20080096258A1 (en) * 2006-10-24 2008-04-24 Christian Korfhage Rolling circle amplification of circular genomes
WO2008063378A2 (fr) 2006-11-01 2008-05-29 Ventana Medical Systems, Inc. Haptènes, conjugués de haptène, compositions de haptène, procédé de fabrication et utilisation
US8551704B2 (en) 2007-02-16 2013-10-08 Pacific Biosciences Of California, Inc. Controllable strand scission of mini circle DNA
WO2008118679A1 (fr) * 2007-03-23 2008-10-02 Ge Healthcare Bio-Sciences Corp. Amplification multi-amorcée de séquences d'acides nucléiques circulaires
US7682789B2 (en) 2007-05-04 2010-03-23 Ventana Medical Systems, Inc. Method for quantifying biomolecules conjugated to a nanoparticle
JP2010528285A (ja) 2007-05-23 2010-08-19 ベンタナ・メデイカル・システムズ・インコーポレーテツド 免疫組織化学およびｉｎｓｉｔｕハイブリダーゼーションのためのポリマー担体
US9598724B2 (en) * 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
JP2010534474A (ja) 2007-07-26 2010-11-11 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド 分子冗長配列決定
US20090227463A1 (en) * 2008-03-04 2009-09-10 Reif John H Autonomous in vitro evolution
WO2009117327A2 (fr) 2008-03-15 2009-09-24 Hologic, Inc. Compositions et procédés pour analyse de molécules d’acide nucléique pendant des réactions d’amplification
MX2010010600A (es) 2008-03-28 2011-03-30 Pacific Biosciences California Inc Composiciones y metodos para secuenciacion de acidos nucleicos.
US20090247426A1 (en) * 2008-03-31 2009-10-01 Pacific Biosciences Of California, Inc. Focused library generation
WO2009141430A1 (fr) * 2008-05-22 2009-11-26 Ge Healthcare Bio-Sciences Corp Amplification améliorée d’acide nucléique avec une protéine de liaison à l’adn simple brin
WO2009149013A2 (fr) 2008-06-05 2009-12-10 Ventana Medical Systems, Inc. Compositions comprenant des nanomatériaux et procédé d'utilisation de ces compositions pour des processus histochimiques
US20100008939A1 (en) * 2008-07-09 2010-01-14 General Electric Company Unprocessed rolling circle amplification product
KR20100019220A (ko) * 2008-08-08 2010-02-18 삼성전자주식회사 열순환을 포함하는 다중 치환 증폭에 의하여 표적 핵산 서열을 증폭하는 방법
US20100055680A1 (en) * 2008-08-28 2010-03-04 Perkinelmer Las, Inc. Genomic dna labeling and amplification
US8795961B2 (en) * 2008-09-05 2014-08-05 Pacific Biosciences Of California, Inc. Preparations, compositions, and methods for nucleic acid sequencing
ES2351294B8 (es) 2009-07-02 2012-06-06 Consejo Superior De Investigaciones Científicas (Csic) Metodo para la replicación, amplificación, o secuenciación de un adn molde.
ES2359058B1 (es) 2009-07-02 2012-03-27 Consejo Superior De Investigaciones Cient�?Ficas (Csic) Quimera de adn polimerasa del fago ph1 29.
