IL157171A0 - Broadspectrum 2-(substituted-amino) -benzothiazole sulfonamide hiv protease inhibitors - Google Patents

Broadspectrum 2-(substituted-amino) -benzothiazole sulfonamide hiv protease inhibitors

Info

Publication number
IL157171A0
IL157171A0 IL15717102A IL15717102A IL157171A0 IL 157171 A0 IL157171 A0 IL 157171A0 IL 15717102 A IL15717102 A IL 15717102A IL 15717102 A IL15717102 A IL 15717102A IL 157171 A0 IL157171 A0 IL 157171A0
Authority
IL
Israel
Prior art keywords
broadspectrum
amino
substituted
protease inhibitors
hiv protease
Prior art date
Application number
IL15717102A
Other languages
English (en)
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of IL157171A0 publication Critical patent/IL157171A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL15717102A 2001-02-14 2002-02-14 Broadspectrum 2-(substituted-amino) -benzothiazole sulfonamide hiv protease inhibitors IL157171A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01200529 2001-02-14
US28775801P 2001-05-02 2001-05-02
PCT/EP2002/001788 WO2002083657A2 (en) 2001-02-14 2002-02-14 Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors

Publications (1)

Publication Number Publication Date
IL157171A0 true IL157171A0 (en) 2004-02-08

Family

ID=26076833

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15717102A IL157171A0 (en) 2001-02-14 2002-02-14 Broadspectrum 2-(substituted-amino) -benzothiazole sulfonamide hiv protease inhibitors
IL157171A IL157171A (en) 2001-02-14 2003-07-30 Benzothiazole Sulfanamide 2 (Amino-Transformed), Methods of Preparation, Preparations Containing Them and Their Use in Preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL157171A IL157171A (en) 2001-02-14 2003-07-30 Benzothiazole Sulfanamide 2 (Amino-Transformed), Methods of Preparation, Preparations Containing Them and Their Use in Preparation

Country Status (30)

Country Link
US (1) US7659404B2 (de)
EP (1) EP1370543B1 (de)
JP (1) JP4530612B2 (de)
KR (1) KR100870184B1 (de)
CN (2) CN100369904C (de)
AP (1) AP1504A (de)
AT (1) ATE343567T1 (de)
AU (1) AU2002302363B2 (de)
BG (1) BG66301B1 (de)
BR (1) BR0207862A (de)
CA (1) CA2438304C (de)
CY (1) CY1108073T1 (de)
CZ (1) CZ304273B6 (de)
DE (1) DE60215623T2 (de)
DK (1) DK1370543T3 (de)
EA (1) EA006096B1 (de)
EE (1) EE05385B1 (de)
ES (1) ES2275866T3 (de)
HR (1) HRP20030735B1 (de)
HU (1) HU229224B1 (de)
IL (2) IL157171A0 (de)
MX (1) MXPA03007236A (de)
NO (1) NO326174B1 (de)
NZ (1) NZ527391A (de)
PL (1) PL213327B1 (de)
PT (1) PT1370543E (de)
SI (1) SI1370543T1 (de)
SK (1) SK287582B6 (de)
WO (1) WO2002083657A2 (de)
ZA (1) ZA200306086B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000073511A1 (en) 1999-05-28 2000-12-07 Virco Nv New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance
RU2318213C2 (ru) 2000-10-20 2008-02-27 Вирко Бвба Новые мутационные профили обратной транскриптазы вич-1, коррелирующие с фенотипической резистентностью к лекарственным средствам
BR0207862A (pt) 2001-02-14 2004-06-22 Tibotec Pharm Ltd Inibidores de protease de hiv 2-(amino-substituìda)-benzotiazol-sulfonamida de amplo espectro
US20040009890A1 (en) 2002-01-07 2004-01-15 Erickson John W. Broad spectrum inhibitors
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
US7217506B2 (en) 2002-07-01 2007-05-15 Tibotec Pharmaceuticals, Ltd. Mutational profiles in HIV-1 protease correlated with phenotypic protease inhibitor resistance
DE60321466D1 (de) 2002-07-01 2008-07-17 Tibotec Pharm Ltd Mit phänotypischer medikamentenresistenz korrelierte mutationsprofile in hiv-1-reverse-transkriptase
EP1545518A1 (de) * 2002-08-02 2005-06-29 Tibotec Pharmaceuticals Ltd. Breitband-2-amino-benzothiazol-sulfonamid-hiv protease-inhibitoren
KR101327772B1 (ko) * 2002-08-02 2013-11-11 얀센 알 앤드 디 아일랜드 광범위 2-아미노-벤조티아졸 설폰아미드 ｈｉｖ 프로테아제 저해제
PL1670773T3 (pl) * 2003-09-30 2007-06-29 Tibotec Pharm Ltd Sposób wytwarzania sulfonamidów benzoksazolu i ich związków pośrednich
DE10360835A1 (de) * 2003-12-23 2005-07-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bicyclische Imidazolverbindungen, deren Herstellung und deren Verwendung als Arzneimittel
MXPA06012909A (es) * 2004-05-07 2007-09-06 Sequoia Pharmaceuticals Inc Inhibidores de proteasa retroviral repelente de resistencia.
AU2006217922B2 (en) 2005-02-25 2012-04-05 Janssen Sciences Ireland Uc Protease inhibitor precursor synthesis
AR053845A1 (es) 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
JO2841B1 (en) * 2006-06-23 2014-09-15 تيبوتيك فارماسيوتيكالز ليمتد 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
JO3090B1 (ar) * 2009-12-11 2017-03-15 Janssen Sciences Ireland Uc 5- امينو-4- هيدروكسي-بنتويل اميدات
US9024038B2 (en) * 2010-12-27 2015-05-05 Purdue Research Foundation Compunds and methods for treating HIV
US9096586B2 (en) 2012-04-20 2015-08-04 Gilead Sciences, Inc. Therapeutic compounds
CN104000824B (zh) * 2014-05-28 2016-07-06 中山大学 苯并五元杂环类化合物在制备抗hiv-1病毒药物中的应用
US11439608B2 (en) 2017-09-25 2022-09-13 Qun Lu Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease
CN116354903B (zh) * 2021-12-28 2025-09-09 南京药石科技股份有限公司 一种6-苯并噻唑磺酰氯的制备方法
WO2024206093A1 (en) * 2023-03-24 2024-10-03 Purdue Research Foundation Hiv-1p rotease inhibitors and uses thereof

