IL165883A0 - Marker genes for determining renal toxicity - Google Patents
Marker genes for determining renal toxicityInfo
- Publication number
- IL165883A0 IL165883A0 IL16588304A IL16588304A IL165883A0 IL 165883 A0 IL165883 A0 IL 165883A0 IL 16588304 A IL16588304 A IL 16588304A IL 16588304 A IL16588304 A IL 16588304A IL 165883 A0 IL165883 A0 IL 165883A0
- Authority
- IL
- Israel
- Prior art keywords
- marker genes
- renal toxicity
- determining renal
- determining
- toxicity
- Prior art date
Links
- 239000003550 marker Substances 0.000 title 1
- 231100000417 nephrotoxicity Toxicity 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0215509.1A GB0215509D0 (en) | 2002-07-04 | 2002-07-04 | Marker genes |
| PCT/EP2003/007111 WO2004005544A2 (en) | 2002-07-04 | 2003-07-03 | Marker genes for determining renal toxicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL165883A0 true IL165883A0 (en) | 2006-01-15 |
Family
ID=9939850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16588304A IL165883A0 (en) | 2002-07-04 | 2004-12-20 | Marker genes for determining renal toxicity |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060008804A1 (de) |
| EP (2) | EP1925677A3 (de) |
| JP (2) | JP2005531321A (de) |
| CN (1) | CN1688715A (de) |
| AU (1) | AU2003250879B2 (de) |
| BR (1) | BR0312405A (de) |
| CA (1) | CA2493860A1 (de) |
| GB (1) | GB0215509D0 (de) |
| IL (1) | IL165883A0 (de) |
| WO (1) | WO2004005544A2 (de) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE425249T1 (de) | 2000-06-16 | 2009-03-15 | Biogen Idec Inc | Renale regulatorische elemente und deren verwendung |
| DK1401869T3 (da) | 2001-06-01 | 2008-04-28 | Biogen Idec Inc | Molekyler og fremgangsmåder til inhibering af udskillkelse af kim 1 |
| EP2025345A1 (de) | 2002-12-30 | 2009-02-18 | Biogen Idec MA Inc. | KIM-1-Antagonisten und ihre Verwendung zur Immunsystemmodulation |
| CA2565701A1 (en) * | 2004-05-06 | 2005-11-17 | Jonathan M. Barasch | Ngal for reduction and amelioration of ischemic and nephrotoxic injuries |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| ES2818028T3 (es) * | 2004-12-20 | 2021-04-09 | Antibodyshop As | Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales |
| KR101213894B1 (ko) | 2005-03-02 | 2012-12-20 | 바이오겐 아이덱 엠에이 인코포레이티드 | Th2 매개성 병태를 치료하기 위한 kim-1 항체 |
| US20070037232A1 (en) * | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
| US20070087387A1 (en) | 2005-04-21 | 2007-04-19 | Prasad Devarajan | Method for the Early Detection of Renal Disease Using Proteomics |
| US7700299B2 (en) * | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
| US20080090304A1 (en) * | 2006-10-13 | 2008-04-17 | Barasch Jonathan Matthew | Diagnosis and monitoring of chronic renal disease using ngal |
| PL2035835T3 (pl) | 2006-05-30 | 2012-05-31 | Antibodyshop As | Sposoby szybkiej oceny ciężkości urazu |
| WO2008017306A1 (en) * | 2006-08-07 | 2008-02-14 | Antibodyshop A/S | Diagnostic test to exclude significant renal injury |
| WO2008113363A1 (en) | 2007-03-21 | 2008-09-25 | Bioporto Diagnostics A/S | Diagnostic test for renal injury |
| CN103399155A (zh) * | 2007-03-26 | 2013-11-20 | 诺瓦提斯公司 | 用于监测肾功能的预测性的肾安全性生物标志物和生物标志物标签 |
| US20090104649A1 (en) | 2007-06-11 | 2009-04-23 | Garovic Vesna D | Markers for preeclampsia |
| US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
| ES2475990T5 (es) * | 2007-11-15 | 2017-07-06 | Bioporto Diagnostics A/S | Uso diagnóstico de formas moleculares individuales de un biomarcador |
| EP2075343A1 (de) * | 2007-12-21 | 2009-07-01 | Gert Mayer | Verfahren zur Diagnose einer fortschreitenden Erkrankung |
| EP2279270B1 (de) * | 2008-04-15 | 2014-06-18 | Oberbauer, Rainer | Marker für akutes nierenversagen |
| US7977110B2 (en) | 2008-06-02 | 2011-07-12 | Children's Hospital Medical Center | Method for distinguishing between kidney dysfunctions |
