IL42154A - Process for the separation of stereoisomeric mixtures of 16a,17a-alkylidenedioxy-pregnane derivatives into their components and components obtained thereby - Google Patents

Process for the separation of stereoisomeric mixtures of 16a,17a-alkylidenedioxy-pregnane derivatives into their components and components obtained thereby

Info

Publication number: IL42154A
Authority: IL; Israel
Prior art keywords: stereoisomeric; hydrogen; fluorine; acid; component
Prior art date: 1972-05-19

Application number

IL42154A

Other languages

English (en)

Other versions

IL42154A0 (en

Original Assignee

Bofors Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-05-19

Filing date

1973-05-01

Publication date

1976-12-31

1973-05-01 Application filed by Bofors Ab filed Critical Bofors Ab

1973-07-30 Publication of IL42154A0 publication Critical patent/IL42154A0/xx

1976-12-31 Publication of IL42154A publication Critical patent/IL42154A/en

Links

238000000034 method Methods 0.000 title claims abstract 11
239000000203 mixture Substances 0.000 title claims abstract 7
238000000926 separation method Methods 0.000 title 1
238000002523 gelfiltration Methods 0.000 claims abstract 10
230000014759 maintenance of location Effects 0.000 claims abstract 4
150000003431 steroids Chemical class 0.000 claims abstract 4
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 9
229910052731 fluorine Inorganic materials 0.000 claims 9
239000011737 fluorine Substances 0.000 claims 9
229910052739 hydrogen Inorganic materials 0.000 claims 6
239000001257 hydrogen Substances 0.000 claims 6
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 5
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
OFFSPAZVIVZPHU-UHFFFAOYSA-N 1-benzofuran-2-carboxylic acid Chemical compound C1=CC=C2OC(C(=O)O)=CC2=C1 OFFSPAZVIVZPHU-UHFFFAOYSA-N 0.000 claims 4
125000000217 alkyl group Chemical group 0.000 claims 4
125000004432 carbon atom Chemical group C* 0.000 claims 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
125000001183 hydrocarbyl group Chemical group 0.000 claims 3
229920006395 saturated elastomer Polymers 0.000 claims 3
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
239000003795 chemical substances by application Substances 0.000 claims 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 2
229960003512 nicotinic acid Drugs 0.000 claims 2
235000001968 nicotinic acid Nutrition 0.000 claims 2
239000011664 nicotinic acid Substances 0.000 claims 2
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 2
XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 claims 1
GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 claims 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
229920005654 Sephadex Polymers 0.000 claims 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
239000002253 acid Substances 0.000 claims 1
OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims 1
GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 claims 1
GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 1
229910052799 carbon Inorganic materials 0.000 claims 1
229920001577 copolymer Polymers 0.000 claims 1
150000002148 esters Chemical class 0.000 claims 1
150000002170 ethers Chemical class 0.000 claims 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
229930195733 hydrocarbon Natural products 0.000 claims 1
150000002430 hydrocarbons Chemical class 0.000 claims 1
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 claims 1
235000019260 propionic acid Nutrition 0.000 claims 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
125000001424 substituent group Chemical group 0.000 claims 1
229940005605 valeric acid Drugs 0.000 claims 1
206010061218 Inflammation Diseases 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

IL42154A 1972-05-19 1973-05-01 Process for the separation of stereoisomeric mixtures of 16a,17a-alkylidenedioxy-pregnane derivatives into their components and components obtained thereby IL42154A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE7206645A SE378110B (fr)	1972-05-19	1972-05-19

Publications (2)

Publication Number	Publication Date
IL42154A0 IL42154A0 (en)	1973-07-30
IL42154A true IL42154A (en)	1976-12-31

Family

ID=20269238

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL42154A IL42154A (en)	1972-05-19	1973-05-01	Process for the separation of stereoisomeric mixtures of 16a,17a-alkylidenedioxy-pregnane derivatives into their components and components obtained thereby

Country Status (17)

