IL156151A0 - Phenanthrene derivatives and pharmaceutical compositions containing the same - Google Patents

Phenanthrene derivatives and pharmaceutical compositions containing the same

Info

Publication number: IL156151A0
Authority: IL; Israel
Prior art keywords: estrogen; compounds; disease; same; pharmaceutical compositions
Prior art date: 2001-01-04

Application number

IL15615101A

Other languages

English (en)

Original Assignee

Karobio Ab

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-04

Filing date

2001-12-24

Publication date

2003-12-23

2001-01-04 Priority claimed from GB0100163A external-priority patent/GB0100163D0/en

2001-01-04 Priority claimed from GB0100164A external-priority patent/GB0100164D0/en

2001-03-15 Priority claimed from GB0106434A external-priority patent/GB0106434D0/en

2001-12-24 Application filed by Karobio Ab, Merck & Co Inc filed Critical Karobio Ab

2003-12-23 Publication of IL156151A0 publication Critical patent/IL156151A0/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000001792 phenanthrenyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
208000010392 Bone Fractures Diseases 0.000 abstract 1
206010065687 Bone loss Diseases 0.000 abstract 1
208000026310 Breast neoplasm Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
201000009273 Endometriosis Diseases 0.000 abstract 1
208000033830 Hot Flashes Diseases 0.000 abstract 1
206010060800 Hot flush Diseases 0.000 abstract 1
206010021639 Incontinence Diseases 0.000 abstract 1
238000008214 LDL Cholesterol Methods 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
208000002495 Uterine Neoplasms Diseases 0.000 abstract 1
206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
210000000481 breast Anatomy 0.000 abstract 1
210000000845 cartilage Anatomy 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
230000001149 cognitive effect Effects 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
230000006735 deficit Effects 0.000 abstract 1
230000007850 degeneration Effects 0.000 abstract 1
230000003412 degenerative effect Effects 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
229940011871 estrogen Drugs 0.000 abstract 1
239000000262 estrogen Substances 0.000 abstract 1
239000002834 estrogen receptor modulator Substances 0.000 abstract 1
102000015694 estrogen receptors Human genes 0.000 abstract 1
108010038795 estrogen receptors Proteins 0.000 abstract 1
201000000079 gynecomastia Diseases 0.000 abstract 1
201000010260 leiomyoma Diseases 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
208000020816 lung neoplasm Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
206010046766 uterine cancer Diseases 0.000 abstract 1
208000010579 uterine corpus leiomyoma Diseases 0.000 abstract 1
201000007954 uterine fibroid Diseases 0.000 abstract 1
210000004291 uterus Anatomy 0.000 abstract 1
210000004509 vascular smooth muscle cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/17—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/42—Halogenated derivatives containing six-membered aromatic rings and other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/93—Spiro compounds
- C07C2603/95—Spiro compounds containing "not free" spiro atoms
- C07C2603/96—Spiro compounds containing "not free" spiro atoms containing at least one ring with less than six members

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Neurology (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pregnancy & Childbirth (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Nutrition Science (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL15615101A 2001-01-04 2001-12-24 Phenanthrene derivatives and pharmaceutical compositions containing the same IL156151A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB0100163A GB0100163D0 (en)	2001-01-04	2001-01-04	Novel estrogen receptor ligands and methods
GB0100164A GB0100164D0 (en)	2001-01-04	2001-01-04	Novel estrogen receptor ligands and methods II
GB0106434A GB0106434D0 (en)	2001-03-15	2001-03-15	Novel estrogwen receptor ligands and methods II
PCT/EP2001/015230 WO2002053522A2 (en)	2001-01-04	2001-12-24	Novel estrogen receptor ligands and methods i

Publications (1)

Publication Number	Publication Date
IL156151A0 true IL156151A0 (en)	2003-12-23

Family

ID=27256041

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15615101A IL156151A0 (en)	2001-01-04	2001-12-24	Phenanthrene derivatives and pharmaceutical compositions containing the same

Country Status (11)

