IL162302A0 - Methods for producing hyaluronan ina recombinant host cell - Google Patents

Methods for producing hyaluronan ina recombinant host cell

Info

Publication number: IL162302A0
Authority: IL; Israel
Prior art keywords: udp; glucose; gene; host cell; hyaluronan synthase
Prior art date: 2001-12-21

Application number

IL16230202A

Other languages

English (en)

Original Assignee

Novozymes Biopolymer As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-21

Filing date

2002-12-20

Publication date

2005-11-20

2002-12-20 Application filed by Novozymes Biopolymer As filed Critical Novozymes Biopolymer As

2005-11-20 Publication of IL162302A0 publication Critical patent/IL162302A0/xx

Links

229920002674 hyaluronan Polymers 0.000 title abstract 4
KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 title 1
229940099552 hyaluronan Drugs 0.000 title 1
108090000320 Hyaluronan Synthases Proteins 0.000 abstract 4
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 3
102000003918 Hyaluronan Synthases Human genes 0.000 abstract 3
229960003160 hyaluronic acid Drugs 0.000 abstract 3
150000007523 nucleic acids Chemical class 0.000 abstract 3
241000193830 Bacillus <bacterium> Species 0.000 abstract 2
101710167959 Putative UTP-glucose-1-phosphate uridylyltransferase Proteins 0.000 abstract 2
108030001662 UDP-glucose 6-dehydrogenases Proteins 0.000 abstract 2
108010061048 UDPacetylglucosamine pyrophosphorylase Proteins 0.000 abstract 2
108010070600 Glucose-6-phosphate isomerase Proteins 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
102100037921 UDP-N-acetylglucosamine pyrophosphorylase Human genes 0.000 abstract 1
102100029640 UDP-glucose 6-dehydrogenase Human genes 0.000 abstract 1
102000048175 UTP-glucose-1-phosphate uridylyltransferases Human genes 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

IL16230202A 2001-12-21 2002-12-20 Methods for producing hyaluronan ina recombinant host cell IL162302A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US34264401P	2001-12-21	2001-12-21
PCT/US2002/041067 WO2003054163A2 (fr)	2001-12-21	2002-12-20	Procedes de production de hyaluronane dans une cellule hote recombinee

Publications (1)

Publication Number	Publication Date
IL162302A0 true IL162302A0 (en)	2005-11-20

Family

ID=23342668

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL16230202A IL162302A0 (en)	2001-12-21	2002-12-20	Methods for producing hyaluronan ina recombinant host cell
IL162302A IL162302A (en)	2001-12-21	2004-06-02	Methods of producing hyaluronic acid in a bacillus host cell

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL162302A IL162302A (en)	2001-12-21	2004-06-02	Methods of producing hyaluronic acid in a bacillus host cell

Country Status (18)

Country	Link
US (5)	US7811806B2 (fr)
EP (1)	EP1572895B1 (fr)
JP (1)	JP2005525091A (fr)
KR (2)	KR100885163B1 (fr)
CN (1)	CN1636052B (fr)
AT (1)	ATE502115T1 (fr)
AU (1)	AU2002366711C1 (fr)
BR (1)	BR0215220A (fr)
CA (2)	CA2471148C (fr)
CZ (1)	CZ2004765A3 (fr)
DE (1)	DE60239495D1 (fr)
DK (1)	DK1572895T3 (fr)
ES (1)	ES2362354T3 (fr)
HU (2)	HU228693B1 (fr)
IL (2)	IL162302A0 (fr)
PL (2)	PL399352A1 (fr)
RU (1)	RU2346049C2 (fr)
WO (1)	WO2003054163A2 (fr)

