IL44791A - Cephalosporin cleavage process - Google Patents

Cephalosporin cleavage process

Info

Publication number: IL44791A
Authority: IL; Israel
Prior art keywords: acid; cephalosporin; hydrazine; treatment; reacted
Prior art date: 1973-06-18

Application number

IL44791A

Other languages

English (en)

Other versions

IL44791A0 (en

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-06-18

Filing date

1974-05-09

Publication date

1976-09-30

1974-05-09 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1974-07-31 Publication of IL44791A0 publication Critical patent/IL44791A0/xx

1976-09-30 Publication of IL44791A publication Critical patent/IL44791A/en

Links

229930186147 Cephalosporin Natural products 0.000 title claims 15
229940124587 cephalosporin Drugs 0.000 title claims 15
238000000034 method Methods 0.000 title claims 13
150000001780 cephalosporins Chemical class 0.000 title claims 7
238000003776 cleavage reaction Methods 0.000 title 1
230000007017 scission Effects 0.000 title 1
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 22
239000002253 acid Substances 0.000 claims 17
229910052739 hydrogen Inorganic materials 0.000 claims 9
239000001257 hydrogen Substances 0.000 claims 9
239000000203 mixture Substances 0.000 claims 8
239000011541 reaction mixture Substances 0.000 claims 7
150000002431 hydrogen Chemical class 0.000 claims 6
-1 acetoxy, methoxy, methylthio Chemical group 0.000 claims 5
FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 claims 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
125000004432 carbon atom Chemical group C* 0.000 claims 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
150000001266 acyl halides Chemical class 0.000 claims 2
150000001875 compounds Chemical class 0.000 claims 2
150000003839 salts Chemical class 0.000 claims 2
150000003512 tertiary amines Chemical class 0.000 claims 2
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 2
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 1
125000000217 alkyl group Chemical group 0.000 claims 1
229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
150000008064 anhydrides Chemical class 0.000 claims 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 claims 1
RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical group CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 claims 1
238000010438 heat treatment Methods 0.000 claims 1
229940098779 methanesulfonic acid Drugs 0.000 claims 1
125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL44791A 1973-06-18 1974-05-09 Cephalosporin cleavage process IL44791A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US371011A US3905966A (en)	1973-06-18	1973-06-18	Cephalosporin cleavage process

Publications (2)

Publication Number	Publication Date
IL44791A0 IL44791A0 (en)	1974-07-31
IL44791A true IL44791A (en)	1976-09-30

Family

ID=23462129

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL44791A IL44791A (en)	1973-06-18	1974-05-09	Cephalosporin cleavage process

Country Status (12)

Country	Link
US (1)	US3905966A (fr)
JP (1)	JPS61352B2 (fr)
BE (1)	BE816408A (fr)
CA (1)	CA1018155A (fr)
CH (1)	CH601313A5 (fr)
DE (1)	DE2429166A1 (fr)
ES (2)	ES427388A1 (fr)
FR (1)	FR2233328B1 (fr)
GB (1)	GB1474544A (fr)
IE (1)	IE39253B1 (fr)
IL (1)	IL44791A (fr)
NL (1)	NL7408170A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3994888A (en) *	1973-06-18	1976-11-30	Eli Lilly And Company	Cephalosporin cleavage process
US4001239A (en) *	1973-06-18	1977-01-04	Eli Lilly And Company	Cephalosporin cleavage process
US4039535A (en) *	1973-12-10	1977-08-02	Eli Lilly And Company	7-[α-(GUANYL-1-UREIDO)PHENYLACETAMIDO]-3-SUBSTITUTED CEPHALOSPORIN ANTIBIOTICS
JPS52124221A (en) *	1976-04-10	1977-10-19	Toshizou Miyai	Water tpa with selffclosing valve
CA2041897A1 (fr) *	1990-05-14	1991-11-15	Leland Otto Weigel	Groupe de protection de fonctions amine
US5239069A (en) *	1990-05-14	1993-08-24	Eli Lilly And Company	Amino protecting group
US5169945A (en) *	1990-05-14	1992-12-08	Eli Lilly And Company	Amino protecting group

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3487070A (en) *	1966-01-14	1969-12-30	Bristol Myers Co	3-blocked amino-4-sulfhydryl-2-azetidinones
US3487074A (en) *	1966-01-14	1969-12-30	Bristol Myers Co	Derivatives of 6-amino-3-penamylcarboxylic acid and 7-amino-2,2-dimethyl-cephalosporanic acid
US3769281A (en) *	1970-07-09	1973-10-30	Lilly Co Eli	Deblocking process for cephalosporin antibiotics

