IL39108A - 2,2'-methylenediphenols,compositions based thereon and methods for preparing them - Google Patents

2,2'-methylenediphenols,compositions based thereon and methods for preparing them

Info

Publication number: IL39108A
Authority: IL; Israel
Prior art keywords: group; compounds; nitro group; substituents; halogen
Prior art date: 1971-04-09

Application number

IL39108A

Other languages

English (en)

Other versions

IL39108A0 (en

Original Assignee

Acf Chemiefarma Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-04-09

Filing date

1972-03-29

Publication date

1976-04-30

1972-03-29 Application filed by Acf Chemiefarma Nv filed Critical Acf Chemiefarma Nv

1972-05-30 Publication of IL39108A0 publication Critical patent/IL39108A0/xx

1976-04-30 Publication of IL39108A publication Critical patent/IL39108A/en

Links

238000000034 method Methods 0.000 title claims 7
239000000203 mixture Substances 0.000 title claims 4
MQCPOLNSJCWPGT-UHFFFAOYSA-N 2,2'-Bisphenol F Chemical class OC1=CC=CC=C1CC1=CC=CC=C1O MQCPOLNSJCWPGT-UHFFFAOYSA-N 0.000 claims abstract 2
150000001875 compounds Chemical class 0.000 claims 12
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 11
125000001424 substituent group Chemical group 0.000 claims 9
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 6
229910052736 halogen Inorganic materials 0.000 claims 5
125000005843 halogen group Chemical group 0.000 claims 5
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 3
150000002148 esters Chemical class 0.000 claims 3
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
238000002360 preparation method Methods 0.000 claims 3
CQRYARSYNCAZFO-UHFFFAOYSA-N salicyl alcohol Chemical class OCC1=CC=CC=C1O CQRYARSYNCAZFO-UHFFFAOYSA-N 0.000 claims 3
150000003839 salts Chemical class 0.000 claims 3
238000006467 substitution reaction Methods 0.000 claims 3
125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 2
239000004480 active ingredient Substances 0.000 claims 2
125000004423 acyloxy group Chemical group 0.000 claims 2
238000006243 chemical reaction Methods 0.000 claims 2
238000009833 condensation Methods 0.000 claims 2
230000005494 condensation Effects 0.000 claims 2
230000008878 coupling Effects 0.000 claims 2
238000010168 coupling process Methods 0.000 claims 2
238000005859 coupling reaction Methods 0.000 claims 2
150000002367 halogens Chemical class 0.000 claims 2
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims 2
230000002378 acidificating effect Effects 0.000 claims 1
230000002141 anti-parasite Effects 0.000 claims 1
239000003096 antiparasitic agent Substances 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 claims 1
230000026030 halogenation Effects 0.000 claims 1
238000005658 halogenation reaction Methods 0.000 claims 1
125000004970 halomethyl group Chemical group 0.000 claims 1
125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
229910001507 metal halide Inorganic materials 0.000 claims 1
150000005309 metal halides Chemical class 0.000 claims 1
150000007522 mineralic acids Chemical class 0.000 claims 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 1
235000005074 zinc chloride Nutrition 0.000 claims 1
239000011592 zinc chloride Substances 0.000 claims 1
241000242711 Fasciola hepatica Species 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
241000242678 Schistosoma Species 0.000 abstract 1
241000191967 Staphylococcus aureus Species 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
208000006275 fascioliasis Diseases 0.000 abstract 1
244000045947 parasite Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Tropical Medicine & Parasitology (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

IL39108A 1971-04-09 1972-03-29 2,2'-methylenediphenols,compositions based thereon and methods for preparing them IL39108A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL7104839.A NL167151C (nl)	1971-04-09	1971-04-09	Werkwijze ter bereiding van geneesmiddelen met anti-parasitaire werking op basis van halogeen bevatten- de 2,2'-methyleendifenolderivaten, alsmede werkwijze ter bereiding van deze geneeskrachtige verbindingen.