ES2628739T3 (es) * 2009-10-15 2017-08-03 Ibis Biosciences, Inc. Amplificación por desplazamiento múltiple
US20110195457A1 (en) * 2010-02-09 2011-08-11 General Electric Company Isothermal amplification of nucleic acid using primers comprising a randomized sequence and specific primers and uses thereof
USPP22463P3 (en) * 2010-02-16 2012-01-17 Menachem Bornstein Gypsophila plant named ‘Pearl Blossom’
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
WO2012044956A1 (fr) * 2010-10-01 2012-04-05 Ibis Biosciences, Inc. Méthodes d'amplification d'un génome cible
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
WO2013024173A1 (fr) 2011-08-17 2013-02-21 Technische Universität München Procédé mis en œuvre par ordinateur pour l'indentification de régions régulatrices ou de variations régulatrices
US9133509B2 (en) 2012-03-22 2015-09-15 Lgc Genomics Limited Polymerase chain reaction detection system
US9777319B2 (en) 2012-06-29 2017-10-03 General Electric Company Method for isothermal DNA amplification starting from an RNA template
CN104797718B (zh) 2012-09-12 2020-05-08 加利福尼亚大学董事会 通过单链扩增和测序对单个细胞进行精确基因组测序
WO2014060483A1 (fr) 2012-10-17 2014-04-24 Spatial Transcriptomics Ab Procédés et produit d'optimisation de la détection localisée ou spatiale de l'expression génique dans un échantillon de tissu
DK2917369T3 (en) 2012-11-07 2019-04-15 Univ Yale ASSESSMENT OF THE RISK OF READING AND LANGUAGE DISORDER
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
CA2904181A1 (fr) 2013-03-13 2014-10-09 Anahit Aghvanyan Dosage immunologique sandwich comprenant un reactif d'ancrage
KR102134168B1 (ko) 2013-03-15 2020-07-15 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 중금속이 없는 씨피브이씨 조성물
EP3013983B1 (fr) 2013-06-25 2023-02-15 Prognosys Biosciences, Inc. Essais biologiques à codage spatial faisant appel à un dispositif microfluidique
US9920305B2 (en) * 2013-10-16 2018-03-20 New England Biolabs, Inc. Reverse transcriptase with enhanced properties
WO2015175856A1 (fr) 2014-05-15 2015-11-19 Meso Scale Technologies, Llc. Méthodes de dosage améliorées
WO2016011177A1 (fr) 2014-07-18 2016-01-21 Fluidigm Corporation Réactifs et kit pour des compositions d'amplification génomique totale à cellule unique
US10774374B2 (en) 2015-04-10 2020-09-15 Spatial Transcriptomics AB and Illumina, Inc. Spatially distinguished, multiplex nucleic acid analysis of biological specimens
CN105695571A (zh) * 2016-01-29 2016-06-22 苏州金唯智生物科技有限公司 一种基于滚环扩增的dna定量方法
EP4354140A3 (fr) 2016-02-26 2024-07-24 The Board of Trustees of the Leland Stanford Junior University Visualisation de molécule simple multiplexée d'arn à l'aide d'un système de ligature de proximité à deux sondes
CN105907752A (zh) * 2016-05-09 2016-08-31 湖南农业大学 基于体外滚环复制的pcv2毒株感染性克隆构建试剂盒及方法
US10350307B2 (en) 2017-09-18 2019-07-16 General Electric Company In vivo RNA or protein expression using double-stranded concatemeric DNA including phosphorothioated nucleotides
CN109971833B (zh) * 2017-12-28 2020-11-20 南京金斯瑞生物科技有限公司 快速均一化环状dna样本的方法
US12480940B2 (en) 2018-05-17 2025-11-25 Meso Scale Technologies, Llc. Methods for isolating surface marker displaying agents
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020086751A1 (fr) 2018-10-23 2020-04-30 Meso Scale Technologies, Llc. Procédés d'isolement d'agents présentant des marqueurs de surface
EP3894590B1 (fr) 2018-12-10 2025-10-22 10X Genomics, Inc. Procédés d'utilisation de réseaux maître/copie pour la détection spatiale
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
AU2020232954B2 (en) 2019-03-01 2026-01-15 Meso Scale Technologies, Llc. Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same
