IL166628A0 - Dehydrophenyl lahistins and analogs thereof and the synthesis of dehydrophenyllahistins and analogs thereof - Google Patents
Dehydrophenyl lahistins and analogs thereof and the synthesis of dehydrophenyllahistins and analogs thereofInfo
- Publication number
- IL166628A0 IL166628A0 IL16662803A IL16662803A IL166628A0 IL 166628 A0 IL166628 A0 IL 166628A0 IL 16662803 A IL16662803 A IL 16662803A IL 16662803 A IL16662803 A IL 16662803A IL 166628 A0 IL166628 A0 IL 166628A0
- Authority
- IL
- Israel
- Prior art keywords
- sub
- analogs
- aldehyde
- lahistins
- dehydrophenyllahistins
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 150000001299 aldehydes Chemical class 0.000 abstract 4
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 abstract 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- TYHOSUCCUICRLM-UHFFFAOYSA-N 1,3-oxazole-2-carbaldehyde Chemical compound O=CC1=NC=CO1 TYHOSUCCUICRLM-UHFFFAOYSA-N 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000003935 benzaldehydes Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40107402P | 2002-08-02 | 2002-08-02 | |
| US41112802P | 2002-09-16 | 2002-09-16 | |
| US45006303P | 2003-02-24 | 2003-02-24 | |
| PCT/US2003/024232 WO2004054498A2 (fr) | 2002-08-02 | 2003-08-01 | Deshydrophenylahistines et analogues de ceux-ci et synthese de ces deshydrophenylahistines et d'analogues de ceux-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL166628A0 true IL166628A0 (en) | 2006-01-15 |
Family
ID=32600863
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16662803A IL166628A0 (en) | 2002-08-02 | 2003-08-01 | Dehydrophenyl lahistins and analogs thereof and the synthesis of dehydrophenyllahistins and analogs thereof |
| IL166628A IL166628A (en) | 2002-08-02 | 2005-02-01 | Dehydrophenylahistins and analogs thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL166628A IL166628A (en) | 2002-08-02 | 2005-02-01 | Dehydrophenylahistins and analogs thereof |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US7064201B2 (fr) |
| EP (1) | EP1529044B1 (fr) |
| JP (1) | JP4616649B2 (fr) |
| KR (2) | KR101184374B1 (fr) |
| CN (1) | CN100540548C (fr) |
| AT (1) | ATE374767T1 (fr) |
| AU (1) | AU2003302721B2 (fr) |
| BR (2) | BR0313363A (fr) |
| CA (1) | CA2494049C (fr) |
| CO (1) | CO5721010A2 (fr) |
| DE (1) | DE60316688T2 (fr) |
| DK (1) | DK1529044T5 (fr) |
| ES (1) | ES2295695T3 (fr) |
| IL (2) | IL166628A0 (fr) |
| MX (1) | MXPA05001217A (fr) |
| NZ (1) | NZ538433A (fr) |
| PT (1) | PT1529044E (fr) |
| WO (1) | WO2004054498A2 (fr) |
| ZA (1) | ZA200501616B (fr) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7026322B2 (en) | 1998-11-12 | 2006-04-11 | Nereus Pharmaceuticals, Inc. | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds |
| CA2403790C (fr) * | 2000-01-18 | 2011-09-27 | Nereus Pharmaceuticals, Inc. | Inhibiteurs de la division cellulaire et procede de production de ces inhibiteurs |
| AU2001279313B2 (en) | 2000-08-04 | 2007-03-01 | Ampio Pharmaceuticals, Inc. | Method of using diketopiperazines and composition containing them |
| US7935704B2 (en) | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| DE60316688T2 (de) | 2002-08-02 | 2008-07-17 | Nereus Pharmaceuticals, Inc., San Diego | Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon |
| ATE520981T1 (de) | 2002-10-02 | 2011-09-15 | Dmi Biosciences Inc | Diagnose und überwachung von krankheiten |
| CA3050734A1 (fr) | 2003-05-15 | 2004-12-02 | Ampio Pharmaceuticals, Inc. | Traitement de maladies a mediation des lymphocytes t |
| WO2005077940A1 (fr) * | 2004-02-04 | 2005-08-25 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistines et leurs analogues et la synthese des dehydrophenylahistines et de leurs analogues |
| JP2008522984A (ja) * | 2004-12-06 | 2008-07-03 | ニューサウス イノベイションズ ピーティーワイ リミテッド | 癌の処置 |
| WO2006105051A2 (fr) | 2005-03-29 | 2006-10-05 | Nereus Pharmaceuticals, Inc. | Synthese de dicetopiperazines |
| JP2008024871A (ja) * | 2006-07-24 | 2008-02-07 | Fujifilm Corp | インク組成物、インクジェット記録方法、印刷物、平版印刷版の製造方法、及び平版印刷版 |
| KR100932093B1 (ko) | 2006-09-27 | 2009-12-16 | 주식회사종근당 | 미세소관 형성 저해제로서 유용한 벤조페논 유도체 |
| US8129527B2 (en) * | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| WO2009146320A1 (fr) | 2008-05-27 | 2009-12-03 | Dmi Life Sciences, Inc. | Procédés et composés thérapeutiques |
| JP2012509878A (ja) * | 2008-11-21 | 2012-04-26 | アイシス ファーマシューティカルズ， インコーポレーテッド | ドセタキセルおよびアンチセンスオリゴヌクレオチドを含む、抗腫瘍併用療法 |
