IL64890A - 2-(3,5-diamino-6-halo-pyrazin)carboxamide derivatives,process for their preparation and pharmaceutical compositions containing them - Google Patents
2-(3,5-diamino-6-halo-pyrazin)carboxamide derivatives,process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL64890A IL64890A IL64890A IL6489082A IL64890A IL 64890 A IL64890 A IL 64890A IL 64890 A IL64890 A IL 64890A IL 6489082 A IL6489082 A IL 6489082A IL 64890 A IL64890 A IL 64890A
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- pharmaceutical compositions
- compositions containing
- pyrazin
- diamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8103131 | 1981-02-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL64890A0 IL64890A0 (en) | 1982-03-31 |
| IL64890A true IL64890A (en) | 1986-09-30 |
Family
ID=10519390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL64890A IL64890A (en) | 1981-02-02 | 1982-01-28 | 2-(3,5-diamino-6-halo-pyrazin)carboxamide derivatives,process for their preparation and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4399138A (fr) |
| EP (1) | EP0057572B1 (fr) |
| JP (1) | JPS57163370A (fr) |
| KR (1) | KR830009069A (fr) |
| AT (1) | ATE14576T1 (fr) |
| AU (1) | AU550763B2 (fr) |
| CA (1) | CA1198110A (fr) |
| DE (1) | DE3264964D1 (fr) |
| DK (1) | DK43382A (fr) |
| ES (1) | ES8304952A1 (fr) |
| FI (1) | FI820266L (fr) |
| GR (1) | GR75872B (fr) |
| HU (1) | HU187634B (fr) |
| IE (1) | IE52345B1 (fr) |
| IL (1) | IL64890A (fr) |
| NO (1) | NO820291L (fr) |
| NZ (1) | NZ199627A (fr) |
| PH (1) | PH18070A (fr) |
| PT (1) | PT74373B (fr) |
| YU (1) | YU22082A (fr) |
| ZA (1) | ZA82562B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3361244D1 (de) * | 1982-01-29 | 1986-01-02 | Ici Plc | Alkanolamine derivatives |
| US4604394A (en) * | 1984-10-01 | 1986-08-05 | Merck & Co., Inc. | Antiarrhythmic compositions and method |
| GB8810934D0 (en) * | 1987-05-26 | 1988-06-15 | Ici America Inc | Amides |
| GB8810933D0 (en) * | 1987-05-26 | 1988-06-15 | Ici America Inc | Heterocyclic compounds |
| US4803206A (en) * | 1988-03-07 | 1989-02-07 | Schering Corporation | Antihypertensive acylpyrazines |
| GB8812342D0 (en) * | 1988-05-25 | 1988-06-29 | Ici America Inc | Bicyclic compounds |
| GB8812343D0 (en) * | 1988-05-25 | 1988-06-29 | Ici America Inc | Amino compounds |
| UY36034A (es) | 2014-03-18 | 2015-09-30 | Astrazeneca Ab | Derivados de 3,5-diamino-6-cloro-pirazina-2-carboxamida y sales farmaceuticamente aceptables de estos |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3472847A (en) * | 1966-08-25 | 1969-10-14 | Merck & Co Inc | Conversion of pyrazinoylcyanamides to pyrazinoylguanidines |
| US3577418A (en) * | 1969-02-12 | 1971-05-04 | Merck & Co Inc | Pyrazinamide derivatives and processes for their preparation |
| US3573306A (en) * | 1969-03-05 | 1971-03-30 | Merck & Co Inc | Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides |
| US3544568A (en) * | 1969-03-18 | 1970-12-01 | Merck & Co Inc | 3-amino-5,6-substituted pyrazinamides |
| US3655663A (en) * | 1969-04-21 | 1972-04-11 | Burton K Wasson | 4-(3-secondary amino-2-hydroxy-proxy) 1 2 5-thiadiazoles |
| US3948895A (en) * | 1971-09-28 | 1976-04-06 | E. I. Du Pont De Nemours And Company | Synthesis of 3,5-diaminopyrazinoic acid from 3,5-diamino-2,6-dicyanopyrazine and intermediates |
