IL308157A - Antibodies against TIGIT, antibodies against CD96, and methods of using them - Google Patents
Antibodies against TIGIT, antibodies against CD96, and methods of using themInfo
- Publication number
- IL308157A IL308157A IL308157A IL30815723A IL308157A IL 308157 A IL308157 A IL 308157A IL 308157 A IL308157 A IL 308157A IL 30815723 A IL30815723 A IL 30815723A IL 308157 A IL308157 A IL 308157A
- Authority
- IL
- Israel
- Prior art keywords
- antibodies
- methods
- tigit
- tigit antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163201537P | 2021-05-04 | 2021-05-04 | |
| PCT/US2022/072099 WO2022236276A2 (fr) | 2021-05-04 | 2022-05-04 | Anticorps anti-tigit, anticorps anti-cd96 et leurs procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL308157A true IL308157A (en) | 2024-01-01 |
Family
ID=83933041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL308157A IL308157A (en) | 2021-05-04 | 2022-05-04 | Antibodies against TIGIT, antibodies against CD96, and methods of using them |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11718669B2 (fr) |
| EP (1) | EP4333893A4 (fr) |
| JP (1) | JP2024516843A (fr) |
| KR (1) | KR20240006054A (fr) |
| CN (1) | CN117425494A (fr) |
| AR (1) | AR125753A1 (fr) |
| AU (1) | AU2022271331A1 (fr) |
| BR (1) | BR112023022319A2 (fr) |
| CA (1) | CA3217289A1 (fr) |
| CL (1) | CL2023003244A1 (fr) |
| CO (1) | CO2023016037A2 (fr) |
| IL (1) | IL308157A (fr) |
| MX (1) | MX2023013078A (fr) |
| PE (1) | PE20240369A1 (fr) |
| TW (1) | TW202304965A (fr) |
| WO (1) | WO2022236276A2 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202304965A (zh) | 2021-05-04 | 2023-02-01 | 美商艾吉納斯公司 | 抗ｔｉｇｉｔ抗體、抗ｃｄ９６抗體及其使用方法 |
| WO2025188697A1 (fr) * | 2024-03-04 | 2025-09-12 | Agenus Inc. | Méthodes de traitement du cancer utilisant des anticorps anti-cd96/anti-tigit et des polythérapies |
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| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE60335552D1 (de) | 2002-09-11 | 2011-02-10 | Genentech Inc | Neue zusammensetzung und verfahren zur behandlung von immunerkrankungen |
| JP2007528723A (ja) | 2003-08-22 | 2007-10-18 | メディミューン，インコーポレーテッド | 抗体のヒト化 |
| CA2607291A1 (fr) | 2005-05-12 | 2006-11-23 | Steven D. Levin | Compositions et procedes permettant de moduler des reponses immunitaires |
| MX2008014977A (es) | 2006-06-06 | 2008-12-05 | Crucell Holland Bv | Moleculas de union humanas que tienen actividad exterminadora contra estafilococos y uso de las mismas. |
| SI2279412T1 (sl) | 2008-04-09 | 2017-10-30 | Genentech, Inc., | Novi sestavki in postopki za zdravljenje imunsko povezanih bolezni |
| EP2542590B2 (fr) | 2010-03-05 | 2020-04-01 | The Johns Hopkins University | Compositions et procédés pour des anticorps et protéines de fusion immunomodulateurs ciblés |
| WO2013160396A1 (fr) | 2012-04-26 | 2013-10-31 | Boehringer Ingelheim International Gmbh | Combinaison d'anticorps cd37 avec la bendamustine |
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| JP2015520192A (ja) | 2012-06-06 | 2015-07-16 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｈｉｐｐｏ経路を調節する結合剤およびその使用 |
| SG11201504943QA (en) | 2012-12-24 | 2015-07-30 | Abbvie Inc | Prolactin receptor binding proteins and uses thereof |
