IL189545A0 - Pyrimidine derivatives and their use as kcnq potassium channels openers - Google Patents
Pyrimidine derivatives and their use as kcnq potassium channels openersInfo
- Publication number
- IL189545A0 IL189545A0 IL189545A IL18954508A IL189545A0 IL 189545 A0 IL189545 A0 IL 189545A0 IL 189545 A IL189545 A IL 189545A IL 18954508 A IL18954508 A IL 18954508A IL 189545 A0 IL189545 A0 IL 189545A0
- Authority
- IL
- Israel
- Prior art keywords
- pyrimidine derivatives
- potassium channels
- kcnq potassium
- channels openers
- openers
- Prior art date
Links
- 102000012359 KCNQ Potassium Channels Human genes 0.000 title 1
- 108010022282 KCNQ Potassium Channels Proteins 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200501262 | 2005-09-09 | ||
| PCT/DK2006/050039 WO2007065449A1 (en) | 2005-09-09 | 2006-09-07 | Pyrimidine derivatives and their use as kcnq potassium channels openers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL189545A0 true IL189545A0 (en) | 2008-06-05 |
Family
ID=37199174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL189545A IL189545A0 (en) | 2005-09-09 | 2008-02-14 | Pyrimidine derivatives and their use as kcnq potassium channels openers |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1937653A1 (pt) |
| JP (1) | JP2009507052A (pt) |
| KR (1) | KR20080043314A (pt) |
| CN (1) | CN101258133A (pt) |
| AR (1) | AR055420A1 (pt) |
| AU (1) | AU2006322461A1 (pt) |
| BR (1) | BRPI0615631A2 (pt) |
| CA (1) | CA2621854A1 (pt) |
| EA (1) | EA200800780A1 (pt) |
| IL (1) | IL189545A0 (pt) |
| MX (1) | MX2008002294A (pt) |
| NO (1) | NO20081713L (pt) |
| UA (1) | UA93387C2 (pt) |
| WO (1) | WO2007065449A1 (pt) |
| ZA (1) | ZA200802174B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101790374A (zh) * | 2007-08-01 | 2010-07-28 | H.隆德贝克有限公司 | Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途 |
| US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| WO2010097379A1 (en) * | 2009-02-24 | 2010-09-02 | Neurosearch A/S | Substituted pyrimidin derivatives and their medical use |
| CA2804165C (en) * | 2010-07-08 | 2015-02-24 | Pfizer Inc. | Piperidinyl pyrimidine amides as kv7 potassium channel openers |
| PE20140199A1 (es) * | 2010-10-20 | 2014-02-16 | Gruenenthal Chemie | 6-amino-nicotinamidas sustituidas como moduladores de kcnq2/3 |
| CN103508943B (zh) * | 2012-06-29 | 2017-06-09 | 江苏先声药业有限公司 | 作为钾通道调节剂的化合物 |
| CN103508960B (zh) * | 2012-06-29 | 2017-12-12 | 江苏先声药业有限公司 | 苯并杂环衍生物 |
| CA2965467A1 (en) | 2014-10-24 | 2016-04-28 | Ono Pharmaceutical Co., Ltd. | Kcnq2-5 channel activator |
| CN114206328B (zh) * | 2019-08-02 | 2024-09-17 | H.隆德贝克有限公司 | 用于在癫痫或癫痫发作中使用的作为Kv7钾通道开放剂的醇衍生物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020183335A1 (en) * | 2001-02-20 | 2002-12-05 | Piyasena Hewawasam | 2, 4-disubstituted pyrimidine-5-carboxamide derivatives as KCNQ potassium channel modulators |
| WO2003068769A1 (en) * | 2002-02-12 | 2003-08-21 | Pfizer Inc. | Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh) |
| US20080261918A1 (en) * | 2004-12-17 | 2008-10-23 | Graham Andrew Showell | Silicon Compounds and Their Use |
-
2006
- 2006-09-07 EP EP06846967A patent/EP1937653A1/en not_active Withdrawn
- 2006-09-07 MX MX2008002294A patent/MX2008002294A/es active IP Right Grant
- 2006-09-07 ZA ZA200802174A patent/ZA200802174B/xx unknown
- 2006-09-07 CA CA002621854A patent/CA2621854A1/en not_active Abandoned
- 2006-09-07 EA EA200800780A patent/EA200800780A1/ru unknown
- 2006-09-07 CN CNA2006800327125A patent/CN101258133A/zh active Pending
- 2006-09-07 BR BRPI0615631-2A patent/BRPI0615631A2/pt not_active IP Right Cessation
- 2006-09-07 JP JP2008529473A patent/JP2009507052A/ja not_active Withdrawn
- 2006-09-07 WO PCT/DK2006/050039 patent/WO2007065449A1/en not_active Ceased
- 2006-09-07 KR KR1020087004306A patent/KR20080043314A/ko not_active Withdrawn
- 2006-09-07 AU AU2006322461A patent/AU2006322461A1/en not_active Abandoned
- 2006-09-07 UA UAA200803570A patent/UA93387C2/ru unknown
- 2006-09-08 AR ARP060103924A patent/AR055420A1/es not_active Application Discontinuation
-
2008
- 2008-02-14 IL IL189545A patent/IL189545A0/en unknown
- 2008-04-09 NO NO20081713A patent/NO20081713L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20081713L (no) | 2008-06-04 |
| JP2009507052A (ja) | 2009-02-19 |
| MX2008002294A (es) | 2008-03-14 |
| UA93387C2 (ru) | 2011-02-10 |
| EP1937653A1 (en) | 2008-07-02 |
| EA200800780A1 (ru) | 2008-06-30 |
| WO2007065449A1 (en) | 2007-06-14 |
| BRPI0615631A2 (pt) | 2011-05-24 |
| CN101258133A (zh) | 2008-09-03 |
| CA2621854A1 (en) | 2007-06-14 |
| AU2006322461A1 (en) | 2007-06-14 |
| ZA200802174B (en) | 2009-10-28 |
| AR055420A1 (es) | 2007-08-22 |
| KR20080043314A (ko) | 2008-05-16 |
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