AR103268A1 - Anticuerpos contra tigit - Google Patents

Anticuerpos contra tigit

Info

Publication number
AR103268A1
AR103268A1 ARP150104279A ARP150104279A AR103268A1 AR 103268 A1 AR103268 A1 AR 103268A1 AR P150104279 A ARP150104279 A AR P150104279A AR P150104279 A ARP150104279 A AR P150104279A AR 103268 A1 AR103268 A1 AR 103268A1
Authority
AR
Argentina
Prior art keywords
antibodies
fragments
treatment
encode
cells
Prior art date
Application number
ARP150104279A
Other languages
English (en)
Inventor
Chakraborty Indrani
F Ardourel Daniel
O Sheppard Paul
H Julien Susan
Srinivasan Mohan
F Maurer Mark
Devaux Brigitte
Timothy Chen Tseng-Hui
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR103268A1 publication Critical patent/AR103268A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Proporciona anticuerpos, o fragmentos de fijación al antígeno de estos, que se fijan a TIGIT humano (inmunorreceptor de linfocitos T con dominios Ig e ITIM), y a los usos de estos anticuerpos o fragmentos en aplicaciones terapéuticas, tales como en el tratamiento de cáncer o infección viral crónica. Tal método de tratamiento incluye el tratamiento conjunto con inhibidores de otras interacciones del receptor inmunomodulador, tales como la interacción PD-1/PD-L1. También proporciona polinucleótidos que codifican la región variable de las cadenas liviana y/o pesada de los anticuerpos, vectores de expresión que comprenden los polinucleótidos que codifican la región variable de las cadenas liviana y/o pesada de los anticuerpos, células que comprenden los vectores y métodos para elaborar anticuerpos o fragmentos expresándolos de las células.
ARP150104279A 2014-12-23 2015-12-22 Anticuerpos contra tigit AR103268A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462096267P 2014-12-23 2014-12-23

Publications (1)

Publication Number Publication Date
AR103268A1 true AR103268A1 (es) 2017-04-26

Family

ID=55168435

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150104279A AR103268A1 (es) 2014-12-23 2015-12-22 Anticuerpos contra tigit

Country Status (23)

Country Link
US (3) US10189902B2 (es)
EP (2) EP4249066A3 (es)
JP (6) JP6180663B2 (es)
KR (1) KR102644115B1 (es)
CN (3) CN107207594B (es)
AR (1) AR103268A1 (es)
AU (2) AU2015369683C1 (es)
BR (1) BR112017013385A2 (es)
CL (1) CL2017001660A1 (es)
CO (1) CO2017006989A2 (es)
EA (1) EA039219B1 (es)
IL (2) IL253013B (es)
MA (1) MA40662B1 (es)
MX (2) MX389267B (es)
MY (1) MY187045A (es)
PE (1) PE20171244A1 (es)
PH (2) PH12022550771A1 (es)
SG (2) SG10202006538TA (es)
TN (1) TN2017000267A1 (es)
TW (1) TWI708786B (es)
UY (1) UY36471A (es)
WO (1) WO2016106302A1 (es)
ZA (2) ZA201704981B (es)

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