Publications (2)

Publication Number	Publication Date
IL39108A0 IL39108A0 (en)	1972-05-30
IL39108A true IL39108A (en)	1976-04-30

Family

ID=19812895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL39108A IL39108A (en)	1971-04-09	1972-03-29	2,2'-methylenediphenols,compositions based thereon and methods for preparing them

Country Status (19)

Country	Link
US (1)	US3884906A (fr)
JP (2)	JPS5525177B1 (fr)
AR (2)	AR194587A1 (fr)
AU (1)	AU459272B2 (fr)
BE (1)	BE781674A (fr)
CH (2)	CH586182A5 (fr)
DE (1)	DE2215409C3 (fr)
DK (1)	DK143227C (fr)
ES (1)	ES401501A1 (fr)
FR (1)	FR2132788B1 (fr)
GB (1)	GB1346266A (fr)
HU (1)	HU165790B (fr)
IE (1)	IE36209B1 (fr)
IL (1)	IL39108A (fr)
NL (1)	NL167151C (fr)
PH (2)	PH15268A (fr)
SE (1)	SE389331B (fr)
SU (1)	SU580828A3 (fr)
ZA (1)	ZA722331B (fr)

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AU4101678A (en) *	1977-11-08	1980-05-01	Ici Australia Ltd	Process for killing parasites
FR2549476B1 (fr) *	1983-07-20	1986-04-25	Rech Ind	Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique
US6403652B1 (en)	2000-06-30	2002-06-11	Colgate-Palmolive Company	Method and composition
CN103030617A (zh) *	2004-03-16	2013-04-10	贝林格尔.英格海姆国际有限公司	吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
UA91546C2 (uk) *	2005-05-03	2010-08-10	Бьорінгер Інгельхайм Інтернаціональ Гмбх	КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ
US7772191B2 (en)	2005-05-10	2010-08-10	Boehringer Ingelheim International Gmbh	Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
PE20080697A1 (es) *	2006-05-03	2008-08-05	Boehringer Ingelheim Int	Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
CL2008002427A1 (es) *	2007-08-16	2009-09-11	Boehringer Ingelheim Int	Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
JP5498392B2 (ja) *	2007-11-30	2014-05-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	１，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用
UA105362C2 (en)	2008-04-02	2014-05-12	Бьорингер Ингельхайм Интернациональ Гмбх	1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
KR20110063447A (ko)	2008-09-08	2011-06-10	베링거 인겔하임 인터내셔날 게엠베하	피라졸로피리미딘 및 ｃｎｓ 장애의 치료를 위한 이들의 용도
US20110014284A1 (en) *	2009-02-13	2011-01-20	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof
DK2396005T3 (da)	2009-02-13	2026-02-09	Boehringer Ingelheim Int	Sglt2 hæmmer til at forbedre glykæmisk kontrol
JP5685550B2 (ja)	2009-02-13	2015-03-18	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｓｇｌｔ２阻害剤、ｄｐｐ−ｉｖ阻害剤、更に必要により抗糖尿病薬を含む医薬組成物及びその使用
PT2414363E (pt)	2009-03-31	2014-02-26	Boehringer Ingelheim Int	Derivados de 1-heterociclil-1,5-di-hidro-pirazolo[3,4- d]pirimidin-4-ona e sua utilização como moduladores de pde9a
TW201118099A (en) *	2009-08-12	2011-06-01	Boehringer Ingelheim Int	New compounds for the treatment of CNS disorders
PT2486029E (pt)	2009-09-30	2015-10-14	Boehringer Ingelheim Int	Processos para a preparação de derivados de benzil-benzeno substituídos com glucopiranosilo
EA020798B1 (ru) *	2009-09-30	2015-01-30	Бёрингер Ингельхайм Интернациональ Гмбх	СПОСОБ ПОЛУЧЕНИЯ КРИСТАЛЛИЧЕСКОЙ ФОРМЫ 1-ХЛОР-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГИДРОФУРАН-3-ИЛОКСИ)БЕНЗИЛ]БЕНЗОЛА
UY32919A (es) *	2009-10-02	2011-04-29	Boehringer Ingelheim Int	Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos
EP2603511B1 (fr)	2010-08-12	2017-03-15	Boehringer Ingelheim International GmbH	Dérivés 6-cycloalkyle-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one et leur utilisation en tant qu'inhibiteurs de pde9a
US8809345B2 (en)	2011-02-15	2014-08-19	Boehringer Ingelheim International Gmbh	6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
AR085689A1 (es)	2011-03-07	2013-10-23	Boehringer Ingelheim Int	Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
US9192617B2 (en)	2012-03-20	2015-11-24	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
TR201901110T4 (tr)	2013-04-05	2019-02-21	Boehringer Ingelheim Int	Empagliflozinin terapötik kullanımları.
US11813275B2 (en)	2013-04-05	2023-11-14	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
HK1213818A1 (zh)	2013-04-05	2016-07-15	勃林格殷格翰国际有限公司	依帕列净的治疗用途
CA2812519A1 (fr)	2013-04-05	2014-10-05	Boehringer Ingelheim International Gmbh	Composition pharmaceutique, procedes pour le traitement et utilisations de celle-ci
EP4678242A3 (fr)	2013-04-18	2026-03-18	Boehringer Ingelheim International GmbH	Composition pharmaceutique, procédés de traitement et utilisations de celle-ci
KR20190084096A (ko)	2016-11-10	2019-07-15	베링거 인겔하임 인터내셔날 게엠베하	약제학적 조성물, 치료 방법 및 이의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2544826A (en) *	1945-05-08	1951-03-13	Dow Chemical Co	Anthelmintic feed composition
US2615052A (en) *	1950-06-23	1952-10-21	Allied Lab Inc	2,2'-methylenebis(4-chloro-6-nitrophenol) and a method for its production
US2739941A (en) *	1952-09-13	1956-03-27	Gen Aniline & Film Corp	Germicidal soap composition
NL283922A (fr) *	1962-10-03