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EP1025211B1 (fr) *	1997-10-31	2004-12-15	The Board of Regents of The University of Oklahoma	Gene de la synthase de l'hyaluronan et utilisation de ce gene
AU2002365206B2 (en) *	2001-06-13	2008-03-20	The Board Of Regents Of The University Of Oklahoma	Hyaluronan synthase genes and expression thereof
DE60239495D1 (de) *	2001-12-21	2011-04-28	Novozymes Biopharma Dk As	Verfahren zur produktion von hyaluronan in einer rekombinanten wirtszelle
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WO2004001054A2 (fr) *	2002-06-20	2003-12-31	Novozymes Biopolymer A/S	Floculation au moyen d'un sel divalent
US7476516B2 (en) *	2002-07-26	2009-01-13	Novozymes, Inc.	Methods for producing biological substances in pigment-deficient mutants of Bacillus cells
EP2287179A3 (fr) *	2004-01-09	2011-05-18	Novozymes A/S	Expression améliorée de Bacillus YweA
CA2563173A1 (fr) *	2004-03-31	2005-10-20	Novozymes Biopolymer A/S	Methodes de production d'acide hyaluronique dans une cellule de bacille
US7002007B2 (en) *	2004-05-28	2006-02-21	Calcigen Corporation	Production of high molecular weight hyaluronates
CN101006174B (zh)	2004-06-21	2010-05-26	诺维信公司	以相同取向稳定保持的至少两个orf的多拷贝
EP1640457A1 (fr) *	2004-09-23	2006-03-29	Bayer CropScience GmbH	Procédé et moyens pour la production de hyaluronan
ES2327944T3 (es)	2004-09-23	2009-11-05	Bayer Cropscience Ag	Metodos y medios para producir hialuronano.
CN101107270B (zh) *	2004-11-24	2011-11-23	诺维信生物制药丹麦公司	用二乙烯基砜交联透明质酸的方法
US20080139501A1 (en) *	2004-12-30	2008-06-12	Novozymes Biopolymer A/S	Hyaluronic Acid Linked With a Polymer of an Alpha Hydroxy Acid
EP1696032A1 (fr) *	2005-02-23	2006-08-30	Bayer CropScience GmbH	Procédés et moyens pour la production d'hyaluronane dans les champignons
JP4639904B2 (ja)	2005-03-30	2011-02-23	チッソ株式会社	蛍光活性を有するルシフェラーゼの活性増強方法
JP4609177B2 (ja)	2005-04-28	2011-01-12	チッソ株式会社	カルシウム結合型発光蛋白質溶液の発光時間延長方法
US20060287512A1 (en) *	2005-05-04	2006-12-21	Novozymes Biopolymer A/S	Method of controlling the content of selected component(s) from polymer(s) using molecular sieve(s)
CA2620210A1 (fr) *	2005-08-25	2007-03-01	Toyo Boseki Kabushiki Kaisha	Vegetal producteur d'acide hyaluronique
EP1772052A1 (fr)	2005-10-05	2007-04-11	Bayer CropScience GmbH	Procédés et moyens améliorés pour la production d'acide hyaluronique
WO2007039314A2 (fr) *	2005-10-05	2007-04-12	Bayer Cropscience Ag	Vegetaux a production d'hyaluronan accrue
JP2007174957A (ja) *	2005-12-27	2007-07-12	Toyobo Co Ltd	ヒアルロン酸生産酵母
