IL166621A0 - Polymorph of n-methyl-n-(3-ä-3-Ä2-thienylcarbonylÜ-pyrazol-Ä1,5-alphaÜpyrimidin-7-ylüacetamide and pharmaceutical compositions containing the same - Google Patents

Polymorph of n-methyl-n-(3-ä-3-Ä2-thienylcarbonylÜ-pyrazol-Ä1,5-alphaÜpyrimidin-7-ylüacetamide and pharmaceutical compositions containing the same

Info

Publication number: IL166621A0
Authority: IL; Israel
Prior art keywords: ylüacetamide; thienylcarbonylü; alphaüpyrimidin; polymorph; pyrazol
Prior art date: 2002-08-26

Application number

IL16662103A

Other languages

English (en)

Original Assignee

Neurocrine Biosciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-26

Filing date

2003-08-26

Publication date

2006-01-15

2003-08-26 Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc

2006-01-15 Publication of IL166621A0 publication Critical patent/IL166621A0/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)

IL16662103A 2002-08-26 2003-08-26 Polymorph of n-methyl-n-(3-ä-3-Ä2-thienylcarbonylÜ-pyrazol-Ä1,5-alphaÜpyrimidin-7-ylüacetamide and pharmaceutical compositions containing the same IL166621A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40607202P	2002-08-26	2002-08-26
PCT/US2003/026870 WO2004018476A1 (en)	2002-08-26	2003-08-26	Novel polymorph of n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto

Publications (1)

Publication Number	Publication Date
IL166621A0 true IL166621A0 (en)	2006-01-15

Family

ID=31946959

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL16662103A IL166621A0 (en)	2002-08-26	2003-08-26	Polymorph of n-methyl-n-(3-ä-3-Ä2-thienylcarbonylÜ-pyrazol-Ä1,5-alphaÜpyrimidin-7-ylüacetamide and pharmaceutical compositions containing the same
IL166621A IL166621A (en)	2002-08-26	2005-02-01	POLYMORPH OF N-METHYL-N-(3-{3-[2-THIENYLCARBONYL]-PYRAZOL-[1,5-a]PYRIMIDIN-7-YL}PHENYL) ACETAMIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL166621A IL166621A (en)	2002-08-26	2005-02-01	POLYMORPH OF N-METHYL-N-(3-{3-[2-THIENYLCARBONYL]-PYRAZOL-[1,5-a]PYRIMIDIN-7-YL}PHENYL) ACETAMIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Country Status (31)

