IL158116A0 - Inhibitors of cyclin dependent kinases as anti-cancer agent - Google Patents

Inhibitors of cyclin dependent kinases as anti-cancer agent

Info

Publication number: IL158116A0
Authority: IL; Israel
Prior art keywords: inhibitors; dependent kinases; cancer agent; cyclin dependent; cyclin
Prior art date: 2001-03-29

Application number

IL15811602A

Other languages

English (en)

Original Assignee

Cyclacel Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-29

Filing date

2002-03-26

Publication date

2004-03-28

2002-03-26 Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd

2004-03-28 Publication of IL158116A0 publication Critical patent/IL158116A0/xx

Links

108091007914 CDKs Proteins 0.000 title abstract 3
102000003903 Cyclin-dependent kinases Human genes 0.000 title abstract 3
108090000266 Cyclin-dependent kinases Proteins 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
208000032839 leukemia Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IL15811602A 2001-03-29 2002-03-26 Inhibitors of cyclin dependent kinases as anti-cancer agent IL158116A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0107901.1A GB0107901D0 (en)	2001-03-29	2001-03-29	Anti-cancer compounds
PCT/GB2002/001445 WO2002079193A1 (en)	2001-03-29	2002-03-26	Inhibitors of cyclin dependent kinases as anti-cancer agent

Publications (1)

Publication Number	Publication Date
IL158116A0 true IL158116A0 (en)	2004-03-28

Family

ID=9911848

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15811602A IL158116A0 (en)	2001-03-29	2002-03-26	Inhibitors of cyclin dependent kinases as anti-cancer agent

Country Status (16)

Country	Link
US (2)	US7262202B2 (de)
EP (1)	EP1373253B1 (de)
JP (1)	JP4294960B2 (de)
CN (1)	CN100519553C (de)
AT (1)	ATE365163T1 (de)
AU (1)	AU2002249389B2 (de)
BR (1)	BR0208447A (de)
CA (1)	CA2440228A1 (de)
CZ (1)	CZ20032637A3 (de)
DE (1)	DE60220771T2 (de)
ES (1)	ES2287263T3 (de)
GB (2)	GB0107901D0 (de)
IL (1)	IL158116A0 (de)
MX (1)	MXPA03008833A (de)
NZ (1)	NZ528347A (de)
WO (1)	WO2002079193A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0012528D0 (en) *	2000-05-23	2000-07-12	Univ Palackeho	Triterpenoid derivatives
AU2003237121A1 (en)	2002-04-26	2003-11-10	Vertex Pharmaceuticals Incorporated	Pyrrole derivatives as inhibitors of erk2 and uses thereof
CA2495386C (en)	2002-08-14	2011-06-21	Vertex Pharmaceuticals Incorporated	Protein kinase inhibitors and uses thereof
GB0219052D0 (en) *	2002-08-15	2002-09-25	Cyclacel Ltd	New puring derivatives
US8129330B2 (en) *	2002-09-30	2012-03-06	Mountain View Pharmaceuticals, Inc.	Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
EP2172460A1 (de)	2002-11-01	2010-04-07	Vertex Pharmaceuticals Incorporated	zusammensetzungen verwendbar als inhibitoren von jak und andere protein kinase
US7348335B2 (en)	2002-11-05	2008-03-25	Vertex Pharmaceuticals Incorporated	Compositions useful as inhibitors of JAK and other protein kinases
GB0226582D0 (en) *	2002-11-14	2002-12-18	Cyclacel Ltd	Anti-viral compounds
GB0226583D0 (en) *	2002-11-14	2002-12-18	Cyclacel Ltd	Compounds
GB0229581D0 (en) *	2002-12-19	2003-01-22	Cyclacel Ltd	Use
US7456190B2 (en) *	2003-03-13	2008-11-25	Vertex Pharmaceuticals Incorporated	Compositions useful as protein kinase inhibitors
GB0311276D0 (en) *	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
KR100932169B1 (ko)	2003-06-06	2009-12-16	피브로겐, 인크.	질소-함유 헤테로아릴 화합물 및 내인성 적혈구생성소의증가에서의 그들의 사용
TW200528101A (en) *	2004-02-03	2005-09-01	Astrazeneca Ab	Chemical compounds
GB0402653D0 (en) *	2004-02-06	2004-03-10	Cyclacel Ltd	Compounds
GB0411791D0 (en) *	2004-05-26	2004-06-30	Cyclacel Ltd	Compounds
US7855205B2 (en)	2004-10-29	2010-12-21	Janssen Pharmaceutica Nv	Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
FR2881426B1 (fr) *	2005-02-03	2007-03-30	Aventis Pharma Sa	Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation
FR2881742B1 (fr) *	2005-02-10	2007-09-07	Aventis Pharma Sa	Pyrroles substitues, compositions les contenant, procede de fabrication et utilisation
GB0520955D0 (en) *	2005-10-14	2005-11-23	Cyclacel Ltd	Compound
GB0520958D0 (en) *	2005-10-14	2005-11-23	Cyclacel Ltd	Compound
EP2203442B1 (de) *	2007-09-28	2012-06-20	Nerviano Medical Sciences S.r.l.	Substituierte pyrrolopyrimidinderivate, verfahren zu ihrer herstellung und ihre verwendung als kinaseinhibitoren
JP2011506303A (ja) *	2007-12-07	2011-03-03	ノバルティスアーゲー	ピラゾール誘導体およびサイクリン依存性キナーゼの阻害剤としてのその使用
GB0805477D0 (en) *	2008-03-26	2008-04-30	Univ Nottingham	Pyrimidines triazines and their use as pharmaceutical agents
US9340511B2 (en) *	2012-07-16	2016-05-17	Fibrogen, Inc.	Process for making isoquinoline compounds
CN112831542B (zh) *	2020-12-30	2022-10-14	厦门大学	一种基于MALDI-TOF-MS体外筛选CDKs家族蛋白激酶抑制剂的方法
AU2022271290A1 (en)	2021-05-07	2023-11-23	Kymera Therapeutics, Inc.	Cdk2 degraders and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE135699T1 (de) *	1986-01-13	1996-04-15	American Cyanamid Co	4,5,6-substituierte 2-pyrimidinamine
US5521184A (en) *	1992-04-03	1996-05-28	Ciba-Geigy Corporation	Pyrimidine derivatives and processes for the preparation thereof
US5516775A (en) *	1992-08-31	1996-05-14	Ciba-Geigy Corporation	Further use of pyrimidine derivatives
US5543520A (en) *	1993-10-01	1996-08-06	Ciba-Geigy Corporation	Pyrimidine derivatives
GB9523675D0 (en) *	1995-11-20	1996-01-24	Celltech Therapeutics Ltd	Chemical compounds
GB9828511D0 (en) *	1998-12-24	1999-02-17	Zeneca Ltd	Chemical compounds
US7122544B2 (en) *	2000-12-06	2006-10-17	Signal Pharmaceuticals, Llc	Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
MY130778A (en) *	2001-02-09	2007-07-31	Vertex Pharma	Heterocyclic inhibitiors of erk2 and uses thereof

