IL162111A0 - Method for the generation of generically modified vertebrate precursor lymphocytes and use thereof for the production of heterologo - Google Patents

Method for the generation of generically modified vertebrate precursor lymphocytes and use thereof for the production of heterologo

Info

Publication number
IL162111A0
IL162111A0 IL16211101A IL16211101A IL162111A0 IL 162111 A0 IL162111 A0 IL 162111A0 IL 16211101 A IL16211101 A IL 16211101A IL 16211101 A IL16211101 A IL 16211101A IL 162111 A0 IL162111 A0 IL 162111A0
Authority
IL
Israel
Prior art keywords
heterologo
generation
production
precursor lymphocytes
modified vertebrate
Prior art date
Application number
IL16211101A
Other languages
English (en)
Original Assignee
4Antibody Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Antibody Ag filed Critical 4Antibody Ag
Publication of IL162111A0 publication Critical patent/IL162111A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL16211101A 2001-12-22 2001-12-22 Method for the generation of generically modified vertebrate precursor lymphocytes and use thereof for the production of heterologo IL162111A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2001/015303 WO2003068819A1 (fr) 2001-12-22 2001-12-22 Methode de generation de lymphocytes precurseurs de vertebres genetiquement modifies et leur utilisation dans la production de proteines de liaison heterologues

Publications (1)

Publication Number Publication Date
IL162111A0 true IL162111A0 (en) 2005-11-20

Family

ID=27675551

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16211101A IL162111A0 (en) 2001-12-22 2001-12-22 Method for the generation of generically modified vertebrate precursor lymphocytes and use thereof for the production of heterologo
IL162111A IL162111A (en) 2001-12-22 2004-05-20 Method for the generation of vertebrate lymphocytes and use thereof for the production of binding proteins or functional fragment(s) thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL162111A IL162111A (en) 2001-12-22 2004-05-20 Method for the generation of vertebrate lymphocytes and use thereof for the production of binding proteins or functional fragment(s) thereof

Country Status (8)

Country Link
US (2) US7741077B2 (fr)
JP (1) JP4238138B2 (fr)
CN (1) CN100360565C (fr)
AU (1) AU2002226390B2 (fr)
CA (1) CA2471392A1 (fr)
IL (2) IL162111A0 (fr)
NZ (1) NZ534205A (fr)
WO (1) WO2003068819A1 (fr)

Families Citing this family (45)

