IL162082A0 - Melt extrusion consisting of salts of active ingredients - Google Patents

Melt extrusion consisting of salts of active ingredients

Info

Publication number: IL162082A0
Authority: IL; Israel
Prior art keywords: active ingredient; salts; granule; meth; active ingredients
Prior art date: 2002-02-27

Application number

IL16208203A

Other languages

English (en)

Original Assignee

Roehm Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-27

Filing date

2003-01-30

Publication date

2005-11-20

2003-01-30 Application filed by Roehm Gmbh filed Critical Roehm Gmbh

2005-11-20 Publication of IL162082A0 publication Critical patent/IL162082A0/xx

Links

239000004480 active ingredient Substances 0.000 title abstract 4
150000003839 salts Chemical class 0.000 title abstract 2
238000001125 extrusion Methods 0.000 title 1
239000008187 granular material Substances 0.000 abstract 3
239000000843 powder Substances 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000129 anionic group Chemical group 0.000 abstract 1
229920001577 copolymer Polymers 0.000 abstract 1
239000002552 dosage form Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000002844 melting Methods 0.000 abstract 1
230000008018 melting Effects 0.000 abstract 1
239000000178 monomer Substances 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
General Preparation And Processing Of Foods (AREA)
Seasonings (AREA)
Compositions Of Macromolecular Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Detergent Compositions (AREA)

IL16208203A 2002-02-27 2003-01-30 Melt extrusion consisting of salts of active ingredients IL162082A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10208344A DE10208344A1 (de)	2002-02-27	2002-02-27	Schmelzextrusion von Wirkstoffsalzen
PCT/EP2003/000935 WO2003072083A2 (fr)	2002-02-27	2003-01-30	Extrusion de fusion de sels d'agents actifs

Publications (1)

Publication Number	Publication Date
IL162082A0 true IL162082A0 (en)	2005-11-20

Family

ID=27675020

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL16208203A IL162082A0 (en)	2002-02-27	2003-01-30	Melt extrusion consisting of salts of active ingredients
IL162082A IL162082A (en)	2002-02-27	2004-05-20	Extrusion molten material containing salts of active ingredients and a process for its preparation

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL162082A IL162082A (en)	2002-02-27	2004-05-20	Extrusion molten material containing salts of active ingredients and a process for its preparation

Country Status (14)