2001
- 2001-03-29 GB GBGB0107901.1A patent/GB0107901D0/en not_active Ceased
2002
- 2002-03-26 MX MXPA03008833A patent/MXPA03008833A/es active IP Right Grant
- 2002-03-26 WO PCT/GB2002/001445 patent/WO2002079193A1/en not_active Ceased
- 2002-03-26 JP JP2002577818A patent/JP4294960B2/ja not_active Expired - Fee Related
- 2002-03-26 CZ CZ20032637A patent/CZ20032637A3/cs unknown
- 2002-03-26 BR BR0208447-3A patent/BR0208447A/pt not_active IP Right Cessation
- 2002-03-26 CN CNB028075536A patent/CN100519553C/zh not_active Expired - Fee Related
- 2002-03-26 IL IL15811602A patent/IL158116A0/xx unknown
- 2002-03-26 DE DE60220771T patent/DE60220771T2/de not_active Expired - Fee Related
- 2002-03-26 CA CA002440228A patent/CA2440228A1/en not_active Abandoned
- 2002-03-26 AT AT02718319T patent/ATE365163T1/de not_active IP Right Cessation
- 2002-03-26 NZ NZ528347A patent/NZ528347A/en unknown
- 2002-03-26 AU AU2002249389A patent/AU2002249389B2/en not_active Ceased
- 2002-03-26 EP EP02718319A patent/EP1373253B1/de not_active Expired - Lifetime
- 2002-03-26 ES ES02718319T patent/ES2287263T3/es not_active Expired - Lifetime
- 2002-03-27 GB GB0207229A patent/GB2375534B/en not_active Expired - Fee Related
2003
- 2003-09-24 US US10/671,747 patent/US7262202B2/en not_active Expired - Fee Related
2006
- 2006-08-21 US US11/507,929 patent/US20070185134A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60220771D1 (de)	2007-08-02
BR0208447A (pt)	2004-03-02
JP4294960B2 (ja)	2009-07-15
WO2002079193A1 (en)	2002-10-10
ATE365163T1 (de)	2007-07-15
EP1373253A1 (de)	2004-01-02
GB2375534A (en)	2002-11-20
CZ20032637A3 (cs)	2004-02-18
ES2287263T3 (es)	2007-12-16
AU2002249389B2 (en)	2008-03-13
DE60220771T2 (de)	2008-03-06
US20040132746A1 (en)	2004-07-08
EP1373253B1 (de)	2007-06-20
MXPA03008833A (es)	2004-10-15
GB2375534B (en)	2003-09-24
US20070185134A1 (en)	2007-08-09
NZ528347A (en)	2005-07-29
CA2440228A1 (en)	2002-10-10
CN1503794A (zh)	2004-06-09
GB0107901D0 (en)	2001-05-23
JP2004538260A (ja)	2004-12-24
US7262202B2 (en)	2007-08-28
WO2002079193A8 (en)	2005-03-17
CN100519553C (zh)	2009-07-29
GB0207229D0 (en)	2002-05-08

Publication	Publication Date	Title
GB2375534B (en)	2003-09-24	Anti-cancer compounds
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MY145332A (en)	2012-01-31	Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
TW200514776A (en)	2005-05-01	Aminotriazole compounds useful as inhibitors of protein kinases
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TW200508214A (en)	2005-03-01	Novel compounds
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TW200510367A (en)	2005-03-16	Novel lapachone compounds, their preparation, and the use thereof
TW200510392A (en)	2005-03-16	Chemical compounds
TW200630090A (en)	2006-09-01	Triazoles useful as inhibitors of protein kinases
WO2003028721A3 (en)	2003-12-11	Substituted benzimidazole compounds and their use for the treatment of cancer
BRPI0408068A (pt)	2006-02-14	derivados de 5-feniltiazol e seus usos como inibidores de pi3 cinase
TW200505452A (en)	2005-02-16	Chemical compounds
MX2023003516A (es)	2023-04-19	Inhibidores no covalentes de la cinasa dependiente de ciclina 7 (cdk7).
MY136840A (en)	2008-11-28	Pyrazolopyridines as cyclin dependent kinase inhibitors
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TW200740808A (en)	2007-11-01	Inhibiteurs de proteines kinases