EP3976820A1 (fr) 2019-05-30 2022-04-06 10X Genomics, Inc. Procédés de détection de l'hétérogénéité spatiale d'un échantillon biologique
WO2021076770A1 (fr) 2019-10-18 2021-04-22 The Board Of Trustees Of The Leland Stanford Junior University Séquençage de tissu intact à l'échelle clinique et industrielle
WO2021092433A2 (fr) 2019-11-08 2021-05-14 10X Genomics, Inc. Amélioration de la spécificité de la liaison d'un analyte
WO2021133849A1 (fr) 2019-12-23 2021-07-01 10X Genomics, Inc. Procédés d'analyse spatiale utilisant une ligature à matrice d'arn
CN115135984B (zh) 2019-12-23 2025-12-23 10X基因组学有限公司 可逆固定试剂及其使用方法
EP4081656A1 (fr) 2019-12-23 2022-11-02 10X Genomics, Inc. Compositions et méthodes d'utilisation d'échantillons biologiques fixés dans des dosages basés sur des compartiments
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US12110548B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Bi-directional in situ analysis
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
WO2021158925A1 (fr) 2020-02-07 2021-08-12 10X Genomics, Inc. Évaluation quantitative et automatisée de la performance de perméabilisation pour la transcriptomique spatiale
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
EP4107284A1 (fr) 2020-02-17 2022-12-28 10X Genomics, Inc. Analyse in situ de l'interaction chromatinienne
EP4484571A3 (fr) 2020-02-21 2025-03-19 10X Genomics, Inc. Procédés et compositions pour un dosage spatial in situ intégré
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
AU2021230282A1 (en) 2020-03-03 2022-09-22 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing double stranded nucleic acids
US12188085B2 (en) 2020-03-05 2025-01-07 10X Genomics, Inc. Three-dimensional spatial transcriptomics with sequencing readout
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
WO2021236584A1 (fr) 2020-05-19 2021-11-25 Meso Scale Technologies, Llc. Méthodes, compositions et kits de détection d'acides nucléiques
EP4553168A3 (fr) 2020-05-22 2025-08-27 10x Genomics, Inc. Analyse spatiale pour détecter des variantes de séquence
EP4153775B1 (fr) 2020-05-22 2024-07-24 10X Genomics, Inc. Mesure spatio-temporelle simultanée de l'expression génique et de l'activité cellulaire
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252499A1 (fr) 2020-06-08 2021-12-16 10X Genomics, Inc. Méthodes de détermination de marge chirurgicale et méthodes d'utilisation associées
US12209273B2 (en) 2020-06-12 2025-01-28 10X Genomics, Inc. Nucleic acid assays using click chemistry bioconjugation
EP4172362B1 (fr) 2020-06-25 2024-09-18 10X Genomics, Inc. Analyse spatiale de la méthylation de l'adn
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US12297499B2 (en) 2020-08-17 2025-05-13 10X Genomics, Inc. Multicomponent nucleic acid probes for sample analysis
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
WO2022051485A2 (fr) 2020-09-02 2022-03-10 Meso Scale Technologies,Llc. Kits de détection d'un ou de plusieurs analytes cibles dans un échantillon et leurs procédés de fabrication et d'utilisation
EP4208720A2 (fr) 2020-09-04 2023-07-12 Meso Scale Technologies, LLC Procédés d'isolement d'agents présentant des marqueurs de surface du système nerveux central
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US12071667B2 (en) 2020-11-04 2024-08-27 10X Genomics, Inc. Sequence analysis using meta-stable nucleic acid molecules
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4012046A1 (fr) 2020-12-11 2022-06-15 10X Genomics, Inc. Procédés et compositions pour l'analyse multimodale in situ
EP4729631A2 (fr) 2020-12-21 2026-04-22 10X Genomics, Inc. Procédés, compositions et systèmes de capture de sondes et/ou de codes à barres
CN116848263A (zh) 2020-12-23 2023-10-03 10X基因组学有限公司 用于分析物检测的方法和组合物
