IL154842A0 - 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors - Google Patents

2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors

Info

Publication number: IL154842A0
Authority: IL; Israel
Prior art keywords: hexenoic; amino; alkyl; acid derivatives; nitric oxide
Prior art date: 2000-09-15

Application number

IL15484201A

Other languages

English (en)

Original Assignee

Pharmacia Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-15

Filing date

2001-09-15

Publication date

2003-10-31

2001-09-15 Application filed by Pharmacia Corp filed Critical Pharmacia Corp

2003-10-31 Publication of IL154842A0 publication Critical patent/IL154842A0/xx

Links

AKYAUBWOTZJUBI-UHFFFAOYSA-N hex-2-ynoic acid Chemical class CCCC#CC(O)=O AKYAUBWOTZJUBI-UHFFFAOYSA-N 0.000 title 1
239000000236 nitric oxide synthase inhibitor Substances 0.000 title 1
CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/06—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
- C07C251/08—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton being acyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL15484201A 2000-09-15 2001-09-15 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors IL154842A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23268000P	2000-09-15	2000-09-15
PCT/US2001/028733 WO2002022559A2 (fr)	2000-09-15	2001-09-15	Derives des acides hexenoique et hexynoique 2-amino-2-alkyl-4 inhibiteurs de la synthase de l'oxyde nitrique

Publications (1)

Publication Number	Publication Date
IL154842A0 true IL154842A0 (en)	2003-10-31

Family

ID=22874106

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15484201A IL154842A0 (en)	2000-09-15	2001-09-15	2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors

Country Status (18)

Country	Link
US (3)	US6756406B2 (fr)
EP (1)	EP1317416A2 (fr)
JP (1)	JP2004509097A (fr)
KR (1)	KR20030059141A (fr)
CN (1)	CN1217922C (fr)
AR (1)	AR031129A1 (fr)
AU (1)	AU2001289086A1 (fr)
BR (1)	BR0113890A (fr)
CA (1)	CA2420007A1 (fr)
CZ (1)	CZ2003647A3 (fr)
EA (1)	EA006548B1 (fr)
IL (1)	IL154842A0 (fr)
MX (1)	MXPA03002210A (fr)
NO (1)	NO20031139L (fr)
NZ (1)	NZ524559A (fr)
PL (1)	PL366028A1 (fr)
WO (1)	WO2002022559A2 (fr)
ZA (1)	ZA200301576B (fr)

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US6489125B1 (en) *	2000-05-10	2002-12-03	The Trustees Of Columbia University In The City Of New York	Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US7393652B2 (en)	2000-05-10	2008-07-01	The Trustees Of Columbia University In The City Of New York	Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20060293266A1 (en) *	2000-05-10	2006-12-28	The Trustees Of Columbia	Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US7879840B2 (en)	2005-08-25	2011-02-01	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the RyR receptors
US8022058B2 (en)	2000-05-10	2011-09-20	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the RyR receptors
US20040229781A1 (en) *	2000-05-10	2004-11-18	Marks Andrew Robert	Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US7718644B2 (en)	2004-01-22	2010-05-18	The Trustees Of Columbia University In The City Of New York	Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US20040048780A1 (en) *	2000-05-10	2004-03-11	The Trustees Of Columbia University In The City Of New York	Method for treating and preventing cardiac arrhythmia
AR031129A1 (es) *	2000-09-15	2003-09-10	Pharmacia Corp	Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
EP1505972A2 (fr) *	2002-05-16	2005-02-16	Pharmacia Corporation	Methodes de traitement de maladies et de troubles respiratoires avec un inhibiteur inos selectif et un inhibiteur pde et compositions a cet effet
CA2494284A1 (fr) *	2002-08-02	2004-02-12	Pharmacia Corporation	Procedes destines au traitement et a la prevention de troubles gastro-intestinaux
US7544678B2 (en)	2002-11-05	2009-06-09	The Trustees Of Columbia University In The City Of New York	Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
EP1603450A4 (fr)	2003-03-07	2009-07-29	Univ Columbia	Procedes utilisant le recepteur de la ryanodine de type 1
US8710045B2 (en)	2004-01-22	2014-04-29	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7776916B2 (en)	2004-04-28	2010-08-17	The Uab Research Foundation	Nitrated lipids and methods of making and using thereof
SG155257A1 (en) *	2004-09-24	2009-09-30	Beth Israel Hospital	Methods of diagnosing and treating complications of pregnancy
US7740849B2 (en) *	2004-09-24	2010-06-22	Beth Israel Deaconess Medical Center	Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders
US7704990B2 (en)	2005-08-25	2010-04-27	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the RyR receptors
US20090286271A1 (en) *	2006-05-31	2009-11-19	Karumanchi Ananth S	Methods of Diagnosing and Treating Complications of Pregnancy
EP2679224A1 (fr)	2007-08-01	2014-01-01	University of Pittsburgh of the Commonwealth System of Higher Education	Modulation d'acide nitro-oléique du diabète de type II
CN102083787A (zh) *	2008-05-01	2011-06-01	康普雷克萨公司	乙烯基取代的脂肪酸
US20140024713A1 (en)	2008-06-19	2014-01-23	University Of Utah Research Foundation	Use of nitrated lipids for treatment of side effects of toxic medical therapies
WO2009155439A2 (fr)	2008-06-19	2009-12-23	University Of Utah Research Foundation	Utilisation de lipides nitrés pour le traitement d'effets secondaires de thérapies médicales toxiques
US8779192B2 (en)	2009-05-14	2014-07-15	Kolon Life Science, Inc.	Process of preparing an alkylamine derivative
EP2459189A4 (fr)	2009-07-31	2013-01-16	Univ Pittsburgh	Acides gras comme agents anti-inflammatoires
WO2011041639A2 (fr)	2009-10-02	2011-04-07	Miller Raymond A	Hétéroatome contenant des acides gras substitués
EP2744491B1 (fr)	2011-08-19	2020-07-29	The University of Utah Research Foundation	Polythérapie avec des lipides nitrés et des inhibiteurs du système rénine-angiotensine-aldostérone
HRP20240082T1 (hr)	2015-07-07	2024-03-29	H. Lundbeck A/S	Inhibitor pde9 s okosnicom imidazopirazinona za liječenje perifernih bolesti
GB201512635D0 (en)	2015-07-17	2015-08-26	Ucl Business Plc	Uses of therapeutic compounds
IL258476B2 (en)	2015-10-02	2023-04-01	Complexa Inc	Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids
EP3398941A1 (fr) *	2017-05-03	2018-11-07	AXXAM S.p.A.	Antagonistes de p2x7 hétérocycliques
FI3801526T3 (fi)	2018-05-25	2024-03-20	Cardurion Pharmaceuticals Inc	6-[(3s,4s)-4-metyyli-1-(pyrimidin-2-yylimetyyli)pyrrolidin-3-yyli]-3-tetrahydropyran-4-yyli-7h-imidatso[1,5-a]pyratsin-8-onin monohydraattimuotoja ja kiteisiä muotoja
EP3843737A4 (fr)	2018-08-31	2022-06-01	Imara Inc.	Inhibiteurs de pde9 pour le traitement de la drépanocytose

