IL40785A - Pharmaceutical compositions comprising 2-p-chlorophenoxy-2-methyl-propionic acid and tocopherol - Google Patents

Pharmaceutical compositions comprising 2-p-chlorophenoxy-2-methyl-propionic acid and tocopherol

Info

Publication number: IL40785A
Authority: IL; Israel
Prior art keywords: composition; tocopherol; chlorophenoxy; ester; pharmaceutically acceptable
Prior art date: 1971-12-16

Application number

IL40785A

Other languages

English (en)

Other versions

IL40785A0 (en

Original Assignee

Ici Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-12-16

Filing date

1972-11-09

Publication date

1976-02-29

1972-11-09 Application filed by Ici Ltd filed Critical Ici Ltd

1973-02-28 Publication of IL40785A0 publication Critical patent/IL40785A0/xx

1976-02-29 Publication of IL40785A publication Critical patent/IL40785A/en

Links

GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title claims abstract 6
229960001295 tocopherol Drugs 0.000 title claims abstract 6
239000011732 tocopherol Substances 0.000 title claims abstract 6
229930003799 tocopherol Natural products 0.000 title claims abstract 4
235000010384 tocopherol Nutrition 0.000 title claims abstract 4
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title claims abstract 4
TXCGAZHTZHNUAI-UHFFFAOYSA-N clofibric acid Chemical compound OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 TXCGAZHTZHNUAI-UHFFFAOYSA-N 0.000 title claims abstract 3
239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
239000000203 mixture Substances 0.000 claims abstract 12
150000002148 esters Chemical class 0.000 claims abstract 6
230000000694 effects Effects 0.000 claims abstract 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
239000004480 active ingredient Substances 0.000 claims 2
239000002775 capsule Substances 0.000 claims 2
KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 claims 2
239000003085 diluting agent Substances 0.000 claims 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
229930003427 Vitamin E Natural products 0.000 claims 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
229910021502 aluminium hydroxide Inorganic materials 0.000 claims 1
159000000007 calcium salts Chemical class 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 claims 1
239000000839 emulsion Substances 0.000 claims 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
239000007903 gelatin capsule Substances 0.000 claims 1
239000011591 potassium Substances 0.000 claims 1
229910052700 potassium Inorganic materials 0.000 claims 1
239000000843 powder Substances 0.000 claims 1
239000011734 sodium Substances 0.000 claims 1
229910052708 sodium Inorganic materials 0.000 claims 1
239000001384 succinic acid Substances 0.000 claims 1
239000000725 suspension Substances 0.000 claims 1
239000006188 syrup Substances 0.000 claims 1
235000020357 syrup Nutrition 0.000 claims 1
239000003826 tablet Substances 0.000 claims 1
239000011709 vitamin E Substances 0.000 claims 1
229940046009 vitamin E Drugs 0.000 claims 1
235000019165 vitamin E Nutrition 0.000 claims 1
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract 1
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 abstract 1
150000001298 alcohols Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
229940111131 antiinflammatory and antirheumatic product propionic acid derivative Drugs 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
239000000969 carrier Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000871 hypocholesterolemic effect Effects 0.000 abstract 1
-1 nicotinoyloxy groups Chemical group 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
125000005936 piperidyl group Chemical group 0.000 abstract 1
150000005599 propionic acid derivatives Chemical class 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
235000019155 vitamin A Nutrition 0.000 abstract 1
239000011719 vitamin A Substances 0.000 abstract 1
229940045997 vitamin a Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL40785A 1971-12-16 1972-11-09 Pharmaceutical compositions comprising 2-p-chlorophenoxy-2-methyl-propionic acid and tocopherol IL40785A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB5839871A GB1382587A (en)	1971-12-16	1971-12-16	Pharmaceutical compositions comprising 2-rho-chlorophenoxy-2- methylpropionic acid or a derivative and a tocopherol possessing vitamin e activity

Publications (2)

Publication Number	Publication Date
IL40785A0 IL40785A0 (en)	1973-02-28
IL40785A true IL40785A (en)	1976-02-29

Family

ID=10481514

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL40785A IL40785A (en)	1971-12-16	1972-11-09	Pharmaceutical compositions comprising 2-p-chlorophenoxy-2-methyl-propionic acid and tocopherol

Country Status (11)

Country	Link
JP (1)	JPS4867420A (fr)
AU (1)	AU470387B2 (fr)
BE (1)	BE792855A (fr)
CA (1)	CA981579A (fr)
DE (1)	DE2261504A1 (fr)
FR (1)	FR2163736B1 (fr)
GB (1)	GB1382587A (fr)
IE (1)	IE36820B1 (fr)
IL (1)	IL40785A (fr)
NL (1)	NL7216837A (fr)
ZA (1)	ZA727855B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2730231B1 (fr) *	1995-02-02	1997-04-04	Fournier Sca Lab	Association de fenofibrate et de vitamine e, utilisation en therapeutique

0
- BE BE792855D patent/BE792855A/fr unknown
1971
- 1971-12-16 GB GB5839871A patent/GB1382587A/en not_active Expired
1972
- 1972-11-02 IE IE1489/72A patent/IE36820B1/xx unknown
- 1972-11-06 ZA ZA727855A patent/ZA727855B/xx unknown
- 1972-11-09 IL IL40785A patent/IL40785A/en unknown
- 1972-11-10 AU AU48736/72A patent/AU470387B2/en not_active Expired
- 1972-11-16 CA CA156,665A patent/CA981579A/en not_active Expired
- 1972-12-12 NL NL7216837A patent/NL7216837A/xx not_active Application Discontinuation
- 1972-12-15 DE DE19722261504 patent/DE2261504A1/de active Pending
- 1972-12-15 FR FR7244922A patent/FR2163736B1/fr not_active Expired
- 1972-12-15 JP JP47126036A patent/JPS4867420A/ja active Pending

Also Published As

Publication number	Publication date
JPS4867420A (fr)	1973-09-14
CA981579A (en)	1976-01-13
NL7216837A (fr)	1973-06-19
AU470387B2 (en)	1976-03-11
GB1382587A (en)	1975-02-05
IE36820B1 (en)	1977-03-02
IE36820L (en)	1973-06-16
BE792855A (fr)	1973-06-15
IL40785A0 (en)	1973-02-28
DE2261504A1 (de)	1973-06-28
AU4873672A (en)	1974-05-16
FR2163736B1 (fr)	1976-03-05
ZA727855B (en)	1973-08-29
FR2163736A1 (fr)	1973-07-27

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JP2003526595A5 (fr)	2005-04-07
GB1389814A (en)	1975-04-09	Cysteine derivatives and production thereof
EP0295637B1 (fr)	1991-09-25	Compositions régularisant les lipides
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US4234601A (en)	1980-11-18	Analgesic potentiation
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US4241055A (en)	1980-12-23	Derivatives of aspirin
IE36820L (en)	1973-06-16	Compositions comprising 2-p-chlorophenoxy-2-methylpropionic¹acid and tocopherol
US3013942A (en)	1961-12-19	Therapeutic erythromycin ester compositions
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GB1280244A (en)	1972-07-05	Serum triglyceride-lowering compositions
IL41564A (en)	1976-02-29	Pharmaceutical compositions containing n-cyclohexylbenzylamine derivatives