IL164167A0 - 4-(N-phenylamino)-quinazolines/ quinolines as tyrosine kinase inhibitors - Google Patents
4-(N-phenylamino)-quinazolines/ quinolines as tyrosine kinase inhibitorsInfo
- Publication number
- IL164167A0 IL164167A0 IL16416703A IL16416703A IL164167A0 IL 164167 A0 IL164167 A0 IL 164167A0 IL 16416703 A IL16416703 A IL 16416703A IL 16416703 A IL16416703 A IL 16416703A IL 164167 A0 IL164167 A0 IL 164167A0
- Authority
- IL
- Israel
- Prior art keywords
- quinazolines
- quinolines
- phenylamino
- tyrosine kinase
- kinase inhibitors
- Prior art date
Links
- 229940111121 antirheumatic drug quinolines Drugs 0.000 title 1
- MTSNDBYBIZSILH-UHFFFAOYSA-N n-phenylquinazolin-4-amine Chemical class N=1C=NC2=CC=CC=C2C=1NC1=CC=CC=C1 MTSNDBYBIZSILH-UHFFFAOYSA-N 0.000 title 1
- 150000003248 quinolines Chemical class 0.000 title 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10214412A DE10214412A1 (de) | 2002-03-30 | 2002-03-30 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE2002131711 DE10231711A1 (de) | 2002-07-13 | 2002-07-13 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| PCT/EP2003/003062 WO2003082290A1 (fr) | 2002-03-30 | 2003-03-25 | 4-(n-phenylamino)-quinazolines / quinolines en tant qu'inhibiteurs de la tyrosine kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL164167A0 true IL164167A0 (en) | 2005-12-18 |
Family
ID=28676040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16416703A IL164167A0 (en) | 2002-03-30 | 2003-03-25 | 4-(N-phenylamino)-quinazolines/ quinolines as tyrosine kinase inhibitors |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1492536B1 (fr) |
| JP (1) | JP4776882B2 (fr) |
| KR (1) | KR101064530B1 (fr) |
| CN (1) | CN1642552B (fr) |
| AR (1) | AR039187A1 (fr) |
| AT (1) | ATE557008T1 (fr) |
| AU (1) | AU2003226705B2 (fr) |
| BR (1) | BR0308902A (fr) |
| CA (1) | CA2476008C (fr) |
| EA (2) | EA200701302A1 (fr) |
| HR (1) | HRP20040898A2 (fr) |
| IL (1) | IL164167A0 (fr) |
| ME (1) | MEP47208A (fr) |
| MX (1) | MXPA04009536A (fr) |
| MY (1) | MY127771A (fr) |
| NO (1) | NO329271B1 (fr) |
| NZ (1) | NZ536114A (fr) |
| PE (1) | PE20040169A1 (fr) |
| PL (1) | PL371188A1 (fr) |
| RS (1) | RS85404A (fr) |
| TW (2) | TW201024269A (fr) |
| UY (1) | UY27737A1 (fr) |
| WO (1) | WO2003082290A1 (fr) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE04748B1 (et) | 1999-06-21 | 2006-12-15 | Boehringer Ingelheim Pharma Kg | Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad ravimid, nende kasutamine ja meetodid nende valmistamiseks |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| EP2280003B1 (fr) * | 2002-07-15 | 2014-04-02 | Symphony Evolution, Inc. | Procédé pour la préparation de modulateurs de kinases de type récepteur |
| CA2527017A1 (fr) * | 2003-05-27 | 2004-12-09 | Pfizer Products Inc. | Quinazolines et pyrido[3,4-d] pyrimidines utilises comme inhibiteurs de recepteurs tyrosine kinase |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| NZ544472A (en) | 2003-07-03 | 2009-04-30 | Myriad Genetics Inc | Compounds and therapeutical use thereof |
| DE10334226A1 (de) * | 2003-07-28 | 2005-02-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
| GB0317665D0 (en) * | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
| JP2007500177A (ja) * | 2003-07-29 | 2007-01-11 | アストラゼネカ アクチボラグ | チロシンキナーゼ阻害剤としてのピペリジルキナゾリン誘導体 |