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Publication number	Priority date	Publication date	Assignee	Title
US5132453A (en)	1991-03-22	1992-07-21	Cornell Research Foundation, Inc.	N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
JP2648897B2 (ja)	1991-07-01	1997-09-03	塩野義製薬株式会社	ピリミジン誘導体
GB9127376D0 (en)	1991-12-24	1992-02-19	Wellcome Found	Amidino derivatives
GB9203347D0 (en)	1992-02-17	1992-04-01	Wellcome Found	Hypolipidaemic compounds
PT751930E (pt) *	1994-03-24	2000-04-28	Searle & Co	Derivados amidino uteis como inibidores da sintetase de oxido nitrico
US5994391A (en)	1994-09-13	1999-11-30	G.D. Searle And Company	Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
GB9516709D0 (en)	1995-08-15	1995-10-18	Zeneca Ltd	Medicament
WO2000024719A1 (fr)	1998-10-27	2000-05-04	Abbott Laboratories	Inhibiteurs de la biosynthese de la prostaglandine endoperoxyde h synthase
WO1999046240A2 (fr) *	1998-03-11	1999-09-16	G.D. Searle & Co.	Derives d'acide amine amidino halogenes, utiles en tant qu'inhibiteurs du monoxyde d'azote synthetase
AR031129A1 (es) *	2000-09-15	2003-09-10	Pharmacia Corp	Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa

2001
- 2001-09-14 AR ARP010104367A patent/AR031129A1/es unknown
- 2001-09-15 KR KR10-2003-7003788A patent/KR20030059141A/ko not_active Withdrawn
- 2001-09-15 US US09/952,906 patent/US6756406B2/en not_active Expired - Fee Related
- 2001-09-15 CN CN018187587A patent/CN1217922C/zh not_active Expired - Fee Related
- 2001-09-15 NZ NZ524559A patent/NZ524559A/xx unknown
- 2001-09-15 EP EP01968875A patent/EP1317416A2/fr not_active Withdrawn
- 2001-09-15 JP JP2002526760A patent/JP2004509097A/ja not_active Withdrawn
- 2001-09-15 CZ CZ2003647A patent/CZ2003647A3/cs unknown
- 2001-09-15 BR BR0113890-1A patent/BR0113890A/pt not_active IP Right Cessation
- 2001-09-15 MX MXPA03002210A patent/MXPA03002210A/es active IP Right Grant
- 2001-09-15 WO PCT/US2001/028733 patent/WO2002022559A2/fr not_active Ceased
- 2001-09-15 IL IL15484201A patent/IL154842A0/xx unknown
- 2001-09-15 CA CA002420007A patent/CA2420007A1/fr not_active Abandoned
- 2001-09-15 AU AU2001289086A patent/AU2001289086A1/en not_active Abandoned
- 2001-09-15 EA EA200300375A patent/EA006548B1/ru not_active IP Right Cessation
- 2001-09-15 PL PL01366028A patent/PL366028A1/xx not_active Application Discontinuation
2003
- 2003-02-26 ZA ZA200301576A patent/ZA200301576B/en unknown
- 2003-03-12 NO NO20031139A patent/NO20031139L/no unknown
2004
- 2004-04-07 US US10/819,853 patent/US7005450B2/en not_active Expired - Fee Related
2005
- 2005-07-21 US US11/186,256 patent/US20050256199A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO20031139D0 (no)	2003-03-12
US20020128510A1 (en)	2002-09-12
CN1474804A (zh)	2004-02-11
NZ524559A (en)	2004-12-24
EP1317416A2 (fr)	2003-06-11
WO2002022559A2 (fr)	2002-03-21
NO20031139L (no)	2003-05-09
EA006548B1 (ru)	2006-02-24
CZ2003647A3 (cs)	2003-10-15
US20050256199A1 (en)	2005-11-17
PL366028A1 (en)	2005-01-24
US6756406B2 (en)	2004-06-29
WO2002022559A3 (fr)	2003-01-23
MXPA03002210A (es)	2003-06-24
US7005450B2 (en)	2006-02-28
US20040192779A1 (en)	2004-09-30
KR20030059141A (ko)	2003-07-07
CN1217922C (zh)	2005-09-07
AR031129A1 (es)	2003-09-10
BR0113890A (pt)	2003-07-22
AU2001289086A1 (en)	2002-03-26
EA200300375A1 (ru)	2003-10-30
ZA200301576B (en)	2004-03-08
JP2004509097A (ja)	2004-03-25
CA2420007A1 (fr)	2002-03-21

Publication	Publication Date	Title
IL154842A0 (en)	2003-10-31	2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors
IL154841A0 (en)	2003-10-31	2-amino-2-alkyl-5- heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
GB0031179D0 (en)	2001-01-31	Nitric oxide synthase inhibitors
AU4941501A (en)	2001-10-08	Amidino compound and salts thereof useful as nitric oxide synthase inhibitors
EP1282413A4 (fr)	2004-12-01	Derives d'acide heptenoique 6, 2-amino-5 halogenes utilises comme inhibiteurs de synthase du monoxyde d'azote
MXPA03000772A (es)	2003-06-04	Derivados de acido hexahidro-7-1h-azepin-2-il-hexanoico como inhibidores de oxido nitrico sintasa inducible.
PL362917A1 (en)	2004-11-02	New mandelic acid derivatives and their use as throbin inhibitors
AP2000001998A0 (en)	2000-12-31	Nitric oxide synthase inhibitors
IS5053A (is)	1999-05-18	6-Fenýlpýridýl-2-amín afleiður nytsamlegar sem nituroxíð sýntasa tálmar
EP1272455A4 (fr)	2005-07-27	Derives halogenes de l'acide 2-amino-4, 5 heptenoique, utiles en tant qu'inhibiteur de l'oxyde nitrique synthase
SI1062201T1 (en)	2005-10-31	Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors
MXPA03002271A (es)	2003-06-06	Derivados de acido 2-amino-2-alquil-3-hexenoico y 2-amino-2-alquil-3-hexinoico utiles como inhibidores de oxido nitrico sintasa.
AU1308400A (en)	2000-05-22	Novel amino acid heterocyclic amide derivatives useful as nitric oxide synthase inhibitors
EP1282420A4 (fr)	2004-12-29	Derives d'acide 2-amino-3, 4 heptenoique halogene utiles en tant qu'inhibiteurs de l'oxyde nitrique synthase
AU2001282746A1 (en)	2002-02-18	Novel phenylheteroazetidines, useful as nitric oxide synthase inhibitors
IL132678A0 (en)	2001-03-19	Amidine derivatives as inhibitors of nitric oxide synthase
GB9810299D0 (en)	1998-07-15	Use of nitric oxide synthase inhibitors
AU2002355706A8 (en)	2008-01-03	Arylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase
MXPA03002211A (es)	2003-06-24	Derivados de acido 2-amino-2-alquil-4-heptenoico y heptinoico utiles como inhibidores de la oxido nitrico sintasa.
MXPA03002272A (es)	2003-06-06	Derivados de acido 2-amino-2-alquil-3-heptenoico y 2-amino-2-alquil-3-heptenoico utiles como inhibidores de oxido nitrico sintasa.
AU6216900A (en)	2001-02-05	Oligomeric amino acid derivatives useful as nitric oxide synthase inhibitors
AU2002320003A1 (en)	2003-02-17	Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase
AU2002355707A1 (en)	2003-02-17	Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase
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