Country	Link
US (2)	US6903106B2 (de)
EP (1)	EP1532152B1 (de)
JP (2)	JP4522859B2 (de)
KR (1)	KR101063033B1 (de)
CN (1)	CN1319974C (de)
AP (1)	AP2005003220A0 (de)
AR (1)	AR044191A1 (de)
AT (1)	ATE343581T1 (de)
AU (1)	AU2003268212B2 (de)
BR (1)	BR0313695A (de)
CA (1)	CA2493359C (de)
DE (1)	DE60309332T2 (de)
DK (1)	DK1532152T3 (de)
EA (1)	EA200500421A1 (de)
EC (1)	ECSP055703A (de)
ES (1)	ES2274260T3 (de)
HR (1)	HRP20050288A2 (de)
IL (2)	IL166621A0 (de)
IS (1)	IS7769A (de)
MA (1)	MA27519A1 (de)
MX (1)	MXPA05002251A (de)
NO (1)	NO20050615L (de)
NZ (1)	NZ538027A (de)
OA (1)	OA12917A (de)
PE (1)	PE20040979A1 (de)
PL (1)	PL374436A1 (de)
PT (1)	PT1532152E (de)
TN (1)	TNSN05058A1 (de)
TW (1)	TWI288135B (de)
WO (1)	WO2004018476A1 (de)
ZA (1)	ZA200501125B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE343581T1 (de) *	2002-08-26	2006-11-15	Neurocrine Biosciences Inc	Polymorph von n-methyl-n-(3- 3- 2-[thienylcarbonylö-pyrazol-[1,5-alphaö-pyrimidin- - yl phenyl)acetamid und zusammensetzungen sowie verfahren hierzu
US7429596B2 (en) *	2003-06-20	2008-09-30	The Regents Of The University Of California	1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
TW200630368A (en) *	2004-10-18	2006-09-01	Neurocrine Biosciences Inc	Hydrate of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and processes and methods related thereto
CN100528875C (zh) *	2005-02-18	2009-08-19	美德（江西）生物科技有限公司	无结晶型态的印地普隆及其制备方法
EP1918290A1 (de) *	2006-10-11	2008-05-07	Ferrer Internacional, S.A.	Polymprph B von N-{2-Fluor-5-[3-(thiophen-2-carbonyl)-pyrazolo[1,5-a]pyrimidin-7-yl]phenyl}-N-methyl-acetamid
EP1956021A1 (de) *	2006-10-11	2008-08-13	Ferrer Internacional, S.A.	Verfahren zur Herstellung von Crystallin pyrazol[1,5-a]pyrimidin Verbindung
CN101177427B (zh) *	2006-11-09	2011-07-20	中国人民解放军军事医学科学院放射与辐射医学研究所	一种用于催眠的化合物的多晶型α和溶剂化物,其制备方法及含该物质的组合物
CN102180879B (zh) *	2006-11-09	2013-05-01	中国人民解放军军事医学科学院放射与辐射医学研究所	一种催眠药的多晶型α的乙酸溶剂化物
AT507187B1 (de)	2008-10-23	2010-03-15	Helmut Dr Buchberger	Inhalator
JP5542238B2 (ja)	2010-03-25	2014-07-09	矢崎総業株式会社	ジョイントコネクタ及びジョイントコネクタにおけるバスバーパターン識別方法
ES2581452T3 (es) *	2010-04-16	2016-09-05	Ivoclar Vivadent Ag	Vitrocerámica y vidrio de silicato de litio con óxido de metal de transición
AT510837B1 (de)	2011-07-27	2012-07-15	Helmut Dr Buchberger	Inhalatorkomponente
CA2824970C (en)	2011-02-11	2016-05-03	Batmark Limited	Inhaler component
CN102174048B (zh) *	2011-03-08	2014-09-17	中国人民解放军军事医学科学院放射与辐射医学研究所	一种催眠药的新多晶型β
PL2753202T3 (pl)	2011-09-06	2016-11-30		Podgrzewanie materiału przeznaczonego do palenia
GB201207039D0 (en)	2012-04-23	2012-06-06	British American Tobacco Co	Heating smokeable material
GB2533135B (en)	2014-12-11	2020-11-11	Nicoventures Holdings Ltd	Aerosol provision systems
GB201511349D0 (en)	2015-06-29	2015-08-12	Nicoventures Holdings Ltd	Electronic aerosol provision systems
GB201511361D0 (en)	2015-06-29	2015-08-12	Nicoventures Holdings Ltd	Electronic vapour provision system
US20170055584A1 (en)	2015-08-31	2017-03-02	British American Tobacco (Investments) Limited	Article for use with apparatus for heating smokable material
US11924930B2 (en)	2015-08-31	2024-03-05	Nicoventures Trading Limited	Article for use with apparatus for heating smokable material
GB2542838B (en)	2015-10-01	2022-01-12	Nicoventures Trading Ltd	Aerosol provision system
US20170119046A1 (en)	2015-10-30	2017-05-04	British American Tobacco (Investments) Limited	Apparatus for Heating Smokable Material
US11744964B2 (en)	2016-04-27	2023-09-05	Nicoventures Trading Limited	Electronic aerosol provision system and vaporizer therefor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6472528B1 (en)	1999-08-10	2002-10-29	Neurocrine Biosciences, Inc.	Synthesis of substituted pyrazolopyrimidines
US6399621B1 (en) *	1999-08-10	2002-06-04	American Cyanamid Company	N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6485746B1 (en)	2000-08-25	2002-11-26	Neurocrine Biosciences, Inc.	Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) *	1999-09-02	2002-05-07	Neurocrine Biosciences, Inc.	Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
DE60011638T2 (de) *	1999-09-02	2004-10-21	Neurocrine Biosciences Inc	POLYMORPHE DES N-METHYL-N-(3-(2-THIENYLCARBONYL)-PYRAZOL[1,5-a]PYRIMIDIN-7-YL PHENYL)ACETAMID UND ZUSAMMENSTELLUNGEN UND DIESBEZÜGLICHE METHODEN
JP2001177971A (ja) *	1999-12-20	2001-06-29	Auto Network Gijutsu Kenkyusho:Kk	回転接続装置
ATE343581T1 (de) *	2002-08-26	2006-11-15	Neurocrine Biosciences Inc	Polymorph von n-methyl-n-(3- 3- 2-[thienylcarbonylö-pyrazol-[1,5-alphaö-pyrimidin- - yl phenyl)acetamid und zusammensetzungen sowie verfahren hierzu