Country	Link
US (1)	US3928326A (fr)
JP (1)	JPS547794B2 (fr)
BE (1)	BE799728A (fr)
CA (1)	CA1003402A (fr)
CY (1)	CY1012A (fr)
DE (1)	DE2323216C3 (fr)
DK (1)	DK133249C (fr)
FI (1)	FI50711C (fr)
FR (1)	FR2185406B1 (fr)
GB (1)	GB1428416A (fr)
HK (1)	HK49079A (fr)
IL (1)	IL42154A (fr)
KE (1)	KE2969A (fr)
NL (1)	NL175917C (fr)
SE (1)	SE378110B (fr)
SU (1)	SU468408A3 (fr)
ZA (1)	ZA732956B (fr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL188581C (nl) *	1974-07-15	1992-08-03	Akzo Nv	Werkwijze voor het bereiden van 11beta-hydroxy-18-alkylestraanverbindingen.
ZA763131B (en) *	1975-05-27	1978-01-25	Syntex Inc	Use of flunisolide to treat respiratory diseases
SE8008524L (sv) *	1980-12-04	1982-06-05	Draco Ab	4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
IT1196142B (it) *	1984-06-11	1988-11-10	Sicor Spa	Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) *	1986-09-25	1986-09-25	Astra Pharma Prod	A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) *	1990-09-07	1994-03-31	Elmuquimica Farm Sl	Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
SE9100341D0 (sv) *	1991-02-04	1991-02-04	Astra Ab	Novel steroids
RU95115547A (ru) *	1993-01-08	1997-06-10	Астра Актиеболаг (SE)	Стероидные соединения, способы их получения и фармацевтический препарат
DE19635498A1 (de) *	1996-09-03	1998-03-26	Byk Gulden Lomberg Chem Fab	Verfahren zur Epimerenanreicherung
IT1291288B1 (it)	1997-04-30	1999-01-07	Farmabios Srl	Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
US6266556B1 (en)	1998-04-27	2001-07-24	Beth Israel Deaconess Medical Center, Inc.	Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
IL144900A (en)	2001-08-14	2013-12-31	Neurim Pharma 1991	Melatonin and medicaments comprising it for use in treating primary insomnia and in the manufacture of such medicaments
AR045536A1 (es) *	2003-08-29	2005-11-02	Ranbaxy Lab Ltd	Inhibidores de la fosfodiesterasa tipo -iv
US20070259874A1 (en) *	2003-11-26	2007-11-08	Palle Venkata P	Phosphodiesterase Inhibitors
WO2005100356A1 (fr)	2004-04-09	2005-10-27	Merck & Co., Inc.	Inhibiteurs de l'activite d'akt
EP1888050B1 (fr)	2005-05-17	2012-03-21	Merck Sharp & Dohme Ltd.	Acide cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl) cyclohexanepropanoique pour le traitement du cancer
US7915286B2 (en)	2005-09-16	2011-03-29	Ranbaxy Laboratories Limited	Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
EP1948167A1 (fr) *	2005-10-19	2008-07-30	Ranbaxy Laboratories, Ltd.	Compositions d'inhibiteurs de la phosphodiesterase de type iv
RU2008119323A (ru)	2005-10-19	2009-11-27	Рэнбакси Лабораториз Лимитед (In)	Фармацевтические композиции мускаринового рецептора
EP2066661A2 (fr) *	2006-09-22	2009-06-10	Ranbaxy Laboratories Limited	Inhibiteurs de phosphodiesterase
JP2010504323A (ja) *	2006-09-22	2010-02-12	ランバクシーラボラトリーズリミテッド	Ｉｖ型ホスホジエステラーゼの阻害物質
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
CA2674084C (fr)	2006-12-26	2013-05-14	Pharmacyclics, Inc.	Procede d'utilisation des inhibiteurs de l'histone desacetylase et de suivi des biomarqueurs dans une therapie combinee
EP2805945B1 (fr)	2007-01-10	2019-04-03	MSD Italia S.r.l.	Indazoles substitués d'amide en tant qu'inhibiteurs PARP de poly(ADP-ribose)polymérase
US20080207659A1 (en) *	2007-02-15	2008-08-28	Asit Kumar Chakraborti	Inhibitors of phosphodiesterase type 4
US20110130403A1 (en) *	2007-03-14	2011-06-02	Ranbaxy Laboratories Limited	Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors
SI2124944T1 (sl) *	2007-03-14	2012-05-31	Ranbaxy Lab Ltd	Derivati pirazolo b piridina kot inhibitorji fosfodiesteraze
US8389553B2 (en)	2007-06-27	2013-03-05	Merck Sharp & Dohme Corp.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
ITMI20080645A1 (it)	2008-04-11	2009-10-12	Ind Chimica Srl	Procedimento per la preparazione di budesonide
EP2111861A1 (fr)	2008-04-21	2009-10-28	Ranbaxy Laboratories Limited	Compositions d'inhibiteurs de type IV de la phosphodiestérase
GB0900484D0 (en)	2009-01-13	2009-02-11	Angeletti P Ist Richerche Bio	Therapeutic agent
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
US8603521B2 (en)	2009-04-17	2013-12-10	Pharmacyclics, Inc.	Formulations of histone deacetylase inhibitor and uses thereof
BR112012005503B1 (pt) *	2009-09-11	2021-10-13	Chiesi Farmaceutici S.P.A.	Derivados de isoxazolidina
GB0916608D0 (en)	2009-09-22	2009-11-04	Angeletti P Ist Richerche Bio	Therapeutic compounds
EP2488028B1 (fr)	2009-10-14	2020-08-19	Merck Sharp & Dohme Corp.	Pipéridines substituées qui accroissent l'activité de p53 et utilisations de ces composés