Country	Link
US (1)	US8642089B2 (fr)
EP (1)	EP1478344B1 (fr)
JP (1)	JP5054278B2 (fr)
KR (1)	KR100707712B1 (fr)
AT (1)	ATE362754T1 (fr)
AU (1)	AU2003210196A1 (fr)
BR (1)	BRPI0307995B8 (fr)
CA (1)	CA2474691C (fr)
DE (2)	DE10208344A1 (fr)
ES (1)	ES2286447T3 (fr)
IL (2)	IL162082A0 (fr)
MX (1)	MXPA04008345A (fr)
PL (1)	PL204465B1 (fr)
WO (1)	WO2003072083A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10239999A1 (de) *	2002-08-27	2004-03-04	Röhm GmbH & Co. KG	Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen
DE10304403A1 (de)	2003-01-28	2004-08-05	Röhm GmbH & Co. KG	Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung
US8025899B2 (en)	2003-08-28	2011-09-27	Abbott Laboratories	Solid pharmaceutical dosage form
US8377952B2 (en)	2003-08-28	2013-02-19	Abbott Laboratories	Solid pharmaceutical dosage formulation
JP2006028028A (ja) *	2004-07-12	2006-02-02	Teikoku Medix Kk	経口医薬組成物
US8481565B2 (en)	2004-12-27	2013-07-09	Eisai R&D Management Co., Ltd.	Method for stabilizing anti-dementia drug
ATE482690T1 (de) *	2005-12-14	2010-10-15	Hoffmann La Roche	Hcv-prodrug-formulierung
US20090317355A1 (en) *	2006-01-21	2009-12-24	Abbott Gmbh & Co. Kg,	Abuse resistant melt extruded formulation having reduced alcohol interaction
US20100172989A1 (en) *	2006-01-21	2010-07-08	Abbott Laboratories	Abuse resistant melt extruded formulation having reduced alcohol interaction
DE102007009242A1 (de) *	2007-02-22	2008-09-18	Evonik Röhm Gmbh	Pellets mit magensaftresistenter Wirkstoff-Matix
DE102007026550A1 (de)	2007-06-08	2008-12-11	Bayer Healthcare Ag	Extrudate mit verbesserter Geschmacksmaskierung
CA2712010A1 (fr) *	2008-01-11	2009-07-12	Cipla Limited	Forme posologique pharmaceutique solide
TW200950776A (en) *	2008-01-24	2009-12-16	Abbott Gmbh & Co Kg	Abuse resistant melt extruded formulation having reduced alcohol interaction
JP2011511782A (ja)	2008-02-12	2011-04-14	アボット・ラボラトリーズ	長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途
KR101753222B1 (ko)	2014-12-12	2017-07-04	강원대학교산학협력단	용융압출하여 제조된 당귀-고체분산체 및 그 제조방법
WO2018111459A1 (fr) *	2016-12-14	2018-06-21	Dow Global Technologies Llc	Procédé de génération de sels d'ingrédients pharmaceutiques actifs
WO2019222856A1 (fr)	2018-05-24	2019-11-28	Nureva Inc.	Procédé, appareil et supports lisibles par ordinateur pour gérer des sources sonores semi-constantes (persistantes) dans des zones de capture/foyer de microphones
AU2019275406B2 (en)	2018-05-24	2024-11-14	Celanese Eva Performance Polymers Llc	Implantable device for sustained release of a macromolecular drug compound
WO2019226519A1 (fr)	2018-05-24	2019-11-28	Celanese EVA Performance Polymers Corporation	Dispositif implantable pour la libération prolongée d'un composé médicamenteux macromoléculaire
WO2022231930A1 (fr)	2021-04-26	2022-11-03	Celanese Eva Performance Polymers Llc	Dispositif implantable pour la libération prolongée d'un composé médicamenteux macromoléculaire

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH668553A5 (de) *	1987-02-02	1989-01-13	Mepha Ag	Arzneimittel mit verzoegerter wirkstofffreisetzung.
US5084278A (en) *	1989-06-02	1992-01-28	Nortec Development Associates, Inc.	Taste-masked pharmaceutical compositions
WO1993007859A1 (fr) *	1991-10-23	1993-04-29	Warner-Lambert Company	Nouveaux granules pharmaceutiques et procede de preparation
US5965161A (en) *	1994-11-04	1999-10-12	Euro-Celtique, S.A.	Extruded multi-particulates
US5695781A (en) *	1995-03-01	1997-12-09	Hallmark Pharmaceuticals, Inc.	Sustained release formulation containing three different types of polymers
AU3404997A (en) *	1996-05-31	1998-01-05	Euro-Celtique S.A.	Sustained release oxycodone formulations with no fed/fast effect
US6673367B1 (en)	1998-12-17	2004-01-06	Euro-Celtique, S.A.	Controlled/modified release oral methylphenidate formulations
DE19958007A1 (de)	1999-12-02	2001-06-07	Roehm Gmbh	Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen
HU229344B1 (en)	2001-02-27	2013-11-28	Evonik Roehm Gmbh	Coating and binding agent for pharmaceutical formulations with improved storage stability
DE10239999A1 (de)	2002-08-27	2004-03-04	Röhm GmbH & Co. KG	Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen

