IL38357A - 2-phenyl-4-acylamido-imidazole derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

2-phenyl-4-acylamido-imidazole derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL38357A
Authority: IL; Israel
Prior art keywords: compound; group; acetamido; imidazole; formula
Prior art date: 1971-08-18

Application number

IL38357A

Other languages

English (en)

Other versions

IL38357A0 (en

Original Assignee

Beecham Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-08-18

Filing date

1971-12-14

Publication date

1976-08-31

1971-12-14 Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd

1972-02-29 Publication of IL38357A0 publication Critical patent/IL38357A0/xx

1976-08-31 Publication of IL38357A publication Critical patent/IL38357A/en

Links

239000008194 pharmaceutical composition Substances 0.000 title claims 2
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract 21
-1 ethoxyl Chemical group 0.000 claims abstract 12
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 5
239000002253 acid Substances 0.000 claims abstract 4
125000005843 halogen group Chemical group 0.000 claims abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 3
229910052739 hydrogen Inorganic materials 0.000 claims abstract 3
239000001257 hydrogen Substances 0.000 claims abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 3
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims abstract 2
125000003545 alkoxy group Chemical group 0.000 claims abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 2
150000003839 salts Chemical class 0.000 claims abstract 2
238000000034 method Methods 0.000 claims 6
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 4
SEULWJSKCVACTH-UHFFFAOYSA-N 1-phenylimidazole Chemical compound C1=NC=CN1C1=CC=CC=C1 SEULWJSKCVACTH-UHFFFAOYSA-N 0.000 claims 1
GTIYLLQEFVPNTN-UHFFFAOYSA-N 2-(4-fluorophenyl)-1h-imidazole Chemical compound C1=CC(F)=CC=C1C1=NC=CN1 GTIYLLQEFVPNTN-UHFFFAOYSA-N 0.000 claims 1
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
XPTVJOMFYFRVEB-UHFFFAOYSA-N 4-acetamido-2-phenyl-1h-imidazole-5-carboxamide Chemical compound NC(=O)C1=C(NC(=O)C)NC(C=2C=CC=CC=2)=N1 XPTVJOMFYFRVEB-UHFFFAOYSA-N 0.000 claims 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
230000021736 acetylation Effects 0.000 claims 1
238000006640 acetylation reaction Methods 0.000 claims 1
150000008065 acid anhydrides Chemical class 0.000 claims 1
125000003277 amino group Chemical group 0.000 claims 1
125000004429 atom Chemical group 0.000 claims 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
238000006243 chemical reaction Methods 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 claims 1
229910052801 chlorine Inorganic materials 0.000 claims 1
125000001309 chloro group Chemical group Cl* 0.000 claims 1
239000002552 dosage form Substances 0.000 claims 1
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
229910052731 fluorine Inorganic materials 0.000 claims 1
125000001153 fluoro group Chemical group F* 0.000 claims 1
125000001207 fluorophenyl group Chemical group 0.000 claims 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
239000000203 mixture Substances 0.000 claims 1
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical group C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
229960003328 benzoyl peroxide Drugs 0.000 abstract 1
125000005518 carboxamido group Chemical group 0.000 abstract 1
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000010561 standard procedure Methods 0.000 abstract 1
239000000829 suppository Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IL38357A 1971-08-18 1971-12-14 2-phenyl-4-acylamido-imidazole derivatives,their preparation and pharmaceutical compositions containing them IL38357A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB3871671A GB1378381A (en)	1971-08-18	1971-08-18	Imidazoles

Publications (2)

Publication Number	Publication Date
IL38357A0 IL38357A0 (en)	1972-02-29
IL38357A true IL38357A (en)	1976-08-31

Family

ID=10405251

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL38357A IL38357A (en)	1971-08-18	1971-12-14	2-phenyl-4-acylamido-imidazole derivatives,their preparation and pharmaceutical compositions containing them

Country Status (11)

Country	Link
JP (1)	JPS4829771A (fr)
BE (1)	BE777738A (fr)
CH (1)	CH584203A5 (fr)
DE (1)	DE2200499A1 (fr)
ES (1)	ES398587A1 (fr)
FR (1)	FR2149329B1 (fr)
GB (1)	GB1378381A (fr)
IL (1)	IL38357A (fr)
NL (1)	NL7200080A (fr)
SE (1)	SE376418B (fr)
ZA (1)	ZA7238B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP4197596A1 (fr) *	2021-12-15	2023-06-21	Eberhard Karls Universität Tübingen Medizinische Fakultät	Dérivés de l'imidazole pour le traitement et la prophylaxie de maladies infectieuses

1971
- 1971-08-18 GB GB3871671A patent/GB1378381A/en not_active Expired
- 1971-12-14 IL IL38357A patent/IL38357A/en unknown
- 1971-12-16 SE SE7116177A patent/SE376418B/xx unknown
- 1971-12-31 JP JP47004138A patent/JPS4829771A/ja active Pending
1972
- 1972-01-04 FR FR7200104A patent/FR2149329B1/fr not_active Expired
- 1972-01-04 ES ES398587A patent/ES398587A1/es not_active Expired
- 1972-01-04 ZA ZA720038A patent/ZA7238B/xx unknown
- 1972-01-04 NL NL7200080A patent/NL7200080A/xx unknown
- 1972-01-05 BE BE777738A patent/BE777738A/fr unknown
- 1972-01-05 DE DE19722200499 patent/DE2200499A1/de active Pending
- 1972-01-05 CH CH13772A patent/CH584203A5/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
NL7200080A (fr)	1973-02-20
CH584203A5 (fr)	1977-01-31
ES398587A1 (es)	1974-09-16
FR2149329B1 (fr)	1975-12-26
ZA7238B (en)	1972-09-27
GB1378381A (en)	1974-12-27
BE777738A (fr)	1972-07-05
DE2200499A1 (de)	1973-03-08
JPS4829771A (fr)	1973-04-19
SE376418B (fr)	1975-05-26
IL38357A0 (en)	1972-02-29
FR2149329A1 (fr)	1973-03-30

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