US20080038780A1 (en)	2006-02-15	2008-02-14	Novozymes Biopolymer A/S	Production of low molecular weight hyaluronic acid
ATE453670T1 (de) *	2006-03-14	2010-01-15	Novozymes Biopharma Dk As	Acrylierte hyaluronsäure
US8202986B2 (en)	2006-08-04	2012-06-19	Novozymes Biopolymer AIS	Branched hyaluronic acid and method of manufacture
EP2089516B1 (fr)	2006-11-29	2011-11-16	Novozymes Inc.	Procédé d'amélioration de l'introduction d'adn dans des cellules bactériennes
WO2008140615A2 (fr)	2006-12-21	2008-11-20	Novozymes, Inc.	Séquences stabilisatrices d'arn messager modifié permettant l'expression de gènes dans des cellules bactériennes
JP2010536387A (ja) *	2007-08-31	2010-12-02	ザ・ユニバーシティ・オブ・クイーンズランド	ヒアルロン酸の生産
EP2031053A1 (fr) *	2007-08-31	2009-03-04	The University Of Queensland	Production de HA
EP2036983A1 (fr) *	2007-09-12	2009-03-18	Bayer CropScience AG	Structures de liaison pour réservoirs et leur procédé de liaison
EP2222715B1 (fr) *	2007-12-19	2019-07-24	Evonik Degussa GmbH	Acide hyaluronique réticulé en émulsion
EP2376626A4 (fr)	2008-12-13	2012-10-17	Dna Microarray	Dosage de niche micro-environnementale pour criblage de cellules souches pluripotentes induites (cips)
EP2213315A1 (fr)	2009-01-30	2010-08-04	Mero S.r.L.	Hydrogel antibactérien et son utilisation en orthopédie
CN102021213B (zh) *	2009-09-17	2014-07-09	上海佰加壹医药有限公司	一种发酵生产透明质酸发酵液的方法
BR112012020309A2 (pt)	2010-03-03	2015-11-03	Novozymes As	"variante isolado de uma xilanase precursora, polinucleotídeo isolado, célula hospedeira, métodos para produzir e para obter um variante, planta transgênica, parte da planta ou célula da planta, e, métodos para degradar um material contendo xilano, para tratar uma polpa, e para produzir xilose."
IT1401498B1 (it)	2010-07-30	2013-07-26	Mero Srl	Idrogelo a base di acido ialuronico e suo uso in ortopedia
IT1402384B1 (it)	2010-09-09	2013-09-04	Fidia Farmaceutici	Processo per la produzione di acido ialuronico in escherichia coli o bacillus megaterium
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CN102911887A (zh) *	2011-08-02	2013-02-06	山东省生物药物研究院	一种利用毕赤酵母基因调控发酵生产不同分子量透明质酸的方法
AU2012300815A1 (en)	2011-09-02	2014-02-20	Novozymes Biopharma Dk A/S	Oral formulations containing hyaluronic acid for sustained drug release
DE102012201297A1 (de) *	2012-01-31	2013-08-01	Basf Se	Expressionsverfahren
CN102559559A (zh) *	2012-02-21	2012-07-11	山东福瑞达生物医药有限公司	一种芽孢杆菌及采用该菌种生产透明质酸酶的方法
JP5957096B2 (ja) *	2012-02-21	2016-07-27	ブルームエイジフリーダバイオファームカンパニーリミテッド	バチルス、ヒアルロン酸酵素、及びそれらの使用