2002
- 2002-02-27 DE DE10208344A patent/DE10208344A1/de not_active Withdrawn
2003
- 2003-01-30 PL PL370426A patent/PL204465B1/pl unknown
- 2003-01-30 AT AT03742925T patent/ATE362754T1/de active
- 2003-01-30 WO PCT/EP2003/000935 patent/WO2003072083A2/fr not_active Ceased
- 2003-01-30 JP JP2003570829A patent/JP5054278B2/ja not_active Expired - Lifetime
- 2003-01-30 KR KR1020047013278A patent/KR100707712B1/ko not_active Expired - Lifetime
- 2003-01-30 IL IL16208203A patent/IL162082A0/xx unknown
- 2003-01-30 US US10/498,829 patent/US8642089B2/en active Active
- 2003-01-30 MX MXPA04008345A patent/MXPA04008345A/es active IP Right Grant
- 2003-01-30 BR BRPI0307995A patent/BRPI0307995B8/pt not_active IP Right Cessation
- 2003-01-30 AU AU2003210196A patent/AU2003210196A1/en not_active Abandoned
- 2003-01-30 EP EP03742925A patent/EP1478344B1/fr not_active Expired - Lifetime
- 2003-01-30 DE DE50307321T patent/DE50307321D1/de not_active Expired - Lifetime
- 2003-01-30 ES ES03742925T patent/ES2286447T3/es not_active Expired - Lifetime
- 2003-01-30 CA CA2474691A patent/CA2474691C/fr not_active Expired - Lifetime
2004
- 2004-05-20 IL IL162082A patent/IL162082A/en active IP Right Grant

Also Published As

Publication number	Publication date
ATE362754T1 (de)	2007-06-15
CA2474691A1 (fr)	2003-09-04
PL370426A1 (en)	2005-05-30
CA2474691C (fr)	2011-04-19
WO2003072083A2 (fr)	2003-09-04
DE50307321D1 (de)	2007-07-05
PL204465B1 (pl)	2010-01-29
EP1478344A2 (fr)	2004-11-24
ES2286447T3 (es)	2007-12-01
IL162082A (en)	2009-11-18
KR100707712B1 (ko)	2007-04-16
US8642089B2 (en)	2014-02-04
BR0307995A (pt)	2004-12-07
US20040253314A1 (en)	2004-12-16
WO2003072083A3 (fr)	2004-04-08
JP2005526731A (ja)	2005-09-08
DE10208344A1 (de)	2003-09-04
BRPI0307995B1 (pt)	2019-02-26
BRPI0307995B8 (pt)	2021-05-25
JP5054278B2 (ja)	2012-10-24
AU2003210196A1 (en)	2003-09-09
MXPA04008345A (es)	2004-11-26
KR20040084936A (ko)	2004-10-06
EP1478344B1 (fr)	2007-05-23

Publication	Publication Date	Title
PL370426A1 (en)	2005-05-30	Melt extrusion consisting of salts of active ingredients
TR200100196T2 (tr)	2001-06-21	Oral veya dermal ilaç biçimleri için kaplama ve birleştirme maddeleri
KR101500769B1 (ko)	2015-03-17	위액 내성인 활성 물질 매트릭스를 포함하는 펠렛
AU2003218641A1 (en)	2003-09-09	Pharmaceutical dosage form and method for the production thereof
EP0381219B1 (fr)	1993-05-05	Composition à base de gemfibrozil à libération modifiée
JP5416586B2 (ja)	2014-02-12	コーティング製剤の製造方法
BR0105102A (pt)	2002-02-19	Medicamento de multiplas camadas para a liberação no cólon
EP0381218B1 (fr)	1993-05-05	Composition à base de gemfibrozil à libération prolongée
AU2003266232A1 (en)	2004-03-19	Granulate or powder for producing coating or binding agents for medicaments
NZ505431A (en)	2002-12-20	Solid thermoformable controlled-release pharmaceutical composition
ATE315605T1 (de)	2006-02-15	Polyakrylsäure-granulate mit gesteuerter freigabe und verfahren zu dessen herstellung
CA2339913A1 (fr)	2001-09-08	Formules et methode de fabrication pharmaceutiques
SG172818A1 (en)	2011-08-29	Abuse resistant melt extruded formulation having reduced alcohol interaction
RU2004127237A (ru)	2005-04-20	Твердая препаративная форма с замедленным/контролируемым высвобождением как новая система доставки лекарственного средства со сниженным риском демпинга дозы
DE19836646A1 (de)	2000-02-17	Verwendung von N-Vinylpyrrolidon- und Vinylacetat-haltigen Copolymeren als Matrix zur Herstellung von festen, oralen pharmazeutischen und kosmetischen Zubereitungen