| ES2305844T3 (es) * | 2003-09-16 | 2008-11-01 | Astrazeneca Ab | Derivados de quinazolina como inhibidores de tirosina cinasa. |
| US20070032508A1 (en) * | 2003-09-16 | 2007-02-08 | Bradbury Robert H | Quinazoline derivatives as tyrosine kinase inhibitors |
| WO2005028469A1 (fr) * | 2003-09-19 | 2005-03-31 | Astrazeneca Ab | Derives de quinazoline |
| CN1882570B (zh) * | 2003-09-19 | 2010-12-08 | 阿斯利康(瑞典)有限公司 | 喹唑啉衍生物 |
| GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
| DE10345875A1 (de) * | 2003-09-30 | 2005-04-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Vewendung und Verfahren zu ihrer Herstellung |
| US7456189B2 (en) | 2003-09-30 | 2008-11-25 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
| DE10350717A1 (de) * | 2003-10-30 | 2005-06-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
| GB0326459D0 (en) | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
| ATE446750T1 (de) * | 2003-12-18 | 2009-11-15 | Janssen Pharmaceutica Nv | 3-cyano-chinolin-derivate mit antiproliferativer wirkung |
| UA83881C2 (en) | 2003-12-18 | 2008-08-26 | Янссен Фармацевтика Н.В. | Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents |
| JP5032851B2 (ja) | 2004-02-03 | 2012-09-26 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
| EP1838712B8 (fr) | 2004-12-14 | 2011-10-12 | AstraZeneca AB | Composes de pyrazolopyrimidine en tant qu`agents antitumoraux |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| CA2592900A1 (fr) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Composes et utilisation therapeutique associee |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| AU2006210175A1 (en) * | 2005-02-04 | 2006-08-10 | Boehringer Ingelheim International Gmbh | Use of tyrosine kinase inhibitors for the treatment of chronic rhinosinusitis |
| WO2006081741A1 (fr) * | 2005-02-05 | 2006-08-10 | Piaoyang Sun | Dérivés de quinazoline ou leurs sels de qualité pharmaceutique, synthèse et applications médicales desdites substances |
| MX2007010399A (es) * | 2005-02-26 | 2007-09-25 | Astrazeneca Ab | Derivados de quinazolina en la forma de inhibidores de cinasa de tirosina. |
| CA2619037A1 (fr) * | 2005-08-22 | 2007-03-01 | Boehringer Ingelheim International Gmbh | Heterocycles bicycliques, produits pharmaceutiques contenant ces composes, leur utilisation et procede pour les preparer |
| WO2007034144A1 (fr) | 2005-09-20 | 2007-03-29 | Astrazeneca Ab | Composes de 4- (ih-indazol-s-yl-amino)-quinazoline utilises comme inhibiteurs des tyrosines kinases erbb associees au recepteur pour traiter le cancer |
| CA2833706C (fr) | 2005-11-11 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Derives de quinazoline pour le traitement des affections cancereuses |
| BRPI0619603A2 (pt) * | 2005-12-12 | 2011-10-11 | Boehringer Ingelheim Int | heterociclos bicìclicos, sais fisiologicamante compatìveis, medicamentos que contêm esses compostos, bem como uso e processos para produção dos heterociclos bicìclicos |
| WO2007101782A1 (fr) * | 2006-03-09 | 2007-09-13 | Boehringer Ingelheim International Gmbh | Heterocycles bicycliques, medicaments contenant ces composes, leur utilisation et leur procede de fabrication |
| CA2654583C (fr) | 2006-07-13 | 2015-11-24 | Janssen Pharmaceutica N.V. | Derives de quinazoline de type mtki |