1971
- 1971-04-09 NL NL7104839.A patent/NL167151C/xx not_active IP Right Cessation
1972
- 1972-03-21 IE IE364/72A patent/IE36209B1/xx unknown
- 1972-03-24 GB GB1405372A patent/GB1346266A/en not_active Expired
- 1972-03-29 DE DE2215409A patent/DE2215409C3/de not_active Expired
- 1972-03-29 IL IL39108A patent/IL39108A/en unknown
- 1972-03-29 US US239341A patent/US3884906A/en not_active Expired - Lifetime
- 1972-04-05 BE BE781674A patent/BE781674A/fr not_active IP Right Cessation
- 1972-04-05 AR AR241303A patent/AR194587A1/es active
- 1972-04-06 ES ES401501A patent/ES401501A1/es not_active Expired
- 1972-04-06 AU AU40850/72A patent/AU459272B2/en not_active Expired
- 1972-04-07 PH PH13428A patent/PH15268A/en unknown
- 1972-04-07 FR FR7212355A patent/FR2132788B1/fr not_active Expired
- 1972-04-07 SE SE7204544A patent/SE389331B/xx unknown
- 1972-04-07 SU SU7201770201A patent/SU580828A3/ru active
- 1972-04-07 HU HUCE872A patent/HU165790B/hu unknown
- 1972-04-07 ZA ZA722331A patent/ZA722331B/xx unknown
- 1972-04-07 DK DK170572A patent/DK143227C/da not_active IP Right Cessation
- 1972-04-08 JP JP3487172A patent/JPS5525177B1/ja active Pending
- 1972-04-10 CH CH524572A patent/CH586182A5/xx not_active IP Right Cessation
- 1972-04-10 CH CH1324975A patent/CH575372A5/xx not_active IP Right Cessation
1973
- 1973-02-26 AR AR246797A patent/AR193590A1/es active
1975
- 1975-02-24 PH PH16845A patent/PH14191A/en unknown
1978
- 1978-08-23 JP JP53101920A patent/JPS5950645B2/ja not_active Expired

