IL24650A - 3-oxime and 3-aza-a-homo-steroids of the pregnane series - Google Patents

3-oxime and 3-aza-a-homo-steroids of the pregnane series

Info

Publication number: IL24650A
Authority: IL; Israel
Prior art keywords: steroids; formula; same meaning; carbon; aza
Prior art date: 1965-06-18

Application number

IL2465065A

Other languages

English (en)

Original Assignee

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1965-06-18

Filing date

1965-11-19

Publication date

1969-08-27

1965-11-19 Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp

1969-08-27 Publication of IL24650A publication Critical patent/IL24650A/en

Links

150000003128 pregnanes Chemical class 0.000 title claims description 4
150000003431 steroids Chemical class 0.000 claims description 11
238000000034 method Methods 0.000 claims description 8
150000001875 compounds Chemical class 0.000 claims description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
229910052799 carbon Inorganic materials 0.000 claims description 4
229910052739 hydrogen Inorganic materials 0.000 claims description 4
239000001257 hydrogen Substances 0.000 claims description 4
238000006237 Beckmann rearrangement reaction Methods 0.000 claims description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
125000000217 alkyl group Chemical group 0.000 claims description 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
229910052794 bromium Inorganic materials 0.000 claims description 2
125000001246 bromo group Chemical group Br* 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
229910052698 phosphorus Inorganic materials 0.000 claims description 2
239000011574 phosphorus Substances 0.000 claims description 2
150000003839 salts Chemical class 0.000 claims description 2
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 2
JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 claims 1
239000012445 acidic reagent Substances 0.000 claims 1
230000002378 acidificating effect Effects 0.000 claims 1
238000002360 preparation method Methods 0.000 claims 1
YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 claims 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
239000000203 mixture Substances 0.000 description 4
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
239000012044 organic layer Substances 0.000 description 3
229910052938 sodium sulfate Inorganic materials 0.000 description 3
235000011152 sodium sulphate Nutrition 0.000 description 3
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 2
WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011343 solid material Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
CSKNSYBAZOQPLR-UHFFFAOYSA-N benzenesulfonyl chloride Chemical compound ClS(=O)(=O)C1=CC=CC=C1 CSKNSYBAZOQPLR-UHFFFAOYSA-N 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000013078 crystal Substances 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000001914 filtration Methods 0.000 description 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
238000006146 oximation reaction Methods 0.000 description 1
229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
235000015497 potassium bicarbonate Nutrition 0.000 description 1
239000011736 potassium bicarbonate Substances 0.000 description 1
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000000583 progesterone congener Substances 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL2465065A 1965-06-18 1965-11-19 3-oxime and 3-aza-a-homo-steroids of the pregnane series IL24650A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US46517565A	1965-06-18	1965-06-18

Publications (1)

Publication Number	Publication Date
IL24650A true IL24650A (en)	1969-08-27

Family

ID=23846768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL2465065A IL24650A (en)	1965-06-18	1965-11-19	3-oxime and 3-aza-a-homo-steroids of the pregnane series

Country Status (4)

Country	Link
CH (1)	CH470378A (de)
DE (1)	DE1593205A1 (de)
GB (1)	GB1104969A (de)
IL (1)	IL24650A (de)

1965
- 1965-11-19 CH CH1594365A patent/CH470378A/de not_active IP Right Cessation
- 1965-11-19 DE DE19651593205 patent/DE1593205A1/de active Pending
- 1965-11-19 GB GB960267A patent/GB1104969A/en not_active Expired
- 1965-11-19 IL IL2465065A patent/IL24650A/en unknown

Also Published As

Publication number	Publication date
CH470378A (de)	1969-03-31
GB1104969A (en)	1968-03-06
DE1593205A1 (de)	1971-01-21

Similar Documents

Publication	Publication Date	Title
DE3875280T2 (de)	1993-04-29	Verfahren zur herstellung von 9(11)-dehydro-steroidderivaten.
CH518927A (de)	1972-02-15	Verfahren zur Herstellung von geschützter 4,6-O-Alkyliden-B-D-glucopyranose
US3095412A (en)	1963-06-25	9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs
DE3127989C2 (de)	1995-05-18	20-Isocyano-3-methoxy-pregna-3,5,17(20)-trien, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung von 17alpha-Hydroxy-progesteron
IL24650A (en)	1969-08-27	3-oxime and 3-aza-a-homo-steroids of the pregnane series
US4055562A (en)	1977-10-25	Process for preparing pregn-20-yne compounds and novel product produced thereby
US5712263A (en)	1998-01-27	Steroid derivatives
EP0447014B1 (de)	1995-11-02	Verfahren zur Herstellung von Zwischenprodukten für die Antigestagensynthese (Onapristonsynthese)
US3459739A (en)	1969-08-05	3 - spiro - 3' - diaziridine- and -3'-diazirinederivatives of the androstane and estrane series
WO1993000354A1 (de)	1993-01-07	Verfahren zur herstellung von 6-methylensteroiden
US3679664A (en)	1972-07-25	3-aza-a-homo-steroids
US2753342A (en)	1956-07-03	Cyclopentanophenanthrene compounds and method for the production thereof
US3069440A (en)	1962-12-18	New 17-oxygenated-delta"-progesterones
US3407219A (en)	1968-10-22	17alpha-alkyl-17beta-methyl-8xi, 9xi, 13xi, 14xi-gona-1,3,5(10)-trien-3-ols and conge
EP0072894A1 (de)	1983-03-02	Cyanosteroidderivat und seine Herstellung
US2636043A (en)	1953-04-21	Method of preparing 16-ketosteroids
US3171835A (en)	1965-03-02	4, 4, 6, 16-tetraalkyl-5-pregnene steroids and process of preparation
US3019243A (en)	1962-01-30	11beta-hydroxy-5beta-pregnane-3, 20-dione bisoximes and the 11alpha-lower-alkyl derivatives thereof
AT200579B (de)	1958-11-10	Verfahren zur Herstellung der neuen 5-Dibenzo[b,f]azepine
Gelbart et al.	1979	Cardenolide analogs. 9. Synthesis and biological activity of 17. beta.-carbomethoxyethylene and 17. beta.-cyanoethylene 14. alpha.-H steroids
US3009935A (en)	1961-11-21	4, 9(11)-pregnadien-17alpha-ol-3, 20-dione compounds and process therefor
AT278261B (de)	1970-01-26	Verfahren zur Herstellung von in 4- bzw. 6-Stellung acylierten Δ<4>-3-Ketosteroiden
EP0127864A2 (de)	1984-12-12	D-Homo-4,9,16-estratriene, deren Herstellung und diese enthaltende pharmazeutische Präparate
US4051150A (en)	1977-09-27	3-(2-Dialkylamino-2-dialkylphosphonylvinyl)-6,11-dihydrodibenzo-[b.e.]-thiepin-11-one
US3406189A (en)	1968-10-15	Aminopregnanes