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| WO2017123981A1 (fr) | 2016-01-15 | 2017-07-20 | Rfemb Holdings, Llc | Immunothérapie du cancer |
| KR20230085220A (ko) | 2013-08-22 | 2023-06-13 | 더 카운실 오브 더 퀸즐랜드 인스티튜트 오브 메디컬 리서치 | 암 및 바이러스 감염을 치료하기 위한 면역수용체 조절 |
| WO2015035112A1 (fr) | 2013-09-05 | 2015-03-12 | The Johns Hopkins University | Thérapie anticancéreuse par l'intermédiaire d'une combinaison de modulation épigénétique et modulation immunitaire |
| CN105765063B (zh) * | 2013-09-30 | 2021-05-07 | 中外制药株式会社 | 应用改变的辅助噬菌体制备抗原结合分子的方法 |
| NZ725006A (en) | 2014-03-12 | 2019-11-29 | Yeda Res & Dev | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
| WO2015143343A2 (fr) | 2014-03-21 | 2015-09-24 | The Brigham And Women's Hospital, Inc. | Procédés et compositions pour le traitement de maladies immunitaires ou de troubles et/ou la surveillance thérapeutique |
| EA201692287A1 (ru) | 2014-05-13 | 2017-06-30 | Чугаи Сеияку Кабушики Каиша | Антигенсвязывающая молекула, перенаправляющая т-клетки на клетки, обладающие иммуносупрессорной функцией |
| CN105233291A (zh) | 2014-07-09 | 2016-01-13 | 博笛生物科技有限公司 | 用于治疗癌症的联合治疗组合物和联合治疗方法 |
| BR112017000703A2 (pt) | 2014-07-16 | 2017-11-14 | Genentech Inc | métodos para tratar ou retardar a progressão do câncer, para reduzir ou inibir a reincidência do câncer, para tratar ou retardar a progressão da imunidade tumoral e para aumentar, intensificar ou estimular uma resposta ou função imune e kit |
| JO3664B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | أجسام مضادة لـ tigit |
| EP3206711B1 (fr) | 2014-10-14 | 2023-05-31 | Novartis AG | Molécules d'anticorps de pd-l1 et leurs utilisations |
| SG11201703326SA (en) | 2014-10-24 | 2017-05-30 | Aladar Szalay | Combination immunotherapy approach for treatment of cancer |
| EP3215536A1 (fr) | 2014-11-06 | 2017-09-13 | F. Hoffmann-La Roche AG | Polythérapie comprenant des agonistes de liaison à ox40 et des inhibiteurs de tigit |
| EA039219B1 (ru) | 2014-12-23 | 2021-12-20 | Бристол-Майерс Сквибб Компани | Антитела к tigit |
| MX2017012131A (es) | 2015-03-25 | 2018-06-15 | Univ Michigan Regents | Composiciones y métodos para la administración de agentes de biomacromoléculas. |
| WO2016180781A1 (fr) | 2015-05-08 | 2016-11-17 | Michele Maio | Polythérapie du mésothéliome |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Ｔｉｇｉｔ結合劑和彼之用途 |
| AU2016285920A1 (en) | 2015-06-29 | 2018-02-01 | Bristol-Myers Squibb Company | Antibodies to CD40 with enhanced agonist activity |
| EP3328363A4 (fr) | 2015-07-31 | 2019-08-21 | Tarveda Therapeutics, Inc. | Compositions et méthodes d'immunomodulation |
| JO3620B1 (ar) | 2015-08-05 | 2020-08-27 | Amgen Res Munich Gmbh | مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم |
| CN115925931A (zh) | 2015-08-14 | 2023-04-07 | 默沙东公司 | 抗tigit抗体 |
| KR20220131277A (ko) | 2015-09-01 | 2022-09-27 | 아게누스 인코포레이티드 | 항-pd-1 항체 및 이를 이용하는 방법 |
| JP6861418B2 (ja) | 2015-09-02 | 2021-04-28 | イッサム リサーチ デベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド | ヒトｔ細胞免疫グロブリン及びｉｔｉｍドメイン（ｔｉｇｉｔ）に特異的な抗体 |