| EP2061772A4 (fr) * | 2006-09-11 | 2011-06-29 | Curis Inc | Petites molécules multifonctionnelles servant d'agents anti-prolifératifs |
| CN101535279B (zh) * | 2006-09-11 | 2015-05-20 | 柯瑞斯公司 | 含锌结合基的喹唑啉基egfr抑制剂 |
| AU2007299080B2 (en) | 2006-09-18 | 2013-04-18 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring EGFR mutations |
| EP1921070A1 (fr) * | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | heterocycles bicycliques, medicaments á base de ces composes, leur usage et procédé pour leur preparation |
| EP2118075A1 (fr) * | 2007-02-06 | 2009-11-18 | Boehringer Ingelheim International GmbH | Hétérocycles bicycliques, agents pharmaceutiques contenant ces composés, leur utilisation et leur procédé de préparation |
| EP1956010A1 (fr) * | 2007-02-06 | 2008-08-13 | Boehringer Ingelheim Pharma GmbH & Co. KG | Hétérocycles bicycliques, médicament contenant cette composition, son utilisation et son procédé de fabrication |
| TWI377944B (en) * | 2007-06-05 | 2012-12-01 | Hanmi Holdings Co Ltd | Novel amide derivative for inhibiting the growth of cancer cells |
| ES2562218T3 (es) | 2007-07-27 | 2016-03-03 | Janssen Pharmaceutica, N.V. | Pirrolopirimidinas útiles para el tratamiento de enfermedades proliferativas |
| CA2711582A1 (fr) * | 2008-02-07 | 2009-08-13 | Boehringer Ingelheim International Gmbh | Heterocycles spirocycliques, formules comportant lesdits composes, leur utilisation et procedes de preparation associes |
| EP2303276B1 (fr) * | 2008-05-13 | 2013-11-13 | AstraZeneca AB | Sel de fumarate de 4-(3-chloro-2-fluoroanilino)-7-méthoxy-6-{[1-(n-méthylcarbamoylméthyl)pipéridin-4-yl]oxy}quinazoline |
| EP2313398A1 (fr) * | 2008-08-08 | 2011-04-27 | Boehringer Ingelheim International GmbH | Hétérocycles à substitution cyclohexyloxy, médicaments contenant ces composés, leur utilisation et procédé pour les préparer |
| CA2733153C (fr) * | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Heterocycles a substitution cyclohexyloxy, medicaments contenant ces composes, leur utilisation et procedes pour les preparer |
| JP5611207B2 (ja) * | 2008-08-08 | 2014-10-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二環式複素環の立体選択的調製方法 |
| CN101659657B (zh) * | 2008-08-29 | 2014-05-14 | 北大方正集团有限公司 | 氰基取代的喹啉衍生物及其制备方法和用途 |
| CN101659658B (zh) * | 2008-08-29 | 2014-04-02 | 北大方正集团有限公司 | 氰基取代的喹啉衍生物 |
| CA2735875A1 (fr) * | 2008-09-03 | 2010-03-11 | Boehringer Ingelheim International Gmbh | Utilisation de derives de quinazoline pour le traitement de maladies virales |
| PL2451445T3 (pl) | 2009-07-06 | 2019-09-30 | Boehringer Ingelheim International Gmbh | Sposób suszenia BIBW2992, jego soli i stałych preparatów farmaceutycznych zawierających tę substancję czynną |
| US8916574B2 (en) | 2009-09-28 | 2014-12-23 | Qilu Pharmaceutical Co., Ltd. | 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors |
| UY33224A (es) * | 2010-02-15 | 2011-09-30 | Boehringer Ingelheim Int | Sales e hidratos de la 4-[(3-cloro-4-fluoro-fenil)amino]-6-(cis-4-{N-[(morf- 1 -olin-4-il)carbonil]-N-metil-amino}-ciclohexan-1-iloxi)-7-metoxi-quinazolina, uso y preparación |
| CN102452988B (zh) * | 2010-10-27 | 2016-01-27 | 中国科学院化学研究所 | 一种喹唑啉衍生物及其制备方法 |
| EA023573B1 (ru) | 2011-02-01 | 2016-06-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Дималеат 9-[4-(3-хлор-2-фторфениламино)-7-метоксихиназолин-6-илокси]-1,4-диазаспиро[5.5]ундекан-5-она, его применение в качестве лекарственного средства и его получение |