1973
- 1973-06-18 US US371011A patent/US3905966A/en not_active Expired - Lifetime
1974
- 1974-05-07 IE IE963/74A patent/IE39253B1/xx unknown
- 1974-05-09 IL IL44791A patent/IL44791A/en unknown
- 1974-05-15 CA CA199,956A patent/CA1018155A/fr not_active Expired
- 1974-06-12 GB GB2683874A patent/GB1474544A/en not_active Expired
- 1974-06-17 BE BE1006024A patent/BE816408A/fr unknown
- 1974-06-18 ES ES427388A patent/ES427388A1/es not_active Expired
- 1974-06-18 JP JP49070086A patent/JPS61352B2/ja not_active Expired
- 1974-06-18 CH CH831974A patent/CH601313A5/xx not_active IP Right Cessation
- 1974-06-18 FR FR7421140A patent/FR2233328B1/fr not_active Expired
- 1974-06-18 NL NL7408170A patent/NL7408170A/xx not_active Application Discontinuation
- 1974-06-18 DE DE2429166A patent/DE2429166A1/de not_active Withdrawn
1976
- 1976-05-17 ES ES448016A patent/ES448016A1/es not_active Expired

Also Published As

Publication number	Publication date
IE39253B1 (en)	1978-08-30
FR2233328A1 (fr)	1975-01-10
ES427388A1 (es)	1976-09-16
CH601313A5 (fr)	1978-07-14
FR2233328B1 (fr)	1977-10-07
IE39253L (en)	1974-12-18
GB1474544A (en)	1977-05-25
CA1018155A (fr)	1977-09-27
US3905966A (en)	1975-09-16
IL44791A0 (en)	1974-07-31
BE816408A (fr)	1974-12-17
JPS61352B2 (fr)	1986-01-08
JPS5036488A (fr)	1975-04-05
DE2429166A1 (de)	1975-01-09
NL7408170A (fr)	1974-12-20
ES448016A1 (es)	1977-07-01

Similar Documents

Publication	Publication Date	Title
ATE52094T1 (de)	1990-05-15	Verfahren zur herstellung von cephalosporinen.
GB1474544A (en)	1977-05-25	Cephalosporin cleavage process
ATE19631T1 (de)	1986-05-15	Verfahren zur herstellung von (3s)-3-(((2-amino-4-thiazolyl)-((1-carboxy-1-me hylethoxy)-imino)acetyl)-amino)-2-oxo-1-azetidinsulfons\|ure und 4- substituierten derivaten.
GB1009302A (en)	1965-11-10	Organic peroxides and a process for preparing them
HUT36799A (en)	1985-10-28	Process for producing cepheme-carboxylic acid derivatives and pharmaceutical compositions containing them
JPS54128591A (en)	1979-10-05	Cephalosporin analog
ATE71383T1 (de)	1992-01-15	Verfahren zur herstellung von cephalosporinestern.
DE3069173D1 (en)	1984-10-18	Substituted phenylamino-2-imidazoline-2 derivatives, their acid addition salts, medicaments containing them and process for their preparation
SE7600585L (sv)	1976-07-23	Forfarande for framstellning av 7-aminocefalosporansyraderivat
GB1474545A (en)	1977-05-25	Penicillin and cephalosporin cleavage process and compounds useful therein
US3825531A (en)	1974-07-23	Process for producing penicillin derivatives
KR100498894B1 (ko)	2005-07-04	1-클로로카르보닐-4-피페리디노피페리딘 또는 그의 염산염 제조방법
US3414586A (en)	1968-12-03	Acetoamido derivatives
US3946002A (en)	1976-03-23	Process for preparing cephalosporins
JPS5653684A (en)	1981-05-13	Production of cephalosporin derivative
KR790001071B1 (ko)	1979-08-24	페니실린 설폭사이드를 전위시켜서 테아세톡시 세팔로스포린을 제조하는 방법
KR790001872B1 (ko)	1979-12-27	세팔로스포린의 제조방법
GB915780A (en)	1963-01-16	21-methylene-progesterone derivatives and compositions thereof
GR3021336T3 (en)	1997-01-31	New process for the preparation of 20-oxo, 17-alpha, 21-dihydroxy derivatives of pregnane and new intermediates thereof.
JPS54112891A (en)	1979-09-04	Preparation of 7-substituted aminocephalosporanic acid derivative
ES8106281A1 (es)	1981-08-01	Procedimiento para la obtencion de derivados de los acidos aminosulfonicos
GB1482388A (en)	1977-08-10	Method of producing 6-beta-amidinopenicillanic acid derivatives
JPS5331628A (en)	1978-03-25	Isolation and purification of aromatic compounds with monohalogenated side chains
IL45101A (en)	1977-01-31	Process for preparing cephalosporins
JPS56158790A (en)	1981-12-07	Preparation of cephalosporin derivative