JP2013518909A (ja)	2010-02-08	2013-05-23	キナゲン，インク．	アロステリックキナーゼ阻害が関係する治療方法および組成物
WO2011163330A1 (fr)	2010-06-24	2011-12-29	Merck Sharp & Dohme Corp.	Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk
CN107090456B (zh)	2010-08-02	2022-01-18	瑟纳治疗公司	使用短干扰核酸的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1基因表达的抑制
JP2013537423A (ja)	2010-08-17	2013-10-03	メルク・シャープ・エンド・ドーム・コーポレイション	低分子干渉核酸（ｓｉＮＡ）を用いたＢ型肝炎ウイルス（ＨＢＶ）遺伝子発現のＲＮＡ干渉媒介性阻害
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (fr)	2010-09-01	2012-03-08	Schering Corporation	Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk
EP2615916B1 (fr)	2010-09-16	2017-01-04	Merck Sharp & Dohme Corp.	Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk
DK2632472T3 (en)	2010-10-29	2018-03-19	Sirna Therapeutics Inc	RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
WO2012087772A1 (fr)	2010-12-21	2012-06-28	Schering Corporation	Dérivés d'indazole utiles en tant qu'inhibiteurs de erk
EP2699568A1 (fr)	2011-04-21	2014-02-26	Piramal Enterprises Limited	Forme cristalline d'un sel d'un dérivé de morpholinosulfonylindole et son procédé de préparation
RU2609833C2 (ru)	2011-09-13	2017-02-06	Фармасайкликс Элэлси	Лекарственные формы ингибитора гистондиацетилазы в комбинации с бендамутином и их применение
WO2013063214A1 (fr)	2011-10-27	2013-05-02	Merck Sharp & Dohme Corp.	Nouveaux composés qui sont des inhibiteurs d'erk
EP2844261B1 (fr)	2012-05-02	2018-10-17	Sirna Therapeutics, Inc.	Compositions de petit acide nucléique interférent (sina)
JP6453218B2 (ja)	2012-08-24	2019-01-16	ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム	疾患を治療するためのｈｉｆ活性の複素環式修飾物質
US9155747B2 (en) *	2012-09-13	2015-10-13	Chiesi Farmaceutici S.P.A.	Isoxazolidine derivatives
CN105050598B (zh)	2012-09-28	2018-04-27	默沙东公司	作为erk抑制剂的新型化合物
RS56680B1 (sr)	2012-11-28	2018-03-30	Merck Sharp & Dohme	Kompozicije i postupci za lečenje kancera
US8846657B2 (en)	2012-12-20	2014-09-30	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as HDM2 inhibitors
WO2014120748A1 (fr)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
EP3041938A1 (fr)	2013-09-03	2016-07-13	Moderna Therapeutics, Inc.	Polynucléotides circulaires
US11066396B2 (en)	2016-06-23	2021-07-20	Merck Sharp & Dohme Corp.	3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
KR20190074310A (ko)	2016-11-08	2019-06-27	리제너론 파마슈티칼스 인코포레이티드	스테로이드 및 이의 단백질-접합체
CA3063871A1 (fr)	2017-05-18	2018-11-22	Regeneron Pharmaceuticals, Inc.	Conjugues medicamenteux proteiques a base de cyclodextrine
JP7426931B2 (ja)	2017-11-07	2024-02-02	レゲネロンファーマシューティカルス，インコーポレーテッド	抗体薬物コンジュゲートのための親水性リンカー
US11098059B2 (en)	2017-11-08	2021-08-24	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
BR112020013492A2 (pt)	2018-01-08	2020-12-08	Regeneron Pharmaceuticals, Inc.	Esteroides e conjugados de anticorpo dos mesmos
KR20210008008A (ko)	2018-05-09	2021-01-20	리제너론 파마슈티칼스 인코포레이티드	항-msr1 항체 및 이의 사용 방법
CA3108388A1 (fr)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Inhibiteurs de prmt5
EP3833668B1 (fr)	2018-08-07	2025-03-19	Merck Sharp & Dohme LLC	Inhibiteurs de prmt5
EP3833667B1 (fr)	2018-08-07	2024-03-13	Merck Sharp & Dohme LLC	Inhibiteurs de prmt5
WO2020033285A1 (fr)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Inhibiteurs de prmt5
EP4076460B1 (fr)	2019-12-17	2026-01-21	Merck Sharp & Dohme LLC	Dérivés de 1,4-dihydro-2h-spiro[isoquinoline-3,4'-piperidine] en tant qu'inhibiteurs de prmt5 pour le traitement du cancer
JP7589247B2 (ja)	2019-12-17	2024-11-25	メルク・シャープ・アンド・ドーム・エルエルシー	Ｐｒｍｔ５阻害剤
WO2021126728A1 (fr)	2019-12-17	2021-06-24	Merck Sharp & Dohme Corp.	Inhibiteurs de prmt5
GEAP202516720A (en)	2022-09-02	2025-07-10	Merck Sharp & Dohme Llc	Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof
IL320396A (en)	2022-10-25	2025-06-01	Merck Sharp & Dohme Llc	Charge-linkers of anti-drug conjugates derived from extacan, pharmaceutical compositions, and uses thereof
US20240207425A1 (en)	2022-12-14	2024-06-27	Merck Sharp & Dohme Llc	Auristatin linker-payloads, pharmaceutical compositions, and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3133940A (en) *	1956-04-10	1964-05-19	Glaxo Group Ltd	Process for the separation of delta-1, 4-3-keto steroid compounds from mixtures thereof with other 3-keto steroids
US3197469A (en) *	1958-08-06	1965-07-27	Pharmaceutical Res Products In	16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3048581A (en) *	1960-04-25	1962-08-07	Olin Mathieson	Acetals and ketals of 16, 17-dihydroxy steroids
US3128238A (en) *	1962-09-14	1964-04-07	Lilly Co Eli	delta1-dehydrogenation of steroids by fermentation with actinoplanaceae