| ES2341419B1 (es) * | 2008-08-14 | 2011-05-03 | Hospital Clinic I Provincial De Barcelona | Wnt1 como biomarcador de daño renal. |
| JP2012508177A (ja) * | 2008-11-05 | 2012-04-05 | アボット・ラボラトリーズ | 尿および組換えチャイニーズハムスター卵巣(cho)細胞から濃縮された好中球ゼラチナーゼ関連リポカリン(ngal)タンパク質アイソフォーム、ならびに関連する組成物、抗体、ならびに濃縮、分析および使用の方法 |
| CN102264230B (zh) * | 2008-11-10 | 2014-12-10 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| MX2011005379A (es) * | 2008-11-22 | 2011-06-09 | Astute Medical Inc | Metodos y composiciones para diagnosis y prognosis de lesion renal y falla renal. |
| CN102301008B (zh) * | 2009-01-19 | 2015-05-13 | 生物梅里埃公司 | 用于确定患者发生医院内感染的易感性以及确立败血性综合征进展的预后的方法 |
| PT2391653E (pt) | 2009-01-28 | 2015-02-13 | Ind Tech Res Inst | Biomarcadores associados a nefropatia |
| US20110065599A1 (en) * | 2009-08-07 | 2011-03-17 | Rules-Based Medicine, Inc. | Methods and Devices for Detecting Kidney Damage |
| WO2011084791A2 (en) * | 2009-12-21 | 2011-07-14 | Mayo Foundation For Medical Education And Research | Early marker of proteinuria in patients treated with an anti-vegf treatment |
| EP2517020B1 (de) | 2009-12-23 | 2015-10-21 | Hill's Pet Nutrition, Inc. | Zusammensetzungen und verfahren zur diagnostizierung und behandlung von nierenerkrankungen bei hunden |
| WO2011149962A1 (en) | 2010-05-24 | 2011-12-01 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625189B1 (de) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Manipulierte nukleinsäuren und anwendungsverfahren dafür |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| JP5804629B2 (ja) * | 2011-07-29 | 2015-11-04 | 株式会社メディクローム | 遺伝子発現変動解析による化学物質の毒性評価方法 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CN106018783A (zh) * | 2011-09-14 | 2016-10-12 | 巴斯夫欧洲公司 | 用于评估肾毒性的手段和方法 |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| SI2912165T1 (sl) * | 2012-10-24 | 2019-11-29 | Inregen | Populacije ledvičnih celic in njihova uporaba |
| EP2925337B1 (de) | 2012-11-21 | 2019-07-03 | The Trustees of Columbia University in the City of New York | Mutante ngal-proteine und verwendungen davon |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| US10420337B2 (en) | 2013-03-15 | 2019-09-24 | Lifeline Scientific, Inc. | Transporter with a glucose sensor for determining viability of an organ or tissue |
| EP2971165A4 (de) | 2013-03-15 | 2016-11-23 | Moderna Therapeutics Inc | Entfernung von dna-fragmenten in mrna-herstellungsverfahren |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2014182330A1 (en) | 2013-05-06 | 2014-11-13 | Hitachi Chemical Company Ltd | Devices and methods for capturing target molecules |
| EP3052521A1 (de) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynukleotide zur codierung von low-density-lipoprotein-rezeptor |
| WO2015153860A1 (en) * | 2014-04-04 | 2015-10-08 | Somalogic, Inc. | Glomerular filtration rate biomarkers and uses thereof |
| WO2015160805A1 (en) * | 2014-04-15 | 2015-10-22 | The Brigham And Women's Hospital, Inc. | Circulating kim-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney |
| US10712349B2 (en) | 2014-04-15 | 2020-07-14 | The Brigham And Women's Hospital, Inc. | Circulating KIM-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney |
| EP3189164B1 (de) | 2014-09-05 | 2021-11-10 | American University Of Beirut | Bestimmung des risikos der entwicklung einer kardiovaskulären krankheit durch messung der konzentrationen von podocin und nephrin-mrna im harn |
| EP3218521B1 (de) * | 2014-11-12 | 2019-12-25 | Hitachi Chemical Co., Ltd. | Verfahren zur diagnose von organverletzung |
| WO2016208776A1 (ja) | 2015-06-25 | 2016-12-29 | 株式会社国際電気通信基礎技術研究所 | 多器官連関システムを基盤とした予測装置、及び予測プログラム |
| DE112016003948T5 (de) | 2015-08-31 | 2018-05-09 | City Of Sapporo | Molekulare verfahren zum beurteilen einer urothelialen erkrankung |
| JP6432962B2 (ja) | 2016-03-29 | 2018-12-05 | 株式会社国際電気通信基礎技術研究所 | 腎機能低下、慢性腎疾患及び腎不全からなる群から選択される少なくとも一種の疾患を予防、又は治療するための有効成分の候補物質のスクリーニング方法 |