| US4115575A (en) * | 1973-02-20 | 1978-09-19 | Ciba-Geigy Corporation | 2-(3-Amino-2-hydroxy-propoxy)-pyrazines |
| GB1509527A (en) * | 1974-06-05 | 1978-05-04 | Ici Ltd | 1-(aryl-or heteroaryl)oxy-3-(substituted-amino)propan-2-ol derivatives processes for their manufacture and pharmaceutical compositions containing them |
| US4139623A (en) * | 1974-05-14 | 1979-02-13 | C-G Corp. | Cyclic-substituted derivatives of 1-amino-2-propanol |
| US4115409A (en) * | 1975-12-05 | 1978-09-19 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
| US4085211A (en) * | 1975-12-15 | 1978-04-18 | Merck & Co., Inc. | Pyrazinecarboxamides and processes for preparing same |
| GB1540463A (en) * | 1976-10-07 | 1979-02-14 | Ici Ltd | Alkanolamine derivatives |
| US4219561A (en) * | 1977-09-22 | 1980-08-26 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
-
1982
- 1982-01-27 IE IE175/82A patent/IE52345B1/en unknown
- 1982-01-27 FI FI820266A patent/FI820266L/fi not_active Application Discontinuation
- 1982-01-28 IL IL64890A patent/IL64890A/xx unknown
- 1982-01-28 EP EP82300443A patent/EP0057572B1/fr not_active Expired
- 1982-01-28 AU AU79946/82A patent/AU550763B2/en not_active Ceased
- 1982-01-28 AT AT82300443T patent/ATE14576T1/de not_active IP Right Cessation
- 1982-01-28 ZA ZA82562A patent/ZA82562B/xx unknown
- 1982-01-28 DE DE8282300443T patent/DE3264964D1/de not_active Expired
- 1982-01-29 PH PH26799A patent/PH18070A/en unknown
- 1982-01-29 HU HU82270A patent/HU187634B/hu unknown
- 1982-02-01 YU YU00220/82A patent/YU22082A/xx unknown
- 1982-02-01 NZ NZ199627A patent/NZ199627A/en unknown
- 1982-02-01 CA CA000395265A patent/CA1198110A/fr not_active Expired
- 1982-02-01 DK DK43382A patent/DK43382A/da not_active Application Discontinuation
- 1982-02-01 NO NO820291A patent/NO820291L/no unknown
- 1982-02-02 JP JP57014428A patent/JPS57163370A/ja active Pending
- 1982-02-02 ES ES509250A patent/ES8304952A1/es not_active Expired
- 1982-02-02 KR KR1019820000429A patent/KR830009069A/ko not_active Withdrawn
- 1982-02-02 GR GR67181A patent/GR75872B/el unknown
- 1982-02-02 US US06/344,969 patent/US4399138A/en not_active Expired - Fee Related
- 1982-02-02 PT PT74373A patent/PT74373B/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR830009069A (ko) | 1983-12-17 |
| PH18070A (en) | 1985-03-18 |
| ZA82562B (en) | 1982-12-29 |
| US4399138A (en) | 1983-08-16 |
| AU7994682A (en) | 1982-08-12 |
| EP0057572A1 (fr) | 1982-08-11 |
| GR75872B (fr) | 1984-08-02 |
| YU22082A (en) | 1985-04-30 |
| IL64890A0 (en) | 1982-03-31 |
| PT74373B (en) | 1983-07-14 |
| IE820175L (en) | 1982-08-02 |
| PT74373A (en) | 1982-03-01 |
| EP0057572B1 (fr) | 1985-07-31 |
| ES509250A0 (es) | 1983-03-16 |
| IE52345B1 (en) | 1987-09-16 |
| FI820266A7 (fi) | 1982-08-03 |
| HU187634B (en) | 1986-02-28 |
| DE3264964D1 (de) | 1985-09-05 |
| JPS57163370A (en) | 1982-10-07 |
| AU550763B2 (en) | 1986-04-10 |
| CA1198110A (fr) | 1985-12-17 |
| FI820266L (fi) | 1982-08-03 |
| ATE14576T1 (de) | 1985-08-15 |
| ES8304952A1 (es) | 1983-03-16 |
| DK43382A (da) | 1982-08-03 |
| NZ199627A (en) | 1984-11-09 |
| NO820291L (no) | 1982-08-03 |
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