1972
- 1972-05-19 SE SE7206645A patent/SE378110B/xx unknown
1973
- 1973-05-01 ZA ZA732956A patent/ZA732956B/xx unknown
- 1973-05-01 IL IL42154A patent/IL42154A/en unknown
- 1973-05-09 CY CY1012A patent/CY1012A/xx unknown
- 1973-05-09 GB GB2219573A patent/GB1428416A/en not_active Expired
- 1973-05-09 DE DE2323216A patent/DE2323216C3/de not_active Expired
- 1973-05-14 US US359913A patent/US3928326A/en not_active Expired - Lifetime
- 1973-05-14 FI FI731543A patent/FI50711C/fi active
- 1973-05-17 DK DK277073A patent/DK133249C/da not_active IP Right Cessation
- 1973-05-18 CA CA171,781A patent/CA1003402A/en not_active Expired
- 1973-05-18 NL NLAANVRAGE7306979,A patent/NL175917C/xx not_active IP Right Cessation
- 1973-05-18 BE BE131271A patent/BE799728A/fr not_active IP Right Cessation
- 1973-05-18 FR FR7318126A patent/FR2185406B1/fr not_active Expired
- 1973-05-18 SU SU1918554A patent/SU468408A3/ru active
- 1973-05-19 JP JP5623473A patent/JPS547794B2/ja not_active Expired
1979
- 1979-06-20 KE KE2969A patent/KE2969A/xx unknown
- 1979-07-19 HK HK490/79A patent/HK49079A/xx unknown