CN104093846B (zh) *	2012-02-22	2017-03-22	诺维信公司	先进的发酵控制
WO2014100837A1 (fr)	2012-12-17	2014-06-26	Bui The Duy	Implantation assistée par ordinateur d'implants corporels
US9187576B2 (en)	2013-11-25	2015-11-17	Deuteria Biomaterials, Llc	Deuterium-enriched hyaluronan
CA2896038C (fr)	2015-07-03	2022-08-09	Glycobiosciences Inc.	Compositions de matrice polymere renfermant une concentration elevee d'hyalluonate de sodium bio-fermente et leurs utilisations
CN106755022B (zh) *	2015-11-25	2020-08-04	中国科学院大连化学物理研究所	乙酰葡萄糖胺磷酸变位酶AtAGM编码基因及其酶、制备、应用与酶活性检测方法
CN109715794A (zh)	2016-07-05	2019-05-03	诺维信公司	果胶裂解酶变体以及编码它们的多核苷酸
CN107653280B (zh) *	2016-07-25	2021-05-04	安琪酵母股份有限公司	透明质酸发酵用的组合物、培养基和方法及其应用
CN106381279B (zh) *	2016-08-29	2019-11-05	中国药科大学	一种细菌胞外多糖、其制备方法及其应用
WO2020122429A1 (fr) *	2018-12-10	2020-06-18	대화제약 주식회사	Protéine mutante de synthase d'acide hyaluronique et procédé de production d'acide hyaluronique l'utilisant
KR102135044B1 (ko) *	2018-12-10	2020-07-17	대화제약 주식회사	히알루론산 합성효소 변이 단백질 및 이를 이용한 히알루론산 생산 방법
WO2020122430A1 (fr) *	2018-12-10	2020-06-18	대화제약 주식회사	Système d'expression pour la production d'acide hyaluronique à l'aide de bactéries non pathogènes et procédé de production d'acide hyaluronique utilisant ledit système d'expression
CN110055201B (zh) *	2019-03-05	2021-05-28	江南大学	一种高产透明质酸寡糖的重组枯草芽孢杆菌的构建方法
RU2723722C1 (ru) *	2019-07-26	2020-06-17	Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех"	ТАНДЕМНЫЙ ПРОМОТОР, ФУНКЦИОНИРУЮЩИЙ В БАКТЕРИИ РОДА Bacillus, ТРАНСФОРМИРОВАННАЯ БАКТЕРИЯ РОДА Bacillus - ПРОДУЦЕНТ ЦЕЛЕВОГО ПРОДУКТА, СОДЕРЖАЩАЯ УКАЗАННЫЙ ПРОМОТОР, И СПОСОБ ПОЛУЧЕНИЯ ЦЕЛЕВОГО ПРОДУКТА С ИСПОЛЬЗОВАНИЕМ УКАЗАННОЙ БАКТЕРИИ
RU2719140C1 (ru)	2019-07-26	2020-04-17	Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех"	Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии
CN111518825B (zh) *	2020-04-30	2022-10-11	浙江工业大学	一种多基因组合表达制备蛹虫草多糖的方法
CN116897160A (zh) *	2021-02-22	2023-10-17	丹尼斯科美国公司	在色素缺陷型芽孢杆菌属细胞中产生目的蛋白的方法和组合物
CA3213227A1 (fr) *	2021-04-01	2022-10-06	Dominique Louis	Cellules recombinees produisant de l'acide hyaluronique
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EP4487834A1 (fr)	2023-07-07	2025-01-08	NuPep AS	Peptides consensus dans hya
EP4487863A1 (fr)	2023-07-07	2025-01-08	NuPep AS	Peptides consensus dans hya destinés à être utilisés dans le traitement d'articulations dégénérées
KR20250148458A (ko) *	2024-04-01	2025-10-14	씨제이제일제당 (주)	신규한 바실러스 프로모터 변이체 및 이를 이용한 단백질 생산 방법