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
EP4284945B1 (fr) 2021-01-26 2024-10-23 10X Genomics, Inc. Sondes analogiques d'acide nucléique pour analyse in situ
US12275984B2 (en) 2021-03-02 2025-04-15 10X Genomics, Inc. Sequential hybridization and quenching
WO2022187366A1 (fr) 2021-03-03 2022-09-09 10X Genomics, Inc. Détection d'analytes in situ à l'aide d'origami d'acide nucléique
EP4428246B1 (fr) 2021-04-14 2025-12-24 10X Genomics, Inc. Procédés de mesure de la localisation erronée d'un analyte
US20240287572A1 (en) 2021-04-16 2024-08-29 Meso Scale Technologies, Llc. Methods, compositions, and kits for detecting hydrolase enzyme activity
US20240210399A1 (en) 2021-04-26 2024-06-27 Meso Scale Technologies, Llc. Methods for isolating and analyzing a target analyte encapsulated by a surface marker displaying agent
EP4320271B1 (fr) 2021-05-06 2025-03-19 10X Genomics, Inc. Procédés pour augmenter la résolution d'une analyse spatiale
WO2022241227A1 (fr) 2021-05-14 2022-11-17 Akoya Biosciences, Inc. Amplification de signaux de détection d'arn dans des échantillons biologiques
US20220380838A1 (en) 2021-06-01 2022-12-01 10X Genomics, Inc. Methods and compositions for analyte detection and probe resolution
WO2022256422A1 (fr) 2021-06-02 2022-12-08 10X Genomics, Inc. Analyse d'échantillon à l'aide de sondes circularisables asymétriques
EP4582555A3 (fr) 2021-06-03 2025-10-22 10X Genomics, Inc. Procédés, compositions, kits et systèmes pour améliorer la capture d'analytes pour une analyse spatiale
WO2023283442A1 (fr) 2021-07-09 2023-01-12 10X Genomics, Inc. Procédés de détection d'analytes à l'aide d'un marquage épars
CN117651855A (zh) 2021-07-13 2024-03-05 10X基因组学有限公司 用于制备具有可控厚度的聚合基质的方法
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
US20250269368A1 (en) 2021-07-21 2025-08-28 Dnae Group Holdings Limited Method and system comprising a cartridge for sequencing target polynucleotides
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
CA3224093A1 (fr) 2021-07-30 2023-02-02 Jorge Ivan Hernandez Neuta Procedes et compositions pour la synchronisation de reactions in situ
US12139751B2 (en) 2021-07-30 2024-11-12 10X Genomics, Inc. Circularizable probes for in situ analysis
US12391984B2 (en) 2021-08-03 2025-08-19 10X Genomics, Inc. Compositions and methods for rolling circle amplification
US12460251B2 (en) 2021-08-03 2025-11-04 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid molecules
US12529096B2 (en) 2021-08-03 2026-01-20 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid structures
EP4381095A1 (fr) 2021-08-03 2024-06-12 10X Genomics, Inc. Concatémères d'acide nucléique et procédés de stabilisation et/ou de compactage de ceux-ci
US12435364B2 (en) 2021-08-16 2025-10-07 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
ES3011462T3 (en) 2021-09-01 2025-04-07 10X Genomics Inc Methods for blocking a capture probe on a spatial array
WO2023086880A1 (fr) 2021-11-10 2023-05-19 10X Genomics, Inc. Procédés, compositions et kits pour déterminer l'emplacement d'un analyte dans un échantillon biologique
EP4305195A2 (fr) 2021-12-01 2024-01-17 10X Genomics, Inc. Procédés, compositions et systèmes pour la détection améliorée d'analytes in situ et analyse spatiale
WO2023108139A2 (fr) 2021-12-10 2023-06-15 10X Genomics, Inc. Décodage in situ multi-résolution
WO2023129898A2 (fr) 2021-12-27 2023-07-06 10X Genomics, Inc. Procédés et compositions pour l'amplification par cercle roulant
EP4733410A2 (fr) 2022-01-21 2026-04-29 10X Genomics, Inc. Signaux de lecture multiples pour analyser un échantillon
WO2023164570A1 (fr) 2022-02-23 2023-08-31 Insitro, Inc. Criblage optique groupé et mesures transcriptionnelles de cellules comprenant des perturbations génétiques à code-barres