| JP5824511B2 (ja) | 2010-05-03 | 2015-11-25 | テイコク ファーマ ユーエスエー インコーポレーテッド | 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法 |
| US8507496B2 (en) | 2010-09-07 | 2013-08-13 | Dmi Acquisition Corp. | Treatment of diseases |
| WO2012035436A1 (fr) * | 2010-09-15 | 2012-03-22 | Tokyo University Of Pharmacy And Life Sciences | Analogues de promédicaments à base de plinabuline et utilisations thérapeutiques associées |
| US8842114B1 (en) | 2011-04-29 | 2014-09-23 | Nvidia Corporation | System, method, and computer program product for adjusting a depth of displayed objects within a region of a display |
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| KR20240110996A (ko) * | 2015-02-12 | 2024-07-16 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 면역 관문 저해제와 조합한 플리나불린의 용도 |
| SG10202008673WA (en) | 2015-03-06 | 2020-10-29 | Beyondspring Pharmaceuticals Inc | Method of treating cancer associated with a ras mutation |
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| CN109563079B (zh) * | 2016-08-12 | 2021-10-26 | 深圳华大海洋科技有限公司 | 脱氢苯基阿夕斯丁类化合物的多晶型及其制备纯化方法和应用 |
| CN107011331A (zh) * | 2016-08-12 | 2017-08-04 | 青岛海洋生物医药研究院股份有限公司 | 脱氢苯基阿夕斯丁类化合物的多晶型及其制备方法 |
| CN107778297B (zh) * | 2016-08-12 | 2021-11-19 | 深圳华大海洋科技有限公司 | 氘代脱氢苯基阿夕斯丁类化合物的多晶型及其制备方法和应用 |
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| NZ778329A (en) | 2017-03-13 | 2026-03-27 | Beyondspring Pharmaceuticals Inc | Compositions of plinabulin and use thereof |
| CN108658945B (zh) * | 2017-03-31 | 2020-11-20 | 深圳海王医药科技研究院有限公司 | 一种微管蛋白抑制剂（vda-1）的a晶型 |
| US11434225B2 (en) | 2017-08-03 | 2022-09-06 | Pliva Hrvatska D.O.O. | Salts and solid state forms of plinabulin |
| CN109498627B (zh) * | 2017-09-15 | 2021-06-04 | 深圳华大海洋科技有限公司 | 一种治疗肿瘤的药物组合物及其应用 |
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| CN109030642B (zh) * | 2018-06-26 | 2021-03-09 | 深圳海王医药科技研究院有限公司 | 一种脱氢苯基阿夕斯丁类似物及其异构体的测定方法 |
| CN111840291B (zh) * | 2020-07-14 | 2021-12-21 | 深圳海王医药科技研究院有限公司 | 一种在肿瘤治疗中具有增效作用的化合物的应用 |
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| CN117285516A (zh) * | 2022-06-16 | 2023-12-26 | 大连万众益生大健康有限公司 | 脱氢苯基阿夕斯汀类化合物、其制备方法及其应用 |
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| CN121127241A (zh) | 2023-03-10 | 2025-12-12 | 万春药业公司 | 肿瘤联合治疗及使用方法 |
| WO2026064527A1 (fr) | 2024-09-19 | 2026-03-26 | Tesseract Medicines Us, Llc | Conjugués médicamenteux à induction covalente ciblant kras comprenant une charge utile d'inhibiteur de tubuline |
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-
2003
- 2003-08-01 DE DE60316688T patent/DE60316688T2/de not_active Expired - Lifetime
- 2003-08-01 AT AT03811651T patent/ATE374767T1/de active
- 2003-08-01 PT PT03811651T patent/PT1529044E/pt unknown
- 2003-08-01 NZ NZ538433A patent/NZ538433A/en not_active IP Right Cessation
- 2003-08-01 BR BR0313363-0A patent/BR0313363A/pt not_active Application Discontinuation
- 2003-08-01 AU AU2003302721A patent/AU2003302721B2/en not_active Expired
- 2003-08-01 KR KR1020117006692A patent/KR101184374B1/ko not_active Expired - Lifetime
- 2003-08-01 DK DK03811651T patent/DK1529044T5/da active
- 2003-08-01 BR BRPI0313363A patent/BRPI0313363A8/pt unknown
- 2003-08-01 CA CA2494049A patent/CA2494049C/fr not_active Expired - Lifetime
- 2003-08-01 JP JP2004560278A patent/JP4616649B2/ja not_active Expired - Lifetime
- 2003-08-01 CN CNB038234645A patent/CN100540548C/zh not_active Expired - Lifetime
- 2003-08-01 ES ES03811651T patent/ES2295695T3/es not_active Expired - Lifetime
- 2003-08-01 IL IL16662803A patent/IL166628A0/xx unknown
- 2003-08-01 MX MXPA05001217A patent/MXPA05001217A/es active IP Right Grant
- 2003-08-01 EP EP03811651A patent/EP1529044B1/fr not_active Expired - Lifetime
- 2003-08-01 WO PCT/US2003/024232 patent/WO2004054498A2/fr not_active Ceased
- 2003-08-01 US US10/632,531 patent/US7064201B2/en not_active Expired - Lifetime
- 2003-08-01 KR KR1020057001947A patent/KR101049100B1/ko not_active Expired - Lifetime
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2005
- 2005-02-01 IL IL166628A patent/IL166628A/en active IP Right Grant
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- 2005-02-28 CO CO05018564A patent/CO5721010A2/es active IP Right Grant
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2006
- 2006-06-07 US US11/448,924 patent/US7956058B2/en not_active Expired - Lifetime
- 2006-06-07 US US11/448,283 patent/US20060223822A1/en not_active Abandoned
- 2006-06-07 US US11/448,948 patent/US7674903B2/en not_active Expired - Lifetime
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