IL160108A0 - Pharmaceutical compositions containing beta-lapachone or derivatives or analogs thereof, and methods of using same - Google Patents
Pharmaceutical compositions containing beta-lapachone or derivatives or analogs thereof, and methods of using sameInfo
- Publication number
- IL160108A0 IL160108A0 IL16010802A IL16010802A IL160108A0 IL 160108 A0 IL160108 A0 IL 160108A0 IL 16010802 A IL16010802 A IL 16010802A IL 16010802 A IL16010802 A IL 16010802A IL 160108 A0 IL160108 A0 IL 160108A0
- Authority
- IL
- Israel
- Prior art keywords
- lapachone
- analogs
- derivatives
- methods
- same
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30893501P | 2001-07-31 | 2001-07-31 | |
| US09/975,776 US6962944B2 (en) | 2001-07-31 | 2001-10-10 | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
| PCT/US2002/024262 WO2003011224A2 (fr) | 2001-07-31 | 2002-07-31 | Compositions pharmaceutiques contenant beta-lapachone ou des derives ou des analogues correspondants, et leurs methodes d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL160108A0 true IL160108A0 (en) | 2004-06-20 |
Family
ID=26976533
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16010802A IL160108A0 (en) | 2001-07-31 | 2002-07-31 | Pharmaceutical compositions containing beta-lapachone or derivatives or analogs thereof, and methods of using same |
| IL192937A IL192937A0 (en) | 2001-07-31 | 2008-07-21 | Pharmaceutical compositions containing beta-lapachone or derivatives or analogs thereof, and methods of using same |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL192937A IL192937A0 (en) | 2001-07-31 | 2008-07-21 | Pharmaceutical compositions containing beta-lapachone or derivatives or analogs thereof, and methods of using same |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6962944B2 (fr) |
| EP (1) | EP1420777A4 (fr) |
| JP (1) | JP2005507861A (fr) |
| KR (1) | KR100734341B1 (fr) |
| CN (1) | CN1561209A (fr) |
| AU (1) | AU2002313713B2 (fr) |
| BR (1) | BR0211613A (fr) |
| CA (1) | CA2455567A1 (fr) |
| EA (1) | EA007075B1 (fr) |
| IL (2) | IL160108A0 (fr) |
| MX (1) | MXPA04000994A (fr) |
| NZ (1) | NZ531335A (fr) |
| WO (1) | WO2003011224A2 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050192360A1 (en) * | 1999-04-14 | 2005-09-01 | Li Chiang J. | Method of treatment of pancreatic cancer |
| US20050197405A1 (en) * | 2000-11-07 | 2005-09-08 | Li Chiang J. | Treatment of hematologic tumors and cancers with beta-lapachone, a broad spectrum anti-cancer agent |
| CN1555253A (zh) * | 2001-09-13 | 2004-12-15 | ������ѧ�����о�Ժ | 化疗栓塞用紫杉醇的油性组合物、制剂及它们的制造方法 |
| US6890950B2 (en) * | 2002-04-23 | 2005-05-10 | Case Western Reserve University | Lapachone delivery systems, compositions and uses related thereto |
| AU2003254029A1 (en) * | 2002-07-17 | 2004-02-02 | Arqule, Inc. | Activated checkpoint therapy and methods of use thereof |
| WO2004050033A2 (fr) * | 2002-12-02 | 2004-06-17 | Arqule, Inc. | Methodes de traitement de cancers |
| US7649013B2 (en) * | 2003-11-26 | 2010-01-19 | Arqule, Inc. | Methods of protecting against radiation injury |
| JP2007523190A (ja) * | 2004-02-20 | 2007-08-16 | アークル・インコーポレーテツド | 肺癌の治療のためのβ−ラパコンの使用 |
