IL325025A - Combination therapy with BRAF inhibitors for cancer treatment - Google Patents

Combination therapy with BRAF inhibitors for cancer treatment

Info

Publication number
IL325025A
IL325025A IL325025A IL32502525A IL325025A IL 325025 A IL325025 A IL 325025A IL 325025 A IL325025 A IL 325025A IL 32502525 A IL32502525 A IL 32502525A IL 325025 A IL325025 A IL 325025A
Authority
IL
Israel
Prior art keywords
cancer
seq
polypeptide
combination
braf
Prior art date
Application number
IL325025A
Other languages
English (en)
Hebrew (he)
Inventor
Fluck Mariano Federico Zacarias
Jastrinjan Kaur
Laura Soucek
Original Assignee
Fundaci? Privada Inst Dinvestigaci? Oncol?Gica De Vall Hebron
Instituci? Catalana De Recerca I Estudis Avan?ats
Fluck Mariano Federico Zacarias
Jastrinjan Kaur
Laura Soucek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundaci? Privada Inst Dinvestigaci? Oncol?Gica De Vall Hebron, Instituci? Catalana De Recerca I Estudis Avan?ats, Fluck Mariano Federico Zacarias, Jastrinjan Kaur, Laura Soucek filed Critical Fundaci? Privada Inst Dinvestigaci? Oncol?Gica De Vall Hebron
Publication of IL325025A publication Critical patent/IL325025A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL325025A 2023-06-07 2024-06-06 Combination therapy with BRAF inhibitors for cancer treatment IL325025A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23382554 2023-06-07
PCT/EP2024/065545 WO2024251854A1 (fr) 2023-06-07 2024-06-06 Polythérapie avec des inhibiteurs de braf pour le traitement du cancer

Publications (1)

Publication Number Publication Date
IL325025A true IL325025A (en) 2026-01-01

Family

ID=86732645

Family Applications (1)

Application Number Title Priority Date Filing Date
IL325025A IL325025A (en) 2023-06-07 2024-06-06 Combination therapy with BRAF inhibitors for cancer treatment

Country Status (7)

Country Link
EP (1) EP4724083A1 (fr)
KR (1) KR20260020418A (fr)
CN (1) CN121263199A (fr)
AU (1) AU2024285758A1 (fr)
IL (1) IL325025A (fr)
TW (1) TW202502371A (fr)
WO (1) WO2024251854A1 (fr)

Family Cites Families (39)

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AU767394C (en) 1999-12-29 2005-04-21 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
US20020130430A1 (en) 2000-12-29 2002-09-19 Castor Trevor Percival Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products
WO2002087541A1 (fr) 2001-04-30 2002-11-07 Protiva Biotherapeutics Inc. Formulations a base de lipides pour transfert genique
US7060498B1 (en) 2001-11-28 2006-06-13 Genta Salus Llc Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
US7141540B2 (en) 2001-11-30 2006-11-28 Genta Salus Llc Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
SG187991A1 (en) 2002-05-02 2013-03-28 Wyeth Corp Calicheamicin derivative-carrier conjugates
DK1545613T3 (da) 2002-07-31 2011-11-14 Seattle Genetics Inc Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
ATE496944T1 (de) 2003-07-21 2011-02-15 Immunogen Inc Ca6-antigenspezifisches zytotoxisches konjugat und verfahren zu dessen anwendung
NZ579482A (en) 2004-06-01 2011-02-25 Genentech Inc Antibody drug conjugates and methods
WO2006135436A2 (fr) 2004-10-22 2006-12-21 University Of Florida Research Foundation, Inc. Inhibition de l'expression genique et ses usages therapeutiques
DK3248613T3 (da) 2005-07-18 2022-03-14 Seagen Inc Beta-glucuronid-lægemiddel-linkerkonjugater
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PE20141937A1 (es) 2011-11-16 2014-12-18 Amgen Inc Metodos para tratar trastornos relacionados con mutante viii de eliminacion de factor de crecimiento epidermico
US9682143B2 (en) 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
EP2988786A4 (fr) 2013-04-22 2016-12-21 Avelas Biosciences Inc Compositions et procédés d'utilisation pour l'administration sélective de médicaments
NZ758049A (en) 2013-10-15 2024-03-22 Seagen Inc Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics
US10550190B2 (en) 2014-04-04 2020-02-04 Merck Sharp & Dohme Corp. Phosphate based linkers for intracellular delivery of drug conjugates
WO2015183883A1 (fr) * 2014-05-29 2015-12-03 Memorial Sloan Kettering Cancer Center Systèmes et procédés permettant d'identifier des combinaisons de médicaments permettant de réduire la résistance aux médicaments dans le cadre d'un traitement contre le cancer
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Also Published As

Publication number Publication date
EP4724083A1 (fr) 2026-04-15
WO2024251854A1 (fr) 2024-12-12
TW202502371A (zh) 2025-01-16
AU2024285758A9 (en) 2026-01-15
CN121263199A (zh) 2026-01-02
KR20260020418A (ko) 2026-02-11
AU2024285758A1 (en) 2025-12-18

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