IL59099A - Process for improving the solubility of biologically active compounds in water and/or lower aliphatic alcohols and such new compounds with improved solubility - Google Patents

Process for improving the solubility of biologically active compounds in water and/or lower aliphatic alcohols and such new compounds with improved solubility

Info

Publication number
IL59099A
IL59099A IL59099A IL5909980A IL59099A IL 59099 A IL59099 A IL 59099A IL 59099 A IL59099 A IL 59099A IL 5909980 A IL5909980 A IL 5909980A IL 59099 A IL59099 A IL 59099A
Authority
IL
Israel
Prior art keywords
solubility
improving
water
biologically active
aliphatic alcohols
Prior art date
Application number
IL59099A
Other languages
English (en)
Other versions
IL59099A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19792901060 external-priority patent/DE2901060A1/de
Priority claimed from DE19792910356 external-priority patent/DE2910356A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL59099A0 publication Critical patent/IL59099A0/xx
Publication of IL59099A publication Critical patent/IL59099A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3348—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing nitrogen in addition to sulfur
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IL59099A 1979-01-12 1980-01-09 Process for improving the solubility of biologically active compounds in water and/or lower aliphatic alcohols and such new compounds with improved solubility IL59099A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792901060 DE2901060A1 (de) 1979-01-12 1979-01-12 Verfahren zur verbesserung der loeslichkeit biologisch aktiver wirkstoffe in wasser und niederen aliphatischen alkoholen sowie neue verbindungen mit verbesserter loeslichkeit
DE19792910356 DE2910356A1 (de) 1979-03-16 1979-03-16 Verfahren zur verbesserung der loeslichkeit biologisch aktiver wirkstoffe in wasser und niederen aliphatischen alkoholen sowie neue verbindungen mit verbesserter loeslichkeit

Publications (2)

Publication Number Publication Date
IL59099A0 IL59099A0 (en) 1980-05-30
IL59099A true IL59099A (en) 1984-03-30

Family

ID=25777372

Family Applications (1)

Application Number Title Priority Date Filing Date
IL59099A IL59099A (en) 1979-01-12 1980-01-09 Process for improving the solubility of biologically active compounds in water and/or lower aliphatic alcohols and such new compounds with improved solubility

Country Status (7)