EP4490737A1 (fr) 2022-03-08 2025-01-15 10X Genomics, Inc. Procédés de conception de code in situ pour réduire à un minimum un chevauchement optique
EP4500481A1 (fr) 2022-03-29 2025-02-05 10X Genomics, Inc. Démixage spectral combiné à un décodage pour une analyse sur site super-multiplexée
CN119234045A (zh) 2022-04-06 2024-12-31 10X基因组学有限公司 用于多重细胞分析的方法
WO2023215612A1 (fr) 2022-05-06 2023-11-09 10X Genomics, Inc. Analyse d'un antigène et des interactions antigène-récepteur
CN119213143A (zh) 2022-05-11 2024-12-27 10X基因组学有限公司 用于原位测序的组合物和方法
WO2023245190A1 (fr) 2022-06-17 2023-12-21 10X Genomics, Inc. DÉ-RÉTICULATION CATALYTIQUE D'ÉCHANTILLONS POUR ANALYSE IN SITU <i />
JP2025528823A (ja) 2022-08-15 2025-09-02 エレメント バイオサイエンシズ，インコーポレイティド コンパクト化オリゴヌクレオチドを使用して核酸ナノ構造を調製するための方法
EP4602344A1 (fr) 2022-10-14 2025-08-20 10X Genomics, Inc. Procédés d'analyse d'échantillons biologiques
WO2024102809A1 (fr) 2022-11-09 2024-05-16 10X Genomics, Inc. Procédés, compositions et kits pour déterminer l'emplacement de plusieurs analytes dans un échantillon biologique
US20240158852A1 (en) 2022-11-16 2024-05-16 10X Genomics, Inc. Methods and compositions for assessing performance of in situ assays
WO2024130203A1 (fr) 2022-12-16 2024-06-20 10X Genomics, Inc. Procédés et compositions d'évaluation de performances
US20240368678A1 (en) 2023-05-03 2024-11-07 10X Genomics, Inc. Methods and compositions for spatial assay
WO2024242845A1 (fr) 2023-05-24 2024-11-28 Meso Scale Technologies, Llc. Procédés d'évaluation du cancer colorectal à l'aide de vésicules extracellulaires
WO2025010160A1 (fr) 2023-07-06 2025-01-09 Pacific Biosciences Of California, Inc. Procédés et compositions pour stabiliser des concatémères
WO2025014758A1 (fr) 2023-07-07 2025-01-16 10X Genomics, Inc. Systèmes et procédés de détection de limites de tissu
WO2025038914A1 (fr) 2023-08-16 2025-02-20 10X Genomics, Inc. Systèmes et procédés de segmentation d'image
WO2025076421A1 (fr) 2023-10-06 2025-04-10 10X Genomics, Inc. Pyramides de caractéristiques pour visualisations de données in situ
US20250163502A1 (en) 2023-11-22 2025-05-22 10X Genomics, Inc. Methods for processing ribonucleic acids in biological samples
US20250188524A1 (en) 2023-12-07 2025-06-12 10X Genomics, Inc. Graphical user interface and method of estimating an instrument run completion time
WO2025137268A1 (fr) 2023-12-20 2025-06-26 Pacific Biosciences Of California, Inc. Procédés et compositions pour pour réduire la dépendance à la cg
US20250207203A1 (en) 2023-12-20 2025-06-26 10X Genomics, Inc. In situ detection of copy number variations in biological samples
WO2025160489A1 (fr) 2024-01-25 2025-07-31 10X Genomics, Inc. Systèmes et procédés de segmentation d'image à l'aide de multiples indicateurs de coloration
WO2025189030A1 (fr) 2024-03-07 2025-09-12 Stellaromics, Inc. Procédés et systèmes d'imagerie volumétrique
WO2025189080A1 (fr) 2024-03-08 2025-09-12 10X Genomics, Inc. Fusion d'image multi-foyer avec élimination d'arrière-plan
WO2025255457A1 (fr) 2024-06-07 2025-12-11 10X Genomics, Inc. Compositions et procédés de profilage spatial sur cible amélioré
WO2025264702A1 (fr) 2024-06-18 2025-12-26 10X Genomics, Inc. Hydrogels 3d pour le séquençage d'acides nucléiques
WO2026055487A1 (fr) 2024-09-06 2026-03-12 10X Genomics, Inc. Nucléotides modifiés avec espaceurs oligomères
WO2026076066A1 (fr) 2024-10-01 2026-04-09 10X Genomics, Inc. Systèmes et procédés d'éclairage d'un échantillon

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US541306A (en) * 1895-06-18 Sectional die
US677183A (en) * 1900-11-30 1901-06-25 Howard W Denham Wheel-repairing device.