Also Published As

Publication number	Publication date
AU459272B2 (en)	1975-03-05
BE781674A (fr)	1972-10-05
HU165790B (fr)	1974-11-28
JPS5525177B1 (fr)	1980-07-04
IL39108A0 (en)	1972-05-30
DE2215409A1 (de)	1973-01-25
DE2215409B2 (de)	1980-02-14
DE2215409C3 (de)	1980-10-09
AR194587A1 (es)	1973-07-31
ES401501A1 (es)	1975-02-16
AR193590A1 (es)	1973-04-30
JPS5950645B2 (ja)	1984-12-10
IE36209L (en)	1972-10-09
CH575372A5 (fr)	1976-05-14
US3884906A (en)	1975-05-20
GB1346266A (en)	1974-02-06
PH15268A (en)	1982-11-02
NL7104839A (fr)	1972-10-11
FR2132788B1 (fr)	1976-05-14
CH586182A5 (fr)	1977-03-31
NL167151B (nl)	1981-06-16
AU4085072A (en)	1973-10-11
FR2132788A1 (fr)	1972-11-24
DK143227C (da)	1981-11-30
DK143227B (da)	1981-07-27
ZA722331B (en)	1973-01-31
IE36209B1 (en)	1976-09-15
PH14191A (en)	1981-03-26
SE389331B (sv)	1976-11-01
JPS557256A (en)	1980-01-19
SU580828A3 (ru)	1977-11-15
NL167151C (nl)	1981-11-16

Publication	Publication Date	Title
IL39108A (en)	1976-04-30	2,2'-methylenediphenols,compositions based thereon and methods for preparing them
SE8304670L (sv)	1983-08-29	Nya cefem- och cefamforeningar och forfaranden for deras framstellning
SE8008533L (sv)	1980-12-04	Antihypertensiva medel
US4147780A (en)	1979-04-03	α-Amino-phosphonous acids for inhibiting bacteria and yeast
GB1282600A (en)	1972-07-19	Basic aryloxyacetamides
DE1951748B2 (de)	1978-06-22	Fluoranthendicarbonsäure-bis-(amino-alkylester) und antivirale Arzneimittel auf deren Basis
US2895993A (en)	1959-07-21	Alkyl substituted anhydrotetracycline compounds and process of preparing the same
IE37655L (en)	1973-11-24	Derivatives of 1-phenoxy-3-aminopropane-2-ol.
GB822659A (en)	1959-10-28	New trimethylhydroxy-phenylchroman derivatives and their preparation
IE43208B1 (en)	1981-01-14	Xanthine derivatives
US3383423A (en)	1968-05-14	Methoxyalkyladamantanes
DE2706227C2 (fr)	1989-09-07
US3857877A (en)	1974-12-31	8-hydroxy quinoline derivatives
IE39269B1 (en)	1978-08-30	Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity
GB1177722A (en)	1970-01-14	Substituted Glucofuranosides, Process for their Manufacture and Compositions Containing Same
US3462437A (en)	1969-08-19	N-dodecyl sulfate of 5-methyl-8-hydroxy quinoline
US1749361A (en)	1930-03-04	Ephedrine-aldehyde compound and solution and process of preparing such compound
GB1377610A (en)	1974-12-18	5-piperidine-4-spiro- oxazolidinones method for their preparation and applications thereof
US2507313A (en)	1950-05-09	5, 8-bis (diethylaminomethyl) quinoline
DE1695849A1 (de)	1971-05-13	Verfahren zur Herstellung neuer Pyrimidinderivate
US3078276A (en)	1963-02-19	- substituted - phenyl-a
US2084033A (en)	1937-06-15	Dichlorohydroxydiphenyl
DE729851C (de)	1943-01-04	Verfahren zur Herstellung von 5, 5-Diphenyl-2, 4-dioxooxazolidin
DE661674C (de)	1938-06-24	Verfahren zur Darstellung von Oxyalkylaminonitrobenzolen
US3439069A (en)	1969-04-15	Monophosphoric acid esters of halogen containing 2,2'-methylenediphenols