| KR101317809B1 (ko) | 2011-06-07 | 2013-10-16 | 한미약품 주식회사 | 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물 |
| EA201400882A1 (ru) | 2012-02-09 | 2015-01-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ стереоселективного синтеза 9-гидрокси-5-оксо-1,4-диазаспиро[5.5]ундеканов, содержащих защитные группы в 1,4-положениях |
| WO2013143057A1 (fr) | 2012-03-26 | 2013-10-03 | 中国科学院福建物质结构研究所 | Dérivé de quinazoline et son application |
| JP2015524400A (ja) | 2012-07-19 | 2015-08-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ９−［４−（３−クロロ−２−フルオロ−フェニルアミノ）−７−メトキシ−キナゾリン−６−イルオキシ］−１，４−ジアザ−スピロ［５．５］ウンデカン−５−オンのフマル酸塩、その薬物としての使用及び調製 |
| KR20140096571A (ko) | 2013-01-28 | 2014-08-06 | 한미약품 주식회사 | 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법 |
| CN105209456B (zh) * | 2013-03-06 | 2018-05-08 | 阿斯利康(瑞典)有限公司 | 表皮生长因子受体的活化突变形式的喹唑啉抑制剂 |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| TWI771327B (zh) * | 2016-10-05 | 2022-07-21 | 英商使命醫療公司 | 新穎化合物 |
| EP3962908A4 (fr) | 2019-04-25 | 2022-10-26 | Board of Regents, The University of Texas System | Inhibiteurs hétérocycliques de tyrosine kinase |
| EP4055014B1 (fr) | 2019-11-06 | 2025-04-30 | Yuhan Corporation | Composés de pyrrolidine et de pipéridine |
| CA3182410A1 (fr) * | 2020-05-04 | 2021-11-11 | Volastra Therapeutics, Inc. | Inhibiteurs imino sulfanone de l'enpp1 |
| WO2025152954A1 (fr) * | 2024-01-15 | 2025-07-24 | 上海脉博实业有限公司 | Composé de benzopyrimidine, son procédé de préparation, composition pharmaceutique et son utilisation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| GB9910577D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| DE10042058A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10042059A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
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- 2003-03-25 EP EP03745271A patent/EP1492536B1/fr not_active Expired - Lifetime
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|---|---|
| TW201024269A (en) | 2010-07-01 |
| HK1079095A1 (zh) | 2006-03-31 |
| HRP20040898A2 (en) | 2005-10-31 |
| PE20040169A1 (es) | 2004-05-24 |
| TWI331604B (en) | 2010-10-11 |
| BR0308902A (pt) | 2005-01-04 |
| JP4776882B2 (ja) | 2011-09-21 |
| MEP47208A (en) | 2011-02-10 |
| NO329271B1 (no) | 2010-09-20 |
| EA009300B1 (ru) | 2007-12-28 |
| CA2476008C (fr) | 2011-12-13 |
| PL371188A1 (en) | 2005-06-13 |
| EA200401191A1 (ru) | 2005-04-28 |
| KR101064530B1 (ko) | 2011-09-14 |
| NO20043997L (no) | 2004-10-27 |
| MXPA04009536A (es) | 2005-01-25 |
| CN1642552B (zh) | 2010-05-12 |
| CN1642552A (zh) | 2005-07-20 |
| AU2003226705A1 (en) | 2003-10-13 |
| RS85404A (sr) | 2007-02-05 |
| EP1492536A1 (fr) | 2005-01-05 |
| KR20040094898A (ko) | 2004-11-10 |
| ATE557008T1 (de) | 2012-05-15 |
| UY27737A1 (es) | 2003-10-31 |
| TW200406211A (en) | 2004-05-01 |
| WO2003082290A1 (fr) | 2003-10-09 |
| EA200701302A1 (ru) | 2007-12-28 |
| JP2005529090A (ja) | 2005-09-29 |
| AU2003226705B2 (en) | 2008-11-06 |
| AR039187A1 (es) | 2005-02-09 |
| EP1492536B1 (fr) | 2012-05-09 |
| NZ536114A (en) | 2007-11-30 |
| CA2476008A1 (fr) | 2003-10-09 |
| MY127771A (en) | 2006-12-29 |
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