IL49897A - Pharmaceutical compositions for inhibiting phenylethanolamine n-methyl transferase containing tetrahydroisoquinolines - Google Patents

Pharmaceutical compositions for inhibiting phenylethanolamine n-methyl transferase containing tetrahydroisoquinolines

Info

Publication number: IL49897A
Authority: IL; Israel
Prior art keywords: tetrahydroisoquinolines; pharmaceutical compositions; methyl transferase; phenylethanolamine; inhibiting
Prior art date: 1975-06-26

Application number

IL49897A

Other languages

English (en)

Other versions

IL49897A0 (en

Original Assignee

Smithkline Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-06-26

Filing date

1976-06-24

Publication date

1979-09-30

1975-06-26 Priority claimed from US05/590,772 external-priority patent/US3988339A/en

1976-06-24 Application filed by Smithkline Corp filed Critical Smithkline Corp

1976-08-31 Publication of IL49897A0 publication Critical patent/IL49897A0/xx

1979-09-30 Publication of IL49897A publication Critical patent/IL49897A/xx

Links

108010002822 Phenylethanolamine N-Methyltransferase Proteins 0.000 title 1
102100028917 Phenylethanolamine N-methyltransferase Human genes 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000003526 tetrahydroisoquinolines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
- C07C45/43—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis of >CX2 groups, X being halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

IL49897A 1975-06-26 1976-06-24 Pharmaceutical compositions for inhibiting phenylethanolamine n-methyl transferase containing tetrahydroisoquinolines IL49897A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/590,772 US3988339A (en)	1974-02-08	1975-06-26	Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase

Publications (2)

Publication Number	Publication Date
IL49897A0 IL49897A0 (en)	1976-08-31
IL49897A true IL49897A (en)	1979-09-30

Family

ID=24363639

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL49897A IL49897A (en)	1975-06-26	1976-06-24	Pharmaceutical compositions for inhibiting phenylethanolamine n-methyl transferase containing tetrahydroisoquinolines

Country Status (12)

Country	Link
US (1)	US4062961A (fr)
JP (1)	JPS527445A (fr)
AU (1)	AU499217B2 (fr)
BE (1)	BE843412A (fr)
CA (1)	CA1069440A (fr)
DE (1)	DE2628425A1 (fr)
FR (1)	FR2315276A1 (fr)
GB (1)	GB1561583A (fr)
IE (1)	IE43794B1 (fr)
IL (1)	IL49897A (fr)
NL (1)	NL7606960A (fr)
ZA (1)	ZA763806B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4258049A (en) *	1979-07-02	1981-03-24	Smithkline Corporation	Inhibiting phenylethanolamine N-methyltransferase with thiadiazolo and oxadiazolotetrahydroisoquinolines
US4340600A (en) *	1980-05-22	1982-07-20	Smithkline Corporation	Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3988339A (en) *	1974-02-08	1976-10-26	Smithkline Corporation	Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase

1976
- 1976-06-21 CA CA255,338A patent/CA1069440A/fr not_active Expired
- 1976-06-22 FR FR7618972A patent/FR2315276A1/fr active Granted
- 1976-06-22 GB GB25785/76A patent/GB1561583A/en not_active Expired
- 1976-06-24 IL IL49897A patent/IL49897A/xx unknown
- 1976-06-24 DE DE19762628425 patent/DE2628425A1/de not_active Ceased
- 1976-06-25 AU AU15323/76A patent/AU499217B2/en not_active Expired
- 1976-06-25 NL NL7606960A patent/NL7606960A/xx not_active Application Discontinuation
- 1976-06-25 ZA ZA763806A patent/ZA763806B/xx unknown
- 1976-06-25 BE BE168314A patent/BE843412A/fr not_active IP Right Cessation
- 1976-06-25 IE IE1396/76A patent/IE43794B1/en unknown
- 1976-06-25 JP JP51075950A patent/JPS527445A/ja active Pending
- 1976-08-05 US US05/712,125 patent/US4062961A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US4062961A (en)	1977-12-13
AU499217B2 (en)	1979-04-12
FR2315276A1 (fr)	1977-01-21
ZA763806B (en)	1977-05-25
AU1532376A (en)	1978-01-05
NL7606960A (nl)	1976-12-28
DE2628425A1 (de)	1977-01-20
FR2315276B1 (fr)	1980-03-14
BE843412A (fr)	1976-12-27
JPS527445A (en)	1977-01-20
IE43794L (en)	1976-12-26
IE43794B1 (en)	1981-06-03
CA1069440A (fr)	1980-01-08
IL49897A0 (en)	1976-08-31
GB1561583A (en)	1980-02-27

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