2003
- 2003-08-26 AT AT03749163T patent/ATE343581T1/de active
- 2003-08-26 HR HR20050288A patent/HRP20050288A2/xx not_active Application Discontinuation
- 2003-08-26 JP JP2004531248A patent/JP4522859B2/ja not_active Expired - Fee Related
- 2003-08-26 EA EA200500421A patent/EA200500421A1/ru unknown
- 2003-08-26 PT PT03749163T patent/PT1532152E/pt unknown
- 2003-08-26 TW TW092123478A patent/TWI288135B/zh not_active IP Right Cessation
- 2003-08-26 AU AU2003268212A patent/AU2003268212B2/en not_active Ceased
- 2003-08-26 DK DK03749163T patent/DK1532152T3/da active
- 2003-08-26 ES ES03749163T patent/ES2274260T3/es not_active Expired - Lifetime
- 2003-08-26 PL PL03374436A patent/PL374436A1/xx not_active Application Discontinuation
- 2003-08-26 DE DE60309332T patent/DE60309332T2/de not_active Expired - Lifetime
- 2003-08-26 PE PE2003000867A patent/PE20040979A1/es not_active Application Discontinuation
- 2003-08-26 IL IL16662103A patent/IL166621A0/xx unknown
- 2003-08-26 MX MXPA05002251A patent/MXPA05002251A/es active IP Right Grant
- 2003-08-26 EP EP03749163A patent/EP1532152B1/de not_active Expired - Lifetime
- 2003-08-26 US US10/648,812 patent/US6903106B2/en not_active Expired - Lifetime
- 2003-08-26 CN CNB03820245XA patent/CN1319974C/zh not_active Expired - Fee Related
- 2003-08-26 WO PCT/US2003/026870 patent/WO2004018476A1/en not_active Ceased
- 2003-08-26 AP AP2005003220A patent/AP2005003220A0/xx unknown
- 2003-08-26 KR KR1020057003193A patent/KR101063033B1/ko not_active Expired - Fee Related
- 2003-08-26 NZ NZ538027A patent/NZ538027A/en not_active IP Right Cessation
- 2003-08-26 CA CA002493359A patent/CA2493359C/en not_active Expired - Lifetime
- 2003-08-26 BR BR0313695-7A patent/BR0313695A/pt not_active Application Discontinuation
- 2003-08-26 OA OA1200500060A patent/OA12917A/en unknown
- 2003-08-27 AR ARP030103086A patent/AR044191A1/es not_active Application Discontinuation
2004
- 2004-12-15 US US11/013,308 patent/US7459458B2/en not_active Expired - Lifetime
2005
- 2005-02-01 IL IL166621A patent/IL166621A/en active IP Right Review Request
- 2005-02-03 NO NO20050615A patent/NO20050615L/no not_active Application Discontinuation
- 2005-02-08 ZA ZA200501125A patent/ZA200501125B/en unknown
- 2005-02-25 TN TNP2005000058A patent/TNSN05058A1/en unknown
- 2005-02-25 MA MA28122A patent/MA27519A1/fr unknown
- 2005-03-23 EC EC2005005703A patent/ECSP055703A/es unknown
- 2005-03-23 IS IS7769A patent/IS7769A/is unknown
2009
- 2009-12-22 JP JP2009291164A patent/JP2010070561A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
WO2004018476A1 (en)	2004-03-04
DE60309332T2 (de)	2007-05-24
CA2493359A1 (en)	2004-03-04
EA200500421A1 (ru)	2005-08-25
OA12917A (en)	2006-10-13
EP1532152A1 (de)	2005-05-25
ES2274260T3 (es)	2007-05-16
AU2003268212A1 (en)	2004-03-11
AU2003268212B2 (en)	2008-08-14
KR20050059082A (ko)	2005-06-17
CN1319974C (zh)	2007-06-06
JP2005538149A (ja)	2005-12-15
HRP20050288A2 (en)	2006-10-31
AP2005003220A0 (en)	2005-03-31
EP1532152B1 (de)	2006-10-25
PT1532152E (pt)	2007-02-28
MXPA05002251A (es)	2005-06-08
PL374436A1 (en)	2005-10-17
TWI288135B (en)	2007-10-11
KR101063033B1 (ko)	2011-09-07
BR0313695A (pt)	2005-06-21
PE20040979A1 (es)	2005-01-07
US20050153988A1 (en)	2005-07-14
ECSP055703A (es)	2005-05-30
NO20050615L (no)	2005-03-22
TNSN05058A1 (en)	2007-05-14
IL166621A (en)	2012-02-29
US7459458B2 (en)	2008-12-02
DE60309332D1 (de)	2006-12-07
JP2010070561A (ja)	2010-04-02
US20040116446A1 (en)	2004-06-17
HK1071373A1 (en)	2005-07-15
JP4522859B2 (ja)	2010-08-11
NZ538027A (en)	2007-08-31
CN1678614A (zh)	2005-10-05
DK1532152T3 (da)	2007-02-26
IS7769A (is)	2005-03-23
ZA200501125B (en)	2006-07-26
AR044191A1 (es)	2005-09-07
US6903106B2 (en)	2005-06-07
TW200406404A (en)	2004-05-01
CA2493359C (en)	2009-10-27
MA27519A1 (fr)	2005-09-01
ATE343581T1 (de)	2006-11-15