| AU2016322934A1 (en) | 2015-09-14 | 2018-04-12 | Compass Therapeutics Llc | Compositions and methods for treating cancer via antagonism of the CD155/TIGIT pathway and TGF-beta |
| CN113912724B (zh) | 2015-09-25 | 2025-03-14 | 豪夫迈·罗氏有限公司 | 抗tigit抗体和使用方法 |
| SG10201912736UA (en) | 2015-10-01 | 2020-02-27 | Potenza Therapeutics Inc | Anti-tigit antigen-binding proteins and methods of use thereof |
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| CN108779162B (zh) | 2015-10-09 | 2021-12-07 | 美天施生物科技有限公司 | 嵌合抗原受体和使用方法 |
| UA125898C2 (uk) | 2016-03-04 | 2022-07-06 | Джн Байосайєнсіз, Ллк | Антитіла до tigit |
| EP3471752B1 (fr) | 2016-06-17 | 2022-03-09 | Varian Medical Systems, Inc. | Modulateurs immunitaires en combinaison avec un traitement par rayonnement |
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| JP7200093B2 (ja) | 2016-09-15 | 2023-01-06 | アイデラ・ファーマシューティカルズ，インコーポレーテッド | がん治療用ｔｌｒ９アゴニストを用いた免疫調節 |
| JP7126269B2 (ja) | 2016-11-30 | 2022-08-26 | メレオ バイオファーマ ５ インコーポレイテッド | Ｔｉｇｉｔ結合物質を含む、がんの処置のための方法 |
| WO2018102746A1 (fr) | 2016-12-02 | 2018-06-07 | Rigel Pharmaceuticals, Inc. | Molécules de liaison à l'antigène destinées à la tigit |
| CN109071656B (zh) | 2017-01-05 | 2021-05-18 | 璟尚生物制药公司 | 检查点调节物拮抗剂 |
| WO2018160704A1 (fr) | 2017-02-28 | 2018-09-07 | Adimab Llc | Anticorps anti-tigit |
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| MA50957A (fr) | 2017-05-01 | 2020-10-14 | Agenus Inc | Anticorps anti-tigit et leurs méthodes d'utilisation |
| US20200354453A1 (en) | 2017-05-02 | 2020-11-12 | Merck Sharp & Dohme Corp. | Stable formulations of anti-tigit antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| WO2018229163A1 (fr) | 2017-06-14 | 2018-12-20 | King's College London | Méthodes d'activation des lymphocytes t v delta 2 négatifs gamma delta |
| GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
| IL272227B2 (en) | 2017-07-27 | 2025-09-01 | iTeos Belgium SA | Anti-tigit antibodies |
| WO2019030377A1 (fr) | 2017-08-11 | 2019-02-14 | Blink Biomedical Sas | Agents de liaison à cd96 utilisés comme immunomodulateurs |
| CN111051347B (zh) | 2017-09-29 | 2021-12-21 | 江苏恒瑞医药股份有限公司 | Tigit抗体、其抗原结合片段及医药用途 |
| TWI758558B (zh) | 2017-11-10 | 2022-03-21 | 大陸商江蘇恒瑞醫藥股份有限公司 | Cd96抗體、其抗原結合片段及醫藥用途 |
| SG11202004158QA (en) | 2017-12-28 | 2020-06-29 | Nanjing Legend Biotech Co Ltd | Single-domain antibodies and variants thereof against tigit |
| TWI816729B (zh) * | 2017-12-30 | 2023-10-01 | 英屬開曼群島商百濟神州有限公司 | 抗tigit抗體及其作為治療和診斷的用途 |
| TW201932489A (zh) | 2018-01-15 | 2019-08-16 | 大陸商南京傳奇生物科技有限公司 | 針對ｔｉｇｉｔ之抗體及其變異體 |
| WO2019152574A1 (fr) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Procédés de traitement du cancer ou d'une infection à l'aide d'une combinaison d'un anticorps anti-pd -1, d'un anticorps anti-lag3 et d'un anticorps anti-tigit |
| WO2019154415A1 (fr) | 2018-02-06 | 2019-08-15 | I-Mab | Anticorps dirigés contre l'immunorécepteur des lymphocytes t avec des domaines ig et itim (tigit) et leurs utilisations |
| CN111836831A (zh) | 2018-02-26 | 2020-10-27 | 豪夫迈·罗氏有限公司 | 用于抗tigit拮抗剂抗体和抗pd-l1拮抗剂抗体治疗的给药 |
| MX2020008795A (es) | 2018-02-28 | 2020-10-08 | Yuhan Corp | Anti cuerpos anti tigit y usos de los mismos. |