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EP1568765A1 (fr) * 2004-02-23 2005-08-31 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Méthode de diversité génétique dans des cellules capables de conversion génique
WO2006072803A2 (fr) * 2005-01-10 2006-07-13 Medical Research Council Anticorps
JPWO2007060864A1 (ja) * 2005-11-24 2009-05-07 国立大学法人 奈良先端科学技術大学院大学 増殖と分化の制御可能な抗体産生前駆ｂ細胞
NZ592159A (en) * 2005-12-09 2012-12-21 Amc Amsterdam Means and methods for influencing the stability of antibody producing cells
US9005974B2 (en) 2005-12-09 2015-04-14 Academish Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for influencing the stability of cells
WO2008097926A2 (fr) * 2007-02-02 2008-08-14 Yale University Transfection transitoire avec de l'arn
US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
US20090075378A1 (en) * 2007-02-20 2009-03-19 Anaptysbio, Inc. Somatic hypermutation systems
JP5537420B2 (ja) 2007-05-31 2014-07-02 ユニヴァーシティ オブ ワシントン 標的遺伝子の誘導性変異誘発
AU2008284015B2 (en) 2007-08-03 2014-05-15 Musc Foundation For Research Development Human monoclonal antibodies and methods for producing the same
EP2098536A1 (fr) * 2008-03-05 2009-09-09 4-Antibody AG Isolation et identification de protéines de liaison spécifiques à des antigènes ou à des ligands
JPWO2010027062A1 (ja) * 2008-09-04 2012-02-02 独立行政法人理化学研究所 Ｂ細胞由来ｉＰＳ細胞およびその用途
US8133727B2 (en) * 2008-11-21 2012-03-13 California Institute Of Technology In vitro human B lymphopoiesis culture system
US9273118B2 (en) 2009-07-15 2016-03-01 Aimm Therapeutics B.V. Means and methods for producing high affinity antibodies
EA201270662A1 (ru) 2009-12-23 2013-01-30 4-Антибоди Аг Связывающие элементы для человеческого цитамегаловируса
US9074223B2 (en) * 2010-01-08 2015-07-07 Immusoft Corporation Vectors and methods for transducing B cells
US20120309034A1 (en) * 2010-02-12 2012-12-06 Nitto Boseki Co., Ltd. METHOD FOR MEASURING IMMUNITY OF COMPLEX OF Ku86 AND AUTOANTIBODY THEREOF, KIT USED THEREFOR, AND METHOD FOR DETERMINING CANCER USING SAME
CA2809089C (fr) 2010-08-23 2018-12-18 Board Of Regents, The University Of Texas System Anticorps anti-ox40 et leurs procedes d'utilisation
CN103429615B (zh) 2010-12-02 2018-03-16 埃姆医疗有限公司 用于生产高亲和力抗体的方式和方法
CN102229960B (zh) * 2011-06-03 2013-04-03 中国科学院微生物研究所 小鼠白血病病毒转化骨髓细胞建立细胞系的方法及其应用
CN107858333B (zh) 2011-10-28 2022-05-27 瑞泽恩制药公司 T细胞受体基因修饰小鼠
US10233424B2 (en) 2011-12-22 2019-03-19 Elwha Llc Compositions and methods including cytotoxic B lymphocyte cell line expressing exogenous membrane immunoglobulin different from secreted immunoglobulin
US10745468B2 (en) * 2011-12-22 2020-08-18 Kota Biotherapeutics, Llc Compositions and methods for modified B cells expressing reassigned biological agents
US8962315B2 (en) 2011-12-22 2015-02-24 Elwha Llc Compositions and methods including recombinant B lymphocyte cell line including at least one endogenous gene expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and including at least one exogenously incorporated nucleic acid expressing at least one exogenous secreted immunoglobulin reactive to a second antigen
US9175072B2 (en) * 2011-12-22 2015-11-03 Elwha Llc Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen
MY178882A (en) * 2013-02-20 2020-10-21 Regeneron Pharma Non-human animals with modified immunoglobulin heavy chain sequences
CN103571796B (zh) * 2013-11-15 2015-04-29 中国农业科学院哈尔滨兽医研究所 鸡白介素-10单克隆抗体及其制备方法和应用
CA2938193C (fr) 2014-01-31 2023-05-02 Aimm Therapeutics B.V. Moyens et procedes de production d'anticorps stables
EP3138903B1 (fr) * 2014-05-02 2022-02-09 Chiome Bioscience Inc. Cellules pour la production d'anticorps humain
KR20170093182A (ko) 2014-12-11 2017-08-14 인바이오모션 에스.엘. 인간 c-maf에 대한 결합 구성원
CA2981077A1 (fr) * 2015-04-03 2016-10-06 Dana-Farber Cancer Institute, Inc. Composition et procedes de correction genomique de cellules b
EP4248744A3 (fr) 2015-04-06 2023-12-27 Regeneron Pharmaceuticals, Inc. Réponses immunitaires médiées par des cellules t humanisées dans des animaux non humains
US11623950B2 (en) * 2015-07-09 2023-04-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Lentiviral vector expressing membrane-anchored or secreted antibody
US20180230431A1 (en) 2015-08-07 2018-08-16 Glaxosmithkline Intellectual Property Development Limited Combination Therapy
HK1258218A1 (zh) * 2015-09-15 2019-11-08 Board Of Regents, The University Of Texas System T细胞受体(tcr)结合抗体及其应用
EP4628587A3 (fr) 2016-04-15 2026-02-25 Memorial Sloan Kettering Cancer Center Compositions de lymphocytes t transgéniques et de lymphocytes t à récepteur antigénique chimérique et procédés associés
CN109563482A (zh) 2016-06-10 2019-04-02 埃尔瓦有限公司 含表达异于分泌免疫球蛋白和细胞溶解功能的膜免疫球蛋白的b淋巴细胞系的组合物和方法
EP3494140A1 (fr) 2016-08-04 2019-06-12 GlaxoSmithKline Intellectual Property Development Ltd Polythérapie à base d'anticorps anti-icos et anti-pd-1
KR20190090823A (ko) 2016-12-01 2019-08-02 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 조합 요법
US20190343803A1 (en) 2016-12-01 2019-11-14 Glaxosmithkline Intellectual Property Development Limited Combination therapy
BR112019025913A2 (pt) 2017-06-09 2020-06-30 Glaxosmithkline Intellectual Property Development Limited métodos para tratar câncer em um paciente em necesssidade do mesmo e para produzir um anticorpo, anticorpo anti-icos ou fragmento de ligação ao antígeno do mesmo e um anticorpo anti-ox40 ou fragmento de ligação ao antígeno do mesmo, uso de um anticorpo anti-icos ou porção de ligação ao antígeno do mesmo e um anticorpo anti-ox40 ou porção de ligação ao antígeno do mesmo na fabricação de um medicamento, polinucleotídeo que codifica um anticorpo, vetor, e, célula hospedeira.
JP2020522556A (ja) 2017-06-09 2020-07-30 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 癌を治療するためのｉｃｏｓアゴニストおよびｏｘ４０アゴニストでの組み合わせ療法
US20230071042A1 (en) * 2019-12-18 2023-03-09 Bristo-Myers Squibb Company Bcr transgenic mice with a common leader sequence
CN118511853A (zh) 2021-03-31 2024-08-20 瑞泽恩制药公司 包含具有改善的tcrb组库多样性的人源化细胞免疫系统组分的基因修饰的小鼠

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Also Published As

Publication number Publication date
JP2005525800A (ja) 2005-09-02
US20060052585A1 (en) 2006-03-09
JP4238138B2 (ja) 2009-03-11
US20110059056A1 (en) 2011-03-10
CN100360565C (zh) 2008-01-09
NZ534205A (en) 2006-04-28
AU2002226390B2 (en) 2007-11-15
IL162111A (en) 2009-07-20
WO2003068819A1 (fr) 2003-08-21
CA2471392A1 (fr) 2003-08-21
CN1633448A (zh) 2005-06-29
AU2002226390A1 (en) 2003-09-04
US7741077B2 (en) 2010-06-22

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