IL157649A0 - Adenosine derivatives having an acetylene group in the 4' position, pharmaceutical compositions containing them and use thereof in decreasing plasma free fatty acid concentration - Google Patents

Adenosine derivatives having an acetylene group in the 4' position, pharmaceutical compositions containing them and use thereof in decreasing plasma free fatty acid concentration

Info

Publication number: IL157649A0
Authority: IL; Israel
Prior art keywords: fatty acid; pharmaceutical compositions; compositions containing; acid concentration; free fatty
Prior art date: 2001-03-20

Application number

IL15764902A

Other languages

English (en)

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-20

Filing date

2002-03-19

Publication date

2004-05-12

2001-03-20 Priority claimed from GB0106877A external-priority patent/GB0106877D0/en

2001-03-20 Priority claimed from GB0106875A external-priority patent/GB0106875D0/en

2001-03-20 Priority claimed from GB0106871A external-priority patent/GB0106871D0/en

2002-03-19 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2004-05-12 Publication of IL157649A0 publication Critical patent/IL157649A0/xx

Links

150000003835 adenosine derivatives Chemical class 0.000 title 1
230000003247 decreasing effect Effects 0.000 title 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 title 1
235000021588 free fatty acids Nutrition 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL15764902A 2001-03-20 2002-03-19 Adenosine derivatives having an acetylene group in the 4' position, pharmaceutical compositions containing them and use thereof in decreasing plasma free fatty acid concentration IL157649A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB0106877A GB0106877D0 (en)	2001-03-20	2001-03-20	Chemical compounds
GB0106875A GB0106875D0 (en)	2001-03-20	2001-03-20	Medicaments
GB0106871A GB0106871D0 (en)	2001-03-20	2001-03-20	Chemical compounds
PCT/GB2002/001317 WO2002074780A1 (en)	2001-03-20	2002-03-19	Chemical compounds

Publications (1)

Publication Number	Publication Date
IL157649A0 true IL157649A0 (en)	2004-05-12

Family

ID=27256108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15764902A IL157649A0 (en)	2001-03-20	2002-03-19	Adenosine derivatives having an acetylene group in the 4' position, pharmaceutical compositions containing them and use thereof in decreasing plasma free fatty acid concentration

Country Status (18)

Country	Link
US (1)	US20040162422A1 (cs)
EP (1)	EP1370568B1 (cs)
JP (1)	JP2004534002A (cs)
KR (1)	KR20030085014A (cs)
CN (1)	CN1501941A (cs)
AR (1)	AR037135A1 (cs)
AT (1)	ATE306492T1 (cs)
BR (1)	BR0208169A (cs)
CA (1)	CA2441202A1 (cs)
CZ (1)	CZ20032543A3 (cs)
DE (1)	DE60206605D1 (cs)
HU (1)	HUP0303533A3 (cs)
IL (1)	IL157649A0 (cs)
MX (1)	MXPA03008493A (cs)
NO (1)	NO20034182D0 (cs)
NZ (1)	NZ527854A (cs)
PL (1)	PL364712A1 (cs)
WO (1)	WO2002074780A1 (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003263846B2 (en) *	2002-08-15	2009-12-17	Gilead Palo Alto, Inc.	Partial and full agonists of A1 adenosine receptors
GB0221694D0 (en) *	2002-09-18	2002-10-30	Glaxo Group Ltd	Compounds
GT200500281A (es) *	2004-10-22	2006-04-24	Novartis Ag	Compuestos organicos.
GB0500785D0 (en)	2005-01-14	2005-02-23	Novartis Ag	Organic compounds
GB0607950D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607948D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607944D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
HRP20120494T1 (hr)	2006-04-21	2012-08-31	Novartis Ag	Derivati purina za uporabu kao agonista adenozin a2a receptora
GB0607953D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607945D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
EP1889846A1 (en)	2006-07-13	2008-02-20	Novartis AG	Purine derivatives as A2a agonists
EP1903044A1 (en) *	2006-09-14	2008-03-26	Novartis AG	Adenosine Derivatives as A2A Receptor Agonists
JP2010508835A (ja) *	2006-11-10	2010-03-25	ノバルティスアーゲー	シクロペンテンジオールモノアセテート誘導体
KR20100068286A (ko) *	2007-10-17	2010-06-22	노파르티스 아게	아데노신 ａ1 수용체 리간드로서의 퓨린 유도체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4996308A (en) *	1988-03-25	1991-02-26	Merrell Dow Pharmaceuticals Inc.	Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
GB9723589D0 (en) *	1997-11-08	1998-01-07	Glaxo Group Ltd	Chemical compounds
YU44900A (sh) *	1998-01-31	2003-01-31	Glaxo Group Limited	Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
GB9813554D0 (en) *	1998-06-23	1998-08-19	Glaxo Group Ltd	Chemical compounds

2002
- 2002-03-12 US US10/471,681 patent/US20040162422A1/en not_active Abandoned
- 2002-03-19 AR ARP020100976A patent/AR037135A1/es not_active Application Discontinuation
- 2002-03-19 HU HU0303533A patent/HUP0303533A3/hu unknown
- 2002-03-19 PL PL02364712A patent/PL364712A1/xx not_active Application Discontinuation
- 2002-03-19 CZ CZ20032543A patent/CZ20032543A3/cs unknown
- 2002-03-19 NZ NZ527854A patent/NZ527854A/en unknown
- 2002-03-19 CA CA002441202A patent/CA2441202A1/en not_active Abandoned
- 2002-03-19 WO PCT/GB2002/001317 patent/WO2002074780A1/en not_active Ceased
- 2002-03-19 KR KR10-2003-7012208A patent/KR20030085014A/ko not_active Withdrawn
- 2002-03-19 BR BR0208169-5A patent/BR0208169A/pt not_active Application Discontinuation
- 2002-03-19 EP EP02714332A patent/EP1370568B1/en not_active Expired - Lifetime
- 2002-03-19 MX MXPA03008493A patent/MXPA03008493A/es unknown
- 2002-03-19 CN CNA028067754A patent/CN1501941A/zh active Pending
- 2002-03-19 AT AT02714332T patent/ATE306492T1/de not_active IP Right Cessation
- 2002-03-19 JP JP2002573789A patent/JP2004534002A/ja not_active Withdrawn
- 2002-03-19 DE DE60206605T patent/DE60206605D1/de not_active Expired - Lifetime
- 2002-03-19 IL IL15764902A patent/IL157649A0/xx unknown
2003
- 2003-09-19 NO NO20034182A patent/NO20034182D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1501941A (zh)	2004-06-02
MXPA03008493A (es)	2003-12-08
KR20030085014A (ko)	2003-11-01
CZ20032543A3 (en)	2004-05-12
ATE306492T1 (de)	2005-10-15
JP2004534002A (ja)	2004-11-11
AR037135A1 (es)	2004-10-27
NO20034182L (no)	2003-09-19
NZ527854A (en)	2004-09-24
EP1370568B1 (en)	2005-10-12
HUP0303533A3 (en)	2005-02-28
WO2002074780A1 (en)	2002-09-26
CA2441202A1 (en)	2002-09-26
BR0208169A (pt)	2004-03-02
PL364712A1 (en)	2004-12-13
EP1370568A1 (en)	2003-12-17
US20040162422A1 (en)	2004-08-19
NO20034182D0 (no)	2003-09-19
HUP0303533A2 (hu)	2004-03-01
DE60206605D1 (de)	2006-02-23

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