| BR112021003156A2 (pt) | 2018-08-23 | 2021-05-11 | Seagen, Inc. | composição, anticorpo que se liga ao tigit humano, formulação farmacêutica, polinucleotídeo isolado, vetor, célula hospedeira, métodos para a produção de um anticorpo que se liga ao tigit humano e de anticorpos afucosilados que se ligam a tigit e para o tratamento de um câncer, e, kit. |
| EP3873923A4 (fr) * | 2018-10-31 | 2023-02-08 | Delinia, Inc. | Modulateurs de lymphocytes t régulateurs multivalents |
| AR117327A1 (es) * | 2018-12-20 | 2021-07-28 | 23Andme Inc | Anticuerpos anti-cd96 y métodos de uso de estos |
| US20220135682A1 (en) * | 2019-03-11 | 2022-05-05 | Jounce Therapeutics, Inc. | Anti-ICOS Antibodies for the Treatment of Cancer |
| TWI760751B (zh) | 2019-05-29 | 2022-04-11 | 美商美國禮來大藥廠 | Tigit及pd-1/tigit-結合分子 |
| BR112021026309A2 (pt) * | 2019-06-26 | 2022-06-07 | Ap Biosciences Inc | Anticorpos para ativação de células t |
| CR20220076A (es) | 2019-08-30 | 2022-06-24 | Agenus Inc | Anticuerpos anti-cd96 y sus métodos de uso |
| TW202304965A (zh) | 2021-05-04 | 2023-02-01 | 美商艾吉納斯公司 | 抗ｔｉｇｉｔ抗體、抗ｃｄ９６抗體及其使用方法 |
| EP4333894A4 (fr) * | 2021-05-04 | 2025-10-08 | Agenus Inc | Anticorps anti-tigit et leurs procédés d'utilisation |
-
2022
- 2022-05-03 TW TW111116719A patent/TW202304965A/zh unknown
- 2022-05-03 AR ARP220101162A patent/AR125753A1/es not_active Application Discontinuation
- 2022-05-04 WO PCT/US2022/072099 patent/WO2022236276A2/fr not_active Ceased
- 2022-05-04 CN CN202280040311.3A patent/CN117425494A/zh active Pending
- 2022-05-04 KR KR1020237041635A patent/KR20240006054A/ko active Pending
- 2022-05-04 IL IL308157A patent/IL308157A/en unknown
- 2022-05-04 MX MX2023013078A patent/MX2023013078A/es unknown
- 2022-05-04 AU AU2022271331A patent/AU2022271331A1/en active Pending
- 2022-05-04 JP JP2023568081A patent/JP2024516843A/ja active Pending
- 2022-05-04 CA CA3217289A patent/CA3217289A1/fr active Pending
- 2022-05-04 PE PE2023003002A patent/PE20240369A1/es unknown
- 2022-05-04 BR BR112023022319A patent/BR112023022319A2/pt unknown
- 2022-05-04 EP EP22799792.1A patent/EP4333893A4/fr active Pending
- 2022-08-10 US US17/818,840 patent/US11718669B2/en active Active
-
2023
- 2023-06-13 US US18/333,882 patent/US12479913B2/en active Active
- 2023-11-02 CL CL2023003244A patent/CL2023003244A1/es unknown
- 2023-11-23 CO CONC2023/0016037A patent/CO2023016037A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR125753A1 (es) | 2023-08-09 |
| US20230014036A1 (en) | 2023-01-19 |
| MX2023013078A (es) | 2023-11-16 |
| CO2023016037A2 (es) | 2023-11-30 |
| CA3217289A1 (fr) | 2022-11-10 |
| AU2022271331A1 (en) | 2023-10-26 |
| US20240141039A1 (en) | 2024-05-02 |
| KR20240006054A (ko) | 2024-01-12 |
| JP2024516843A (ja) | 2024-04-17 |
| WO2022236276A3 (fr) | 2023-01-19 |
| AU2022271331A9 (en) | 2023-11-09 |
| US12479913B2 (en) | 2025-11-25 |
| TW202304965A (zh) | 2023-02-01 |
| PE20240369A1 (es) | 2024-03-04 |
| EP4333893A2 (fr) | 2024-03-13 |
| WO2022236276A2 (fr) | 2022-11-10 |
| US11718669B2 (en) | 2023-08-08 |
| CN117425494A (zh) | 2024-01-19 |
| EP4333893A4 (fr) | 2025-06-18 |
| BR112023022319A2 (pt) | 2024-02-20 |
| CL2023003244A1 (es) | 2024-04-19 |
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