Country	Link
US (1)	US20040127576A1 (de)
EP (1)	EP1399406B1 (de)
JP (2)	JP2004523508A (de)
KR (1)	KR20030076600A (de)
AT (1)	ATE301629T1 (de)
AU (2)	AU2002219219B2 (de)
CA (1)	CA2433828A1 (de)
DE (1)	DE60112624T2 (de)
ES (1)	ES2247010T3 (de)
IL (1)	IL156151A0 (de)
WO (1)	WO2002053522A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7524866B2 (en)	2001-11-29	2009-04-28	Gtx, Inc.	Prevention and treatment of androgen—deprivation induced osteoporosis
CA2512000C (en) *	2002-12-26	2011-08-09	Eisai Co., Ltd.	Selective estrogen receptor modulator
CA2574400A1 (en)	2004-07-19	2006-02-09	Janssen Pharmaceutica N.V.	Spiro-benzo[c]chromene derivatives useful as modulators of the estrogen receptors
WO2006042172A2 (en) *	2004-10-09	2006-04-20	The Regents Of The University Of Michigan	Gender differences in experimental aortic aneurysm formation
CN113133983B (zh) *	2020-01-20	2023-12-12	鲁南制药集团股份有限公司	一种治疗前列腺癌的药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5116865A (en) *	1990-09-05	1992-05-26	Peters Richard H	15,16-seco-19-nor progestins
CA2111138A1 (en) *	1993-01-15	1994-07-16	Thierry Godel	Octahydrophenanthrene derivatives
AU7467398A (en) *	1997-04-25	1998-11-24	Eli Lilly And Company	Indene compounds having activity as serms
AU4701299A (en) *	1998-06-23	2000-01-10	Stuart R. Adler	Therapeutic applications of estrogenic carboxylic acids
JP4331913B2 (ja) *	2000-02-14	2009-09-16	メルクエンドカムパニーインコーポレーテッド	エストロゲンレセプターモデュレーター

2001
- 2001-12-24 DE DE60112624T patent/DE60112624T2/de not_active Expired - Lifetime
- 2001-12-24 AT AT01272663T patent/ATE301629T1/de not_active IP Right Cessation
- 2001-12-24 IL IL15615101A patent/IL156151A0/xx unknown
- 2001-12-24 EP EP01272663A patent/EP1399406B1/de not_active Expired - Lifetime
- 2001-12-24 KR KR10-2003-7008991A patent/KR20030076600A/ko not_active Ceased
- 2001-12-24 AU AU2002219219A patent/AU2002219219B2/en not_active Ceased
- 2001-12-24 JP JP2002554641A patent/JP2004523508A/ja active Pending
- 2001-12-24 WO PCT/EP2001/015230 patent/WO2002053522A2/en not_active Ceased
- 2001-12-24 CA CA002433828A patent/CA2433828A1/en not_active Abandoned
- 2001-12-24 US US10/250,521 patent/US20040127576A1/en not_active Abandoned
- 2001-12-24 ES ES01272663T patent/ES2247010T3/es not_active Expired - Lifetime
2007
- 2007-03-28 AU AU2007201347A patent/AU2007201347A1/en not_active Abandoned
2008
- 2008-09-11 JP JP2008233904A patent/JP2009067794A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
AU2002219219B2 (en)	2006-12-21
WO2002053522A2 (en)	2002-07-11
WO2002053522A3 (en)	2004-01-08
ATE301629T1 (de)	2005-08-15
EP1399406B1 (de)	2005-08-10
AU2007201347A1 (en)	2007-04-19
ES2247010T3 (es)	2006-03-01
EP1399406A2 (de)	2004-03-24
US20040127576A1 (en)	2004-07-01
KR20030076600A (ko)	2003-09-26
DE60112624T2 (de)	2006-06-08
JP2004523508A (ja)	2004-08-05
DE60112624D1 (de)	2005-09-15
JP2009067794A (ja)	2009-04-02
CA2433828A1 (en)	2002-07-11

Publication	Publication Date	Title
SI1501819T1 (sl)	2011-01-31	Modulatorji estrogen receptorjev
ATE524170T1 (de)	2011-09-15	Östrogenrezeptor modulatoren
WO2002091993A3 (en)	2003-03-20	Estrogen receptor modulators
AU2696502A (en)	2002-06-03	Estrogen receptor modulators
WO2004073612A3 (en)	2004-10-28	Estrogen receptor modulators
NO20072771L (no)	2007-07-18	Ostrogenreseptormodulatorer
MX2007006878A (es)	2007-06-22	Moduladores del receptor de estrogeno.
WO2002032377A3 (en)	2002-08-22	Estrogen receptor modulators
WO2004091488A3 (en)	2005-04-07	Estrogen receptor modulators
AU2003288644A1 (en)	2004-10-25	Mercapto-phenyl-naphthyl-methane derivatives and preparation thereof
HK1048761A1 (zh)	2003-04-17	结合雌激素的选择性雌激素受体调节剂
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WO2002032373A3 (en)	2002-07-04	Estrogen receptor modulators
ATE301629T1 (de)	2005-08-15	Estrogenrezeptorliganden und verfahren
WO2004073610A3 (en)	2004-11-25	Estrogen receptor modulators
WO2006081152A3 (en)	2007-02-08	Estrogen receptor modulators
WO2005097141A3 (en)	2006-03-23	Estrogen receptor modulators
ATE276995T1 (de)	2004-10-15	Halogenierte triphenylethylene derivate als selektive östrogenrezeptormodulatoren
WO2002058639A3 (en)	2002-10-24	Pyranoflavonoid compounds and their use as estrogen receptor modulators
WO2007089291A3 (en)	2007-11-15	Estrogen receptor modulators
AR039282A1 (es)	2005-02-16	Moduladores de receptores de estrogeno
WO2004026887A3 (en)	2005-02-24	Estrogen receptor modulators
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