| EP2033639A2 (fr) | 2004-02-20 | 2009-03-11 | Arqule, Inc. | Béta-lapachone pour le traitement du cancer du colon |
| US20050187288A1 (en) * | 2004-02-20 | 2005-08-25 | Chiang Li | Beta-lapachone and methods of treating cancer |
| EP2033638A2 (fr) | 2004-02-20 | 2009-03-11 | Arqule, Inc. | Béta-lapachone pour le traitement du cancer pancréatique |
| US20050192247A1 (en) * | 2004-02-23 | 2005-09-01 | Li Chiang J. | Method of treating cancers |
| US20050256097A1 (en) * | 2004-05-11 | 2005-11-17 | Kosan Biosciences, Inc. | Pharmaceutical solution formulations containing 17-AAG |
| US8614228B2 (en) * | 2004-08-11 | 2013-12-24 | Arqule, Inc. | Quinone prodrug compositions and methods of use |
| EP1877097B1 (fr) * | 2004-08-11 | 2012-06-20 | Arqule, Inc. | Conjugués d'acides aminés et de bêta-lapachone pour le ciblage de tumeurs |
| ITMI20041763A1 (it) * | 2004-09-16 | 2004-12-16 | Altergon Sa | Nuove formulazioni iniettabili contenenti progesterone |
| LT3311805T (lt) * | 2005-08-31 | 2020-04-27 | Abraxis Bioscience, Llc | Kompozicijos, apimančios silpnai vandenyje tirpius farmacinius agentus ir priešmikrobinius agentus |
| TW200824692A (en) * | 2006-08-21 | 2008-06-16 | Arqule Inc | Novel lapachone compounds and methods of use thereof |
| ES2532656T3 (es) * | 2007-04-30 | 2015-03-30 | Arqule, Inc. | Compuestos de hidroxi sulfonato de quinona y sus usos |
| KR20100024494A (ko) | 2007-06-22 | 2010-03-05 | 아르퀼 인코포레이티드 | 퀴나졸리논 화합물 및 이의 사용 방법 |
| EP3889261A1 (fr) | 2007-08-27 | 2021-10-06 | 1Globe Health Institute LLC | Compositions d'arn interférent asymétrique et leurs utilisations |
| CN101821247A (zh) | 2007-10-12 | 2010-09-01 | 艾科尔公司 | 作为hsp90抑制剂的抗癌用5-(2-羟基苯基)四唑化合物 |
| US8067459B2 (en) * | 2007-10-16 | 2011-11-29 | Arqule, Inc. | Lapachone compounds and methods of use thereof |
| KR101405823B1 (ko) | 2007-12-24 | 2014-06-12 | 주식회사 케이티앤지생명과학 | 녹내장의 치료 및 예방을 위한 약제 조성물 |
| KR20090071829A (ko) * | 2007-12-28 | 2009-07-02 | 주식회사 머젠스 | 신장질환의 치료 및 예방을 위한 약제 조성물 |
| KR20090073381A (ko) * | 2007-12-31 | 2009-07-03 | 주식회사 머젠스 | 심장질환의 치료 및 예방을 위한 약제 조성물 |
| KR101528265B1 (ko) * | 2010-04-16 | 2015-06-11 | 코웨이 주식회사 | 베타-라파콘을 유효성분으로 포함하는 주름개선용 화장료 조성물 |
| US20130261142A1 (en) * | 2010-12-15 | 2013-10-03 | Hung-Cheng Lai | Compounds used for treating cancer and the use thereof |
| KR101583755B1 (ko) | 2012-10-29 | 2016-01-19 | 코웨이 주식회사 | 베타-라파콘을 유효성분으로 포함하는 신경계 질환 예방 및 치료용 조성물 |
| RU2530886C1 (ru) * | 2013-06-24 | 2014-10-20 | Государственное бюджетное учреждение "Уфимский научно-исследовательский институт глазных болезней Академии наук Республики Башкортостан" | Водорастворимый комплекс включения бета-циклодекстрин-гистохром, обладающий пролонгированным антиоксидантным действием |
| CN111867580B (zh) * | 2018-01-18 | 2023-05-26 | （株）娜迪安生物公司 | 用于预防或改善脱发的包含有效成分董尼酮的组合物 |
| CN112076157B (zh) * | 2019-06-14 | 2022-04-26 | 首都医科大学 | 拉帕醇纳米脂质体制剂及其制备方法和应用 |
| KR20220007554A (ko) * | 2020-07-10 | 2022-01-18 | (주)나디안바이오 | 나프토퀴논계 화합물 및 면역관문 억제제를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 |
| KR20240014532A (ko) | 2021-05-29 | 2024-02-01 | 1글로브 헬스 인스티튜트 엘엘씨 | 신규한 유전자 침묵 기술로서의 비대칭의 짧은 듀플렉스 dna 및 이의 용도 |
| EP4347828A1 (fr) | 2021-05-29 | 2024-04-10 | 1Globe Health Institute LLC | Adn duplex court en tant que nouvelle technologie d'inactivation de gènes et utilisation de celle-ci |