| EP3466446B1 (de) | 2016-03-29 | 2023-12-27 | Karydo Therapeutix, Inc. | Pharmazeutische zusammensetzung oder nahrungsmittelzusammensetzung und verfahren zur beurteilung der wirkung eines wirkstoffs in vivo |
| JP7012033B2 (ja) * | 2016-06-17 | 2022-02-10 | エフ.ホフマン-ラ ロシュ アーゲー | インビトロ腎毒性スクリーニングアッセイ |
| EP3695224A4 (de) * | 2017-10-12 | 2021-12-29 | Cedars-Sinai Medical Center | Prognose- und progressionsbiomarker für chronische nierenkrankheit |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA951461B (en) * | 1994-02-22 | 1996-01-24 | Univ Illinois | Genes and genetic elements associated with sensitivity to platimun-based drugs |
| US6586389B1 (en) * | 1998-01-22 | 2003-07-01 | Administrators Of The Tulane Educational Fund | Cubilin protein, DNA sequences encoding cubilin and uses thereof |
| CA2340589A1 (en) * | 1998-08-28 | 2000-03-09 | Incyte Pharmaceuticals, Inc. | Toxicological response markers |
| WO2000047761A2 (en) * | 1999-02-12 | 2000-08-17 | Phase-1 Molecular Toxicology, Inc. | High-throughput toxicological testing using cultured organisms and cells |
| US20010034023A1 (en) * | 1999-04-26 | 2001-10-25 | Stanton Vincent P. | Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing |
| WO2001032928A2 (en) * | 1999-11-05 | 2001-05-10 | Phase-1 Molecular Toxicology | Methods of determining individual hypersensitivity to an agent |
| US20020037508A1 (en) * | 2000-01-19 | 2002-03-28 | Michele Cargill | Human single nucleotide polymorphisms |
| ATE425249T1 (de) * | 2000-06-16 | 2009-03-15 | Biogen Idec Inc | Renale regulatorische elemente und deren verwendung |
| EP1356093A2 (de) * | 2000-06-21 | 2003-10-29 | Hitachi Chemical Co., Ltd. | Genmarker für lungenkrebs |
| US20020142284A1 (en) * | 2000-07-13 | 2002-10-03 | Debasish Raha | Methods of identifying renal protective factors |
| CA2395781C (en) * | 2000-07-13 | 2010-04-13 | The Johns Hopkins University School Of Medicine | Detection and treatment of polycystic kidney disease |
| CA2414421A1 (en) * | 2000-07-31 | 2002-02-07 | Gene Logic, Inc. | Molecular toxicology modeling |
| DE10056802B4 (de) * | 2000-11-14 | 2005-06-16 | Epigenomics Ag | Verfahren zur Detektion von Methylierungszuständen zur toxikologischen Diagnostik |
| WO2002066682A2 (en) * | 2001-01-29 | 2002-08-29 | Phase-1 Molecular Toxicology, Inc. | Rat toxicologically relevant genes and uses thereof |
-
2002
- 2002-07-04 GB GBGB0215509.1A patent/GB0215509D0/en not_active Ceased
-
2003
- 2003-07-03 AU AU2003250879A patent/AU2003250879B2/en not_active Ceased
- 2003-07-03 JP JP2004518691A patent/JP2005531321A/ja active Pending
- 2003-07-03 BR BR0312405-3A patent/BR0312405A/pt not_active IP Right Cessation
- 2003-07-03 CN CNA038187833A patent/CN1688715A/zh active Pending
- 2003-07-03 EP EP07119607A patent/EP1925677A3/de not_active Withdrawn
- 2003-07-03 CA CA002493860A patent/CA2493860A1/en not_active Abandoned
- 2003-07-03 WO PCT/EP2003/007111 patent/WO2004005544A2/en not_active Ceased
- 2003-07-03 EP EP03762612A patent/EP1521847A2/de not_active Withdrawn
- 2003-07-03 US US10/518,575 patent/US20060008804A1/en not_active Abandoned
-
2004
- 2004-12-20 IL IL16588304A patent/IL165883A0/xx unknown
-
2009
- 2009-10-07 JP JP2009233624A patent/JP2010042019A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR0312405A (pt) | 2005-04-26 |
| JP2010042019A (ja) | 2010-02-25 |
| WO2004005544A3 (en) | 2004-04-22 |
| EP1925677A3 (de) | 2008-07-02 |
| US20060008804A1 (en) | 2006-01-12 |
| EP1925677A2 (de) | 2008-05-28 |
| AU2003250879A1 (en) | 2004-01-23 |
| AU2003250879B2 (en) | 2007-07-26 |
| GB0215509D0 (en) | 2002-08-14 |
| EP1521847A2 (de) | 2005-04-13 |
| CN1688715A (zh) | 2005-10-26 |
| CA2493860A1 (en) | 2004-01-15 |
| WO2004005544A2 (en) | 2004-01-15 |
| JP2005531321A (ja) | 2005-10-20 |
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