Publication	Publication Date	Title
IL166621A0 (en)	2006-01-15	Polymorph of n-methyl-n-(3-ä-3-Ä2-thienylcarbonylÜ-pyrazol-Ä1,5-alphaÜpyrimidin-7-ylüacetamide and pharmaceutical compositions containing the same
IL190218A0 (en)	2008-11-03	Novel compounds, pharmaceutical compositions containing same, and methods of use for same
IL164798A0 (en)	2005-12-18	Benzothiadiazepine derivatives, processes for their preparation and pharmaceutical compositions containing them
IL162548A0 (en)	2005-11-20	4-Oxoquinoline derivatives and pharmaceutical compositions containing the same
IL173602A0 (en)	2006-07-05	Heteroarylaminosulfonylphenyl derivatives and pharmaceutical compositions containing the same
IL173627A0 (en)	2006-07-05	2-amido-4-aryloxy-1-carbonylpyrrolidine derivatives and pharmaceutical compositions containing the same
AU2002363236A1 (en)	2003-05-12	Compounds, pharmaceutical compositions and methods of use therefor
AU2003246810A1 (en)	2003-10-20	Diphenylpyridine derivatives, the preparation thereof, and pharmaceutical compositions containing said derivatives
IL165977A (en)	2010-12-30	Substituted pyrimidinylaminobenzamides , process for the preparation thereof and pharmaceutical compositions comprising the same
IL163366A (en)	2010-11-30	Glucocorticoid mimetics, pharmaceutical compositions thereof and uses thereof for the preparation of pharmaceutical compositions
IL166482A0 (en)	2006-01-15	Dihydropyrazolopyridine derivatives and pharmaceutical compositions containing the same
IL173051A0 (en)	2006-06-11	N-glucoside derivatives and pharmaceutical compositions containing the same
IL173639A0 (en)	2006-07-05	Ppar-activating compound and pharmaceutical composition containing same
IL171997A0 (en)	2011-08-01	Pyrrolodihydroisoquinoline derivatives and pharmaceutical compositions containing the same
AU2003291103A8 (en)	2004-06-15	Pharmaceutical composition
IL175214A0 (en)	2006-09-05	2-cyanopyrrolidinecarboxamide derivatives and pharmaceutical compositions containing the same
HUP0401898A3 (en)	2005-08-29	3-substituted-4-pyrimidone derivatives, pharmaceutical compositions containing them and their intermediates
HUP0401900A3 (en)	2005-08-29	3-substituted-4-pyrimidone derivatives, pharmaceutical compositions containing them and their intermediates
IL164547A0 (en)	2005-12-18	Pharmaceutical composition
IL172159A0 (en)	2006-04-10	2-oxo-pyridine derivatives and pharmaceutical compositions containing the same
IL158898A0 (en)	2004-05-12	PHARMACEUTICAL COMPOSITIONS CONTAINING APOMORPHINE, 6aR-(-)-N-PROPYL-NORAPOMORPHINE AND DERIVATIVES THEREOF
AU2003250372A8 (en)	2004-01-06	Pharmaceutical composition
ZA200500203B (en)	2009-09-30	Novel compounds, pharmaceutical compositions containing same, and methods of use for same
IL181216A0 (en)	2007-07-04	3, 5-seco-4-norcholestane derivatives and pharmaceutical compositions containing the same
PL374761A1 (en)	2005-10-31	N-benzodioxolyl, n-benzodioxanyl and n-benzodioxepinyl arylcarbonxamide derivatives, and pharmaceutical compositions comprising them