US5023243A (en) * 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
US4994373A (en) * 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US5118800A (en) * 1983-12-20 1992-06-02 California Institute Of Technology Oligonucleotides possessing a primary amino group in the terminal nucleotide
US4748111A (en) * 1984-03-12 1988-05-31 Molecular Diagnostics, Inc. Nucleic acid-protein conjugate used in immunoassay
FR2567892B1 (fr) * 1984-07-19 1989-02-17 Centre Nat Rech Scient Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
US5242794A (en) * 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US5185444A (en) * 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5276019A (en) * 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
US5188897A (en) * 1987-10-22 1993-02-23 Temple University Of The Commonwealth System Of Higher Education Encapsulated 2',5'-phosphorothioate oligoadenylates
US4924624A (en) * 1987-10-22 1990-05-15 Temple University-Of The Commonwealth System Of Higher Education 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
CA1340807C (fr) 1988-02-24 1999-11-02 Lawrence T. Malek Procede d'amplification d'une sequence d'acide nucleique
WO1989009221A1 (fr) * 1988-03-25 1989-10-05 University Of Virginia Alumni Patents Foundation N-alkylphosphoramidates oligonucleotides
US5278302A (en) * 1988-05-26 1994-01-11 University Patents, Inc. Polynucleotide phosphorodithioates
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5001050A (en) 1989-03-24 1991-03-19 Consejo Superior Investigaciones Cientificas PHφ29 DNA polymerase
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5591722A (en) * 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
US5516663A (en) * 1990-01-26 1996-05-14 Abbott Laboratories Ligase chain reaction with endonuclease IV correction and contamination control
US5427930A (en) * 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5321131A (en) * 1990-03-08 1994-06-14 Hybridon, Inc. Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
ES2116977T3 (es) * 1990-05-11 1998-08-01 Microprobe Corp Soportes solidos para ensayos de hibridacion de acidos nucleicos y metodos para inmovilizar oligonucleotidos de modo covalente.
AU649066B2 (en) 1990-07-25 1994-05-12 Syngene, Inc. Circular extension for generating multiple nucleic acid complements
US5610289A (en) * 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5602240A (en) * 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5489677A (en) * 1990-07-27 1996-02-06 Isis Pharmaceuticals, Inc. Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
US5623070A (en) * 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
BR9106702A (pt) * 1990-07-27 1993-06-08 Isis Pharmaceuticals Inc Analogo de oligonucleotideos e processos para modular a producao de uma proteina por um organismo e para tratar um organismo
US5608046A (en) * 1990-07-27 1997-03-04 Isis Pharmaceuticals, Inc. Conjugated 4'-desmethyl nucleoside analog compounds
US5618704A (en) * 1990-07-27 1997-04-08 Isis Pharmacueticals, Inc. Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
US5177196A (en) * 1990-08-16 1993-01-05 Microprobe Corporation Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
US5214134A (en) * 1990-09-12 1993-05-25 Sterling Winthrop Inc. Process of linking nucleosides with a siloxane bridge
CA2092002A1 (fr) * 1990-09-20 1992-03-21 Mark Matteucci Liaisons internucleosidiques modifiees
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5599921A (en) * 1991-05-08 1997-02-04 Stratagene Oligonucleotide families useful for producing primers
US5714331A (en) * 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
EP0538194B1 (fr) * 1991-10-17 1997-06-04 Novartis AG Nucléosides et oligonucléosides bicycliques, leur procédé de préparation et leurs intermédiaires
US5594121A (en) * 1991-11-07 1997-01-14 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5484908A (en) * 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
FR2687679B1 (fr) * 1992-02-05 1994-10-28 Centre Nat Rech Scient Oligothionucleotides.