Also Published As

Publication number	Publication date
IL42154A0 (en)	1973-07-30
ZA732956B (en)	1974-04-24
JPS4941379A (fr)	1974-04-18
FI50711B (fr)	1976-03-01
KE2969A (en)	1979-07-20
US3928326A (en)	1975-12-23
CY1012A (en)	1979-11-23
BE799728A (fr)	1973-09-17
NL175917C (nl)	1985-01-16
GB1428416A (en)	1976-03-17
AU5525273A (en)	1974-11-07
DE2323216A1 (de)	1973-11-29
DE2323216B2 (de)	1977-11-03
DK133249B (da)	1976-04-12
CA1003402A (en)	1977-01-11
DK133249C (da)	1976-09-13
HK49079A (en)	1979-07-27
NL7306979A (fr)	1973-11-21
JPS547794B2 (fr)	1979-04-10
DE2323216C3 (de)	1978-06-22
NL175917B (nl)	1984-08-16
FR2185406B1 (fr)	1976-12-31
SE378110B (fr)	1975-08-18
FI50711C (fi)	1976-06-10
FR2185406A1 (fr)	1974-01-04
SU468408A3 (ru)	1975-04-25

Publication	Publication Date	Title
IL42154A (en)	1976-12-31	Process for the separation of stereoisomeric mixtures of 16a,17a-alkylidenedioxy-pregnane derivatives into their components and components obtained thereby
US3929768A (en)	1975-12-30	Steroids, processes for their manufacture and preparations containing same
Ellingboe et al.	1970	Liquid-gel chromatography on lipophilic-hydrophobic Sephadex derivatives
Horst et al.	1976	Lymphatic absorption and metabolism of orally administered testosterone undecanoate in man
KR0138777B1 (ko)	1998-04-30	9α-히드록시-17-메틸렌 스테로이드, 그의 제조방법 및 코르티코스테로이드 제조에의 이용
CA1183835A (fr)	1985-03-12	Derives du 4-pregnene, procede de preparation compose et methode de traitement des inflammations
Eneroth et al.	1971	Extraction, purification, and chromatographic analysis of bile acids in biological materials
ES8308571A1 (es)	1983-09-16	Procedimiento para preparar complejos de inclusion de esteroides pobremente solubles en agua con -ciclodextrina.
Pasqualini et al.	1962	Identification of 3β, 21-dihydroxy-5-pregnene-20-one disulfate in human urine
HU178088B (en)	1982-03-28	Process for preparing 3,20-dioxo-4,9-dieno-21-hydroxy-steroids
EP0246654A2 (fr)	1987-11-25	Utilisation d'un polysaccharide sulfaté
Kirson et al.	1975	Withanolides Q and R, two new 23-hydroxy-steroidal lactones
CS195722B2 (en)	1980-02-29	Process for preparing steriod retinoste
Young et al.	1987	Triterpenoid glycosides from Rosa rugosa
D'Auria et al.	1989	Isolation and structure elucidation of seven new polyhydroxylated sulfated sterols from the ophiuroid Ophiolepis superba
Anderson et al.	1973	Preparation and evaluation of a hydroxycyclohexyl derivative of sephadex LH-20
HU176558B (en)	1981-03-28	Process for preparing new n-enolesters of steroids
GB1495531A (en)	1977-12-21	11beta-alkyl steroids of the estrane series
Smith et al.	1976	Trimethylsilyl group migration during electron impact and chemical ionization mass spectrometry of the trimethylsilyl ethers of 20‐hydroxy‐5α‐pregnan‐3‐ones and 20‐hydroxy‐4‐pregnen‐3‐ones
Monder	1964	A new approach to the characterization of steroids containing the 17α-ketol side chain
Pis et al.	2013	Analysis of ecdysteroid conjugates: chromatographic characterization of sulfates, phosphates and glucosides
Rao	1974	Synthesis of compounds of potential value in the radioimmunoassay of 17α-ethynylestradiol and mestranol
Lin et al.	1984	High-performance liquid chromatography of steroidal sapogenins
FANTL et al.	1973	Urinary pregn-5-ene-3α, 16α, 20α-triol in adrenal dysfunction
Heller et al.	1965	The synthesis of some 21-chloro-16α, 17α-acetonides