| MX2024007452A (es) * | 2021-12-15 | 2024-07-09 | Sillajen Inc | Composiciones farmaceuticas que comprenden beta-ciclodextrinas modificadas. |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2827452A (en) | 1955-05-31 | 1958-03-18 | Univ Minnesota | Stabilization of materials |
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| US3453259A (en) | 1967-03-22 | 1969-07-01 | Corn Products Co | Cyclodextrin polyol ethers and their oxidation products |
| HU184066B (en) | 1979-12-28 | 1984-06-28 | Chinoin Gyogyszer Es Vegyeszet | Plant growth regulating substance and process for preparing such compound |
| HU181703B (en) | 1980-05-09 | 1983-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing aqueus solutuins of water insoluble or hardly soluble vitamines, steroides, localanesthetics, prostanoides and non-steroid and antiphlogistic agents |
| US4371673A (en) | 1980-07-21 | 1983-02-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble forms of retinoids |
| JPS57182301A (en) | 1981-01-23 | 1982-11-10 | Wellcome Found | Composite body of sugar-containing compound and cycloamlose and manufacture |
| JPS57126802A (en) | 1981-01-30 | 1982-08-06 | Mitsubishi Petrochem Co Ltd | Benzophenone-3,3'-disulfonate-capped compound of beta-cyclodextrin |
| JPS57200361A (en) | 1981-06-03 | 1982-12-08 | Sumitomo Chem Co Ltd | "indomethacin(r)" pharmaceutical with low irritant action |
| US4383992A (en) | 1982-02-08 | 1983-05-17 | Lipari John M | Water-soluble steroid compounds |
| JPS58144376A (ja) | 1982-02-23 | 1983-08-27 | Sumitomo Chem Co Ltd | ベンゾジアゼピン誘導体−シクロデキストリン包接化合物 |
| HU190818B (en) | 1982-11-09 | 1986-11-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for producing complexes of piperonyl-butoxide-cyclodextrin |
| HU190584B (en) | 1983-03-11 | 1986-09-29 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara,Rt,Hu | Process for the production of heptakis/2,6-di-o-methyl-beta-cyclodextrin |
| DE3400488A1 (de) | 1983-03-16 | 1984-09-20 | Kraftwerk Union AG, 4330 Mülheim | Elektrohydraulischer kompaktantrieb fuer ventile von turbomaschinen, insbesondere turbinen |
| EP0147685B1 (fr) | 1983-12-17 | 1989-04-26 | Hoechst Aktiengesellschaft | Ether de bêta-cyclodextrine et procédé pour sa préparation |
| EP0146841A3 (fr) | 1983-12-17 | 1986-11-20 | Consortium für elektrochemische Industrie GmbH | Ether mixte de bêta-cyclodextrine soluble dans l'eau et procédé pour sa préparation |
| DE3346123A1 (de) | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| US4596795A (en) | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
| US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| MC1710A1 (fr) * | 1984-11-26 | 1986-09-22 | Ciba Geigy Ag | Composes azotes de derives oxo |
| MC1711A1 (fr) | 1984-11-26 | 1986-09-22 | Ciba Geigy Ag | Compose alkylidene-dioxy |
| US6407079B1 (en) | 1985-07-03 | 2002-06-18 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| WO1994004145A1 (fr) | 1992-08-21 | 1994-03-03 | Dana Farber Cancer Institute | Traitement d'infections virales chez l'homme |