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US6455304B1 (en) *	1994-07-01	2002-09-24	The Board Of Regents Of The University Of Oklahoma	Hyaluronate synthase gene and uses thereof
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IT1271001B (it)	1994-07-26	1997-05-26	Poli Ind Chimica Spa	Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus
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AU2002365206B2 (en) *	2001-06-13	2008-03-20	The Board Of Regents Of The University Of Oklahoma	Hyaluronan synthase genes and expression thereof
DE60239495D1 (de) *	2001-12-21	2011-04-28	Novozymes Biopharma Dk As	Verfahren zur produktion von hyaluronan in einer rekombinanten wirtszelle

2002
- 2002-12-20 DE DE60239495T patent/DE60239495D1/de not_active Expired - Lifetime
- 2002-12-20 IL IL16230202A patent/IL162302A0/xx active IP Right Grant
- 2002-12-20 EP EP02805661A patent/EP1572895B1/fr not_active Expired - Lifetime
- 2002-12-20 CA CA2471148A patent/CA2471148C/fr not_active Expired - Lifetime
- 2002-12-20 US US10/326,185 patent/US7811806B2/en not_active Expired - Lifetime
- 2002-12-20 DK DK02805661.2T patent/DK1572895T3/da active
- 2002-12-20 AU AU2002366711A patent/AU2002366711C1/en not_active Expired
- 2002-12-20 CA CA2803931A patent/CA2803931A1/fr not_active Abandoned
- 2002-12-20 KR KR1020087002156A patent/KR100885163B1/ko not_active Expired - Lifetime
- 2002-12-20 PL PL399352A patent/PL399352A1/pl unknown
- 2002-12-20 BR BRPI0215220-7A patent/BR0215220A/pt not_active Application Discontinuation
- 2002-12-20 CZ CZ2004765A patent/CZ2004765A3/cs unknown
- 2002-12-20 WO PCT/US2002/041067 patent/WO2003054163A2/fr not_active Ceased
- 2002-12-20 CN CN02828283.3A patent/CN1636052B/zh not_active Expired - Lifetime
- 2002-12-20 AT AT02805661T patent/ATE502115T1/de active
- 2002-12-20 HU HU0700154A patent/HU228693B1/hu unknown
- 2002-12-20 ES ES02805661T patent/ES2362354T3/es not_active Expired - Lifetime
- 2002-12-20 JP JP2003554868A patent/JP2005525091A/ja active Pending
- 2002-12-20 RU RU2004122420/13A patent/RU2346049C2/ru active
- 2002-12-20 PL PL375190A patent/PL212928B1/pl unknown
- 2002-12-20 KR KR1020047009883A patent/KR100879908B1/ko not_active Expired - Lifetime
2004
- 2004-06-02 IL IL162302A patent/IL162302A/en unknown
2007
- 2007-05-29 HU HUP1300136 patent/HU1300136D0/hu not_active Application Discontinuation
2010
- 2010-09-27 US US12/891,548 patent/US8093036B2/en not_active Expired - Fee Related
2011
- 2011-04-11 US US13/084,230 patent/US8137951B2/en not_active Expired - Fee Related
2012
- 2012-02-21 US US13/401,663 patent/US8574886B2/en not_active Expired - Fee Related
2013
- 2013-10-10 US US14/050,866 patent/US20140038235A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HU1300136D0 (hu)	2007-05-29
US7811806B2 (en)	2010-10-12
KR100885163B1 (ko)	2009-02-23
US20140038235A1 (en)	2014-02-06
PL375190A1 (en)	2005-11-28
US20030175902A1 (en)	2003-09-18
BR0215220A (pt)	2007-01-09
EP1572895B1 (fr)	2011-03-16
US8137951B2 (en)	2012-03-20
EP1572895A4 (fr)	2007-07-25
JP2005525091A (ja)	2005-08-25
CA2471148A1 (fr)	2003-07-03
CZ2004765A3 (cs)	2004-12-15
CN1636052A (zh)	2005-07-06
CA2471148C (fr)	2013-04-09
HU228693B1 (hu)	2013-05-28
US20120149067A1 (en)	2012-06-14
US20110189737A1 (en)	2011-08-04
US20110014662A1 (en)	2011-01-20
AU2002366711B2 (en)	2007-11-29
WO2003054163A2 (fr)	2003-07-03
KR20040085142A (ko)	2004-10-07
ATE502115T1 (de)	2011-04-15
WO2003054163A3 (fr)	2005-10-27
AU2002366711A1 (en)	2003-07-09
US8574886B2 (en)	2013-11-05
KR20080018965A (ko)	2008-02-28
KR100879908B1 (ko)	2009-01-21
DE60239495D1 (de)	2011-04-28
RU2004122420A (ru)	2005-10-10
HUP0700154A2 (en)	2007-05-29
EP1572895A2 (fr)	2005-09-14
PL399352A1 (pl)	2012-10-08
CA2803931A1 (fr)	2003-07-03
PL212928B1 (pl)	2012-12-31
DK1572895T3 (da)	2011-07-11
RU2346049C2 (ru)	2009-02-10
CN1636052B (zh)	2014-07-02
AU2002366711C1 (en)	2009-01-22
IL162302A (en)	2011-01-31
ES2362354T3 (es)	2011-07-04
US8093036B2 (en)	2012-01-10

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