Country Link
US (1) US4684728A (fr)
EP (1) EP0014263B1 (fr)
JP (1) JPS5594337A (fr)
BR (1) BR8000192A (fr)
DE (1) DE2962754D1 (fr)
DK (1) DK13580A (fr)
IL (1) IL59099A (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581434A (en) * 1982-09-04 1986-04-08 Bayer Aktiengesellschaft Process for increasing the duration of action of agents for combating pests
DE4017439C2 (de) * 1990-05-30 1994-06-23 Deutsches Krebsforsch Polyethersubstituierte Tumormittel
JPH06506217A (ja) * 1991-03-18 1994-07-14 エンゾン，インコーポレーテッド ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体
JPH0653222U (ja) * 1992-10-23 1994-07-19 節子 相野谷 トランク・ルームの保冷装置
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
DE69531506T2 (de) * 1994-12-13 2004-06-24 Euroceltique S.A. Arylthioxanthine
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
EP0799040B1 (fr) * 1994-12-13 2003-08-20 Euroceltique S.A. Thioxanthines trisubstituees
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US5780462A (en) * 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
JP2003507382A (ja) * 1999-08-18 2003-02-25 ワイス 水溶性ｓｄｚ−ｒａｄエステル
US6331547B1 (en) 1999-08-18 2001-12-18 American Home Products Corporation Water soluble SDZ RAD esters
MXPA03008192A (es) * 2001-03-23 2004-01-29 Enzon Inc Profarmacos de agentes anticancerigenos que emplean acidos aromaticos sustituidos.
WO2005042641A1 (fr) * 2003-11-04 2005-05-12 Suprapolix B.V. Preparation de polymeres supramoleculaires contenant des unites de liaison hydrogene quadruples dans le squelette polymere
MXPA06011420A (es) * 2004-04-01 2007-04-20 Cardiome Pharma Corp Compuestos pegilados de modulacion de canal de iones.
US7705036B2 (en) * 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
CA2561819A1 (fr) 2004-04-01 2005-12-01 Cardiome Pharma Corp. Promedicaments de composes modulant les canaux ioniques et leurs utilisations
JP5183198B2 (ja) * 2004-07-12 2013-04-17 スープラポリックス ビー．ブイ． 超分子イオノマー
US8692002B2 (en) * 2004-11-18 2014-04-08 Cardiome Pharma Corp. Synthetic process for aminocyclohexyl ether compounds
JP5130201B2 (ja) * 2005-05-04 2013-01-30 スープラポリックス ビー．ブイ． モジュール式生体吸収性又は生物医学用生物活性超分子材料
DE102005023588A1 (de) 2005-05-18 2006-11-23 Grünenthal GmbH Salze substituierter Allophansäureester und deren Verwendung in Arzneimitteln
MX2007016248A (es) 2005-06-15 2008-03-07 Cardiome Pharma Corp Procedimiento sintetico para la preparacion de compuestos de eter aminociclohexilico.
WO2008063057A2 (fr) 2006-11-20 2008-05-29 Suprapolix B.V. Polymères supramoléculaires obtenus à partir d'éléments constitutifs faciles à mettre en œuvre et à bas point de fusion
US8628789B2 (en) * 2007-03-23 2014-01-14 Suprapolix, B.V. Strong reversible hydrogels
EP2310376B1 (fr) * 2008-07-04 2014-11-05 SupraPolix B.V. Composés supra-moléculaires à haut débit
WO2011054795A1 (fr) * 2009-11-03 2011-05-12 Bayer Materialscience Ag Uréthanes fluorés utilisés comme additifs dans une formulation photopolymère
JP5745540B2 (ja) 2009-12-30 2015-07-08 スリーエム イノベイティブ プロパティズ カンパニー オキサリルアミノ基を有するペルフルオロポリエーテル含有化合物
JP6196775B2 (ja) 2009-12-30 2017-09-13 スリーエム イノベイティブ プロパティズ カンパニー ペルフルオロポリエーテルセグメント及びポリジオルガノシロキサンセグメントを有するコポリマー
WO2011082069A1 (fr) 2009-12-30 2011-07-07 3M Innovative Properties Company Procédés de fabrication de copolymères de type polydiorganosiloxane polyoxamide
CN102770478B (zh) 2009-12-30 2014-03-12 3M创新有限公司 具有全氟聚醚链段和多个氨基乙二酰胺基的共聚物
EP2450394B1 (fr) 2010-11-05 2017-06-07 SupraPolix B.V. Procédé de préparation d'un polymère supra-moléculaire
EP4090374A4 (fr) * 2020-01-17 2024-10-09 Children's Medical Center Corporation Promédicaments macromoléculaires pour diodes électroluminescentes et leurs utilisations
CN119306953A (zh) * 2023-07-14 2025-01-14 宁德时代新能源科技股份有限公司 聚合物、制备方法、分散剂、正极浆料、正极极片、二次电池和用电装置

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US2857261A (en) * 1954-04-27 1958-10-21 Monsanto Chemicals Herbicidal sulfoalkyl esters of phenoxyacetates
US4039576A (en) * 1972-03-28 1977-08-02 Ciba-Geigy Corporation Process for the manufacture of alkoxylated N-methylol ureas
CA1023376A (en) * 1972-08-04 1977-12-27 Hermann O. Wirth Hydrophilic and difficultly volatile biocidal triorganometallic compounds
CS179484B1 (en) * 1972-08-18 1977-11-30 Otto Wichterle Method of producing polymeric acrylated or methacrylated carriers of biological active compounds
FR2264522A1 (en) * 1974-03-22 1975-10-17 Rouchy Maurice Vitamin F cpds having surface active properties - comprise linoleic, linolenic and arachidonic acid radical joined via O or N to polyalcohols
US4178427A (en) * 1976-05-05 1979-12-11 Texaco Development Corp. Polyether urea epoxy curing agent
US4154724A (en) * 1976-06-28 1979-05-15 Texaco Development Corp. Polyether polyureides and resinous compositions therefrom
DE2645079A1 (de) * 1976-10-06 1978-04-13 Bayer Ernst Polymere sauerstofftraeger und verfahren zu ihrer herstellung
DE2723248A1 (de) * 1977-05-24 1978-11-30 Bayer Ag Insektizide mittel

Also Published As

Publication number Publication date
EP0014263B1 (fr) 1982-05-05
DE2962754D1 (en) 1982-06-24
EP0014263A2 (fr) 1980-08-20
EP0014263A3 (en) 1980-09-17
DK13580A (da) 1980-07-13
JPS5594337A (en) 1980-07-17
US4684728A (en) 1987-08-04
IL59099A0 (en) 1980-05-30
BR8000192A (pt) 1980-10-21

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