| AU3684395A (en) | 1994-10-06 | 1996-05-02 | Leon T. Atlas | Use of camptothecin or derivatives thereof for the manufacture of a medicament for the treatment of viral diseases |
| US5763625A (en) | 1995-04-25 | 1998-06-09 | Wisconsin Alumni Research Foundation | Synthesis and use of β-lapachone analogs |
| US6245807B1 (en) | 1995-08-24 | 2001-06-12 | Dana-Farber Cancer Institute | Treatment of human prostate disease |
| WO1997007797A1 (fr) * | 1995-08-25 | 1997-03-06 | Dana-Farber Cancer Institute | Traitement de l'affection de la prostate chez l'homme au moyen de derives beta-lapachone |
| WO1997008162A1 (fr) * | 1995-08-24 | 1997-03-06 | Dana-Farber Cancer Institute | Agents anti-tumoraux derives de beta-lapachones |
| US5883270A (en) | 1996-02-20 | 1999-03-16 | Wisconsin Alumni Research Foundation | 4-substituted-1, 2-naphthoquinones and their use in the inhibition of neoplastic cell growth |
| US5824700A (en) | 1996-02-20 | 1998-10-20 | Wisconsin Alumni Research Foundation | Ortho-quinone derivatives novel synthesis therefor and their use in the inhibition of neoplastic cell growth |
| DE60031268T2 (de) | 1999-04-14 | 2007-05-24 | Dana-Farber Cancer Institute, Inc., Boston | Verfahren und zusammansetzung zur behandlung von krebs |
| ATE407676T1 (de) | 2000-02-28 | 2008-09-15 | Univ British Columbia | Topoisomerasehemmern zur behandlung von chirurgischen verklebungen |
| US6890950B2 (en) | 2002-04-23 | 2005-05-10 | Case Western Reserve University | Lapachone delivery systems, compositions and uses related thereto |
-
2001
- 2001-10-10 US US09/975,776 patent/US6962944B2/en not_active Expired - Fee Related
-
2002
- 2002-07-31 KR KR1020047001569A patent/KR100734341B1/ko not_active Expired - Fee Related
- 2002-07-31 WO PCT/US2002/024262 patent/WO2003011224A2/fr not_active Ceased
- 2002-07-31 CA CA002455567A patent/CA2455567A1/fr not_active Abandoned
- 2002-07-31 EA EA200400242A patent/EA007075B1/ru not_active IP Right Cessation
- 2002-07-31 CN CNA028190297A patent/CN1561209A/zh active Pending
- 2002-07-31 BR BR0211613-8A patent/BR0211613A/pt not_active IP Right Cessation
- 2002-07-31 IL IL16010802A patent/IL160108A0/xx unknown
- 2002-07-31 EP EP02753423A patent/EP1420777A4/fr not_active Withdrawn
- 2002-07-31 NZ NZ531335A patent/NZ531335A/en unknown
- 2002-07-31 MX MXPA04000994A patent/MXPA04000994A/es active IP Right Grant
- 2002-07-31 JP JP2003516456A patent/JP2005507861A/ja active Pending
- 2002-07-31 AU AU2002313713A patent/AU2002313713B2/en not_active Ceased
-
2008
- 2008-07-21 IL IL192937A patent/IL192937A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL192937A0 (en) | 2009-02-11 |
| WO2003011224A3 (fr) | 2003-05-08 |
| EP1420777A4 (fr) | 2009-03-04 |
| CN1561209A (zh) | 2005-01-05 |
| AU2002313713B2 (en) | 2007-03-29 |
| KR20040054667A (ko) | 2004-06-25 |
| EP1420777A2 (fr) | 2004-05-26 |
| CA2455567A1 (fr) | 2003-02-13 |
| NZ531335A (en) | 2007-08-31 |
| US6962944B2 (en) | 2005-11-08 |
| US20030091639A1 (en) | 2003-05-15 |
| KR100734341B1 (ko) | 2007-07-03 |
| BR0211613A (pt) | 2004-11-09 |
| JP2005507861A (ja) | 2005-03-24 |
| MXPA04000994A (es) | 2005-02-17 |
| WO2003011224A2 (fr) | 2003-02-13 |
| EA007075B1 (ru) | 2006-06-30 |
| EA200400242A1 (ru) | 2004-12-30 |
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