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EP0445926B1 (de) 1990-03-09 1996-08-21 Milliken Research Corporation Organische Materialien, die sulfonamidogebundene Poly(oxyalkylen)gruppen tragen und ihre Herstellung
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
JP3657002B2 (ja) 1992-08-25 2005-06-08 ジー．ディー．サール アンド カンパニー レトロウイルスプロテアーゼ阻害剤として有用なα−およびβ−アミノ酸ヒドロキシエチルアミノスルホンアミド
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
AU7669794A (en) * 1993-08-24 1995-03-21 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
SK283569B6 (sk) 1993-10-01 2003-09-11 Astra Aktiebolag Spôsob spracovania jemne deleného práškového liečiva, zariadenie na vykonávanie tohto spôsobu a aglomeráty vyrobené týmto spôsobom
WO1996022287A1 (en) 1995-01-20 1996-07-25 G.D. Searle & Co. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5756533A (en) * 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6140505A (en) * 1995-03-10 2000-10-31 G. D. Searle & Co. Synthesis of benzo fused heterocyclic sulfonyl chlorides
AU717598B2 (en) * 1995-03-10 2000-03-30 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) * 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6143788A (en) * 1995-03-10 2000-11-07 G.D. Searle & Co. Bis-amino acid hydroxyethlamino sulfonamide retroviral protease inhibitors
JP2000515488A (ja) * 1995-11-15 2000-11-21 ジー．ディー．サール アンド カンパニー 置換スルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド レトロウイルスプロテアーゼ阻害剤
DK0904060T3 (da) 1996-05-20 2004-04-13 Janssen Pharmaceutica Nv Antifungale præparater med forbedret biotilgængelighed
WO1998042318A1 (en) 1997-03-26 1998-10-01 Janssen Pharmaceutica N.V. Pellets having a core coated with an antifungal and a polymer
BR9814484A (pt) 1997-12-24 2000-10-10 Vertex Pharma "pró-drogas de inibidores de aspartil protease"
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
WO1999033795A1 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
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NZ508855A (en) 1998-06-19 2003-10-31 Vertex Pharma Sulfonamide inhibitors of HIV aspartyl protease
JP4776775B2 (ja) 1998-06-23 2011-09-21 アメリカ合衆国 Ｈｉｖ感染哺乳動物を治療するための医薬組成物
WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
BR0207862A (pt) 2001-02-14 2004-06-22 Tibotec Pharm Ltd Inibidores de protease de hiv 2-(amino-substituìda)-benzotiazol-sulfonamida de amplo espectro

Also Published As

Publication number Publication date
JP4530612B2 (ja) 2010-08-25
PT1370543E (pt) 2007-02-28
HRP20030735A2 (en) 2005-08-31
CZ304273B6 (cs) 2014-02-12
ES2275866T3 (es) 2007-06-16
BG108143A (en) 2004-07-30
EA200300891A1 (ru) 2004-02-26
CA2438304C (en) 2011-04-12
CN101230067B (zh) 2011-06-15
SK11022003A3 (sk) 2004-07-07
NZ527391A (en) 2005-04-29
PL213327B1 (pl) 2013-02-28
NO20033584D0 (no) 2003-08-13
HK1061233A1 (en) 2004-09-10
ZA200306086B (en) 2005-01-26
EE05385B1 (et) 2011-02-15
HUP0303257A2 (hu) 2004-01-28
HRP20030735B1 (en) 2012-02-29
DK1370543T3 (da) 2007-02-19
AU2002302363B2 (en) 2008-05-01
PL363778A1 (en) 2004-11-29
NO326174B1 (no) 2008-10-13
KR20030077017A (ko) 2003-09-29
KR100870184B1 (ko) 2008-11-24
SI1370543T1 (sl) 2007-04-30
WO2002083657A2 (en) 2002-10-24
BG66301B1 (bg) 2013-03-29
NO20033584L (no) 2003-10-14
SK287582B6 (sk) 2011-03-04
CN101230067A (zh) 2008-07-30
CZ20032415A3 (cs) 2004-04-14
CA2438304A1 (en) 2002-10-24
CN100369904C (zh) 2008-02-20
EP1370543A2 (de) 2003-12-17
DE60215623D1 (de) 2006-12-07
HU229224B1 (en) 2013-09-30
AP2003002856A0 (en) 2003-09-30
MXPA03007236A (es) 2003-12-04
CN1525962A (zh) 2004-09-01
ATE343567T1 (de) 2006-11-15
US20040116485A1 (en) 2004-06-17
WO2002083657A3 (en) 2003-02-13
BR0207862A (pt) 2004-06-22
EE200300381A (et) 2003-12-15
US7659404B2 (en) 2010-02-09
CY1108073T1 (el) 2014-02-12
DE60215623T2 (de) 2007-08-30
JP2004518767A (ja) 2004-06-24
IL157171A (en) 2012-10-31
EA006096B1 (ru) 2005-08-25
AP1504A (en) 2005-12-10
EP1370543B1 (de) 2006-10-25

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