US5633360A (en) * 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
EP0577558A2 (fr) * 1992-07-01 1994-01-05 Ciba-Geigy Ag Nucléosides carbocycliques contenant des noyaux bicycliques, oligonucléotides en dérivant, procédé pour leur préparation, leur application et des intermédiaires
US5710028A (en) * 1992-07-02 1998-01-20 Eyal; Nurit Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
US5733733A (en) * 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5614389A (en) * 1992-08-04 1997-03-25 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
WO1994003624A1 (fr) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Procedes d'amplification isothermique de molecules d'acide nucleique
US6077668A (en) 1993-04-15 2000-06-20 University Of Rochester Highly sensitive multimeric nucleic acid probes
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
US6096880A (en) 1993-04-15 2000-08-01 University Of Rochester Circular DNA vectors for synthesis of RNA and DNA
US5502177A (en) * 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5523204A (en) * 1993-12-10 1996-06-04 Becton Dickinson And Company Detection of nucleic acids in cells by strand displacement amplification
US5519134A (en) * 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
SE9400522D0 (sv) 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
WO1995025180A1 (fr) * 1994-03-16 1995-09-21 Gen-Probe Incorporated Amplification d'acide nucleique par deplacement de la souche isotherme
US5596091A (en) * 1994-03-18 1997-01-21 The Regents Of The University Of California Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
US5625050A (en) * 1994-03-31 1997-04-29 Amgen Inc. Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
US5525711A (en) * 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
US5876924A (en) 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US5942391A (en) 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US5597909A (en) * 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5516134A (en) * 1994-09-20 1996-05-14 Perfect Season, Inc. Seat for a wheeled vehicle
FR2726277B1 (fr) * 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
US5766891A (en) * 1994-12-19 1998-06-16 Sloan-Kettering Institute For Cancer Research Method for molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase
EP1505159B1 (fr) * 1995-03-17 2008-05-28 John Wayne Cancer Institute Dépistage des métastases dans le sein à l'aide d'un titrage par marqueurs multiples
US5629179A (en) * 1995-03-17 1997-05-13 Novagen, Inc. Method and kit for making CDNA library
US5728526A (en) * 1995-06-07 1998-03-17 Oncor, Inc. Method for analyzing a nucleotide sequence
AT402203B (de) * 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
AU714486B2 (en) * 1995-11-21 2000-01-06 Yale University Unimolecular segment amplification and detection
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5877637A (en) * 1996-02-05 1999-03-02 Trofimenkoff; Frederick N. Resistance bridge and its use in conversion systems
GB9609213D0 (en) 1996-05-02 1996-07-03 Tepnel Medical Ltd Amplification of nucleic acids
US5614390A (en) * 1996-06-14 1997-03-25 Becton, Dickinson And Company Species-specific detection of Mycobacterium kansasii
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6017703A (en) * 1997-03-06 2000-01-25 Bard Diagnostic Sciences, Inc. Methods and compositions for screening for or modulating a tumor associated antigen
US6124120A (en) * 1997-10-08 2000-09-26 Yale University Multiple displacement amplification
US6054274A (en) * 1997-11-12 2000-04-25 Hewlett-Packard Company Method of amplifying the signal of target nucleic acid sequence analyte
US6203984B1 (en) * 1998-07-02 2001-03-20 Pacron, Inc. Proportional amplification of mRNA from a linear template in vitro
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
US6235502B1 (en) * 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
US6830884B1 (en) * 1998-12-15 2004-12-14 Molecular Staging Inc. Method of amplification
US6355431B1 (en) * 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6277607B1 (en) * 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits
WO2001040516A2 (fr) * 1999-12-02 2001-06-07 Molecular Staging Inc. Generation d'adn circulaire a un seul brin a partir de segments lineaires de renaturation automatique
US6221603B1 (en) * 2000-02-04 2001-04-24 Molecular Dynamics, Inc. Rolling circle amplification assay for nucleic acid analysis
JP2004516806A (ja) * 2000-04-05 2004-06-10 モレキュラー ステージング，インコーポレイテッド プライマー伸長法を用いた対立遺伝子識別のためのプロセス
US6368801B1 (en) * 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase
US6531283B1 (en) * 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
AU7172201A (en) * 2000-06-30 2002-01-14 Molecular Staging Inc Signal amplification with lollipop probes
US6713257B2 (en) * 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
US6861222B2 (en) * 2000-11-09 2005-03-01 Yale University Nucleic acid detection using structured probes
US6635425B2 (en) * 2001-01-05 2003-10-21 Molecular Staging, Inc. 5′-thio phosphate directed ligation of oligonucleotides and use in detection of single nucleotide polymorphisms
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
WO2002103058A2 (fr) * 2001-06-19 2002-12-27 Molecular Staging, Inc. Procedes d'augmentation de detection de cible moleculaire au moyen d'amplification par cercle deroulant en couches
US20040091857A1 (en) * 2001-07-20 2004-05-13 Nallur Girish N. Gene expression profiling
US6703885B1 (en) * 2002-09-18 2004-03-09 Richtek Technology Corp. Trimmer method and device for circuits

Also Published As

Publication number Publication date
DE60123980T2 (de) 2007-06-21
AU2001268725B2 (en) 2006-08-03
JP4718756B2 (ja) 2011-07-06
WO2002000934A3 (fr) 2003-04-03
JP2004512823A (ja) 2004-04-30
EP1315833A2 (fr) 2003-06-04
ATE343003T1 (de) 2006-11-15
US20030207267A1 (en) 2003-11-06
AU6872501A (en) 2002-01-08
DE60123980D1 (de) 2006-11-30
EP1315833B1 (fr) 2006-10-18
WO2002000934A2 (fr) 2002-01-03
CA2410951A1 (fr) 2002-01-03
US6323009B1 (en) 2001-11-27

Similar Documents

Publication Publication Date Title
IL153097A0 (en) A process for selectively amplifying nucleic acid sequences
WO2002052031A3 (fr) Amplification d&#39;acide nucleique
NO20021223L (no) Fremgangsmater og sammensetninger for lineaer, isoterm amplifisering av polynukleotidsekvenser
AU6846698A (en) Method of nucleic acid amplification
WO2003004614A3 (fr) Identification et utilisation de sequences non codantes conservees
WO1996012040A3 (fr) Compositions et procedes de detection de chlamydia trachomatis
WO2002072773A3 (fr) Methodes et compositions pour amplification de sequences d&#39;arn
WO2001077335A3 (fr) Genome de listeria monocytogenes, polypeptides et utilisations
ZA996367B (en) Process for the preparation of pantothenic acid by amplification of nucleotide sequences which code for ketopantoate reductase.
EP1212449A4 (fr) Amplification de sequences flanquantes a partir d&#39;adn inconnu
WO2001004361A3 (fr) Detection du vih par amplification de l&#39;acide nucleique
BRPI0001536B8 (fr)
IL149791A0 (en) Oligonucleotides and assemblies thereof useful in the detection of the presence or absence of target nucleic acid sequences in a sample
WO2002101042A1 (fr) Procede de stabilisation d&#39;un reactif pour amplifier ou detecter l&#39;acide nucleique et procede de memorisation
FR2878254B1 (fr) Composition pour l&#39;amplification d&#39;acides nucleiques
WO1996015264A3 (fr) Procede d&#39;identification de sequences nucleotidiques a partir de differentes sources biologiques par amplification des sequences
WO2001044510A3 (fr) Amplification d&#39;acides nucleiques et detection d&#39;especes de mycobacteries
WO2004097003A3 (fr) Amplification de sequences d&#39;acide nucleique par plusieurs amorces
WO1990009457A3 (fr) Paires d&#39;amorce d&#39;oligonucleotides pour l&#39;amplification genetique independante de la sequence et leurs procedes d&#39;utilisation
WO2002008460A3 (fr) Procede de detection d&#39;arnm de papillomavirus humain
ATE312204T1 (de) Methoden und zusammensetzungen zur detektion von spezies des mycobacterium avium-komplexes
EP1598431A4 (fr) Procede de detection du chlamydia trachomatis et trousse a cet effet
WO2004085681A3 (fr) Amplification globale lineaire non biaisee d&#39;acide nucleique
GB2362212A (en) Method for the identification and speciation of bacteria of the burkholderia cepacia complex
WO2002036813A3 (fr) Detection d&#39;especes rares de candida